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Oslo University Hospital: Oslo, NO

2009-09-06 to present | Senior Researcher (Department of Medical Genetics)
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Timothy Hughes

Works (10)

Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

2024-11-20 | Preprint
DOI: 10.7554/eLife.101499.1
Contributors: Tobias Kaufmann; Pål Marius Bjørnstad; Martin Falck; Stener Nerland; Kevin O’Connell; Oleksandr Frei; Ole A Andreassen; Lars T Westlye; Srdjan Djurovic; Timothy Hughes
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Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

2024-11-20 | Preprint
DOI: 10.7554/eLife.101499
Contributors: Tobias Kaufmann; Pål Marius Bjørnstad; Martin Falck; Stener Nerland; Kevin O’Connell; Oleksandr Frei; Ole A Andreassen; Lars T Westlye; Srdjan Djurovic; Timothy Hughes
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Bipolar patients display stoichiometric imbalance of gene expression in post-mortem brain samples

Molecular Psychiatry
2024-04 | Journal article
DOI: 10.1038/s41380-023-02398-0
Contributors: Asbjørn Holmgren; Ibrahim Akkouh; Kevin Sean O’Connell; Jordi Requena Osete; Pål Marius Bjørnstad; Srdjan Djurovic; Timothy Hughes
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Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids

Molecular Psychiatry
2023-07 | Journal article
DOI: 10.1038/s41380-023-01944-0
Contributors: Jordi Requena Osete; Ibrahim A. Akkouh; Oleksandr Ievglevskyi; Matthieu Vandenberghe; Denis Reis de Assis; Thor Ueland; Elena Kondratskaya; Børge Holen; Attila Szabo; Timothy Hughes et al.
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Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes

Translational Psychiatry
2023-05-05 | Journal article
DOI: 10.1038/s41398-023-02442-1
Contributors: Anja Torsvik; Hans-Richard Brattbakk; Andrea Trentani; Rita Holdhus; Christine Stansberg; Christoffer A. Bartz-Johannessen; Timothy Hughes; Nils Eiel Steen; Ingrid Melle; Srdjan Djurovic et al.
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Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

2022-08-22 | Preprint
DOI: 10.1101/2022.08.19.22278950
Contributors: Tobias Kaufmann; Pål Marius Bjørnstad; Martin Falck; Stener Nerland; Kevin O’Connell; Oleksandr Frei; Ole A. Andreassen; Lars T. Westlye; Srdjan Djurovic; Timothy Hughes
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Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain

Translational Psychiatry
2022-01-28 | Journal article
DOI: 10.1038/s41398-022-01784-6
Contributors: Asbjørn Holmgren; Lars Hansson; Kristine Bjerkaas-Kjeldal; Agata Antonia Rita Impellizzeri; Gregor D. Gilfillan; Srdjan Djurovic; Timothy Hughes
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Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders

Molecular Psychiatry
2021-11 | Journal article
DOI: 10.1038/s41380-021-01164-4
Contributors: Jordi Requena Osete; Ibrahim A. Akkouh; Denis Reis de Assis; Attila Szabo; Evgeniia Frei; Timothy Hughes; Olav B. Smeland; Nils Eiel Steen; Ole A. Andreassen; Srdjan Djurovic
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A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

Translational Psychiatry
2021-10-29 | Journal article
DOI: 10.1038/s41398-021-01681-4
Contributors: Attila Szabo; Ibrahim A. Akkouh; Matthieu Vandenberghe; Jordi Requena Osete; Timothy Hughes; Vivi Heine; Olav B. Smeland; Joel C. Glover; Ole A. Andreassen; Srdjan Djurovic
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Exploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step study

Neuropsychopharmacology
2020-05-25 | Journal article
DOI: 10.1038/s41386-019-0556-8
Contributors: Ibrahim A. Akkouh; Silje Skrede; Asbjørn Holmgren; Kari M. Ersland; Lars Hansson; Shahram Bahrami; Ole A. Andreassen; Vidar M. Steen; Srdjan Djurovic; Timothy Hughes
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