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Works (26)

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism
2021-06 | Journal article
DOI: 10.1016/j.molmet.2021.101206
Contributors: Giles S.H. Yeo; Daniela Herrera Moro Chao; Anna-Maria Siegert; Zoe M. Koerperich; Mark D. Ericson; Stephanie E. Simonds; Courtney M. Larson; Serge Luquet; Iain Clarke; Shubh Sharma et al.
Source: check_circle
Crossref

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.

ACS Chemical Neuroscience
2021-01-20 | Journal article
DOI: 10.1021/acschemneuro.0c00755
PMID: 33470098
Source: Self-asserted source
Mark Ericson

Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist.

ACS Medicinal Chemistry Letters
2020-12-17 | Journal article
DOI: 10.1021/acsmedchemlett.0c00561
PMID: 33488972
Source: Self-asserted source
Mark Ericson

Comparative Intracerebroventricular and Intrathecal Administration of a Nanomolar Macrocyclic Melanocortin Receptor Agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) Decreases Food Intake in Mice.

ACS Chemical Neuroscience
2020-09-10 | Journal article
DOI: 10.1021/acschemneuro.0c00409
PMID: 32822157
Source: Self-asserted source
Mark Ericson

Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup>-DPro<sup>8</sup>] Scaffolds Maintain Mouse MC4R Antagonist Potency.

ACS Medicinal Chemistry Letters
2020-03-27 | Journal article
DOI: 10.1021/acsmedchemlett.9b00641
PMID: 33062177
Source: Self-asserted source
Mark Ericson

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists.

Journal of Medicinal Chemistry
2020-01-06 | Journal article
DOI: 10.1021/acs.jmedchem.9b00860
PMID: 31845801
Source: Self-asserted source
Mark Ericson

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy.

ACS Medicinal Chemistry Letters
2019-07-02 | Journal article
DOI: 10.1021/acsmedchemlett.9b00198
PMID: 32184956
Source: Self-asserted source
Mark Ericson

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(<i>p</i>I)DPhe-Tic-NH<sub>2</sub> at the Mouse Melanocortin Receptors: Modification at the (<i>p</i>I)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Molecules
2019-04 | Journal article | Author
DOI: 10.3390/molecules24081463
Contributors: Katherine N. Schlasner; Mark Ericson; Skye R. Doering; Katie T. Freeman; Mary Weinrich; Carrie Haskell-Luevano
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Multidisciplinary Digital Publishing Institute

Synergistic Multi-Residue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists

Journal of Medicinal Chemistry
2018-07-23 | Journal article
DOI: 10.1021/acs.jmedchem.8b00684
Source: Self-asserted source
Mark Ericson

Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles

ACS Chemical Neuroscience
2018-07-20 | Journal article
DOI: 10.1021/acschemneuro.8b00218
Source: Self-asserted source
Mark Ericson

A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors

ACS Chemical Neuroscience
2018-05-11 | Journal article
DOI: 10.1021/acschemneuro.8b00151
Source: Self-asserted source
Mark Ericson

Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors

Journal of Medicinal Chemistry
2018-04-09 | Journal article
DOI: 10.1021/acs.jmedchem.8b00251
Source: Self-asserted source
Mark Ericson

Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice

ACS Chemical Neuroscience
2018-02-13 | Journal article
DOI: 10.1021/acschemneuro.7b00495
Source: Self-asserted source
Mark Ericson

Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016

BBA Molecular Basis of Disease
2017-10 | Journal article
DOI: 10.1016/j.bbadis.2017.03.020
Source: Self-asserted source
Mark Ericson

Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor

Journal of Medicinal Chemistry
2017-10-12 | Journal article
DOI: 10.1021/acs.jmedchem.7b00856
Source: Self-asserted source
Mark Ericson

A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands

Journal of Medicinal Chemistry
2017-01-17 | Journal article
DOI: 10.1021/acs.jmedchem.6b01707
Source: Self-asserted source
Mark Ericson

Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors

ACS Chemical Neuroscience
2016-07-20 | Journal article
DOI: 10.1021/acschemneuro.6b00098
Source: Self-asserted source
Mark Ericson

A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

Bioorganic & Medicinal Chemistry Letters
2015-11-15 | Journal article
DOI: 10.1016/j.bmcl.2015.09.046
Source: Self-asserted source
Mark Ericson

Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology

Journal of Medicinal Chemistry
2015-06-11 | Journal article
DOI: 10.1021/acs.jmedchem.5b00184
Source: Self-asserted source
Mark Ericson

Macromolecular conjugates for nucleic acid delivery

Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology
2014 | Book chapter
Source: Self-asserted source
Mark Ericson

PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression

Journal of Controlled Release
2013-09-28 | Journal article
DOI:

10.1016/j.jconrel.2013.05.024
Source: Self-asserted source
Mark Ericson

A convergent synthesis of homogeneous reducible polypeptides

Tetrahedron Letters
2013-08-23 | Journal article
DOI:

10.1016/j.tetlet.2013.06.118
Source: Self-asserted source
Mark Ericson

Iterative reducible ligation to form homogeneous penicillamine cross-linked polypeptides

Tetrahedron Letters
2013-06-26 | Journal article
DOI:

10.1016/j.tetlet.2013.04.086
Source: Self-asserted source
Mark Ericson

Synthesis of homogeneous disulfide cross-linked polypeptides by iterative reducible ligation

Peptide Science
2012 | Journal article
DOI:

10.1002/bip.22117
Source: Self-asserted source
Mark Ericson

Metabolically stabilized long-circulating PEGylated polyacridine peptide polyplexes mediate hydrodynamically stimulated gene expression in liver

Gene Therapy
2011-01 | Journal article
DOI:

10.1038/gt.2010.117
Source: Self-asserted source
Mark Ericson

Change in surface hardness of enamel by a cola drink and CPP-ACP paste

Journal of Dentistry
2008-01 | Journal article
DOI:

10.1016/j.jdent.2007.10.008
Source: Self-asserted source
Mark Ericson
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