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Employment (6)

AstraZeneca: CAMBRIDGE, Cambridgeshire, GB

2022-06 to present | Director, Data Science & Genomics (Centre for Genomics Research)
Employment
Source: Self-asserted source
Dimitrios Vitsios

AstraZeneca: CAMBRIDGE, Cambridgeshire, GB

2020-11 to 2022-06 | Associate Director (Centre for Genomics Research)
Employment
Source: Self-asserted source
Dimitrios Vitsios

AstraZeneca: CAMBRIDGE, Cambridgeshire, GB

2020-02 to 2020-11 | Senior Research Scientist (Centre for Genomics Research)
Employment
Source: Self-asserted source
Dimitrios Vitsios

AstraZeneca UK Limited: Cambridge, Cambridgeshire, GB

2018-02 to 2020-02 | Post Doc Fellow (Centre for Genomics Research)
Employment
Source: Self-asserted source
Dimitrios Vitsios

European Bioinformatics Institute: Cambridge, Cambridgeshire, GB

2017-09 to 2018-02 | Bridging Post Doc
Employment
Source: Self-asserted source
Dimitrios Vitsios

European Bioinformatics Institute: Cambridge, Cambridgeshire, GB

2013-09-01 to 2017-08 | Predoctoral Fellow
Employment
Source: Self-asserted source
Dimitrios Vitsios

Education and qualifications (2)

University of Cambridge: Cambridge, Cambridgeshire, GB

2013-09-01 to 2017-08-15 | PhD in Bioinformatics (EMBL - European Bioinformatics Institute)
Education
Source: Self-asserted source
Dimitrios Vitsios

Aristotle University of Thessaloniki: Thessaloniki, GR

2006 to 2012 | Diploma in Electrical and Computer Engineering (Electrical and Computer Engineering)
Education
Source: Self-asserted source
Dimitrios Vitsios

Works (26)

Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities

Nature Communications
2025-03-03 | Journal article
DOI: 10.1038/s41467-025-56695-z
Contributors: Douglas P. Loesch; Manik Garg; Dorota Matelska; Dimitrios Vitsios; Xiao Jiang; Scott C. Ritchie; Benjamin B. Sun; Heiko Runz; Christopher D. Whelan; Rury R. Holman et al.
Source: check_circle
Crossref

Assessing the role of rare pathogenic variants in heart failure progression by exome sequencing in 8,089 patients

2023-08-05 | Preprint
DOI: 10.1101/2023.07.28.23293350
Contributors: Olympe Chazara; Marie-Pierre Dubé; Quanli Wang; Lawrence Middleton; Dimitrios Vitsios; Anna Walentinsson; Qing-Dong Wang; Kenny M. Hansson; Christopher B. Granger; John Kjekshus et al.
Source: check_circle
Crossref

Author Correction: DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets

Communications Biology
2023-07-11 | Journal article
DOI: 10.1038/s42003-023-05086-5
Contributors: Arwa Raies; Ewa Tulodziecka; James Stainer; Lawrence Middleton; Ryan S. Dhindsa; Pamela Hill; Ola Engkvist; Andrew R. Harper; Slavé Petrovski; Dimitrios Vitsios
Source: check_circle
Crossref

DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets

Communications Biology
2022-11-24 | Journal article
DOI: 10.1038/s42003-022-04245-4
Contributors: Arwa Raies; Ewa Tulodziecka; James Stainer; Lawrence Middleton; Ryan S. Dhindsa; Pamela Hill; Ola Engkvist; Andrew R. Harper; Slavé Petrovski; Dimitrios Vitsios
Source: check_circle
Crossref

Genome-wide prediction of dominant and recessive neurodevelopmental disorder risk genes

2022-11-21 | Preprint
DOI: 10.1101/2022.11.21.517436
Contributors: Ryan S. Dhindsa; Blake Weido; Justin S. Dhindsa; Arya J. Shetty; Chloe Sands; Slavé Petrovski; Dimitrios Vitsios; Anthony W. Zoghbi
Source: check_circle
Crossref

Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

Science Advances
2022-11-16 | Journal article
DOI: 10.1126/sciadv.add5430
Contributors: Abhishek Nag; Ryan S. Dhindsa; Jonathan Mitchell; Chirag Vasavda; Andrew R. Harper; Dimitrios Vitsios; Andrea Ahnmark; Bilada Bilican; Katja Madeyski-Bengtson; Bader Zarrouki et al.
Source: check_circle
Crossref

Cancer-driving mutations are enriched in genic regions intolerant to germline variation

Science Advances
2022-08-26 | Journal article
DOI: 10.1126/sciadv.abo6371
Contributors: Dimitrios Vitsios; Ryan S. Dhindsa; Dorota Matelska; Jonathan Mitchell; Xuequing Zou; Joshua Armenia; Fengyuan Hu; Quanli Wang; Ben Sidders; Andrew R. Harper et al.
Source: check_circle
Crossref

A minimal role for synonymous variation in human disease

2022-07-15 | Preprint
DOI: 10.1101/2022.07.13.499964
Contributors: Ryan S. Dhindsa; Quanli Wang; Dimitrios Vitsios; Oliver S. Burren; Fengyuan Hu; James E. DiCarlo; Leonid Kruglyak; Daniel G. MacArthur; Matthew E. Hurles; Slavé Petrovski
Source: check_circle
Crossref

Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses

Nucleic Acids Research
2022-05-06 | Journal article
DOI: 10.1093/nar/gkac274
Contributors: Lawrence Middleton; Andrew R Harper; Abhishek Nag; Quanli Wang; Anna Reznichenko; Dimitrios Vitsios; Slavé Petrovski
Source: check_circle
Crossref

Cancer-driving mutations are enriched in genic regions intolerant to germline variation

2022-01-09 | Preprint
DOI: 10.1101/2022.01.07.475416
Contributors: Dimitrios Vitsios; Ryan S. Dhindsa; Jonathan Mitchell; Dorota Matelska; Zoe Zou; Joshua Armenia; Quanli Wang; Ben Sidders; Andrew R. Harper; Slavé Petrovski
Source: check_circle
Crossref

Assessing the contribution of rare-to-common protein-coding variants to circulating metabolic biomarker levels via 412,394 UK Biobank exome sequences

2021-12-27 | Preprint
DOI: 10.1101/2021.12.24.21268381
Contributors: Abhishek Nag; Lawrence Middleton; Ryan S. Dhindsa; Dimitrios Vitsios; Eleanor Wigmore; Erik L. Allman; Anna Reznichenko; Keren Carss; Katherine R. Smith; Quanli Wang et al.
Source: check_circle
Crossref

Human genetic evidence supports MAP3K15 inhibition as a therapeutic strategy for diabetes

2021-11-15 | Other
DOI: 10.1101/2021.11.14.21266328
Contributors: Abhishek Nag; Ryan S. Dhindsa; Andrew R. Harper; Dimitrios Vitsios; Andrea Ahnmark; Bilada Bilican; Katja Madeyski-Bengtson; Bader Zarrouki; Quanli Wang; Katherine Smith et al.
Source: check_circle
Crossref

Surveying the contribution of rare variants to the genetic architecture of human disease through exome sequencing of 177,882 UK Biobank participants

2020-12-13 | Preprint
DOI: 10.1101/2020.12.13.422582
Contributors: Quanli Wang; Ryan S. Dhindsa; Keren Carss; Andrew Harper; Abhishek Nag; Ioanna Tachmazidou; Dimitrios Vitsios; Sri VV Deevi; Alex Mackay; Daniel Muthas et al.
Source: check_circle
Crossref

Identification of a novel missense variant inSPDL1associated with idiopathic pulmonary fibrosis

2020-06-29 | Preprint
DOI: 10.1101/2020.06.29.178079
Contributors: Ryan S. Dhindsa; Johan Mattsson; Abhishek Nag; Quanli Wang; Louise V. Wain; Richard Allen; Eleanor M. Wigmore; Kristina Ibanez; Dimitrios Vitsios; Sri VV. Deevi et al.
Source: check_circle
Crossref

Re-annotation of 191 developmental and epileptic encephalopathy-associated genes unmasks de novo variants in SCN1A

npj Genomic Medicine
2019 | Journal article
DOI: 10.1038/s41525-019-0106-7
Part of ISSN: 2056-7944
Contributors: Charles A. Steward; Jolien Roovers; Marie-Marthe Suner; Jose M. Gonzalez; Barbara Uszczynska-Ratajczak; Dmitri Pervouchine; Stephen Fitzgerald; Margarida Viola; Hannah Stamberger; Fadi F. Hamdan et al.
Source: Self-asserted source
Dimitrios Vitsios via Crossref Metadata Search

Stochastic semi-supervised learning to prioritise genes from high-throughput genomic screens

2019-05-30 | Other
DOI: 10.1101/655449
Contributors: Dimitrios Vitsios; Slavé Petrovski
Source: check_circle
Crossref

A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

Cell Research
2019-03 | Journal article
DOI: 10.1038/s41422-018-0128-1
Contributors: Marcos Morgan; Yuka Kabayama; Christian Much; Ivayla Ivanova; Monica Di Giacomo; Tatsiana Auchynnikava; Jack Michael Monahan; Dimitrios Michael Vitsios; Lina Vasiliauskaitė; Stefano Comazzetto et al.
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Crossref

RNA-sequencing analysis of umbilical cord plasma microRNAs from healthy newborns

PLOS ONE
2018-12-03 | Journal article
DOI: 10.1371/journal.pone.0207952
Contributors: Gary P. Brennan; Klaus Roemer; Dimitrios M. Vitsios; Sophie Casey; Ann-Marie Looney; Boubou Hallberg; David C. Henshall; Geraldine B. Boylan; Deirdre M. Murray; Catherine Mooney
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Crossref

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

Nature Communications
2017-12-13 | Journal article
DOI: 10.1038/s41467-017-00686-2
Contributors: Qianxin Wu; Quentin R. V. Ferry; Toni A. Baeumler; Yale S. Michaels; Dimitrios M. Vitsios; Omer Habib; Roland Arnold; Xiaowei Jiang; Stefano Maio; Bruno R. Steinkraus et al.
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Crossref

Mirnovo: genome-free prediction of microRNAs from small RNA sequencing data and single-cells using decision forests.

Nucleic acids research
2017-09 | Journal article
DOI: 10.1093/nar/gkx836
PMID: 29036314
Source: Self-asserted source
Dimitrios Vitsios via Europe PubMed Central

mRNA 3' uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome.

Nature
2017-08 | Journal article
DOI: 10.1038/nature23318
PMID: 28792939
Source: Self-asserted source
Dimitrios Vitsios via Europe PubMed Central

A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming

Nature Structural & Molecular Biology
2017-07-22 | Journal article
DOI: 10.1038/nsmb.3413
Contributors: Lina Vasiliauskaitė; Dimitrios Vitsios; Rebecca V Berrens; Claudia Carrieri; Wolf Reik; Anton J Enright; Dónal O'Carroll
Source: check_circle
Crossref

Large-scale analysis of microRNA expression, epi-transcriptomic features and biogenesis.

2017-02 | Journal article
DOI: 10.1093/nar/gkw1031
PMID: 28180281
PMC: PMC5388392
Contributors: Vitsios DM; Davis MP; van Dongen S; Enright AJ
Source: Self-asserted source
Dimitrios Vitsios via Europe PubMed Central

BioPAXViz: a cytoscape application for the visual exploration of metabolic pathway evolution.

2017-01 | Journal article
DOI: 10.1093/bioinformatics/btw813
PMID: 28122780
Contributors: Psomopoulos FE; Vitsios DM; Baichoo S; Ouzounis CA
Source: Self-asserted source
Dimitrios Vitsios via Europe PubMed Central

Large-scale analysis of microRNA expression, epi-transcriptomic features and biogenesis.

2016-11 | Journal article
PMID: 27899663
Contributors: Vitsios DM; Davis MP; van Dongen S; Enright AJ
Source: Self-asserted source
Dimitrios Vitsios via Europe PubMed Central

Chimira: analysis of small RNA sequencing data and microRNA modifications.

2015-10 | Journal article
DOI: 10.1093/bioinformatics/btv380
PMID: 26093149
PMC: PMC4595902
Contributors: Vitsios DM; Enright AJ
Source: Self-asserted source
Dimitrios Vitsios via Europe PubMed Central

Peer review (2 reviews for 2 publications/grants)

Review activity for Nature (1)
Review activity for Nature communications (1)
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