Personal information

Verified email domains

QM/MM, Snake venom, Drug discovery, Biochemistry
Portugal

Biography

Juliana de Castro Amorim received a bachelor's degree (BSc) in Biology (2015) and a master's degree (MSc) in Biochemistry (2021) by the Sciences Faculty of the University of Porto (FCUP), Portugal. During her bachelor’s internship, she joined the Evolutionary Genomics and Bioinformatics group at the Interdisciplinary Centre of Marine and Environmental Research (CIIMAR, University of Porto) where she acquired some basic competences on the use of bioinformatic tools, comparative genomics, phylogenetic and natural selection studies. In 2021, joined the computational biochemistry group at FCUP where her master thesis research was conducted. This project allowed her to deepen knowledge on some computational techniques (homology modelling, molecular dynamics simulations , molecular docking, virtual screening, and QM/MM calculations). Currently, she is a researcher in REQUIMTE LAQV Porto and a PhD student at FCUP. Her research focuses on the study of snake venom enzyme's reaction mechanisms using hybrid quantum/classical methods and in drug discovery.

Activities

Education and qualifications (3)

University of Porto: Porto, PT

2021-12 to present | PhD in Chemistry (Chemistry and Biochemistry Department)
Education
Source: Self-asserted source
Juliana Castro-Amorim

University of Porto: Porto, PT

2019-09 to 2021-11 | Master's degree in Biochemistry (Chemistry and Biochemistry Department)
Education
Source: Self-asserted source
Juliana Castro-Amorim

University of Porto: Porto, PT

2015-09 to 2019-07 | Bachelor's degree in Biology (Department of Biology)
Education
Source: Self-asserted source
Juliana Castro-Amorim

Funding (3)

Development of an antidote against vipers' envenomation, Nature's deadliest weapon for man.

2024-11-01 to present | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

2024.05812.BD

Source: check_circle
CIÊNCIAVITAE

Murderous Venom- An Universal and Affordable Antidote Against Snakebite

2023-03-08 to 2023-03-27 | Contract
Partnership for Advanced Computing In Europe (Brussels, BE)
GRANT_NUMBER:

EHPC-REG-2022R03-205

Source: check_circle
CIÊNCIAVITAE

Murderous Venom - Towards a Universal Antidote Against Snakebite

2022-01-01 to 2024-10-31 | Grant
REQUIMTE LAQV Porto (Porto, PT)
Part of GRANT_NUMBER:

PTDC/QUI-OUT/1401/2020

GRANT_NUMBER:

REQUIMTE 2021-46

Source: check_circle
CIÊNCIAVITAE

Works (9)

Beyond Fang's fury: a computational study of the enzyme–membrane interaction and catalytic pathway of the snake venom phospholipase A2 toxin

Chemical Science
2025 | Journal article
Contributors: Juliana Castro-Amorim; Alexandre V. Pinto; Ashis K. Mukherjee; Maria J. Ramos; Pedro A. Fernandes
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The application of snake venom in anticancer drug discovery: an overview of the latest developments

Expert Opinion on Drug Discovery
2025-02-26 | Journal article
SOURCE-WORK-ID:

cv-prod-id-4615590

Part of ISSN: 1746-0441
Part of ISSN: 1746-045X
Contributors: da Silva, Joana R.; Castro-Amorim, Juliana; Mukherjee, Ashis K.; Ramos, Maria João; Fernandes, Pedro A.
Source: check_circle
CIÊNCIAVITAE

On the intriguing world of snake venom toxins: Unravelling the catalytic pathway of phospholipase A2 toxin in a membrane model

30th Meeting in Toxinology (RT30) of the SFET, Nice, France
2024-12-02 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4443681

Contributors: Castro-Amorim, Juliana; Alexandre V. Pinto; Ramos, Maria João; Fernandes, Pedro Alexandrino; Autor correspondente: Castro-Amorim, Juliana.
Source: check_circle
CIÊNCIAVITAE

Exploring the Membrane Binding Interactions and Reaction Pathways of Snake Venom Phospholipase A2 Toxin: A Computational Study

XXVIII ENCONTRO GALEGO-PORTUGUÉS DE QUÍMICA
2024-11-14 | Conference abstract
SOURCE-WORK-ID:

cv-prod-id-4407080

Contributors: Castro-Amorim, Juliana
Source: check_circle
CIÊNCIAVITAE

Unraveling the Reaction Mechanism of Russell’s Viper Venom Factor X Activator: A Paradigm for the Reactivity of Zinc Metalloproteinases?

Journal of Chemical Information and Modeling
2023-07-10 | Journal article
Contributors: Juliana Castro-Amorim; Ana Oliveira; Ashis K. Mukherjee; Maria J. Ramos; Pedro A. Fernandes
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction

Journal of Medicinal Chemistry
2023-04-27 | Journal article
Contributors: Juliana Castro-Amorim; Ana Novo de Oliveira; Saulo Luís Da Silva; Andreimar M. Soares; Ashis K. Mukherjee; Maria João Ramos; Pedro A. Fernandes
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Revealing the enzymatic catalysis of Russell's viper venom factor X activator (RVV-X) using computational methods

VII Jornadas da Bioquímica
2022-04-24 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-3374036

Contributors: Castro-Amorim, Juliana; Ana Luísa Novo de Oliveira; Ramos, Maria João; Fernandes, Pedro Alexandrino
Source: check_circle
CIÊNCIAVITAE

Disclosing the molecular basis of substrate recognition of Russell's viper (Daboia russelii russelii) venom factor X activating enzyme (RVVX)

VII Jornadas da Bioquímica
2021-05-09 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-3374064

Contributors: Castro-Amorim, Juliana; Ana Luísa Novo de Oliveira; Ramos, Maria João; Fernandes, Pedro Alexandrino
Source: check_circle
CIÊNCIAVITAE

Hop Extract: An Efficacious Antimicrobial and Anti-biofilm Agent Against Multidrug-Resistant Staphylococci Strains and Cutibacterium acnes

Frontiers in Microbiology
2020-08-13 | Journal article
SOURCE-WORK-ID:

cv-prod-id-3082875

Part of ISSN: 1664-302X
Contributors: Di Lodovico, S.; Menghini, L.; Ferrante, C; Recchia, E.; Castro-Amorim, J.; Gameiro, P.; Cellini, L.; Bessa, L.J.
Source: check_circle
CIÊNCIAVITAE