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IAP, apoptosis, cell signaling, ubiquitination, NF-kB, macrophage differentiation, cell proliferatio
France

Activities

Employment (5)

Inserm: Dijon, Burgundy, FR

2004 to present | CRHC Inserm, PI Full time researcher, PhD, HDR (LNC UMR1231, Inserm / Université Bourgogne-Franche-Comté)
Employment
Source: Self-asserted source
Dubrez Laurence

Université de Bourgogne: Dijon, Bourgogne, FR

2001-01-01 to 2003-12-31 | Post-Doc, PhD, full-time researcher (Inserm U517 "Mort cellulaire et Cancer)
Employment
Source: Self-asserted source
Dubrez Laurence

Institut Albert Bonniot: La Tronche, Rhône-Alpes, FR

1998-02 to 2000-12-31 | PhD, Post-Doc Full-time researcher (Inserm E9924)
Employment
Source: Self-asserted source
Dubrez Laurence

University of Manchester: Manchester, Greater Manchester, GB

1997-02 to 1998-02 | PhD (Molecular and Cellular Pharmacology Department, School of Biological Sciences)
Employment
Source: Self-asserted source
Dubrez Laurence

Université de Bourgogne: Dijon, Bourgogne, FR

1993-01-01 to 1996-12 | Doctorant (Inserm CJF 94-04 "Biologie et Thérapie des Cancers")
Employment
Source: Self-asserted source
Dubrez Laurence

Education and qualifications (2)

Université de Bourgogne: Dijon, Bourgogne, FR

2010-01-19 to present | HDR (Ecole Doctorale des Sciences de la vie)
Education
Source: Self-asserted source
Dubrez Laurence

Université de Bourgogne: Dijon, Bourgogne, FR

1996-12-16 to present | PhD (Ecole Doctorale des Sciences de la vie et de la santé)
Education
Source: Self-asserted source
Dubrez Laurence

Professional activities (1)

Université de Bourgogne: Dijon, Bourgogne, FR

2020-09-01 to present | Responsable Master SCM (UFR SVTE, Département SAVAN)
Service
Source: Self-asserted source
Dubrez Laurence

Works (50 of 74)

Items per page:
Page 1 of 2

Towards New Anti‐inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2

ChemMedChem
2024-10-04 | Journal article
Part of ISSN: 1860-7179
Part of ISSN: 1860-7187
Contributors: Marc Ragui Farag; Nicolas Guedeney; Florian Schwalen; Aymeric Zadorovnyj; Amélie Barczyk; Martin Giret; Kevin Antraygues; Alice Wang; Marie Cornu; Peggy Suzanne et al.
Source: Self-asserted source
Dubrez Laurence

From the Design of Innovative Ti‐Pt Heterometallic Complexes to the Development of Highly Anti‐Proliferative Water‐Soluble Cationic Titanocenes

ChemBioChem
2024-07-26 | Journal article
Part of ISSN: 1439-4227
Part of ISSN: 1439-7633
Contributors: Audrey Trommenschlager; Nesrine Mabrouk; Cindy Racoeur; GODARD Amélie; Cédric Balan; Laurence Dubrez; Ali Bettaïeb; Jérôme Husson; Pierre Le Gendre; Catherine Paul et al.
Source: Self-asserted source
Dubrez Laurence

Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2

Nature Structural & Molecular Biology
2023-09 | Journal article | Author
Part of ISSN: 1545-9993
Part of ISSN: 1545-9985
Contributors: Adam H. Tencer; Yucong Yu; Sebastien Z. Causse; Grant R Campbell; Brianna Klein; Hongwen Xuan; Jessy Cartier; Mark Miles; Nitika Gaurav; Aymeric Zadoroznyj et al.
Source: Self-asserted source
Dubrez Laurence

cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3

Oncogene
2023-01-12 | Journal article | Author
Part of ISSN: 0950-9232
Part of ISSN: 1476-5594
Contributors: Baptiste Dumétier; Aymeric Zadoroznyj; Jean Berthelet; Sébastien Causse; Jennifer Allègre; Pauline Bourgeois; Florine Cattin; Cindy Racoeur; Catherine Paul; Carmen Garrido et al.
Source: Self-asserted source
Dubrez Laurence

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

Biomolecules
2022-06-28 | Journal article
Contributors: Gabriel Ichim; Benjamin Gibert; Sahil Adriouch; Catherine Brenner; Nathalie Davoust; Solange Desagher; David Devos; Svetlana Dokudovskaya; Laurence Dubrez; Jérôme Estaquier et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Cytoplasmic and Nuclear Functions of cIAP1

Biomolecules
2022-02-17 | Journal article
Contributors: Aymeric Zadoroznyj; Laurence Dubrez
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Endoplasmic Reticulum Chaperones in Viral Infection: Therapeutic Perspectives

Microbiology and Molecular Biology Reviews
2021-12-15 | Journal article
Part of ISSN: 1092-2172
Part of ISSN: 1098-5557
Source: Self-asserted source
Dubrez Laurence

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death

Frontiers in Immunology
2021-03-08 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Dubrez Laurence

IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling

Cells
2020-04 | Journal article | Author
Contributors: Baptiste Dumétier; Aymeric Zadoroznyj; Dubrez Laurence
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Heat-shock proteins: chaperoning DNA repair

Oncogene
2020-01-16 | Journal article
Contributors: Laurence Dubrez; Sébastien Causse; Natalia Borges Bonan; Baptiste Dumétier; Carmen Garrido
Source: check_circle
Crossref

Rôle inattendu des IAP dans la régulation transcriptionnelle

médecine/sciences
2019-05 | Journal article
Contributors: Baptiste Dumétier; Valérie Glorian; Jennifer Allègre; Laurence Dubrez
Source: check_circle
Crossref

Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia

2019-05 | Journal article
Part of ISSN: 0946-2716
Part of ISSN: 1432-1440
Source: Self-asserted source
Dubrez Laurence

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

2019-05-08 | Journal article
Part of ISSN: 1350-9047
Part of ISSN: 1476-5403
Source: Self-asserted source
Dubrez Laurence

HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells

2019-04 | Journal article
Part of ISSN: 0950-9232
Part of ISSN: 1476-5594
Source: Self-asserted source
Dubrez Laurence

SMAC Mimetics: Promising Therapeutic Agents in Cancer and other Diseases

2018 | Journal article
Part of ISSN: 2167-0501
Source: Self-asserted source
Dubrez Laurence

E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding

2018-10-25 | Journal article
Part of ISSN: 1932-6203
Source: Self-asserted source
Dubrez Laurence

E2F1 interacts with BCL ‐ xL and regulates its subcellular localization dynamics to trigger cell death

EMBO reports
2018-02 | Journal article
Contributors: Céline Vuillier; Steven Lohard; Aurélie Fétiveau; Jennifer Allègre; Cémile Kayaci; Louise E King; Frédérique Braun; Sophie Barillé‐Nion; Fabien Gautier; Laurence Dubrez et al.
Source: check_circle
Crossref

IAPs and Resistance to Death Receptors in Cancer

TRAIL, Fas Ligand, TNF and TLR3 in Cancer
2017 | Other
Part of ISBN: 9783319568041
Part of ISSN: 2196-5501
Contributors: Laurence Dubrez; Simone Fulda
Source: Self-asserted source
Dubrez Laurence via Crossref Metadata Search

Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation

International Journal of Molecular Sciences
2017-10-19 | Journal article
Contributors: Laurence Dubrez
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.

Cell death & disease
2017-05 | Journal article
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

IAPs: Mediators of Oncogenesis and Targets for Anticancer Therapy

2016 | Journal article
Part of ISSN: 0893-9675
Source: Self-asserted source
Dubrez Laurence
grade
Preferred source (of 2)‎

IAPs and cell migration.

2015-03 | Journal article
Contributors: Dubrez L; Rajalingam K
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

Towards the elaboration of new gold-based optical theranostics.

2015-03 | Journal article
Contributors: Doulain PE; Decréau R; Racoeur C; Goncalves V; Dubrez L; Bettaieb A; Le Gendre P; Denat F; Paul C; Goze C et al.
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

[IAP and Rho finally connected].

2014-03 | Journal article
Contributors: Dubrez L; Marivin A; Berthelet J
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central

IAP proteins as targets for drug development in oncology.

2013 | Journal article
Contributors: Dubrez L; Berthelet J; Glorian V
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs).

2013 | Journal article
Contributors: Berthelet J; Dubrez L
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 3)‎

cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation.

2013-11 | Journal article
Contributors: Marivin A; Berthelet J; Cartier J; Paul C; Gemble S; Morizot A; Boireau W; Saleh M; Bertoglio J; Solary E et al.
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress.

2012 | Journal article
Contributors: Marivin A; Berthelet J; Plenchette S; Dubrez L
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 3)‎

[IAPs: a central element in the NF-κB activating signaling pathway].

2012-01 | Journal article
Contributors: Cartier J; Marivin A; Berthelet J; Dubrez L
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

2011-07 | Journal article
Contributors: Cartier J; Berthelet J; Marivin A; Gemble S; Edmond V; Plenchette S; Lagrange B; Hammann A; Dupoux A; Delva L et al.
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 3)‎

cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand.

2009-01 | Journal article
Contributors: Dupoux A; Cartier J; Cathelin S; Filomenko R; Solary E; Dubrez-Daloz L
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

cIAP1-Dependent TRAF2 Degradation Is Required for Macrophage Differentiation and Function

Blood
2008 | Journal article
WOSUID:

WOS:000262104704469

Contributors: Dupoux, Alban; Cartier, Jessy; Marivin, Arthur; Cathelin, Severine; Filomenko, Rodolphe; Solary, Eric; Dubrez-Daloz, Laurence
Source: Self-asserted source
Dubrez Laurence via ResearcherID

IAPs - More than just inhibitors of apoptosis proteins

Cell Cycle
2008 | Journal article
WOSUID:

WOS:000256102600010

Contributors: Dubrez-Daloz, Laurence; Dupoux, Alban; Cartier, Jessy
Source: Self-asserted source
Dubrez Laurence via ResearcherID

Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation

Cell Death and Differentiation
2008 | Journal article
WOSUID:

WOS:000254960500007

Contributors: Didelot, C.; Lanneau, D.; Brunet, M.; Bouchot, A.; Cartier, J.; Jacquel, A.; Ducoroy, P.; Cathelin, S.; Decologne, N.; Chiosis, G. et al.
Source: Self-asserted source
Dubrez Laurence via ResearcherID

IAPs: more than just inhibitors of apoptosis proteins.

2008-04 | Journal article
Contributors: Dubrez-Daloz L; Dupoux A; Cartier J
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central

Analysis of the role of the inhibitory apoptosis protein c-iap1 during cardiomyocyte differentiation

Journal of Molecular and Cellular Cardiology
2005 | Journal article
WOSUID:

WOS:000229806700236

Contributors: Vandroux, D.; Brochot, A.; Dubrez-Daloz, L.; Tissier, C.; Duvillard, L.; Rochette, L.; Athias, P.
Source: Self-asserted source
Dubrez Laurence via ResearcherID

Cooperation of amphiregulin and insulin-like growth factor-1 inhibits bax- and bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells

Journal of Biological Chemistry
2005 | Journal article
WOSUID:

WOS:000229113700042

Contributors: Hurbin, A.; Coll, J. L.; Dubrez-Daloz, L.; Mari, B.; Auberger, P.; Brambilla, C.; Favrot, M. C.
Source: Self-asserted source
Dubrez Laurence via ResearcherID

Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.

2005-05 | Journal article
Contributors: Hurbin A; Coll JL; Dubrez-Daloz L; Mari B; Auberger P; Brambilla C; Favrot MC
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central

Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event.

2004-10 | Journal article
Contributors: Plenchette S; Cathelin S; Rébé C; Launay S; Ladoire S; Sordet O; Ponnelle T; Debili N; Phan TH; Padua RA et al.
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

Bcl-2 proteins: targets and tools for chemosensitisation of tumor cells

Current medicinal chemistry. Anti-cancer agents
2003 | Journal article
WOSUID:

MEDLINE:12769775

Contributors: Bettaieb, Ali; Dubrez-Daloz, Laurence; Launay, Sophie; Plenchette, Stephanie; Rebe, Cedric; Cathelin, Severine; Solary, Eric
Source: Self-asserted source
Dubrez Laurence via ResearcherID

Longterm protection of mice against collagen-induced arthritis after short-term LF 15-0195 treatment: Modulation of B and T lymphocyte activation

Journal of Rheumatology
2003 | Journal article
WOSUID:

WOS:000182639000007

Contributors: Ducoroy, P.; de Fornel, D.; Dubrez-Daloz, L.; Solary, E.; Dutartre, P.
Source: Self-asserted source
Dubrez Laurence via ResearcherID

Regulation of the mitochondrial pathway of apoptosis in MDS erythroid progenitors

Blood
2003 | Journal article
WOSUID:

WOS:000186536700495

Contributors: Claessens, Y. E.; Park, S. V.; Dubrez-Daloz, L.; Garrido-Pelina, C.; Lacombe, C.; Dreyfus, F.; Solary, E.; Fontenay, M.
Source: Self-asserted source
Dubrez Laurence via ResearcherID

Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines.

2003-12 | Journal article
Contributors: Hurbin A; Dubrez L; Coll JL; Favrot MC
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
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Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells.

2003-10 | Journal article
Contributors: Delmas D; Rébé C; Lacour S; Filomenko R; Athias A; Gambert P; Cherkaoui-Malki M; Jannin B; Dubrez-Daloz L; Latruffe N et al.
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

Bcl-2 proteins: targets and tools for chemosensitisation of tumor cells.

2003-07 | Journal article
Contributors: Bettaieb A; Dubrez-Daloz L; Launay S; Plenchette S; Rébé C; Cathelin S; Solary E
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central

Longterm protection of mice against collagen-induced arthritis after short-term LF 15-0195 treatment: modulation of B and T lymphocyte activation.

2003-05 | Journal article
Contributors: Ducoroy P; de Fornel D; Dubrez-Daloz L; Solary E; Dutartre P
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central

Mitochondria as a target for inducing death of malignant hematopoietic cells.

2003-04 | Journal article
Contributors: Solary E; Bettaieb A; Dubrez-Daloz L; Corcos L
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level.

2003-01 | Journal article
Contributors: Ducoroy P; Micheau O; Perruche S; Dubrez-Daloz L; de Fornel D; Dutartre P; Saas P; Solary E
Source: Self-asserted source
Dubrez Laurence via Europe PubMed Central
grade
Preferred source (of 2)‎

Alteration of cell death-related genes in human diseases

M S-Medecine Sciences
2002 | Journal article
WOSUID:

WOS:000177964000018

Contributors: Salary, E.; Bettaieb, A.; Dubrez-Daloz, L.; Garrido, C.
Source: Self-asserted source
Dubrez Laurence via ResearcherID

Intracellular redistribution of procaspases during TPA-induced differentiation of U937 human leukemic cells

Leukemia
2002 | Journal article
WOSUID:

WOS:000177436500029

Contributors: Sordet, O.; Rebe, C.; Dubrez-Daloz, L.; Boudard, D.; Solary, E.
Source: Self-asserted source
Dubrez Laurence via ResearcherID
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Peer review (7 reviews for 5 publications/grants)

Review activity for Cell death and disease. (2)
Review activity for iScience. (1)
Review activity for Journal of experimental & clinical cancer research. (1)
Review activity for Molecules. (2)
Review activity for PloS one. (1)