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Works (19)

Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila

Biology Open
2024-07-15 | Journal article
Contributors: Andrew P. K. Wodrich; Brent T. Harris; Edward Giniger
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Manipulating mitochondrial reactive oxygen species alters survival in unexpected ways in a Drosophila Cdk5 model of neurodegeneration

Biology Open
2024-07-15 | Journal article
Contributors: Andrew P. K. Wodrich; Brent T. Harris; Edward Giniger
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MANIPULATING MITOCHONDRIAL REACTIVE OXYGEN SPECIES ALTERS SURVIVAL IN UNEXPECTED WAYS IN ADROSOPHILAMODEL OF NEURODEGENERATION

2024-03-29 | Preprint
Contributors: Andrew P. K. Wodrich; Brent T. Harris; Edward Giniger
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Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration inDrosophila

2024-02-14 | Preprint
Contributors: Andrew P. K. Wodrich; Brent T. Harris; Edward Giniger
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A new view of axon growth and guidance grounded in the stochastic dynamics of actin networks

Open Biology
2023-06 | Journal article
Contributors: Rameen Forghani; Aravind Chandrasekaran; Garegin Papoian; Edward Giniger
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Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila

Cell Reports
2022-12 | Journal article
Contributors: Yildiz Koca; Linh T. Vuong; Jaskirat Singh; Edward Giniger; Marek Mlodzik
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Computational simulations reveal that Abl activity controls cohesiveness of actin networks in growth cones

Molecular Biology of the Cell
2022-09-15 | Journal article
Contributors: Aravind Chandrasekaran; Akanni Clarke; Philip McQueen; Hsiao Yu Fang; Garegin A. Papoian; Edward Giniger; Alex Mogilner
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Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone inDrosophila

2022-06-03 | Preprint
Contributors: Hsiao Yu Fang; Rameen Forghani; Akanni Clarke; Philip G. McQueen; Aravind Chandrasekaran; Kate M. O’Neill; Wolfgang Losert; Garegin A. Papoian; Edward Giniger
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Computational simulations reveal that Abl activity controls cohesiveness of actin networks in growth cones

2021-11-02 | Other
Contributors: Aravind Chandrasekaran; Akanni Clarke; Philip McQueen; Hsiao Yu Fang; Garegin A. Papoian; Edward Giniger
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Htt is a repressor of Abl activity required for APP-induced axonal growth

PLOS Genetics
2021-01-19 | Journal article
Contributors: Claire Marquilly; Hongyan Wang; Germain U. Busto; Brittany S. Leger; Ana Boulanger; Edward Giniger; James A. Walker; Lee G. Fradkin; Jean-Maurice Dura
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Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin

Molecular Biology of the Cell
2020-03-15 | Journal article
Contributors: Akanni Clarke; Philip G. McQueen; Hsiao Yu Fang; Ramakrishnan Kannan; Victor Wang; Evan McCreedy; Stephen Wincovitch; Edward Giniger; Richard Fehon
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Expression of a Fragment of Ankyrin 2 Disrupts the Structure of the Axon Initial Segment and Causes Axonal Degeneration in Drosophila

Molecular Neurobiology
2019-08-21 | Journal article
Contributors: Joshua Spurrier; Arvind K. Shukla; Tyler Buckley; Svetlana Smith-Trunova; Irina Kuzina; Qun Gu; Edward Giniger
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Reduced autophagy efficiency induces innate immune activation leading to neurodegeneration

Autophagy
2019-06-03 | Journal article
Contributors: Arvind K. Shukla; Edward Giniger
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Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5

Cell Reports
2019-01 | Journal article
Contributors: Arvind Kumar Shukla; Joshua Spurrier; Irina Kuzina; Edward Giniger
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Abl signaling shapes the intrinsic fluctuations of actin to direct growth of a pioneer axon in Drosophila

2019-01-04 | Other
Contributors: Akanni Clarke; Philip G. McQueen; Hsiao Yu Fang; Ramakrishnan Kannan; Victor Wang; Evan McCreedy; Stephen Wincovitch; Edward Giniger
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Tyrosine phosphorylation and proteolytic cleavage of Notch are required for non-canonical Notch/Abl signaling in Drosophila axon guidance

Development
2018-01-15 | Journal article
Contributors: Ramakrishnan Kannan; Eric Cox; Lei Wang; Irina Kuzina; Qun Gu; Edward Giniger
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Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration in part by accelerating the rate of aging

Disease Models & Mechanisms
2018-01-01 | Journal article
Contributors: Joshua Spurrier; Arvind Kumar Shukla; Kristina McLinden; Kory Johnson; Edward Giniger
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New perspectives on the roles of Abl tyrosine kinase in axon patterning

Fly
2017-10-02 | Journal article
Contributors: Ramakrishnan Kannan; Edward Giniger
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The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila

Development
2017-02-01 | Journal article
Contributors: Ramakrishnan Kannan; Jeong-Kuen Song; Tatiana Karpova; Akanni Clarke; Madhuri Shivalkar; Benjamin Wang; Lyudmila Kotlyanskaya; Irina Kuzina; Qun Gu; Edward Giniger
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Peer review (10 reviews for 10 publications/grants)

Review activity for Biology open (1)
Review activity for BMC biology. (1)
Review activity for Cell death and disease. (1)
Review activity for Developmental biology. (1)
Review activity for Mechanisms of ageing and development. (1)
Review activity for Molecular psychiatry. (1)
Review activity for Nature communications (1)
Review activity for NPJ Parkinson's disease. (1)
Review activity for PLoS biology. (1)
Review activity for PLOS genetics. (1)