Personal information

Keywords

pharmacokinetics, hepatic clearance, isolated hepatocytes, isolated perfused liver, drug interactions

Countries

Poland

Activities

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Employment (2)

Uniwersytet Jagiellonski Collegium Medicum: Krakow, PL

2013-10-01 to present | Assistant Professor (Pharmacokinetics and Physical Pharmacy)
Employment
Source: Self-asserted source
Malgorzata Szafarz

Uniwersytet Jagiellonski Collegium Medicum: Krakow, PL

2007-02-01 to 2013-10-01 | Research Assistant (Pharmacokinetics and Physical Pharmacy)
Employment
Source: Self-asserted source
Malgorzata Szafarz

Education and qualifications (2)

Uniwersytet Jagiellonski Collegium Medicum: Krakow, PL

2007-02-01 to 2012-12-20 | PhD (Pharmacokinetics and Physical Pharmacy)
Education
Source: Self-asserted source
Malgorzata Szafarz

Uniwersytet Jagiellonski Collegium Medicum: Krakow, PL

2001-10-01 to 2007-02-01 | Master's Degree (Pharmacokinetics and Physical Pharmacy)
Education
Source: Self-asserted source
Malgorzata Szafarz

Funding (1)

Opracowanie metodyki badań pomocnej w ocenie ryzyka wystąpienia interakcji farmakokinetycznych na przykładzie leków przeciwgrzybiczych i sylimaryny - badania pilotażowe w warunkach in vitro/ex vivo.

2017-11-09 to 2018-11-08 | Grant
National Science Center (Krakow, PL)
URL: https://app.dimensions.ai/details/grant/grant.7409528
GRANT_NUMBER:

2017/01/X/NZ7/01072
Source: Self-asserted source
Malgorzata Szafarz via DimensionsWizard

Works (18)

Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.

Neuropharmacology
2019-08-01 | Journal article
DOI: 10.1016/j.neuropharm.2019.107733
PMID: 31377197
Source: Self-asserted source
Malgorzata Szafarz

KSK19 - Novel histamine H3 receptor ligand reduces body weight in diet induced obese mice.

Biochemical pharmacology
2019-07-08 | Journal article
DOI: 10.1016/j.bcp.2019.07.006
PMID: 31295465
Source: Self-asserted source
Malgorzata Szafarz

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands.

Bioorganic chemistry
2019-06-20 | Journal article
DOI: 10.1016/j.bioorg.2019.103071
PMID: 31362197
Source: Self-asserted source
Malgorzata Szafarz

Beneficial effects of non-quinazoline α1-adrenolytics on hypertension and altered metabolism in fructose-fed rats. A comparison with prazosin.

Nutrition, metabolism, and cardiovascular diseases : NMCD
2019-04-13 | Journal article
DOI: 10.1016/j.numecd.2019.04.003
PMID: 31133498
Source: Self-asserted source
Malgorzata Szafarz

Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice.

Neurotoxicity research
2018-02 | Journal article
DOI: 10.1007/s12640-018-9876-4
PMID: 29427285
Contributors: Socała K; Nieoczym D; Pieróg M; Wyska E; Szafarz M; Doboszewska U; Wlaź P
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method.

Naunyn-Schmiedeberg's archives of pharmacology
2017-12 | Journal article
DOI: 10.1007/s00210-017-1448-2
PMID: 29230490
PMC: PMC5778159
Contributors: Szafarz M; Wencel A; Pociecha K; Fedak FA; Wlaź P; Wyska E
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Pharmacokinetic Profile of 1-Methylnicotinamide Nitrate in Rats.

Journal of pharmaceutical sciences
2017-01 | Journal article
DOI: 10.1016/j.xphs.2017.01.022
PMID: 28153597
Contributors: Szafarz M; Kus K; Walczak M; Zakrzewska A; Niemczak M; Pernak J; Chlopicki S
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

QUANTIFICATION AND PHARMACOKINETICS OF 1 -METHYLPYRIDINIUM AND 1,4-DIMETHYLPYRIDINIUM IN RATS BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY. TISSUE DISTRIBUTION OF 1,4-DIMETHYLPYRIDINIUM IN RATS.

Acta poloniae pharmaceutica
2016-09 | Journal article
PMID: 29638051
Contributors: Zakrzewska A; Szafarz M; Kus K; Kij A; Gonciarz A; Walczak M
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Differential involvement of IL-6 in the early and late phase of 1-methylnicotinamide (MNA) release in Concanavalin A-induced hepatitis.

International immunopharmacology
2015-05 | Journal article
DOI: 10.1016/j.intimp.2015.04.053
PMID: 25976094
Contributors: Sternak M; Jakubowski A; Czarnowska E; Slominska EM; Smolenski RT; Szafarz M; Walczak M; Sitek B; Wojcik T; Jasztal A et al.
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Pharmacokinetics and tissue distribution of the new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy) propyl]piperidine in rats.

Xenobiotica; the fate of foreign compounds in biological systems
2015-04 | Journal article
DOI: 10.3109/00498254.2015.1025117
PMID: 25869247
Contributors: Szafarz M; Kryczyk A; Lazewska D; Kiec-Kononowicz K; Wyska E
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Binding of 1-[3-(4-tert-butyl-phenoxy)propyl]piperidine, a new non imidazole histamine H3 receptor antagonist to bovine serum albumin.

Acta poloniae pharmaceutica
2012-11 | Journal article
PMID: 23285664
Contributors: Szymura-Oleksiak J; Kryczyk A; Szafarz M; Jawień W; Łazewska D; Kieć-Kononowicz K
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Capillary electrophoresis/frontal analysis versus equilibrium dialysis in dexamethasone sodium phosphate-serum albumin binding studies.

Electrophoresis
2012-10 | Journal article
DOI: 10.1002/elps.201200166
PMID: 23097126
Contributors: Gonciarz A; Kus K; Szafarz M; Walczak M; Zakrzewska A; Szymura-Oleksiak J
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Liquid chromatography-mass spectrometry method for the analysis of 1,4-dimethylpyridinium in rat plasma--application to pharmacokinetic studies.

Biomedical chromatography : BMC
2012-04 | Journal article
DOI: 10.1002/bmc.2750
PMID: 22549824
Contributors: Szafarz M; Szymura-Oleksiak J; Zakrzewska A; Walczak M; Kus K; Gonciarz A
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6.

Pharmacological reports : PR
2012-01 | Journal article
DOI: 10.1016/s1734-1140(12)70777-6
PMID: 22661188
Contributors: Chłopicki S; Kurdziel M; Sternak M; Szafarz M; Szymura-Oleksiak J; Kamiński K; Żołądź JA
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

LC-MS-MS Method for the Analysis of New Non-Imidazole Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine in Rat Serum-Application to Pharmacokinetic Studies.

Chromatographia
2011-02 | Journal article
DOI: 10.1007/s10337-011-1983-9
PMID: 21544189
PMC: PMC3073091
Contributors: Szafarz M; Szymura-Oleksiak J; Lazewska D; Kiec-Kononowicz K
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse.

Pharmacological reports : PR
2010-05 | Journal article
DOI: 10.1016/s1734-1140(10)70304-2
PMID: 20631412
Contributors: Sternak M; Khomich TI; Jakubowski A; Szafarz M; Szczepański W; Białas M; Stojak M; Szymura-Oleksiak J; Chłopicki S
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS).

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2010-02 | Journal article
DOI: 10.1016/j.jchromb.2010.02.009
PMID: 20223714
Contributors: Szafarz M; Lomnicka M; Sternak M; Chlopicki S; Szymura-Oleksiak J
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Application of liquid chromatography-tandem mass spectrometry method for the analysis of new nonselective beta-adrenergic blocker 1-(1-H-indol-4-yloxy)-3-{[2-(2-methoxy phenoxy)ethylo]amino}propan-2-ol (2F109) in rat plasma.

Chirality
2007-07 | Journal article
DOI: 10.1002/chir.20411
PMID: 17457833
Contributors: Walczak M; Szafarz M; Szymura-Oleksiak J; Groszek G; Bednarski M; Filipek B
Source: Self-asserted source
Malgorzata Szafarz via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for Pharmacological Reports. (1)
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