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Biography

Since Oct. 2013 Research Associate, Fraunhofer Institute for Cell Therapy
and Immunology

Focus:
• Heterologous expression and purification of metalloproteases
• Biochemical characterization of metalloproteases
• Structure elucidation of metalloproteases
• Cell based assay development
• Project management


July 1997 – April 2013 Research Associate, Probiodrug AG

Focus:
• Physicochemical and biochemical analysis of Aβ
• Development of GIP receptor antagonists as novel anti diabetic drugs
• Structure elucidation of GIP receptor N-terminal domain
• Development of Dipeptidyl peptidase IV inhibitors as novel antidiabetic drugs
(PhD thesis)

Sept. 1994 – Sept. 1997 Research Associate, Hans-Knöll-Institute Jena

Focus:
• Liquid and solid phase peptide synthesis
• Synthesis of peptide-based protease inhibitors
• Enzyme kinetic characterization of protease inhibitors

Sept. 1986 – May 1993 Study of Biochemistry, Martin-Luther-University Halle-
Wittenberg

Activities

Works (2)

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

Journal of Enzyme Inhibition and Medicinal Chemistry
2023-12-31 | Journal article
Contributors: Kathrin Tan; Christian Jäger; Stefanie Geissler; Dagmar Schlenzig; Mirko Buchholz; Daniel Ramsbeck
Source: check_circle
Crossref

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

Nature Communications
2022-10-19 | Journal article
Contributors: Charles Bayly-Jones; Christopher J. Lupton; Claudia Fritz; Hariprasad Venugopal; Daniel Ramsbeck; Michael Wermann; Christian Jäger; Alex de Marco; Stephan Schilling; Dagmar Schlenzig et al.
Source: check_circle
Crossref