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HKUST Profile: wang-jiguang
Google Scholar: OIWfp-QAAAAJ
ResearcherID: B-2717-2012
Scopus Author ID: 56394267500
Scopus Author ID: 53879035100
Scopus Author ID: 57189995520
Loop profile: 887117

Keywords

Computational Biology, Cancer Genomics, Precision Medicine, Machine Learning, Complex Network

Countries

Hong Kong SAR China

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Employment (1)

Hong Kong University of Science and Technology: Hong Kong, HK

Employment
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Hong Kong University of Science and Technology

Works (50 of 101)

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Page 1 of 3

DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration

Briefings in Bioinformatics
2021 | Journal article
DOI: 10.1093/bib/bbab048
HANDLE: 1783.1/109230
Contributors: Wang, Yongcui; Yang, Yingxi; Chen, Shilong; Wang, Jiguang
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Hong Kong University of Science and Technology

EmPC-seq: Accurate RNA-sequencing and Bioinformatics Platform to Map RNA Polymerases and Remove Background Error

Bio-protocol
2021 | Journal article
DOI: 10.21769/BioProtoc.3921
HANDLE: 1783.1/107847
Contributors: Wang, Yuqing; Chong, Tin Hang; Unarta, Ilona Christy; Xu, Xinzhou; Suarez, Gianmarco Domenico; Wang, Jiguang; Lis, John; Huang, Xuhui; Cheung, Pak Hang Peter
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Hong Kong University of Science and Technology

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

Nature Genetics
2021 | Journal article
DOI: 10.1038/s41588-020-00772-0
HANDLE: 1783.1/109246
Contributors: Laffleur, Brice; Lim, Junghyun; Zhang, Wanwei; Chen, Yiyun; Pefanis, Evangelos; Bizarro, Jonathan; Batista, Carolina R.; Wu, Lijing; Economides, Aris N.; Wang, Jiguang et al.
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Hong Kong University of Science and Technology

Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation

American Journal of Human Genetics
2021 | Journal article
DOI: 10.1016/j.ajhg.2021.04.005
HANDLE: 1783.1/109718
Contributors: Weng, Jiancong; Yang, Yingxi; Song, Dong; Huo, Ran; Li, Hao; Chen, Yiyun; Nam, Yoonhee; Zhou, Qiuxia; Jiao, Yuming; Fu, Weilun et al.
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Hong Kong University of Science and Technology

A Hepatocyte Differentiation Model Reveals Two Subtypes of Liver Cancer With Different Oncofetal Properties and Therapeutic Targets

Proceedings of the National Academy of Sciences of the United States of America
2020 | Journal article
DOI: 10.1073/pnas.1912146117
HANDLE: 1783.1/103728
Contributors: Liu, Ming; Yan, Qian; Sun, Yi; Nam, Yoonhee; Hu, Liang; Loong, Jane H. C.; Qi, Ouyang; Zhang, Yu; Li, Hao-Long; Kong, Fan-En et al.
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Hong Kong University of Science and Technology

Alternative Splicing of Three Genes Encoding Mechanotransduction-Complex Proteins in Auditory Hair Cells

eNeuro
2020 | Journal article
DOI: 10.1523/eneuro.0381-20.2020
HANDLE: 1783.1/108887
Contributors: Zhou, Zijing; Yu, Xiaojie; Jiang, Biaobin; Feng, Wanying; Tian, Ye; Liu, Zhiyong; Wang, Jiguang; Huang, Pingbo
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Hong Kong University of Science and Technology

CELLO: a longitudinal data analysis toolbox untangling cancer evolution

Quantitative Biology
2020 | Journal article
DOI: 10.1007/s40484-020-0218-1
HANDLE: 1783.1/105836
Contributors: Jiang, Biaobin; Song, Dong; Mu, Quanhua; Wang, Jiguang
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Hong Kong University of Science and Technology

Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-On Circular-Sequencing Coupled with Background Error Modeling

Journal of Molecular Biology
2020 | Journal article
DOI: 10.1016/j.jmb.2020.04.011
HANDLE: 1783.1/102091
Contributors: Cheung, Pak Hang Peter; Jiang, Biaobin; Booth, Gregory T.; Chong, Tin Hang; Unarta, Ilona Christy; Wang, Yuqing; Suarez, Gianmarco Domenico; Wang, Jiguang; Lis, John T.; Huang, Xuhui
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Hong Kong University of Science and Technology

MGMT Genomic Rearrangements Contribute to Chemotherapy Resistance in Gliomas

Nature Communications
2020 | Journal article
DOI: 10.1038/s41467-020-17717-0
HANDLE: 1783.1/104315
Contributors: Oldrini, Barbara; Vaquero-Siguero, Nuria; Mu, Quanhua; Kroon, Paula; Zhang, Ying; Galán-Ganga, Marcos; Bao, Zhaoshi; Wang, Zhang; Liu, Hanjie; Sa, Jason K. et al.
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Hong Kong University of Science and Technology

Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization

Cancer Discovery
2020 | Journal article
DOI: 10.1158/2159-8290.CD-19-1330
HANDLE: 1783.1/104019
Contributors: Liu, Zhaoqi; Yoshimi, Akihide; Wang, Jiguang; Cho, Hana; Lee, Stanley Chun-Wei; Ki, Michelle; Bitner, Lillian; Chu, Timothy; Shah, Harshal; Liu, Bo et al.
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Hong Kong University of Science and Technology

Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination

Science Immunology
2020 | Journal article
DOI: 10.1126/sciimmunol.aay5864
HANDLE: 1783.1/102742
Contributors: Rothschild, Gerson; Zhang, Wanwei; Lim, Junghyun; Giri, Pankaj Kumar; Laffleur, Brice; Chen, Yiyun; Fang, Mingyan; Chen, Yuling; Nair, Lekha; Liu, Zhi-Ping et al.
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Hong Kong University of Science and Technology

Structural Basis for the High-Affinity Interaction between CASK and Mint1

Structure
2020 | Journal article
DOI: 10.1016/j.str.2020.04.001
HANDLE: 1783.1/102810
Contributors: Wu, Xiandeng; Cai, Qixu; Chen, Yiyun; Zhu, Shihan; Mi, Jing; Wang, Jiguang; Zhang, Mingjie
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Hong Kong University of Science and Technology

A Mini-review on Spatiotemporal Evolution of Glioma Under Treatment

Progress in Biochemistry and Biophysics
2019 | Journal article
DOI: 10.16476/j.pibb.2019.0216
HANDLE: 1783.1/101792
Contributors: Lui, Ming-Hong; Jiang, Biaobin; Bao, Zhao-Shi; Wang, Jiguang
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Hong Kong University of Science and Technology

CNAPE: A Machine Learning Method for Copy Number Alteration Prediction from Gene Expression

IEEE/ACM Transactions on Computational Biology and Bioinformatics
2019 | Journal article
DOI: 10.1109/TCBB.2019.2944827
HANDLE: 1783.1/101794
Contributors: Mu, Quanhua; Wang, Jiguang
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Hong Kong University of Science and Technology

Deciphering Brain Complexity Using Single-cell Sequencing

Genomics, Proteomics & Bioinformatics
2019 | Journal article
DOI: 10.1016/j.gpb.2018.07.007
HANDLE: 1783.1/101793
Contributors: Mu, Quanhua; Chen, Yiyun; Wang, Jiguang
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Hong Kong University of Science and Technology

Dynamic MAPK Signaling Activity Underlies a Transition From Growth Arrest to Proliferation in Drosophila Scribble Mutant Tumors

DMM Disease Models and Mechanism
2019 | Journal article
DOI: 10.1242/dmm.040147
HANDLE: 1783.1/98648
Contributors: Ji, Tiantian; Zhang, Lina; Deng, Mingxi; Huang, Shengshuo; Wang, Ying; Pham, Tri Thanh; Smith, Andrew Alan; Sridhar, Varun; Cabernard, Clemens; Wang, Jiguang et al.
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Hong Kong University of Science and Technology

Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma

Annals of Oncology
2019 | Journal article
DOI: 10.1093/annonc/mdz103
HANDLE: 1783.1/98652
Contributors: Xu, L.M.; He, M.H.; Dai, Z.H.; Yu, J.; Wang, Jiguang; Li, X.C.; Jiang, Biaobin; Ke, Z.F.; Su, T.H.; Peng, Z.W. et al.
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Hong Kong University of Science and Technology

Hierarchical Graphical Model Reveals HFR1 Bridging Circadian Rhythm and Flower Development in Arabidopsis Thaliana

NPJ Systems Biology and Applications
2019 | Journal article
DOI: 10.1038/s41540-019-0106-3
HANDLE: 1783.1/98647
Contributors: Duren, Zhana; Wang, Yaling; Wang, Jiguang; Zhao, Xing Ming; Lv, Le; Li, Xiaobo; Liu, Jingdong; Zhu, XinGuang; Chen, Luonan; Wang, Yong
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Hong Kong University of Science and Technology

Repurposing dasatinib for diffuse large B cell lymphoma

PNAS
2019 | Journal article
DOI: 10.1073/pnas.1905239116
HANDLE: 1783.1/98650
Contributors: Scuoppo, Claudio; Wang, Jiguang; Persaud, Mirjana; Mittan, Sandeep K.; Basso, Katia; Pasqualucci, Laura; Rabadan, Raul; Inghirami, Giorgio; Grandori, Carla; Bosch, Francesc et al.
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Hong Kong University of Science and Technology

Single cell transcriptomic landscapes of pattern formation, proliferation and growth in <i>Drosophila</i> wing imaginal discs

Development
2019 | Journal article
DOI: 10.1242/dev.179754
HANDLE: 1783.1/100187
Contributors: Deng, Mingxi; Wang, Ying; Zhang, Lina; Yang, Yang; Huang, Shengshuo; Wang, Jiguang; Ge, H.; Ishibashi, Toyotaka; Yan, Yan
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Hong Kong University of Science and Technology

The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function

CELL METABOLISM
2019 | Journal article
DOI: 10.1016/j.cmet.2019.09.013
HANDLE: 1783.1/101046
Contributors: Singer, Ruth A.; Arnes, Luis; Cui, Yi; Wang, Jiguang; Gao, Yuqian; Guney, Michelle A.; Burnum-Johnson, Kristin E.; Rabadan, Raul; Ansong, Charles; Orr, Galya et al.
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Hong Kong University of Science and Technology

Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma

Gut
2018 | Journal article
Source: Self-asserted source
Wang, Jiguang

Comprehensive Characterisation of Compartment-specific Long Non-coding RNAs Associated With Pancreatic Ductal Adenocarcinoma

Gut
2018 | Journal article
DOI: 10.1136/gutjnl-2017-314353
HANDLE: 1783.1/92434
Contributors: Arnes, Luis; Liu, Zhaoqi; Wang, Jiguang; Maurer, Hans Carlo; Sagalovskiy, Irina; Sanchen-Martin, Marta; Bommarkanti, Nikhil; Garofalo, Diana C.; Balderes, Dina A.; Sussel, Lori et al.
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Hong Kong University of Science and Technology

GeneCT: a generalizable cancerous status and tissue origin classifier for pan-cancer biopsies

Bioinformatics
2018 | Journal article
DOI: 10.1093/bioinformatics/bty524
HANDLE: 1783.1/92431
Contributors: Sun, Kun; Wang, Jiguang; Wang, Huating; Sun, Hao
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Hong Kong University of Science and Technology

GeneCT: a generalizable cancerous status and tissue origin classifier for pan-cancer biopsies

Bioinformatics
2018 | Journal article
Source: Self-asserted source
Wang, Jiguang

Genetic landscape of ultra-stable chronic lymphocytic leukemia patients

Annals of Oncology
2018 | Journal article
DOI: 10.1093/annonc/mdy021
HANDLE: 1783.1/90581
Contributors: Raponi, S.; Del Giudice, I.; Marinelli, M.; Wang, Jiguang; Cafforio, L.; Ilari, C.; Piciocchi, A.; Messina, M.; Bonina, S.; Tavolaro, S. et al.
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Hong Kong University of Science and Technology

Genetic Landscape of Ultra-Stable Chronic Lymphocytic Leukemia Patients

Annals of Oncology
2018 | Journal article
Source: Self-asserted source
Wang, Jiguang

Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Genes & development
2018 | Journal article
Source: Self-asserted source
Wang, Jiguang

Increased HOXA5 Expression Provides a Selective Advantage for Gain of Whole Chromosome 7 in IDH Wild-type Glioblastoma

Genes and Development
2018 | Journal article
DOI: 10.1101/gad.312157.118
HANDLE: 1783.1/90584
Contributors: Cimino, Patrick J.; Kim, Youngmi; Wu, Hua-Jun; Alexander, Jes; Wirsching, Hans-Georg; Szulzewsky, Frank; Pitter, Ken; Ozawa, Tatsuya; Wang, Jiguang; Vazquez, Julio et al.
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Hong Kong University of Science and Technology

Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor

Cell
2018 | Journal article
DOI: 10.1016/j.cell.2018.09.038
HANDLE: 1783.1/93870
Contributors: Hu, Huimin; Mu, Quanhua; Bao, Zhaoshi; Chen, Yiyun; Liu, Yanwei; Chen, Jing; Wang, Kuanyu; Wang, Zheng; Nam, Yoonhee; Jiang, Biaobin et al.
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Hong Kong University of Science and Technology

Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor

Cell
2018 | Journal article
Source: Self-asserted source
Wang, Jiguang

Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization

2018 | Other
Source: Self-asserted source
Wang, Jiguang

Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

Nature Genetics
2018 | Journal article
DOI: 10.1038/s41588-018-0209-6
HANDLE: 1783.1/94128
Contributors: Lee, Jin-Ku; Liu, Zhaoqi; Sa, Jason K.; Shin, Sang; Wang, Jiguang; Bordyuh, Mykola; Cho, Heejin; Elliott, Oliver; Chu, Timothy; Choi, Seung Won et al.
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Hong Kong University of Science and Technology

Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

Nature Genetics
2018 | Journal article
Source: Self-asserted source
Wang, Jiguang

Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low-and very-low-risk genetic profile

Leukemia
2018 | Journal article
DOI: 10.1038/leu.2017.292
HANDLE: 1783.1/92435
Contributors: Giudice, I Del; Rigolin, G. M.; Raponi, S.; Cafforio, L.; Ilari, C.; Wang, Jiguang; Bordyuh, M.; Piciocchi, A.; Marinelli, M.; Nanni, M. et al.
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Hong Kong University of Science and Technology

Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low-and very-low-risk genetic profile

Leukemia
2018 | Journal article
Source: Self-asserted source
Wang, Jiguang

An NF-$κ$B Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

Immunity
2017 | Journal article
Source: Self-asserted source
Wang, Jiguang

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

Immunity
2017 | Journal article
DOI: 10.1016/j.immuni.2017.08.010
HANDLE: 1783.1/89587
Contributors: Hyunju oh; Yenkel grinberg-bleyer; Will liao; Dillon maloney; Pingzhang wang; Zikai wu; Wang, Jiguang; Dev m. bhatt; Nicole heise; Roland m. schmid et al.
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Hong Kong University of Science and Technology

Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas

npj Genomic Medicine
2017 | Journal article
Source: Self-asserted source
Wang, Jiguang

Identification of Potentially Oncogenic Alterations from Tumor-only Samples Reveals Fanconi Anemia Pathway Mutations in Bladder Carcinomas

NPJ Genomic Medicine
2017 | Journal article
DOI: 10.1038/s41525-017-0032-5
HANDLE: 1783.1/87889
Contributors: Madubata, Chioma J.; Roshan-ghias, Alireza; Chu, Timothy; Resnick, Samuel; Zhao, Junfei; Arnes, Luis; Wang, Jiguang; Rabadan, Raul
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Hong Kong University of Science and Technology

Repurposing Dasatinib for Ibrutinib-Resistant Diffuse Large B-Cell Lymphoma

2017 | Other
Source: Self-asserted source
Wang, Jiguang

Repurposing Dasatinib for Ibrutinib-Resistant Diffuse Large B-Cell Lymphoma

Blood
2017 | Journal article
HANDLE: 1783.1/89579
Contributors: Claudio scuoppo; Wang, Jiguang; Mirjana persaud; Sandeep mittan; Laura pasqualucci; Raul rabadan; Carla grandori; Riccardo dalla-favera
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Hong Kong University of Science and Technology

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells

Stem Cell Reports
2017 | Journal article
DOI: 10.1016/j.stemcr.2017.08.024
HANDLE: 1783.1/87641
Contributors: Skamagki, Maria; Zhang, Cheng; Ross, Christian A.; Ananthanarayanan, Aparna; Liu, Zhong; Mu, Quanhua; Basu, Uttiya; Wang, Jiguang; Zhao, Rui; Li, Hu et al.
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Hong Kong University of Science and Technology

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells

Stem Cell Reports
2017 | Journal article
Source: Self-asserted source
Wang, Jiguang

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Nature Genetics
2017 | Journal article
Source: Self-asserted source
Wang, Jiguang

Spatiotemporal Genomic Architecture Informs Precision Oncology in Glioblastoma

Nature Genetics
2017 | Journal article
DOI: 10.1038/ng.3806
HANDLE: 1783.1/85162
Contributors: Lee, Jin-Ku; Wang, Jiguang; Sa, Jason K.; Ladewig, Erik; Lee, Hae-Ock; Lee, In-Hee; Kang, Hyun Ju; Rosenbloom, Daniel S.; Camara, Pablo G.; Liu, Zhaoqi et al.
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Hong Kong University of Science and Technology

Clonal evolution of glioblastoma under therapy

Nature Genetics
2016 | Journal article
DOI: 10.1038/ng.3590
HANDLE: 1783.1/81446
Contributors: Wang, Jiguang; Cazzato, Emanuela; Ladewig, Erik; Frattini, Veronique; Rosenbloom, Daniel I.S.; Zairis, Sakellarios; Abate, Francesco; Liu, Zhaoqi; Elliott, Oliver; Shin, Yongjae et al.
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Hong Kong University of Science and Technology

Genetic Landscape and Gene Expression Profile of Chronic Lymphocytic Leukemia Patients with Ultra-Stable Disease

Clinical Lymphoma Myeloma and Leukemia
2016 | Journal article
DOI: 10.1016/j.clml.2016.07.061
HANDLE: 1783.1/81544
Contributors: Giudice, Ilaria Del; Raponi, Sara; Marinelli, Marilisa; Wang, Jiguang; Cafforio, Luciana; Ilari, Caterina; Messina, Monica; Bonina, Silvia; Tavolaro, Simona; Bordyuh, Mykola et al.
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Hong Kong University of Science and Technology

Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments

British Journal of Haematology
2016 | Journal article
DOI: 10.1111/bjh.13859
HANDLE: 1783.1/81482
Contributors: Del Giudice, Ilaria; Marinelli, Marilisa; Wang, Jiguang; Bonina, Silvia; Messina, Monica; Chiaretti, Sabina; Ilari, Caterina; Cafforio, Luciana; Raponi, Sara; Mauro, Francesca Romana et al.
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Hong Kong University of Science and Technology

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors

eLife
2016 | Journal article
DOI: 10.7554/eLife.14709
HANDLE: 1783.1/81461
Contributors: Yamamoto, Kenta; Wang, Jiguang; Sprinzen, Lisa; Xu, Jun; Haddock, Christopher J.; Li, Chen; Lee, Brian J.; Loredan, Denis G.; Jiang, Wenxia; Vindigni, Alessandro et al.
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Hong Kong University of Science and Technology
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Peer review (13 reviews for 7 publications/grants)

Review activity for Cell genomics. (1)
Review activity for Genome medicine. (1)
Review activity for Genomics, Proteomics & Bioinformatics. (1)
Review activity for Nature communications (5)
Review activity for Nature machine intelligence. (2)
Review activity for Neuro-oncology advances. (2)
Review activity for npj systems biology and applications. (1)
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