Personal information

Endocrinology, Islet biology
Japan

Activities

Employment (6)

Jichi Medical University: Shimotsuke, Tochigi, JP

2024-04-01 to present | Professor (Department of Anatomy)
Employment
Source: Self-asserted source
Wataru Nishimura

International University of Health and Welfare School of Medicine: Narita, Chiba, JP

2017-04-01 to 2024-03-31 | Professor (Department of Molecular Biology)
Employment
Source: Self-asserted source
Wataru Nishimura

Jichi Medical University: Shimotsuke-shi, Tochigi, JP

2014-10-01 to 2017-03-31 | Associate Profesor (Division of Anatomy, Bio-imaging and Neuro-cell Science)
Employment
Source: Self-asserted source
Wataru Nishimura

Diabetes Center, NCGM: Shinjuku-ku, Tokyo, JP

2009-10-01 to 2014-09-30 | Division Cheif (Metabolic Disorders)
Employment
Source: Self-asserted source
Wataru Nishimura

Joslin Diabetes Center: Boston, MA, US

2003-04-01 to 2009-09-30 | Postdoctoral Fellow (Islet Cell & Regenerative Medicine)
Employment
Source: Self-asserted source
Wataru Nishimura

Tokyo Medical and Dental University: Bunkyo-ku, Tokyo, JP

2001-06-01 to 2003-03-31 | Assistant Professor (Medical Biochemistry)
Employment
Source: Self-asserted source
Wataru Nishimura

Education and qualifications (1)

Okayama University: Okayama, Okayama, JP

M.D., Ph.D. (Gastroenterological Surgery)
Education
Source: Self-asserted source
Wataru Nishimura

Funding (19)

Role of extracellular matrix on function, differentiation and proliferation of pancreatic beta-cells

2023-04-01 to 2026-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 23K07995
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Analyses of effects of beta-cell disallowed genes on glucose metabolism

2020-04-01 to 2023-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20K08915
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Identification of biomarker for dysfunction of pancreatic beta-cells

2018-12 to 2019-11 | Grant
Japan Diabetes Foundation (Tokyo, JP)
Source: Self-asserted source
Wataru Nishimura

Analysis of genes specifically repressed in mature beta-cells of pancreas

2017-04-01 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 17K09843
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Analysis of regulatory mechanism of inflammatory cytokine by miRNAs and development to novel treatment.

2016-04-01 to 2019-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 16K10471
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Effects of confinement stress on homeostasis of the mammalian endocrine system and metabolism

2016-04-01 to 2018-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 16H01647
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Novel therapy for beta-cell dedifferentiation

2016-04 to 2017-03 | Grant
Novartis Foundation (Basel, CH)
Source: Self-asserted source
Wataru Nishimura

Lineage tracing and improvement of pancreatic β-cells after transplantation

2015-04 to 2016-03 | Grant
Okinaka Memorial Institute for Medical Research (Tokyo, JP)
Source: Self-asserted source
Wataru Nishimura

Role of incretin for dedifferentiation of pancreatic β-cells

2015-04 to 2016-03 | Grant
Lilly-Incretin Japan Diabetes Foundation (Tokyo, JP)
Source: Self-asserted source
Wataru Nishimura

Genome wide methylation analysis for homeostasis of pancreatic beta-cells

2014-04-01 to 2017-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 26461351
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Elucidation of novel mechanism regulating mass and function of pancreatic β-cells

2013-04 to 2014-09 | Grant
National Center for Global Health and Medicine (Tokyo, JP)
GRANT_NUMBER:

25-110

Source: Self-asserted source
Wataru Nishimura

Molecular mechanism regulating neonatal proliferation of pancreatic β-cells

2012-04 to 2013-03 | Grant
Japan Diabetes Foundation (Tokyo, JP)
Source: Self-asserted source
Wataru Nishimura

Development of system evaluating pancreatic β-cell function

2011-04 to 2012-03 | Grant
National Center for Global Health and Medicine (Tokyo, JP)
GRANT_NUMBER:

23-110

Source: Self-asserted source
Wataru Nishimura

Imaging of pancreatic β-cell function

2010-04 to 2013-03 | Grant
Grant from the National Center for Global Health and Medicine (Tokyo, JP)
GRANT_NUMBER:

22-103

Source: Self-asserted source
Wataru Nishimura

Role of nicotinamide and NAD-dependent enzyme on pancreatic β-cells

2010-04 to 2013-03 | Grant
National Center for Global Health and Medicine (Tokyo, JP)
GRANT_NUMBER:

22-117

Source: Self-asserted source
Wataru Nishimura

Expression of transcription factors in compromised β-cells

2010-04 to 2011-03 | Grant
Takeda Science Foundation (Osaka, JP)
Source: Self-asserted source
Wataru Nishimura

Rescue of beta-cell function by transcription factors MafA and Pdx1

2010-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 22591022
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Characterization of cMaf in Development of Pancreatic Endocrine Cells

2005-04-01 to 2007-03-30 | Grant
Juvenile Diabetes Research Foundation (New York, US)
GRANT_NUMBER:

3-2005-74

Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Protein-protein interactions underlying the formation of microdomains on the cell surface

2002-01-01 to 2003-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 14370042
Source: Self-asserted source
Wataru Nishimura via DimensionsWizard

Works (41)

Gene expression of cytokines and prostaglandin metabolism-related proteins in eosinophilic otitis media.

The journal of allergy and clinical immunology. Global
2024-03 | Journal article
Contributors: Oka A; Takahashi M; Nishimura W; Oyamada S; Oka S; Iwasaki S; Kanai K; Okano M
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells.

Scientific reports
2023-10 | Journal article
Contributors: Udagawa H; Funahashi N; Nishimura W; Uebanso T; Kawaguchi M; Asahi R; Nakajima S; Nammo T; Hiramoto M; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Macroarray expression analysis of cytokines and prostaglandin metabolism-related genes in chronic rhinosinusitis.

The journal of allergy and clinical immunology. Global
2023-06 | Journal article
Contributors: Oka A; Kanai K; Higaki T; Makihara S; Noda Y; Kariya S; Ando M; Nishimura W; Okano M
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Role of the Transcription Factor MAFA in the Maintenance of Pancreatic β-Cells

International Journal of Molecular Sciences
2022-04-19 | Journal article
Contributors: Wataru Nishimura; Hiroaki Iwasa; Munkhtuya Tumurkhuu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Effect of long-term confinement on metabolic and physiological parameters in mice.

Physiology & behavior
2021-03 | Journal article
Contributors: Nishimura W; Takayanagi Y; Tumurkhuu M; Zhou R; Miki H; Noda Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.

JCI insight
2021-01 | Journal article
Contributors: Amo-Shiinoki K; Tanabe K; Hoshii Y; Matsui H; Harano R; Fukuda T; Takeuchi T; Bouchi R; Takagi T; Hatanaka M et al.
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Characterization of the taste receptor-related G-protein, α-gustducin, in pancreatic β-cells.

Journal of diabetes investigation
2020-02 | Journal article
Contributors: Udagawa H; Hiramoto M; Kawaguchi M; Uebanso T; Ohara-Imaizumi M; Nammo T; Nishimura W; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice

Diabetologia
2018-12-03 | Journal article
Contributors: Takao Nammo; Haruhide Udagawa; Nobuaki Funahashi; Miho Kawaguchi; Takashi Uebanso; Masaki Hiramoto; Wataru Nishimura; Kazuki Yasuda
Source: check_circle
Crossref

Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons.

Experimental cell research
2018-07 | Journal article
Contributors: Mochizuki S; Miki H; Zhou R; Kido Y; Nishimura W; Kikuchi M; Noda Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Optical clearing of the pancreas for visualization of mature β-cells and vessels in mice

Islets
2018-05-04 | Journal article
Contributors: Wataru Nishimura; Asako Sakaue-Sawano; Satoru Takahashi; Atsushi Miyawaki; Kazuki Yasuda; Yasuko Noda
Source: check_circle
Crossref

Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2-positive breast cancer.

Oncology letters
2017-01 | Journal article
Contributors: Ohzawa H; Miki A; Teratani T; Shiba S; Sakuma Y; Nishimura W; Noda Y; Fukushima N; Fujii H; Hozumi Y et al.
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Mechanism of the Dendritic Translation and Localization of Brain-derived Neurotrophic Factor.

2016-03 | Journal article
Contributors: Oe S; Miki H; Nishimura W; Noda Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors.

2015 | Journal article
Contributors: Nishimura W; Kapoor A; El Khattabi I; Jin W; Yasuda K; Bonner-Weir S; Sharma A
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Generation and characterization of MafA-Kusabira Orange mice.

2015 | Journal article
Contributors: Nishimura W; Oishi H; Funahashi N; Fujiwara T; Takahashi S; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Comparative analysis of type 2 diabetes-associated SNP alleles identifies allele-specific DNA-binding proteins for the KCNQ1 locus.

2015-07 | Journal article
Contributors: Hiramoto M; Udagawa H; Watanabe A; Miyazawa K; Ishibashi N; Kawaguchi M; Uebanso T; Nishimura W; Nammo T; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.

2015-07 | Journal article
Contributors: Asahara S; Etoh H; Inoue H; Teruyama K; Shibutani Y; Ihara Y; Kawada Y; Bartolome A; Hashimoto N; Matsuda T et al.
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Demethylation of the MafB promoter in a compromised β-cell model.

2015-06 | Journal article
Contributors: Nishimura W; Ishibashi N; Eto K; Funahashi N; Udagawa H; Miki H; Oe S; Noda Y; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

MafA is critical for maintenance of the mature beta cell phenotype in mice.

2015-03 | Journal article
Contributors: Nishimura W; Takahashi S; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Comparison between the antiemetic effects of palonosetron and granisetron in breast cancer patients treated with anthracycline-based regimens.

2015-01 | Journal article
Contributors: Ohzawa H; Miki A; Hozumi Y; Miyazaki C; Sagara Y; Tanaka Y; Shiba S; Joutoku H; Sakuragi M; Takehara M et al.
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

MafA is required for postnatal proliferation of pancreatic β-cells.

2014 | Journal article
Contributors: Eto K; Nishimura W; Oishi H; Udagawa H; Kawaguchi M; Hiramoto M; Fujiwara T; Takahashi S; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Quantitative assessment of Pdx1 promoter activity in vivo using a secreted luciferase reporter system.

2013-11 | Journal article
Contributors: Nishimura W; Eto K; Miki A; Goto M; Kawaguchi M; Nammo T; Udagawa H; Hiramoto M; Shimizu Y; Okamura T et al.
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells.

2013-06 | Journal article
Contributors: Yokouchi H; Eto K; Nishimura W; Takeda N; Kaburagi Y; Yamamoto S; Yasuda K
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats.

2010-08 | Journal article
Contributors: Li WC; Rukstalis JM; Nishimura W; Tchipashvili V; Habener JF; Sharma A; Bonner-Weir S
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.

2010-01 | Journal article
Contributors: Vetere A; Li WC; Paroni F; Juhl K; Guo L; Nishimura W; Dai X; Bonner-Weir S; Sharma A
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.

2009-09 | Journal article
Contributors: Nishimura W; Bonner-Weir S; Sharma A
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

p38 MAPK is a major regulator of MafA protein stability under oxidative stress.

2009-08 | Journal article
Contributors: Kondo T; El Khattabi I; Nishimura W; Laybutt DR; Geraldes P; Shah S; King G; Bonner-Weir S; Weir G; Sharma A
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin.

2008-10 | Journal article
Contributors: Jiang Y; Nishimura W; Devor-Henneman D; Kusewitt D; Wang H; Holloway MP; Dohi T; Sabo E; Robinson ML; Altieri DC et al.
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

2008-02 | Journal article
Contributors: Nishimura W; Rowan S; Salameh T; Maas RL; Bonner-Weir S; Sell SM; Sharma A
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.

2006-05 | Journal article
Contributors: Nishimura W; Kondo T; Salameh T; El Khattabi I; Dodge R; Bonner-Weir S; Sharma A
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Regulation of insulin gene expression by overlapping DNA-binding elements.

2005-11 | Journal article
Contributors: Nishimura W; Salameh T; Kondo T; Sharma A
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Synaptic scaffolding molecule interacts with axin.

2004-07 | Journal article
Contributors: Hirabayashi S; Nishimura W; Iida J; Kansaku A; Kishida S; Kikuchi A; Tanaka N; Hata Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains.

2003-11 | Journal article
Contributors: Ohno H; Hirabayashi S; Kansaku A; Yao I; Tajima M; Nishimura W; Ohnishi H; Mashima H; Fujita T; Omata M et al.
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.

2003-06 | Journal article
Contributors: Hirabayashi S; Tajima M; Yao I; Nishimura W; Mori H; Hata Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Synaptic localization of SAPAP1, a synaptic membrane-associated protein.

2003-02 | Journal article
Contributors: Yao I; Iida J; Nishimura W; Hata Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein.

2002-07 | Journal article
Contributors: Yao I; Iida J; Nishimura W; Hata Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain.

2002-05 | Journal article
Contributors: Iida J; Nishimura W; Yao I; Hata Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Interaction of synaptic scaffolding molecule and Beta -catenin.

2002-02 | Journal article
Contributors: Nishimura W; Yao I; Iida J; Tanaka N; Hata Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Basaloid-squamous cell carcinoma of the esophagus: diagnosis based on immunohistochemical analysis.

2001-05 | Journal article
Contributors: Nishimura W; Naomoto Y; Hamaya K; Toda S; Miyagi K; Tanaka N
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Localization of BAI-associated protein1/membrane-associated guanylate kinase-1 at adherens junctions in normal rat kidney cells: polarized targeting mediated by the carboxyl-terminal PDZ domains.

2000-12 | Journal article
Contributors: Nishimura W; Iizuka T; Hirabayashi S; Tanaka N; Hata Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071.

2000-09 | Journal article
Contributors: Deguchi M; Iizuka T; Hata Y; Nishimura W; Hirao K; Yao I; Kawabe H; Takai Y
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

The beneficial effect of tamoxifen therapy in patients with resected adenocarcinoma of the pancreas.

1996 | Journal article
PMID: 8908555
Contributors: Horimi T; Takasaki M; Toki A; Nishimura W; Morita S
Source: Self-asserted source
Wataru Nishimura via Europe PubMed Central

Peer review (2 reviews for 2 publications/grants)

Review activity for Anatomical science international. (1)
Review activity for Communications biology. (1)