Audray Harris (0000-0002-8875-1874)

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Our research area is the structural biology of viruses and vaccine particles. One goal of the research is to understand the molecular organization of viruses in order to gain insights into virus assembly and function. Another goal is to study the organization of conserved viral epitopes on vaccine particles to help inform vaccine development. The research program exploits 3D electron microscopy of viruses and protein complexes with antibodies to obtain structural information on epitope disposition and conformational states. Structural analyses are supported by other structural, biochemical, and immunological analyses in order to understand immunogenicity, antigen-antibody interactions and aid in structure-assisted design of nanoparticles for vaccines. A major focus is on the structure, assembly, and epitope display of influenza proteins and viral particles.

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National Institutes of Health: Bethesda, MD, US

2013 to present | Investigator

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Audray Harris

https://orcid.org/0000-0002-8875-1874

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Biography

Activities

Employment (1)

National Institutes of Health: Bethesda, MD, US

Works (35)

Commercial influenza vaccines vary in HA-complex structure and in induction of cross-reactive HA antibodies

Designed nanoparticles elicit cross-reactive antibody responses to conserved influenza virus hemagglutinin stem epitopes

Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses

Commercial influenza vaccines vary in both the structural arrangements of HA complexes and in induction of antibodies to cross-reactive HA epitopes

Impact of adjuvant: Trivalent vaccine with quadrivalent-like protection against heterologous Yamagata-lineage influenza B virus

Vaccine-elicitation of cross-group neutralizing protective antibodies to influenza A viruses

Cryo-EM cools down swine fever

Phase-plate Cryo-electron Tomography Facilitates the Identification of Influenza Virus Condensed Core Structures

Immunoelectron Microscopy of Viral Antigens

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses (vol 20, pg 362, 2019)

Negative-Stain Transmission Electron Microscopy of Molecular Complexes for Image Analysis by 2D Class Averaging

Probing the Structural Organization of Virions and Genomic Ribonucleoprotein Complexes from Type B Influenza Virus by Cryo-electron Microscopy

Conserved Structural Anatomy Between Divergent Viral Capsid Nanoparticles for Vaccine Design

Observed Structural Heterogeneity of Human Hepatitis B Virus Surface Antigen Particles by Cryo-electron Microscopy

Structural analysis of influenza vaccine virus-like particles reveals a multicomponent organization

Characterization of Hemagglutinin Antigens on Influenza Virus and within Vaccines Using Electron Microscopy

Characterization of the disassembly and reassembly of the HBV glycoprotein surface antigen, a pliable nanoparticle vaccine platform

Phantoms models to characterize influenza hemagglutinin-based vaccines

Structural studies of influenza virus RNPs by electron microscopy indicate molecular contortions within NP supra-structures

Characterization of Influenza Vaccine Hemagglutinin Complexes by Cryo-Electron Microscopy and Image Analyses Reveals Structural Polymorphisms

Cryo-electron microscopy of influenza vaccine nanoparticles indicates full occupancy of displayed epitopes is facilitated by particle design

Rapid development of a DNA vaccine for Zika virus

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

HIV-1 Envelope Glycoprotein Trimers Display Open Quaternary Conformation When Bound to the gp41 Membrane-Proximal External-Region-Directed Broadly Neutralizing Antibody Z13e1

Molecular Structures of Native HA Trimers on 2009 H1N1 Pandemic Influenza Virus Complexed with Neutralizing Antibodies

Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies

Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

Molecular Basis for the High Degree of Antigenic Cross-Reactivity between Hepatitis B Virus Capsids (HBcAg) and Dimeric Capsid-Related Protein (HBeAg): Insights into the Enigmatic Nature of the e-Antigen

Epitope diversity of hepatitis B virus capsids: Quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope

Influenza virus pleiomorphy characterized by cryoelectron tomography

Antigenic diversity of the hepatitis B virus capsid

Structure, assembly, and antigenicity of hepatitis B virus capsid proteins

The crystal structure of the influenza matrix protein M1 at neutral pH: M1-M1 protein interfaces can rotate in the oligomeric structures of M1

Structural similarities between influenza virus matrix protein M1 and human immunodeficiency virus matrix and capsid proteins: an evolutionary link between negative-stranded RNA viruses and retroviruses

Peer review (21 reviews for 10 publications/grants)