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Employment (3)

The third Xiangya Hospital of Central South University, : Changsha, Hunan, CN

2013-11-01 to present | Professor (Critical care medicine)
Employment
Source: Self-asserted source
Ben Lu

The Third Xiangya Hospital of Central South University: Changsha, Hunan, CN

2013-11-01 to present | Professor (Hematology)
Employment
Source: Self-asserted source
Ben Lu

Northwell Health Feinstein Institutes for Medical Research: Manhasset, NY, US

2008-11-01 to 2013-10-31 | Post doc
Employment
Source: Self-asserted source
Ben Lu

Education and qualifications (1)

Central South University Xiangya School of Medicine: Changsha, Hunan, CN

2001-09-01 to 2010-06-01 | Professor (Hematology and Critical Care Medicine)
Qualification
Source: Self-asserted source
Ben Lu

Professional activities (1)

Ben Lu: New York, NY, US

2008-10-30 to 2013-10-30 | Post-Doc (Feinstein Institute for Medical Research)
Invited position
Source: Self-asserted source
Ben Lu

Works (33)

Acetylation is required for full activation of the NLRP3 inflammasome

Nature Communications
2023-12-18 | Journal article
DOI: 10.1038/s41467-023-44203-0
Contributors: Yening Zhang; Ling Luo; Xueming Xu; Jianfeng Wu; Fupeng Wang; Yanyan Lu; Ningjie Zhang; Yingying Ding; Ben Lu; Kai Zhao
Source: check_circle
Crossref

YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3.

Nature communications
2021-05-11 | Journal article
DOI: 10.1038/s41467-021-22987-3
PMID: 33976226
PMC: PMC8113592
Source: Self-asserted source
Ben Lu

A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis

Cell Death & Disease
2021-04-14 | Journal article
DOI: 10.1038/s41419-021-03652-5
Contributors: Xiangyu Wang; Zhaozheng Li; Yang Bai; Rui Zhang; Ran Meng; Fangping Chen; Haichao Wang; Timothy R. Billiar; Xianzhong Xiao; Ben Lu et al.
Source: check_circle
Crossref

Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties.

Immunity
2021-01-30 | Journal article
DOI: 10.1016/j.immuni.2021.01.007
PMID: 33561388
Source: Self-asserted source
Ben Lu

Silencing IFNγ inhibits A1 astrocytes and attenuates neurogenesis decline and cognitive impairment in endotoxemia.

Biochemical and biophysical research communications
2020-11-04 | Journal article
DOI: 10.1016/j.bbrc.2020.10.084
PMID: 33158480
Source: Self-asserted source
Ben Lu

LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling.

Frontiers in immunology
2020-04-03 | Journal article
DOI: 10.3389/fimmu.2020.00229
PMID: 32328059
PMC: PMC7160675
Source: Self-asserted source
Ben Lu

The role of type 1 interferons in coagulation induced by gram-negative bacteria.

Blood
2020-04-01 | Journal article
DOI: 10.1182/blood.2019002282
PMID: 32016282
PMC: PMC7118812
Source: Self-asserted source
Ben Lu

β-catenin promotes NLRP3 inflammasome activation via increasing the association between NLRP3 and ASC.

Molecular immunology
2020-03-31 | Journal article
DOI: 10.1016/j.molimm.2020.02.017
PMID: 32244067
Source: Self-asserted source
Ben Lu

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure.

Immunity
2019-12-10 | Journal article
DOI: 10.1016/j.immuni.2019.11.005
PMID: 31836429
Source: Self-asserted source
Ben Lu

Caspase-11 signaling enhances graft-versus-host disease.

Nature communications
2019-09-06 | Journal article
DOI: 10.1038/s41467-019-11895-2
PMID: 31492850
PMC: PMC6731232
Source: Self-asserted source
Ben Lu

High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice.

The Journal of biological chemistry
2019-04-18 | Journal article
DOI: 10.1074/jbc.ra118.007040
PMID: 31000631
Source: Self-asserted source
Ben Lu

The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages.

The Journal of biological chemistry
2019-04-10 | Journal article
DOI: 10.1074/jbc.ra118.006508
PMID: 30971430
Source: Self-asserted source
Ben Lu

Bacteria-released outer membrane vesicles promote disseminated intravascular coagulation.

Thrombosis research
2019-03-28 | Journal article
DOI: 10.1016/j.thromres.2019.03.019
PMID: 30953960
Source: Self-asserted source
Ben Lu

Caspse-11-GSDMD pathway is required for serum ferritin secretion in sepsis.

Clinical immunology (Orlando, Fla.)
2019-02-05 | Journal article
DOI: 10.1016/j.clim.2018.11.005
PMID: 30731209
Source: Self-asserted source
Ben Lu

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Immunity
2018-10-09 | Journal article
DOI: 10.1016/j.immuni.2018.08.016
PMID: 30314759
Source: Self-asserted source
Ben Lu

Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation.

Shock (Augusta, Ga.)
2018-09-01 | Journal article
DOI: 10.1097/shk.0000000000001012
PMID: 28991049
PMC: PMC5882614
Source: Self-asserted source
Ben Lu

Lupus nephritis pathology prediction with clinical indices.

Scientific reports
2018-07-06 | Journal article
DOI: 10.1038/s41598-018-28611-7
PMID: 29980727
PMC: PMC6035173
Source: Self-asserted source
Ben Lu

Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity.

Molecular medicine (Cambridge, Mass.)
2018-03-15 | Journal article
DOI: 10.1186/s10020-018-0006-9
PMID: 30134814
PMC: PMC6016887
Source: Self-asserted source
Ben Lu

Biopsy-Free Prediction of Pathologic Type of Primary Nephrotic Syndrome Using a Machine Learning Algorithm.

Kidney & blood pressure research
2017-12-04 | Journal article
DOI: 10.1159/000485592
PMID: 29197864
Source: Self-asserted source
Ben Lu
grade
Preferred source (of 2)‎

ChemSAR: an online pipelining platform for molecular SAR modeling.

Journal of cheminformatics
2017-05-04 | Journal article
DOI: 10.1186/s13321-017-0215-1
PMID: 29086046
PMC: PMC5418185
Source: Self-asserted source
Ben Lu

Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein.

The Journal of biological chemistry
2016-05-17 | Journal article
DOI: 10.1074/jbc.m116.717942
PMID: 27226571
PMC: PMC4946926
Source: Self-asserted source
Ben Lu

Regulation of Posttranslational Modifications of HMGB1 During Immune Responses.

Antioxidants & redox signaling
2016-02-05 | Journal article
DOI: 10.1089/ars.2015.6409
PMID: 26715031
PMC: PMC5349223
Source: Self-asserted source
Ben Lu

HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4.

Arteriosclerosis, thrombosis, and vascular biology
2015-10-29 | Journal article
DOI: 10.1161/atvbaha.115.305789
PMID: 26515416
PMC: PMC4880018
Source: Self-asserted source
Ben Lu

MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.

The Journal of experimental medicine
2015-01-05 | Journal article
DOI: 10.1084/jem.20141318
PMID: 25559892
PMC: PMC4291531
Source: Self-asserted source
Ben Lu

Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis.

PloS one
2014-08-15 | Journal article
DOI: 10.1371/journal.pone.0103992
PMID: 25127031
PMC: PMC4134190
Source: Self-asserted source
Ben Lu

α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release.

Molecular medicine (Cambridge, Mass.)
2014-08-14 | Journal article
DOI: 10.2119/molmed.2013.00117
PMID: 24849809
PMC: PMC4153835
Source: Self-asserted source
Ben Lu

Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review.

Expert review of clinical immunology
2014-04-19 | Journal article
DOI: 10.1586/1744666x.2014.909730
PMID: 24746113
PMC: PMC4056343
Source: Self-asserted source
Ben Lu

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.

Proceedings of the National Academy of Sciences of the United States of America
2014-01-27 | Journal article
DOI: 10.1073/pnas.1316925111
PMID: 24469805
PMC: PMC3939889
Source: Self-asserted source
Ben Lu

Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.

Gastroenterology
2013-12-17 | Journal article
DOI: 10.1053/j.gastro.2013.12.015
PMID: 24361123
PMC: PMC3965592
Source: Self-asserted source
Ben Lu

High-mobility group box 1 mediates persistent splenocyte priming in sepsis survivors: evidence from a murine model.

Shock (Augusta, Ga.)
2013-12-01 | Journal article
DOI: 10.1097/shk.0000000000000050
PMID: 24089009
PMC: PMC4582752
Source: Self-asserted source
Ben Lu

Regulation of HMGB1 release by inflammasomes.

Protein & cell
2013-03-13 | Journal article
DOI: 10.1007/s13238-012-2118-2
PMID: 23483477
PMC: PMC4533838
Source: Self-asserted source
Ben Lu

Novel role of PKR in inflammasome activation and HMGB1 release.

Nature
2012-08-01 | Journal article
DOI: 10.1038/nature11290
PMID: 22801494
PMC: PMC4163918
Source: Self-asserted source
Ben Lu

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.

Proceedings of the National Academy of Sciences of the United States of America
2010-06-14 | Journal article
DOI: 10.1073/pnas.1003893107
PMID: 20547845
PMC: PMC2900689
Source: Self-asserted source
Ben Lu
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