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Loop profile: 1562523

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Employment (1)

Vilya: South San Francisco, CA, US

2023-08-29 to present | Head of Structural Biology (Structural Biology)
Employment
Source: Self-asserted source
Jeffrey Holden

Education and qualifications (1)

University of California, Irvine: Irvine, CA, US

2010 to 2015 | PhD (Molecular Biology and Biochemistry)
Education
Source: Self-asserted source
Jeffrey Holden

Works (15)

Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.

Nature communications
2024-03-23 | Journal article
DOI: 10.1038/s41467-024-46816-5
PMID: 38521763
Contributors: Juan A Perez-Bermejo; Efagene O; William Matern; Holden JK; Kabir S; Glen Chew; Gaia Andreoletti; Catton E; Ennis CL; Garcia A et al.
Source: Self-asserted source
Jeffrey Holden

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.

Nature communications
2022-09-05 | Journal article
DOI: 10.1038/s41467-022-32760-9
PMID: 36064790
PMC: PMC9445180
Contributors: Stefan Gerhardy; Ultsch M; Wanjian Tang; Green E; Holden JK; Li W; Estevez A; Arthur C; Tom I; Alexis Rohou et al.
Source: Self-asserted source
Jeffrey Holden

Computational Site Saturation Mutagenesis of Canonical and Non-Canonical Amino Acids to Probe Protein-Peptide Interactions.

Frontiers in molecular biosciences
2022-04-14 | Journal article
DOI: 10.3389/fmolb.2022.848689
PMID: 35495632
PMC: PMC9047896
Contributors: Holden JK; Pavlovicz R; Gobbi A; Song Y; Cunningham CN
Source: Self-asserted source
Jeffrey Holden

Incorporating NOE-Derived Distances in Conformer Generation of Cyclic Peptides with Distance Geometry.

Journal of chemical information and modeling
2022-01-14 | Journal article
DOI: 10.1021/acs.jcim.1c01165
PMID: 35029985
Contributors: Shuzhe Wang; Krummenacher K; Gregory Landrum; Benjamin Sellers; Di Lello P; Robinson SJ; Martin B; Holden JK; Tom JYK; Murthy AC et al.
Source: Self-asserted source
Jeffrey Holden

Hippo Pathway

Encyclopedia of Molecular Pharmacology
2021 | Book chapter
DOI: 10.1007/978-3-030-57401-7_10059
Contributors: Jeffrey K. Holden; James J. Crawford
Source: Self-asserted source
Jeffrey Holden

Hippo Pathway

Encyclopedia of Molecular Pharmacology
2021 | Book chapter
DOI: 10.1007/978-3-030-21573-6_10059-1
Source: Self-asserted source
Jeffrey Holden

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Cell Reports
2020-06 | Journal article
DOI: 10.1016/j.celrep.2020.107809
Part of ISSN: 2211-1247
Source: Self-asserted source
Jeffrey Holden

Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors

Cancers
2018-03-20 | Journal article
DOI: 10.3390/cancers10030081
Part of ISSN: 2072-6694
Source: Self-asserted source
Jeffrey Holden

Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors

Biochemistry
2016-10-04 | Journal article
DOI: 10.1021/acs.biochem.6b00786
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Jeffrey Holden

Elucidating nitric oxide synthase domain interactions by molecular dynamics

Protein Science
2016-02 | Journal article
DOI: 10.1002/pro.2824
Part of ISSN: 0961-8368
Part of ISSN: 1469-896X
Source: Self-asserted source
Jeffrey Holden

Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase

Biochemistry
2015-07-07 | Journal article
DOI: 10.1021/acs.biochem.5b00431
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Jeffrey Holden

Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus

Chemistry & Biology
2015-06 | Journal article
DOI: 10.1016/j.chembiol.2015.05.013
Part of ISSN: 1074-5521
Source: Self-asserted source
Jeffrey Holden

Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors

Journal of Medicinal Chemistry
2015-01-22 | Journal article
DOI: 10.1021/jm501723p
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Jeffrey Holden

Identification of Redox Partners and Development of a Novel Chimeric Bacterial Nitric Oxide Synthase for Structure Activity Analyses

Journal of Biological Chemistry
2014-10 | Journal article
DOI: 10.1074/jbc.m114.595165
Part of ISSN: 0021-9258
Source: Self-asserted source
Jeffrey Holden

Structural and biological studies on bacterial nitric oxide synthase inhibitors

Proceedings of the National Academy of Sciences
2013-11-05 | Journal article
DOI: 10.1073/pnas.1314080110
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Jeffrey Holden
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