Luc Malaval (0000-0002-8640-2646)

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I study cell/extracellular matrix relationship in the bone tissue and organ.
Specifically, we analyse the functions of the SIBLING matricellular proteins BSP and osteopontin in bone, using knockout (KO) mouse models of either protein, and a double-KO model. Our present focus is on the regulation of phosphate metabolism by SIBLING proteins.
Since my retirement (August 2022), I am working part time in the same lab as a volunteer researcher.

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INSERM: Saint-Etienne, Rhône-Alpes, FR

2022-08-23 to present | Volunteer research scientist (U1059, Sainbose, Université Jean Monnet, Saint-Etienne)

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Luc Malaval

https://orcid.org/0000-0002-8640-2646

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Employment (5)

INSERM: Saint-Etienne, Rhône-Alpes, FR

INSERM: Saint-Etienne, Rhône-Alpes, FR

INSERM: Lyon, Rhône-Alpes, FR

University of Toronto: Toronto, ON, CA

INSERM: Lyon, Rhône-Alpes, FR

Education and qualifications (2)

Université Claude Bernard Lyon 1 Faculté des Sciences et Technologies: Villeurbanne, FR

Université Claude Bernard Lyon 1 Faculté des Sciences et Technologies: Villeurbanne, FR

Works (50 of 86)

OPN, BSP, and Bone Quality—Structural, Biochemical, and Biomechanical Assessment in OPN−/−, BSP−/−, and DKO Mice

Deletion of osteopontin or bone sialoprotein induces opposite bone responses to mechanical stimulation in mice

Parathyroid Hormone Remodels Bone Transitional Vessels and the Leptin Receptor-Positive Pericyte Network in Mice

Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover.

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study.

Bone Shaft Revascularization After Marrow Ablation Is Dramatically Accelerated in BSP-/- Mice, Along With Faster Hematopoietic Recolonization.

Macrotopographic closure promotes tissue growth and osteogenesis in vitro.

High-acceleration whole body vibration stimulates cortical bone accrual and increases bone mineral content in growing mice.

The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics.

Absence of bone sialoprotein (BSP) alters profoundly hematopoiesis and upregulates osteopontin.

Validation of an in vitro 3D bone culture model with perfused and mechanically stressed ceramic scaffold.

Blocking the expression of both bone sialoprotein (BSP) and osteopontin (OPN) impairs the anabolic action of PTH in mouse calvaria bone.

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation.

The impairment of osteogenesis in bone sialoprotein (BSP) knockout calvaria cell cultures is cell density dependent.

In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment.

Parathyroid hormone 1-84 targets bone vascular structure and perfusion in mice: impacts of its administration regimen and of ovariectomy.

Skeletal development of mice lacking bone sialoprotein (BSP)--impairment of long bone growth and progressive establishment of high trabecular bone mass.

Validated Laser Doppler protocol for measurement of mouse bone blood perfusion - response to age or ovariectomy differs with genetic background.

Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge.

Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites.

Structure and quantification of microvascularisation within mouse long bones: what and how should we measure?

Thyroid hormone receptor β mediates thyroid hormone effects on bone remodeling and bone mass.

Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro.

Mice lacking bone sialoprotein (BSP) lose bone after ovariectomy and display skeletal site-specific response to intermittent PTH treatment.

Imaging and quantitative assessment of long bone vascularization in the adult rat using microcomputed tomography.

Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing.

New insight into the bony labyrinth: a microcomputed tomography study.

Absence of bone sialoprotein (BSP) impairs cortical defect repair in mouse long bone.

Role of the small integrin-binding ligand N-linked glycoprotein (SIBLING), bone sialoprotein (BSP) in bone development and remodeling.

The effect of dual frequency cyclic compression on matrix deposition by osteoblast-like cells grown in 3D scaffolds and on modulation of VEGF variant expression.

Low dose beta-blocker prevents ovariectomy-induced bone loss in rats without affecting heart functions.

Effects of whole body vibration on the skeleton and other organ systems in man and animal models: what we know and what we need to know.

Cellular accumulation and distribution of uranium and lead in osteoblastic cells as a function of their speciation.

Cytotoxic and phenotypic effects of uranium and lead on osteoblastic cells are highly dependent on metal speciation.

Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis.

Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation.

Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain.

Plasticity of osteoprogenitor cells.

Opposite effects of leptin on bone metabolism: a dose-dependent balance related to energy intake and insulin-like growth factor-I pathway.

Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice.

Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis.

Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism.

Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation.

GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors.

Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages.

Global amplification polymerase chain reaction reveals novel transitional stages during osteoprogenitor differentiation.

Expression of leukemia inhibitory factor (LIF)/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF.

Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth.

Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.

Biphasic effects of leukemia inhibitory factor on osteoblastic differentiation.

Peer review (1 review for 1 publication/grant)