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Professional activities (2)

Academy of Medical Sciences: London, London, GB

Fellow of the Academy of Medical Sciences
Invited position
Source: Self-asserted source
Laurence Pearl

Royal Society: London, GB

2008-05 | Fellow of the Royal society (FRS)
Distinction
Source: Self-asserted source
Laurence Pearl

Funding (2)

Structure of the Smc5-6 DNA repair and chromosome maintenance protein complex

Source: Self-asserted source
Laurence Pearl via DimensionsWizard

Infrastructure support to the Section of Structural Biology

2002-10-01 to 2007-09-30 | Grant
Cancer Research UK (London, GB)
URL: https://grants.uberresearch.com/501100000289/A3512/Infrastructure-support-to-the-Section-of-Structural-Biology
GRANT_NUMBER:

None
Source: Self-asserted source
Laurence Pearl via DimensionsWizard
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Preferred source (of 6)‎

Works (50 of 214)

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Page 1 of 5

Identifying actionable synthetically lethal cancer gene pairs using mutual exclusivity

FEBS Letters
2024-08 | Journal article
DOI: 10.1002/1873-3468.14950
Contributors: Sarah K. Wooller; Laurence H. Pearl; Frances M. G. Pearl
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Crossref

HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation

Nature Communications
2022-11-29 | Journal article
DOI: 10.1038/s41467-022-35143-2
Contributors: Jasmeen Oberoi; Xavi Aran Guiu; Emily A. Outwin; Pascale Schellenberger; Theodoros I. Roumeliotis; Jyoti S. Choudhary; Laurence H. Pearl
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Crossref

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus

Nature Communications
2022-11-18 | Journal article
DOI: 10.1038/s41467-022-34843-z
Contributors: Angel Rivera-Calzada; Raquel Arribas-Bosacoma; Alba Ruiz-Ramos; Paloma Escudero-Bravo; Jasminka Boskovic; Rafael Fernandez-Leiro; Antony W. Oliver; Laurence H. Pearl; Oscar Llorca
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Crossref

Structure of the human RAD17–RFC clamp loader and 9–1–1 checkpoint clamp bound to a dsDNA–ssDNA junction

Nucleic Acids Research
2022-08-12 | Journal article
DOI: 10.1093/nar/gkac588
Contributors: Matthew Day; Antony W Oliver; Laurence H Pearl
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Crossref

HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation

2022-05-03 | Preprint
DOI: 10.1101/2022.05.03.490524
Contributors: Jasmeen Oberoi; Xavi Aran-Guiu; Emily A. Outwin; Pascale Schellenberger; Theodoros I. Roumeliotis; Jyoti S. Choudhary; Laurence H. Pearl
Source: check_circle
Crossref

Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction

2022-03-12 | Preprint
DOI: 10.1101/2022.03.11.484023
Contributors: Matthew Day; Antony W. Oliver; Laurence H. Pearl
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Crossref

Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1

DNA Repair
2021-12 | Journal article
DOI: 10.1016/j.dnarep.2021.103232
Contributors: Matthew Day; Antony W. Oliver; Laurence H. Pearl
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Crossref

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

2020-11-30 | Other
DOI: 10.1101/2020.11.30.403493
Contributors: X. Chen; Y. Ali; C.E.L. Fisher; R. Arribas-Bosacoma; M.B. Rajasekaran; G. Williams; S. Walker; S.M. Roe; L. H. Pearl; S. E. Ward et al.
Source: check_circle
Crossref

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

2020-11-09 | Preprint
DOI: 10.1101/2020.11.09.374355
Contributors: Mohinder Pal; Hugo Muñoz-Hernandez; Dennis Bjorklund; Lihong Zhou; Gianluca Degliesposti; J. Mark Skehel; Emma L. Hesketh; Rebecca F. Thompson; Laurence H. Pearl; Oscar Llorca et al.
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Crossref

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

2020-10-02 | Preprint
DOI: 10.1101/2020.10.02.323733
Contributors: Matthew Day; Sarah P. Morris; Jack Houghton-Gisby; Antony W. Oliver; Laurence H. Pearl
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Crossref

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

Scientific Reports
2020-09-29 | Journal article
DOI: 10.1038/s41598-020-71969-w
Contributors: John F. Darby; Lewis R. Vidler; Peter J. Simpson; Bissan Al-Lazikani; Stephen J. Matthews; Swee Y. Sharp; Laurence H. Pearl; Swen Hoelder; Paul Workman
Source: check_circle
Crossref

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

eLife
2019-05-28 | Journal article
DOI: 10.7554/eLife.44353
Contributors: Nicolas Bigot; Matthew Day; Robert A Baldock; Felicity Z Watts; Antony W Oliver; Laurence H Pearl
Source: check_circle
Crossref

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

2019-01-02 | Other
DOI: 10.1101/510032
Contributors: Nicolas Bigot; Matthew Day; Robert A. Baldock; Felicity Z. Watts; Antony W. Oliver; Laurence H. Pearl
Source: check_circle
Crossref

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

eLife
2018-10-08 | Journal article
DOI: 10.7554/eLife.39979
Contributors: Matthew Day; Mathieu Rappas; Katie Ptasinska; Dominik Boos; Antony W Oliver; Laurence H Pearl
Source: check_circle
Crossref

N-terminal BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

2018-07-13 | Other
DOI: 10.1101/368936
Contributors: Matthew Day; Mathieu Rappas; Katie Ptasińska; Dominik Boos; Antony W. Oliver; Laurence H. Pearl
Source: check_circle
Crossref

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Nature Communications
2017-01-30 | Journal article
DOI: 10.1038/ncomms14011
Contributors: Aaron Alt; Hung Q. Dang; Owen S. Wells; Luis M. Polo; Matt A. Smith; Grant A. McGregor; Thomas Welte; Alan R. Lehmann; Laurence H. Pearl; Johanne M. Murray et al.
Source: check_circle
Crossref

DNA repair, genome stability and cancer: a historical perspective

Nat Rev Cancer
2016 | Journal article
DOI: 10.1038/nrc.2015.4
Source: Self-asserted source
Laurence Pearl

Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

Nature Chemical Biology
2016-08 | Journal article
DOI: 10.1038/nchembio.2111
Contributors: Andrea Schulze; Gerti Beliu; Dominic A Helmerich; Jonathan Schubert; Laurence H Pearl; Chrisostomos Prodromou; Hannes Neuweiler
Source: check_circle
Crossref

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

Nature Communications
2016-04-11 | Journal article
DOI: 10.1038/ncomms11242
Contributors: Gabrielle J. Grundy; Stuart L. Rulten; Raquel Arribas-Bosacoma; Kathryn Davidson; Zuzanna Kozik; Antony W. Oliver; Laurence H. Pearl; Keith W. Caldecott
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Crossref

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gammaH2AX

Cell Rep
2015 | Journal article
DOI: 10.1016/j.celrep.2015.10.074
Source: Self-asserted source
Laurence Pearl

Corrigendum: The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

Nat Struct Mol Biol
2015 | Journal article
DOI: 10.1038/nsmb0815-645a
Source: Self-asserted source
Laurence Pearl

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Med. Chem. Commun.
2015 | Journal article
DOI: 10.1039/C5MD00210A
Source: Self-asserted source
Laurence Pearl

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

Oncogene
2015 | Journal article
DOI: 10.1038/onc.2013.519
Source: Self-asserted source
Laurence Pearl

Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes

Acta Crystallogr D Biol Crystallogr
2015 | Journal article
DOI: 10.1107/S1399004715004551
Source: Self-asserted source
Laurence Pearl

Therapeutic opportunities within the DNA damage response

Nat Rev Cancer
2015 | Journal article
DOI: 10.1038/nrc3891
Source: Self-asserted source
Laurence Pearl

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors

Anal Biochem
2014 | Journal article
DOI: 10.1016/j.ab.2014.03.004
Source: Self-asserted source
Laurence Pearl

Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1

Structure
2014 | Journal article
DOI: 10.1016/j.str.2014.04.001
Source: Self-asserted source
Laurence Pearl

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

J Med Chem
2013 | Journal article
DOI: 10.1021/jm301575n
Source: Self-asserted source
Laurence Pearl

A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus

PLoS Pathog
2013 | Journal article
DOI: 10.1371/journal.ppat.1003649
Source: Self-asserted source
Laurence Pearl

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

Nat Chem Biol
2013 | Journal article
DOI: 10.1038/nchembio.1212
Source: Self-asserted source
Laurence Pearl

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP(1))

Mol Cell
2013 | Journal article
DOI: 10.1016/j.molcel.2013.08.030
Source: Self-asserted source
Laurence Pearl

The BAH domain of Rsc2 is a histone H3 binding domain

Nucleic Acids Res
2013 | Journal article
DOI: 10.1093/nar/gkt662
Source: Self-asserted source
Laurence Pearl

Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

J Struct Biol
2012 | Journal article
DOI: 10.1016/j.jsb.2012.01.002
Source: Self-asserted source
Laurence Pearl

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

J Med Chem
2012 | Journal article
DOI: 10.1021/jm301034u
Source: Self-asserted source
Laurence Pearl

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

Nat Struct Mol Biol
2012 | Journal article
DOI: 10.1038/nsmb.2335
Source: Self-asserted source
Laurence Pearl

Visualization of a DNA-PK/PARP1 complex

Nucleic Acids Res
2012 | Journal article
DOI: 10.1093/nar/gkr1231
Source: Self-asserted source
Laurence Pearl

A combinatorial method to enable detailed investigation of protein-protein interactions

Future Med Chem
2011 | Journal article
DOI: 10.4155/fmc.10.289
Source: Self-asserted source
Laurence Pearl

CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors

Cancer Res
2011 | Journal article
DOI: 10.1158/0008-5472.CAN-10-1252
Source: Self-asserted source
Laurence Pearl

Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition

J Biol Chem
2011 | Journal article
DOI: 10.1074/jbc.M110.173872
Source: Self-asserted source
Laurence Pearl

Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

Nucleic Acids Res
2011 | Journal article
DOI: 10.1093/nar/gkr146
Source: Self-asserted source
Laurence Pearl

Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90

FASEB J
2011 | Journal article
DOI: 10.1096/fj.11-188821
Source: Self-asserted source
Laurence Pearl

p185, an immunodominant epitope, is an autoantigen mimotope

J Biol Chem
2011 | Journal article
DOI: 10.1074/jbc.M111.224303
Source: Self-asserted source
Laurence Pearl

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans

Curr Biol
2011 | Journal article
DOI: 10.1016/j.cub.2011.05.057
Source: Self-asserted source
Laurence Pearl

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

Nucleic Acids Res
2011 | Journal article
DOI: 10.1093/nar/gkq743
Source: Self-asserted source
Laurence Pearl

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

EMBO J
2011 | Journal article
DOI: 10.1038/emboj.2011.18
Source: Self-asserted source
Laurence Pearl

Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2

J Med Chem
2011 | Journal article
DOI: 10.1021/jm101150b
Source: Self-asserted source
Laurence Pearl

Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies

ACS Chem Biol
2011 | Journal article
DOI: 10.1021/cb200196e
Source: Self-asserted source
Laurence Pearl

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

EMBO J
2011 | Journal article
DOI: 10.1038/emboj.2011.208
Source: Self-asserted source
Laurence Pearl

The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase

Mol Cell
2011 | Journal article
DOI: 10.1016/j.molcel.2011.08.036
Source: Self-asserted source
Laurence Pearl

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

Mol Cell
2011 | Journal article
DOI: 10.1016/j.molcel.2011.02.011
Source: Self-asserted source
Laurence Pearl
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