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Employment (2)

Saint Louis University: Saint Louis, MO, US

2019 to present
Employment
Source: Self-asserted source
Sofia Origanti

Marquette University: Milwaukee, WI, US

2017 to 2019
Employment
Source: Self-asserted source
Sofia Origanti

Education and qualifications (2)

Washington University School of Medicine/HHMI: St. Louis, US

Postdoctoral Associate (Helen Piwnica-Worms Lab)
Education
Source: Self-asserted source
Sofia Origanti

Penn State Medical Center : Hershey, PA, US

2002-08 to 2007-03 | PhD (Cell and Molecular Physiology)
Qualification
Source: Self-asserted source
Sofia Origanti

Works (22)

Mechanism of RPA phosphocode priming and tuning by Cdk1/Wee1 signaling circuit

2025-01-16 | Preprint
DOI: 10.1101/2025.01.16.633180
Contributors: Poonam Roshan; Vikas Kaushik; Ayush Mistry; Abhinav Vayyeti; Aidan Antony; Riley Luebbers; Jaigeeth Deveryshetty; Edwin Antony; Sofia Origanti
Source: check_circle
Crossref

Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

BioRxiv
2024-06-24 | Preprint | Author
DOI: 10.1101/2024.06.24.600220
Contributors: Poonam Roshan; Aparna Biswas; Stella Anagnos; Riley Luebbers; Kavya Harish; Sinthyia Ahmed; Megan Li; Nicholas Nguyen; Gao Zhou; Frank Tedeschi et al.
Source: Self-asserted source
Sofia Origanti

Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation

2024-03-29 | Preprint
DOI: 10.1101/2024.03.28.587234
Contributors: Rahul Chadda; Vikas Kaushik; Iram Munir Ahmad; Jaigeeth Deveryshetty; Alex Holehouse; Snorri Th.d Sigurdsson; Brian Bothner; Reza Dastvan; Sofia Origanti; Edwin Antony
Source: check_circle
Crossref

An Aurora B-RPA signaling axis secures chromosome segregation fidelity

Nature Communications
2023-05-25 | Journal article | Author
DOI: 10.1038/s41467-023-38711-2
Part of ISSN: 2041-1723
Contributors: Poonam Roshan; Sahiti Kuppa; Jenna R. Mattice; Vikas Kaushik; Nilisha Pokhrel; Brunda R. Tumala; Aparna Biswas; Brian Bothner; Edwin Antony; Sofia Origanti
Source: Self-asserted source
Sofia Origanti

Site-specific labeling of SBDS to monitor interactions with the 60S ribosomal subunit

Methods
2023-02 | Journal article
DOI: 10.1016/j.ymeth.2023.02.004
Part of ISSN: 1046-2023
Contributors: Aparna Biswas; Yu-Fong Peng; Vikas Kaushik; Sofia Origanti
Source: Self-asserted source
Sofia Origanti
grade
Preferred source (of 2)‎

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.

2022-12-22 | Other
DOI: 10.1093/nar/gkac1266
Contributors: Jonah Elliff; Aparna Biswas; Poonam Roshan; Sahiti Kuppa; Mathivanan Chinnaraj; Ryan Burd; Sarah Walker; Nicola Pozzi; Sofia Origanti; Jenna Mattice et al.
Source: check_circle
Crossref

An Aurora B-RPA signaling axis secures chromosome segregation fidelity

2022-09-26 | Preprint
DOI: 10.1101/2022.09.26.509563
Contributors: Poonam Roshan; Sahiti Kuppa; Jenna R. Mattice; Vikas Kaushik; Rahul Chadda; Nilisha Pokhrel; Brunda Tumala; Brian Bothner; Edwin Antony; Sofia Origanti
Source: check_circle
Crossref

Generation of Fluorescent Versions of Saccharomyces cerevisiae RPA to Study the Conformational Dynamics of Its ssDNA-Binding Domains

Methods in Molecular Biology
2021 | Journal article
DOI: 10.1007/978-1-0716-1290-3_9
Part of ISBN: 9781071612897
Part of ISBN: 9781071612903
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Contributors: Sahiti Kuppa; Nilisha Pokhrel; Elliot Corless; Sofia Origanti; Edwin Antony
Source: Self-asserted source
Sofia Origanti

Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3

Journal of Biological Chemistry
2020-09 | Journal article
DOI: 10.1074/jbc.RA120.013324
Contributors: Courtney F. Jungers; Jonah M. Elliff; Daniela S. Masson-Meyers; Christopher J. Phiel; Sofia Origanti
Source: check_circle
Crossref

Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acids

Nucleic Acids Research
2017-07 | Journal article
DOI: 10.1093/nar/gkx598
Part of ISSN: 0305-1048
Contributors: Nilisha Pokhrel; Sofia Origanti; Eric Parker Davenport; Disha Gandhi; Kyle Kaniecki; Ryan A. Mehl; Eric C. Greene; Chris Dockendorff; Edwin Antony
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Rad51 Nucleoprotein Filament Disassembly Captured Using Fluorescent Plasmodium falciparum SSB as a Reporter for Single-Stranded DNA

PLOS ONE
2016-07 | Journal article
DOI: 10.1371/journal.pone.0159242
Part of ISSN: 1932-6203
Contributors: Eric Parker Davenport; Derek F. Harris; Sofia Origanti; Edwin Antony; Arthur J. Lustig
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin

Amino Acids
2016-05 | Journal article
DOI: 10.1007/s00726-016-2261-9
Part of ISSN: 0939-4451
Contributors: Shannon L. Nowotarski; Sofia Origanti; Suzanne Sass-Kuhn; Lisa M. Shantz
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair

Cell Host & Microbe
2015-01 | Journal article
DOI: 10.1016/j.chom.2014.11.004
Part of ISSN: 1931-3128
Contributors: Lulu Sun; Hiroyuki Miyoshi; Sofia Origanti; Timothy J. Nice; Alexandra C. Barger; Nicholas A. Manieri; Leslie A. Fogel; Anthony R. French; David Piwnica-Worms; Helen Piwnica-Worms et al.
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Context-Dependent Remodeling of Rad51–DNA Complexes by Srs2 Is Mediated by a Specific Protein–Protein Interaction

Journal of Molecular Biology
2014-05 | Journal article
DOI: 10.1016/j.jmb.2014.02.014
Part of ISSN: 0022-2836
Contributors: Anna K. Lytle; Sofia S. Origanti; Yupeng Qiu; Jeffrey VonGermeten; Sua Myong; Edwin Antony
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

Oncogene
2012-03 | Journal article
DOI: 10.1038/onc.2012.84
Part of ISSN: 0950-9232
Contributors: S Origanti; S-r Cai; A Z Munir; L S White; H Piwnica-Worms
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells

Biochemical Journal
2012-01 | Journal article
DOI: 10.1042/bj20111464
Part of ISSN: 0264-6021
Contributors: Sofia Origanti; Shannon L. Nowotarski; Theresa D. Carr; Suzanne Sass-Kuhn; Lan Xiao; Jian-Ying Wang; Lisa M. Shantz
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Contributions Made by CDC25 Phosphatases to Proliferation of Intestinal Epithelial Stem and Progenitor Cells

PLoS ONE
2011-01 | Journal article
DOI: 10.1371/journal.pone.0015561
Part of ISSN: 1932-6203
Contributors: Gwanghee Lee; Sofia Origanti; Lynn S. White; Jinwu Sun; Thaddeus S. Stappenbeck; Helen Piwnica-Worms; Ming Tat Ling
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Posttranscriptional Regulation of Ornithine Decarboxylase

Methods in Molecular Biology
2011-01 | Other
DOI: 10.1007/978-1-61779-034-8_17
Part of ISSN: 1064-3745
Contributors: Shannon L. Nowotarski; Sofia Origanti; Lisa M. Shantz
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Ras Transformation of RIE-1 Cells Activates Cap-Independent Translation of Ornithine Decarboxylase: Regulation by the Raf/MEK/ERK and Phosphatidylinositol 3-Kinase Pathways

Cancer Research
2007-05 | Journal article
DOI: 10.1158/0008-5472.can-06-4627
Part of ISSN: 0008-5472
Contributors: S. Origanti; L. M. Shantz
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

Carcinogenesis
2006-01-07 | Journal article
DOI: 10.1093/carcin/bgi343
Part of ISSN: 1460-2180
Contributors: David J. Feith; Sofia Origanti; Paula L. Shoop; Suzanne Sass-Kuhn; Lisa M. Shantz
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

The yeast rRNA biosynthesis factor Ebp2p is also required for efficient nuclear division

Yeast
2004 | Journal article
DOI: 10.1002/yea.1177
Part of ISSN: 0749-503X
Contributors: Costin N. Ionescu; Sofia Origanti; Michael A. McAlear
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search

The flexible N-terminus of BchL protects its [4Fe-4S] cluster in oxygenic environments and autoinhibits activity

Other
DOI: 10.1101/840439
Contributors: Elliot Corless; Syed Muhammad Saad Imran; Maxwell B. Watkins; Sofia Origanti; John-Paul Bacik; Robert Kitelinger; Mark Soffe; Karamatullah Danyal; Lance C. Seefeldt; Brian Bennett et al.
Source: Self-asserted source
Sofia Origanti via Crossref Metadata Search
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