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Scopus Author ID: 55863952600

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Works (32)

Paired CRISPR screens to map gene regulation incisandtrans

2024-11-27 | Preprint
DOI: 10.1101/2024.11.27.625752
Contributors: Xinhe Xue; Zoran Z. Gajic; Christina M. Caragine; Mateusz Legut; Conor Walker; James Y.S. Kim; Xiao Wang; Rachel E. Yan; Hans-Hermann Wessels; Congyi Lu et al.
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Multiomics-guided cellular immunotherapies

Nature Reviews Cancer
2023-06 | Journal article
DOI: 10.1038/s41568-023-00570-w
Contributors: Mateusz Legut
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Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells

Cell Chemical Biology
2022 | Journal article
DOI: 10.1016/j.chembiol.2021.07.011
EID:

2-s2.0-85124522537

Part of ISSN: 24519448 24519456
Contributors: Méndez-Mancilla, A.; Wessels, H.-H.; Legut, M.; Kadina, A.; Mabuchi, M.; Walker, J.; Robb, G.B.; Holden, K.; Sanjana, N.E.
Source: Self-asserted source
Mateusz Legut via Scopus - Elsevier

Publisher Correction: Recurrent somatic mutations as predictors of immunotherapy response

Nature Communications
2022-08-05 | Journal article
DOI: 10.1038/s41467-022-32460-4
Contributors: Zoran Z. Gajic; Aditya Deshpande; Mateusz Legut; Marcin Imieliński; Neville E. Sanjana
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Expanding the scope of bacterial CRISPR activation with PAM-flexible dCas9 variants

2022-07-15 | Preprint
DOI: 10.1101/2022.07.14.500123
Contributors: Cholpisit Kiattisewee; Ava V. Karanjia; Mateusz Legut; Zharko Daniloski; Samantha E. Koplik; Joely Nelson; Benjamin P. Kleinstiver; Neville E. Sanjana; James M. Carothers; Jesse G. Zalatan
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Recurrent somatic mutations as predictors of immunotherapy response

Nature Communications
2022-07-08 | Journal article
DOI: 10.1038/s41467-022-31055-3
Contributors: Zoran Z. Gajic; Aditya Deshpande; Mateusz Legut; Marcin Imieliński; Neville E. Sanjana
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A genome-scale screen for synthetic drivers of T cell proliferation

Nature
2022-03-24 | Journal article
DOI: 10.1038/s41586-022-04494-7
Contributors: Mateusz Legut; Zoran Gajic; Maria Guarino; Zharko Daniloski; Jahan A. Rahman; Xinhe Xue; Congyi Lu; Lu Lu; Eleni P. Mimitou; Stephanie Hao et al.
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Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells

Cell
2021 | Journal article
DOI: 10.1016/j.cell.2020.10.030
EID:

2-s2.0-85095819080

Part of ISSN: 10974172 00928674
Contributors: Daniloski, Z.; Jordan, T.X.; Wessels, H.-H.; Hoagland, D.A.; Kasela, S.; Legut, M.; Maniatis, S.; Mimitou, E.P.; Lu, L.; Geller, E. et al.
Source: Self-asserted source
Mateusz Legut via Scopus - Elsevier

Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells

2021-05-14 | Other
DOI: 10.1101/2021.05.12.443920
Contributors: Alejandro Méndez-Mancilla; Hans-Hermann Wessels; Mateusz Legut; Anastasia Kadina; Megumu Mabuchi; John Walker; G. Brett Robb; Kevin Holden; Neville E. Sanjana
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Massively parallel Cas13 screens reveal principles for guide RNA design.

Nature biotechnology
2020-03-16 | Journal article
DOI: 10.1038/s41587-020-0456-9
PMID: 32518401
Source: Self-asserted source
Mateusz Legut
grade
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Author Correction: Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1.

Nature immunology
2020-03-02 | Journal article
DOI: 10.1038/s41590-020-0640-6
PMID: 32123375
Source: Self-asserted source
Mateusz Legut
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High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation.

Cell Reports
2020-03-01 | Journal article
DOI: 10.1016/j.celrep.2020.02.010
PMID: 32130891
Source: Self-asserted source
Mateusz Legut
grade
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High-throughput screens of PAM-flexible Cas9 variants for gene knock-out and transcriptional modulation

2020-01-23 | Preprint
DOI: 10.1101/2020.01.22.916064
Contributors: Mateusz Legut; Zharko Daniloski; Xinhe Xue; Dayna McKenzie; Xinyi Guo; Hans-Hermann Wessels; Neville E. Sanjana
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Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1.

Nature immunology
2020-01-20 | Journal article
DOI: 10.1038/s41590-019-0578-8
PMID: 31959982
PMC: PMC6983325
Source: Self-asserted source
Mateusz Legut
grade
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Principles for rational Cas13d guide design

2019-12-28 | Preprint
DOI: 10.1101/2019.12.27.889089
Contributors: Hans-Hermann Wessels; Alejandro Méndez-Mancilla; Xinyi Guo; Mateusz Legut; Zharko Daniloski; Neville E. Sanjana
Source: check_circle
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Immunomagnetic cell sorting.

Nature biomedical engineering
2019-10-01 | Journal article
DOI: 10.1038/s41551-019-0459-3
PMID: 31548593
Source: Self-asserted source
Mateusz Legut
grade
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TCR-induced alteration of primary MHC peptide anchor residue.

European journal of immunology
2019-05-27 | Journal article
DOI: 10.1002/eji.201948085
PMID: 31091334
PMC: PMC6618058
Source: Self-asserted source
Mateusz Legut
grade
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Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells.

Nature methods
2019-04-22 | Journal article
DOI: 10.1038/s41592-019-0392-0
PMID: 31011186
PMC: PMC6557128
Source: Self-asserted source
Mateusz Legut
grade
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Expanding the CITE-seq tool-kit: Detection of proteins, transcriptomes, clonotypes and CRISPR perturbations with multiplexing, in a single assay

2018-11-08 | Other
DOI: 10.1101/466466
Contributors: Eleni Mimitou; Anthony Cheng; Antonino Montalbano; Stephanie Hao; Marlon Stoeckius; Mateusz Legut; Timothy Roush; Alberto Herrera; Efthymia Papalexi; Zhengquing Ouyang et al.
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Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

Nature communications
2018-07-13 | Journal article
DOI: 10.1038/s41467-018-05288-0
PMID: 30006605
PMC: PMC6045629
Source: Self-asserted source
Mateusz Legut
grade
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Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells.

Frontiers in immunology
2018-06-29 | Journal article
DOI: 10.3389/fimmu.2018.01378
PMID: 30008714
PMC: PMC6034003
Source: Self-asserted source
Mateusz Legut
grade
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Designer T-cells and T-cell receptors for customized cancer immunotherapies.

Current opinion in pharmacology
2018-05-29 | Journal article
DOI: 10.1016/j.coph.2018.05.005
PMID: 29852403
Source: Self-asserted source
Mateusz Legut
grade
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Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.

Journal of immunology (Baltimore, Md. : 1950)
2018-02-26 | Journal article
DOI: 10.4049/jimmunol.1700242
PMID: 29483360
PMC: PMC5857646
Source: Self-asserted source
Mateusz Legut
grade
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Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.

Nature medicine
2017-11-13 | Journal article
DOI: 10.1038/nm.4444
PMID: 29131157
Source: Self-asserted source
Mateusz Legut
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Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.

Frontiers in immunology
2017-11-10 | Journal article
DOI: 10.3389/fimmu.2017.01503
PMID: 29209312
PMC: PMC5701626
Source: Self-asserted source
Mateusz Legut
grade
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CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells.

Blood
2017-11-09 | Journal article
DOI: 10.1182/blood-2017-05-787598
PMID: 29122757
PMC: PMC5774207
Source: Self-asserted source
Mateusz Legut
grade
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PD-1+ Polyfunctional T Cells Dominate the Periphery after Tumor-Infiltrating Lymphocyte Therapy for Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research
2017-07-05 | Journal article
DOI: 10.1158/1078-0432.ccr-16-1692
PMID: 28679768
PMC: PMC7115919
Source: Self-asserted source
Mateusz Legut
grade
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The T cell antigen receptor: the Swiss army knife of the immune system.

Clinical and experimental immunology
2015-05-14 | Journal article
DOI: 10.1111/cei.12622
PMID: 25753381
PMC: PMC4469151
Source: Self-asserted source
Mateusz Legut
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Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies.

Human gene therapy
2015-05-01 | Journal article
DOI: 10.1089/hum.2015.015
PMID: 25919378
PMC: PMC4442602
Source: Self-asserted source
Mateusz Legut
grade
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The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.

Cellular & molecular immunology
2015-04-13 | Journal article
DOI: 10.1038/cmi.2015.28
PMID: 25864915
PMC: PMC4716630
Source: Self-asserted source
Mateusz Legut
grade
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Anacardic acid enhances the anticancer activity of liposomal mitoxantrone towards melanoma cell lines - in vitro studies.

International journal of nanomedicine
2014-01-23 | Journal article
DOI: 10.2147/ijn.s54911
PMID: 24489469
PMC: PMC3904835
Source: Self-asserted source
Mateusz Legut
grade
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Vitamin C-driven epirubicin loading into liposomes.

International journal of nanomedicine
2013-09-23 | Journal article
DOI: 10.2147/ijn.s47745
PMID: 24101870
PMC: PMC3790897
Source: Self-asserted source
Mateusz Legut
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