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Scopus Author ID: 6507431108
Loop profile: 499634

Countries

United Kingdom

Biography

Dr. Concetta Bubici holds the position of Senior Lecturer in Biomedical Science at Brunel University London, within the College of Health, Medicine, and Life Sciences. Additionally, she holds positions as an honorary lecturer at Imperial College London and a visiting senior lecturer at the University of Leeds. She is deeply involved in cutting-edge research exploring the physiological functions of protein kinases and transcription factors and their impact on human diseases such as cancer, inflammation, and immunity. Furthermore, Dr. Bubici is dedicated to educating the next generation of scientists through her teaching in both undergraduate and postgraduate programs in biological science. Her focus on molecular and cell biology ensures that students receive a comprehensive and up-to-date education in these critical areas of study.

Activities

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Employment (4)

Brunel University London: London, GB

2019 to present | Senior Lecturer (Department of Life Sciences, College of Health, Medicine and Life Sciences)
Employment
Source: Self-asserted source
Concetta Bubici

Imperial College London: London, London, GB

2012 to present | Honorary Lecturer
Employment
Source: Self-asserted source
Concetta Bubici

Brunel University: Uxbridge, Middlesex, GB

2013 to 2018 | Lecturer (Department of Life Sciences)
Employment
Source: Self-asserted source
Concetta Bubici

Imperial College London: London, London, GB

2007 to 2012 | Lecturer
Employment
Source: Self-asserted source
Concetta Bubici

Education and qualifications (4)

Higher Education Academy: London, GB

Fellow of the Higher Education Academy
Education
Source: Self-asserted source
Concetta Bubici

University of L'Aquila: L’Aquila, IT

2003 to present | PhD in Experimental Medicine
Education
Source: Self-asserted source
Concetta Bubici

Imperial College London: London, London, GB

2011 to 2012 | Certificate of Advanced Study in Learning and Teaching
Education
Source: Self-asserted source
Concetta Bubici

University of L'Aquila: L’Aquila, IT

1992 to 1998 | 'Laurea Doctorate' in Biological Science 5-years course
Education
Source: Self-asserted source
Concetta Bubici

Professional activities (4)

University of Leeds: Leeds, GB

2023 to present | Visiting Senior Lecturer (Faculty of Medicine and Health)
Invited position
Source: Self-asserted source
Concetta Bubici

Frontiers Media SA: Lausanne, VD, CH

2020 to present | Associate Editor
Membership
Source: Self-asserted source
Concetta Bubici

Imperial College London: London, London, GB

2012 to present | Honorary Lecturer
Invited position
Source: Self-asserted source
Concetta Bubici

Springer Nature Limited: London, London, GB

2021 to 2023 | Guest Editor for Methods in Molecular Biology
Service
Source: Self-asserted source
Concetta Bubici

Funding (7)

Mechanisms of cancer resistance

2024-05 to present | Grant
Leukaemia & Myeloma Research (London, GB)
GRANT_NUMBER: 2024
Source: Self-asserted source
Concetta Bubici

Inflammation and liver cancer

2021 to 2024 | Grant
Guts UK (London, GB)
Source: Self-asserted source
Concetta Bubici

The survival mechanisms of myeloma cells

2021 to 2024 | Grant
Kay Kendall Leukaemia Fund (London, GB)
GRANT_NUMBER:

KKL1361
Source: Self-asserted source
Concetta Bubici

Mechanisms of liver diseases

2020-05 to 2023 | Grant
Rosetrees Trust (London, GB)
Source: Self-asserted source
Concetta Bubici

Reversing treatment resistance in myeloma

2018 to 2022 | Grant
Blood Cancer UK (London, GB)
GRANT_NUMBER: 17014
Source: Self-asserted source
Concetta Bubici

CONTROL OF APOPTOSIS IN CANCER

2016 to 2017 | Award
Brunel University London (London, GB)
GRANT_NUMBER:

.
Source: Self-asserted source
Concetta Bubici

Mechanisms for NF-κB-mediated survival of multiple myeloma

2010 to 2013 | Grant
Kay Kendall Leukaemia Fund (London, GB)
GRANT_NUMBER:

KKL443
Source: Self-asserted source
Concetta Bubici

Works (33)

An Integrated Methodology to Quantify the Glycolytic Stress in Plasma Cell Myeloma in Response to Cytotoxic Drugs

2023 | Book chapter
DOI: 10.1007/978-1-0716-3247-5_21
Contributors: Alessio Lepore; Fatma Necmiye Kaci; Concetta Bubici; Salvatore Papa
Source: check_circle
Crossref

Screening Kinase-Dependent Phosphorylation of Key Metabolic Reprogramming Regulators

2023 | Book chapter
DOI: 10.1007/978-1-0716-3247-5_16
Contributors: Fatma Necmiye Kaci; Alessio Lepore; Salvatore Papa; Concetta Bubici
Source: check_circle
Crossref

STARD1: a new rising StAR in cholesterol-mediated hepatocarcinogenesis.

Hepatobiliary surgery and nutrition
2021-12 | Journal article
DOI: 10.21037/hbsn-21-374
PMID: 35004970
PMC: PMC8683904
Contributors: Papa S; Bubici C; Syn WK
Source: Self-asserted source
Concetta Bubici via Europe PubMed Central

Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth.

Hepatology (Baltimore, Md.)
2021-09 | Journal article
DOI: 10.1002/hep.31983
PMID: 34048060
Contributors: Lepore A; Choy PM; Lee NCW; Carella MA; Favicchio R; Briones-Orta MA; Glaser SS; Alpini G; D'Santos C; Tooze RM et al.
Source: Self-asserted source
Concetta Bubici via Europe PubMed Central

ASKing No More: The Emerging Role of Dual‐Specific Phosphatase 12 in the Regulation of Hepatic Lipid Metabolism

Hepatology
2019-10 | Journal article
DOI: 10.1002/hep.30851
Contributors: Concetta Bubici; Alessio Lepore; Salvatore Papa
Source: check_circle
Crossref

The ERK and JNK pathways in the regulation of metabolic reprogramming

Oncogene
2019-03-28 | Journal article
DOI: 10.1038/s41388-018-0582-8
Contributors: Salvatore Papa; Pui Man Choy; Concetta Bubici
Source: check_circle
Crossref

Feeding the Hedgehog: A new meaning for JNK signalling in liver regeneration

Journal of Hepatology
2018 | Journal article
DOI: 10.1016/j.jhep.2018.05.026
EID:

2-s2.0-85048349248
Contributors: Papa, S.; Bubici, C.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

High expression of glycolytic genes in Cirrhosis correlates with the risk of developing liver cancer

Frontiers in Cell and Developmental Biology
2018 | Journal article
DOI: 10.3389/fcell.2018.00138
EID:

2-s2.0-85055828388
Contributors: Lee, N.C.; Carella, M.A.; Papa, S.; Bubici, C.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Linking apoptosis to cancer metabolism: Another missing piece of JuNK

Molecular and Cellular Oncology
2016 | Journal article
DOI: 10.1080/23723556.2015.1103398
EID:

2-s2.0-85025438421
Contributors: Papa, S.; Bubici, C.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

Nature Communications
2015 | Journal article
DOI: 10.1038/ncomms8882
EID:

2-s2.0-84938936173
Contributors: Iansante, V.; Choy, P.M.; Fung, S.W.; Liu, Y.; Chai, J.-G.; Dyson, J.; Del Rio, A.; D'Santos, C.; Williams, R.; Chokshi, S. et al.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

JNK signalling in cancer: In need of new, smarter therapeutic targets

British Journal of Pharmacology
2014 | Journal article
DOI: 10.1111/bph.12432
EID:

2-s2.0-84890284499
Contributors: Bubici, C.; Papa, S.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma

Oncogene
2013 | Journal article
DOI: 10.1038/onc.2012.448
EID:

2-s2.0-84883743073
Contributors: Barbarulo, A.; Iansante, V.; Chaidos, A.; Naresh, K.; Rahemtulla, A.; Franzoso, G.; Karadimitris, A.; Haskard, D.O.; Papa, S.; Bubici, C.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Mechanisms of liver disease: Cross-talk between the NF-κB and JNK pathways

Biological Chemistry
2009 | Journal article
DOI: 10.1515/BC.2009.111
EID:

2-s2.0-70349308534
Contributors: Papa, S.; Bubici, C.; Zazzeroni, F.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

The NF-kappaB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-kappaB activity.

Methods in molecular biology (Clifton, N.J.)
2009 | Journal article
DOI: 10.1007/978-1-60327-530-9_10
EID:

2-s2.0-67650376399
Contributors: Mauro, C.; Zazzeroni, F.; Papa, S.; Bubici, C.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

Journal of Clinical Investigation
2008 | Journal article
DOI: 10.1172/JCI33913
EID:

2-s2.0-43049132158
Contributors: Papa, S.; Zazzeroni, F.; Fu, Y.-X.; Bubici, C.; Alvarez, K.; Dean, K.; Christiansen, P.A.; Anders, R.A.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

A method for isolating prosurvival targets of NF-kappaB/Rel transcription factors.

Methods in molecular biology (Clifton, N.J.)
2007 | Journal article
EID:

2-s2.0-40949115420
Contributors: Kuntzen, C.; Zazzeroni, F.; Pham, C.G.; Papa, S.; Bubici, C.; Knabb, J.R.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Insights into the structural basis of the GADD45β-mediated inactivation of the JNK kinase, MKK7/JNKK2

Journal of Biological Chemistry
2007 | Journal article
DOI: 10.1074/jbc.M703112200
EID:

2-s2.0-34547102525
Contributors: Papa, S.; Monti, S.M.; Vitale, R.M.; Bubici, C.; Jayawardena, S.; Alvarez, K.; De Smaele, E.; Dathan, N.; Pedone, C.; Ruvo, M. et al.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Upregulation of twist-1 by NF-κB blocks cytotoxicity induced by chemotherapeutic drugs

Molecular and Cellular Biology
2007 | Journal article
DOI: 10.1128/MCB.01219-06
EID:

2-s2.0-34347358621
Contributors: Pham, C.G.; Bubici, C.; Zazzeroni, F.; Knabb, J.R.; Papa, S.; Kuntzen, C.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

A method for isolating prosurvival targets of NF-kappaB/Rel transcription factors.

Methods in molecular biology (Clifton, N.J.)
2007-01 | Journal article
DOI: 10.1007/978-1-59745-504-6_8
PMID: 18309928
Contributors: Kuntzen C; Zazzeroni F; Pham CG; Papa S; Bubici C; Knabb JR; Franzoso G
Source: Self-asserted source
Concetta Bubici via Europe PubMed Central

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: Molecular basis and biological significance

Oncogene
2006 | Journal article
DOI: 10.1038/sj.onc.1209936
EID:

2-s2.0-33750471197
Contributors: Bubici, C.; Papa, S.; Dean, K.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

The NF-κB-mediated control of ROS and JNK signaling

Histology and Histopathology
2006 | Journal article
EID:

2-s2.0-29844439695
Contributors: Bubici, C.; Papa, S.; Pham, C.G.; Zazzeroni, F.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

Cell Death and Differentiation
2006 | Journal article
DOI: 10.1038/sj.cdd.4401865
EID:

2-s2.0-33645983982
Contributors: Papa, S.; Bubici, C.; Zazzeroni, F.; Pham, C.G.; Kuntzen, C.; Knabb, J.R.; Dean, K.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis

Proceedings of the National Academy of Sciences of the United States of America
2006 | Journal article
DOI: 10.1073/pnas.0604008103
EID:

2-s2.0-33745892099
Contributors: Yang, H.; Bocchetta, M.; Kroczynska, B.; Elmishad, A.G.; Chen, Y.; Liu, Z.; Bubici, C.; Mossman, B.T.; Pass, H.I.; Testa, J.R. et al.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

The NF-kappaB-mediated control of ROS and JNK signaling.

Histology and histopathology
2006-01 | Journal article
DOI: 10.14670/hh-21.69
PMID: 16267788
Contributors: Bubici C; Papa S; Pham CG; Zazzeroni F; Franzoso G
Source: Self-asserted source
Concetta Bubici via Europe PubMed Central

In the crosshairs: NF-κB targets the JNK signaling cascade

Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents
2005 | Journal article
DOI: 10.2174/156801405774933188
EID:

2-s2.0-28444453331
Contributors: Pham, C.G.; Papa, S.; Bubici, C.; Zazzeroni, F.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

NF-κB meets ROS: An 'iron-ic' encounter

Cell Death and Differentiation
2005 | Journal article
DOI: 10.1038/sj.cdd.4401694
EID:

2-s2.0-27144526668
Contributors: Papa, S.; Bubici, C.; Pham, C.G.; Zazzeroni, F.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Oxygen JNKies: Phosphatases overdose on ROS

Developmental Cell
2005 | Journal article
DOI: 10.1016/j.devcel.2005.03.005
EID:

2-s2.0-16244413999
Contributors: Pham, C.G.; Papa, S.; Bubici, C.; Zazzeroni, F.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

EMBO Journal
2004 | Journal article
DOI: 10.1038/sj.emboj.7600325
EID:

2-s2.0-4143108125
Contributors: Barnhart, B.C.; Legembre, P.; Pietras, E.; Bubici, C.; Franzoso, G.; Peter, M.E.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species

Cell
2004 | Journal article
DOI: 10.1016/j.cell.2004.10.017
EID:

2-s2.0-8344260568
Contributors: Pham, C.G.; Bubici, C.; Zazzeroni, F.; Papa, S.; Jones, J.; Alvarez, K.; Jayawardena, S.; De Smaele, E.; Cong, R.; Beaumont, C. et al.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2

Nature Cell Biology
2004 | Journal article
DOI: 10.1038/ncb1093
EID:

2-s2.0-1642602694
Contributors: Papa, S.; Zazzeroni, F.; Bubici, C.; Jayawardena, S.; Alvarez, K.; Matsuda, S.; Nguyen, D.U.; Pham, C.G.; Nelsbach, A.H.; Melis, T. et al.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Linking JNK signaling to NF-κB: A key to survival

Journal of Cell Science
2004 | Journal article
DOI: 10.1242/jcs.01483
EID:

2-s2.0-9444245015
Contributors: Papa, S.; Zazzeroni, F.; Pham, C.G.; Bubici, C.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

NF-κB and JNK: An intricate affair

Cell Cycle
2004 | Journal article
DOI: 10.4161/cc.3.12.1321
EID:

2-s2.0-17144384376
Contributors: Bubici, C.; Papa, S.; Pham, C.G.; Zazzeroni, F.; Franzoso, G.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Gadd45β mediates the protective effects of CD40 costimulation against Fas-induced apoptosis

Blood
2003 | Journal article
DOI: 10.1182/blood-2003-03-0689
EID:

2-s2.0-0142152436
Contributors: Zazzeroni, F.; Papa, S.; Algeciras-Schimnich, A.; Alvarez, K.; Melis, T.; Bubici, C.; Majewski, N.; Hay, N.; De Smaele, E.; Peter, M.E. et al.
Source: Self-asserted source
Concetta Bubici via Scopus - Elsevier

Peer review (9 reviews for 6 publications/grants)

Review activity for Cancer gene therapy. (2)
Review activity for Cell communication and signaling. (1)
Review activity for Cell reports. (2)
Review activity for Journal of Molecular Biology. (2)
Review activity for Nature communications (1)
Review activity for Oncogene. (1)
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