Personal information

Websites & social links

https://rcb.res.in/index.php?param=empdetails/rajender

Keywords

Calcium signaling, Inter-organelle crosstalk, Mitochondria, Skin Pigmentation

Countries

India

Activities

Collapse all

Employment (3)

Regional Centre for Biotechnology: Faridabad, IN

2024-01-01 to present | Associate Professor
Employment
Source: Self-asserted source
Rajender K Motiani

Regional Centre for Biotechnology: Faridabad, IN

2018-11-01 to 2023-12-31 | Assistant Professor
Employment
Source: Self-asserted source
Rajender K Motiani

CSIR Institute of Genomics & Integrative Biology: New Delhi, Delhi, IN

2013-05-01 to 2018-10-01 | INSPIRE Faculty Fellow (Chemical and Systems Biology)
Employment
Source: Self-asserted source
Rajender K Motiani

Education and qualifications (2)

Albany Medical College: Albany, NY, US

2007-08-23 to 2012-08-17 | Ph.D. (Department of Molecular and Cellular Physiology)
Education
Source: Self-asserted source
Rajender K Motiani

Nagpur Veterinary College: Nagpur, IN

2002-08 to 2007-07 | Bachelor in Veterinary Sciences and Animal Husbandry
Education
Source: Self-asserted source
Rajender K Motiani

Funding (2)

Decoding role of ER and Mitochondria in melanogenesis.

Award
The Wellcome Trust DBT India Alliance (Hyderabad, IN)
Source: Self-asserted source
Rajender K Motiani

Understanding STIM1 augmentation during melanogenesis.

Grant
Science and Engineering Research Board (New Delhi, IN)
Source: Self-asserted source
Rajender K Motiani

Works (44)

Remodeling Ca2+dynamics by targeting a promising E-box containing G-quadruplex atORAI1promoter in triple-negative breast cancer

2024-03-29 | Preprint
DOI: 10.1101/2024.03.28.587164
Contributors: Oishika Chatterjee; Jagannath Jana; Suman Panda; Anindya Dutta; Akshay Sharma; Suman Saurav; Rajender K. Motiani; Klaus Weisz; Subhrangsu Chatterjee
Source: check_circle
Crossref

Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy.

EMBO molecular medicine
2024-01-02 | Journal article | Author
DOI: 10.1038/s44321-023-00014-w
PMID: 38177535
PMC: PMC10897192
Contributors: Prajapat SK; Mishra L; Khera S; Owusu SD; Ahuja K; Sharma P; Choudhary E; Chhabra S; Kumar N; Rajan Singh et al.
Source: Self-asserted source
Rajender K Motiani

Telomeres control regulation of the human Telomerase (hTERT) gene through non-telomeric TRF2 and independent of Telomere looping

2023-10-10 | Preprint
DOI: 10.1101/2023.10.09.561466
Contributors: Antara Sengupta; Soujanya Vinayagamurthy; Drishti Soni; Rajlekha Deb; Ananda Kishore Mukherjee; Subhajit Dutta; Jushta Jaiswal; Mukta Yadav; SHALU SHARMA; Sulochana Bagri et al.
Source: Self-asserted source
Rajender K Motiani

A novel gain of function mutation in TPC2 reiterates pH-pigmentation interplay: Emerging role of ionic homeostasis as a master pigmentation regulator

Cell Calcium
2023-05 | Journal article
DOI: 10.1016/j.ceca.2023.102705
Contributors: Nutan Sharma; Akshay Sharma; Rajender K Motiani
Source: check_circle
Crossref

Mitochondrial calcium signaling mediated transcriptional regulation of keratin filaments is a critical determinant of melanogenesis

2023-05 | Preprint
DOI: 10.1101/2023.05.26.542250
PPR: PPR666637
Contributors: Tanwar J; Ahuja K; Sharma A; Sehgal P; Ranjan G; Sultan F; Priya A; Venkatesan M; Yenamandra VK; Singh A et al.
Source: Self-asserted source
Rajender K Motiani via Europe PubMed Central

MITF is a novel transcriptional regulator of the calcium sensor STIM1: Significance in physiological melanogenesis.

The Journal of biological chemistry
2022-11-07 | Journal article
DOI: 10.1016/j.jbc.2022.102681
PMID: 36356899
PMC: PMC9723939
Contributors: jyoti tanwar; Sharma A; Saurav S; Shyamveer; Nidhi Jatana; Motiani RK
Source: Self-asserted source
Rajender K Motiani

Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis

Cell Calcium
2022-09 | Journal article
DOI: 10.1016/j.ceca.2022.102637
Contributors: Farina Sultan; Kriti Ahuja; Rajender K. Motiani
Source: check_circle
Crossref

Temporal analysis of melanogenesis identifies fatty acid metabolism as key skin pigment regulator.

PLoS biology
2022-05-18 | Journal article
DOI: 10.1371/journal.pbio.3001634
PMID: 35584084
PMC: PMC9116682
Contributors: Dr Farina Sultan; Reelina Basu; Divya Murthy; Manisha Kochar; Kuldeep S. Attri; Aggarwal A; Pooja Kumari; Dnyane P; Tanwar J; Motiani RK et al.
Source: Self-asserted source
Rajender K Motiani

Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation

Cells
2022-02 | Journal article | Author
DOI: 10.3390/cells11040701
Contributors: jyoti tanwar; Suman Saurav; Reelina Basu; Jaya Bharti Singh; Anshu Priya; Maitreyee Dutta; Uma Santhanam; Manoj Joshi; Stephen Madison; Archana Singh et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry Channel

Cancers
2021-11-25 | Journal article
DOI: 10.3390/cancers13235937
Contributors: Samriddhi Arora; Jyoti Tanwar; Nutan Sharma; Suman Saurav; Rajender K. Motiani
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Dysregulation of host cell calcium signaling during viral infections: Emerging paradigm with high clinical relevance.

Molecular aspects of medicine
2021-07-23 | Journal article
DOI: 10.1016/j.mam.2021.101004
PMID: 34304899
PMC: PMC8299155
Source: Self-asserted source
Rajender K Motiani

LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy.

The EMBO journal
2021-06-28 | Journal article
DOI: 10.15252/embj.2020107134
PMID: 34180064
PMC: PMC8327952
Source: Self-asserted source
Rajender K Motiani

Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics

Mitochondrion
2021-03 | Journal article
DOI: 10.1016/j.mito.2020.12.001
Contributors: Jyoti Tanwar; Jaya Bharti Singh; Rajender K. Motiani
Source: check_circle
Crossref

Pathophysiological significance of calcium signaling at Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs)

Current Opinion in Physiology
2020-10 | Journal article
DOI: 10.1016/j.cophys.2020.08.012
Part of ISSN: 2468-8673
Source: Self-asserted source
Rajender K Motiani

Orai3: Oncochannel with therapeutic potential.

Cell calcium
2020-06-26 | Journal article
DOI: 10.1016/j.ceca.2020.102247
PMID: 32659517
Source: Self-asserted source
Rajender K Motiani

Histone variant dictates fate biasing of neural crest cells to melanocyte lineage.

Development (Cambridge, England)
2020-03-12 | Journal article
DOI: 10.1242/dev.182576
PMID: 32098766
Source: Self-asserted source
Rajender K Motiani

Successful cloning of a superior buffalo bull.

Scientific reports
2019-08-06 | Journal article
DOI: 10.1038/s41598-019-47909-8
PMID: 31388074
PMC: PMC6684639
Source: Self-asserted source
Rajender K Motiani

Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing.

Nucleic acids research
2019-06-01 | Journal article
DOI: 10.1093/nar/gkz371
PMID: 31081026
PMC: PMC6582341
Source: Self-asserted source
Rajender K Motiani

Regulation of proto-oncogene Orai3 by miR18a/b and miR34a.

Cell calcium
2018-09-03 | Journal article
DOI: 10.1016/j.ceca.2018.08.006
PMID: 30216788
Source: Self-asserted source
Rajender K Motiani

STIM 1 activation of adenylyl cyclase 6 connects Ca 2+ and cAMP signaling during melanogenesis

The EMBO Journal
2018-03 | Journal article
DOI: 10.15252/embj.201797597
Contributors: Rajender K Motiani; Jyoti Tanwar; Desingu Ayyappa Raja; Ayushi Vashisht; Shivangi Khanna; Sachin Sharma; Sonali Srivastava; Sridhar Sivasubbu; Vivek T Natarajan; Rajesh S Gokhale
Source: check_circle
Crossref

Deciphering the role of hydrophobic and hydrophilic bile acids in angiogenesis using in vitro and in vivo model systems

MedChemComm
2017 | Journal article
DOI: 10.1039/C7MD00475C
Contributors: Somanath Kundu; Sandhya Bansal; Kalai Mangai Muthukumarasamy; Chetana Sachidanandan; Rajender K. Motiani; Avinash Bajaj
Source: check_circle
Crossref

Role of SOCE architects STIM and Orai proteins in Cell Death.

Cell calcium
2017-06-09 | Journal article
DOI: 10.1016/j.ceca.2017.06.002
PMID: 28629579
Source: Self-asserted source
Rajender K Motiani

Mitochondria control store-operated Ca<sup>2+</sup> entry through Na<sup>+</sup> and redox signals.

The EMBO journal
2017-02-20 | Journal article
DOI: 10.15252/embj.201592481
PMID: 28219928
PMC: PMC5350565
Source: Self-asserted source
Rajender K Motiani

Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders.

Advances in experimental medicine and biology
2017-01-01 | Journal article
DOI: 10.1007/978-3-319-57732-6_22
PMID: 28900927
Source: Self-asserted source
Rajender K Motiani

Water Buffalo (Bubalus bubalis) as a spontaneous animal model of Vitiligo.

Pigment cell & melanoma research
2016-07-01 | Journal article
DOI: 10.1111/pcmr.12485
PMID: 27124831
Source: Self-asserted source
Rajender K Motiani

STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis.

American journal of physiology. Cell physiology
2015-05-27 | Journal article
DOI: 10.1152/ajpcell.00064.2015
PMID: 26017146
PMC: PMC4593768
Source: Self-asserted source
Rajender K Motiani

Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin.

Nanoscale
2014-11-01 | Journal article
DOI: 10.1039/c4nr04064c
PMID: 25227567
Source: Self-asserted source
Rajender K Motiani

Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy.

MedChemComm
2014-10-15 | Journal article
DOI: 10.1039/c4md00223g
PMID: 25685308
PMC: PMC4322782
Source: Self-asserted source
Rajender K Motiani

Design, synthesis, and mechanistic investigations of bile acid-tamoxifen conjugates for breast cancer therapy.

Bioconjugate chemistry
2013-08-21 | Journal article
DOI: 10.1021/bc300664k
PMID: 23909664
Source: Self-asserted source
Rajender K Motiani

Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.

Molecular and cellular biology
2013-07-22 | Journal article
DOI: 10.1128/mcb.00554-13
PMID: 23878392
PMC: PMC3753864
Source: Self-asserted source
Rajender K Motiani

Emerging roles of Orai3 in pathophysiology.

Channels (Austin, Tex.)
2013-05-21 | Journal article
DOI: 10.4161/chan.24960
PMID: 23695829
PMC: PMC3913762
Source: Self-asserted source
Rajender K Motiani

What role for store-operated Ca²⁺ entry in muscle?

Microcirculation (New York, N.Y. : 1994)
2013-05-01 | Journal article
DOI: 10.1111/micc.12042
PMID: 23312019
PMC: PMC3646967
Source: Self-asserted source
Rajender K Motiani

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion.

Pflugers Archiv : European journal of physiology
2013-03-21 | Journal article
DOI: 10.1007/s00424-013-1254-8
PMID: 23515871
PMC: PMC3748246
Source: Self-asserted source
Rajender K Motiani

STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry.

Science signaling
2013-03-19 | Journal article
DOI: 10.1126/scisignal.2003425
PMID: 23512989
PMC: PMC4030669
Source: Self-asserted source
Rajender K Motiani

miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat.

Cardiovascular research
2013-02-26 | Journal article
DOI: 10.1093/cvr/cvt045
PMID: 23447642
PMC: PMC3656613
Source: Self-asserted source
Rajender K Motiani

Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

Circulation research
2013-01-24 | Journal article
DOI: 10.1161/circresaha.111.300220
PMID: 23349245
PMC: PMC3658112
Source: Self-asserted source
Rajender K Motiani

Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration.

Pflugers Archiv : European journal of physiology
2012-09-27 | Journal article
DOI: 10.1007/s00424-012-1160-5
PMID: 23014880
PMC: PMC3489062
Source: Self-asserted source
Rajender K Motiani

Orai3 is an estrogen receptor α-regulated Ca²⁺ channel that promotes tumorigenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2012-09-19 | Journal article
DOI: 10.1096/fj.12-213801
PMID: 22993197
PMC: PMC3528310
Source: Self-asserted source
Rajender K Motiani

Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury.

Circulation research
2011-07-07 | Journal article
DOI: 10.1161/circresaha.111.246777
PMID: 21737791
PMC: PMC3164514
Source: Self-asserted source
Rajender K Motiani

A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells.

The Journal of biological chemistry
2010-04-15 | Journal article
DOI: 10.1074/jbc.m110.102582
PMID: 20395295
PMC: PMC2885196
Source: Self-asserted source
Rajender K Motiani

Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration.

American journal of physiology. Cell physiology
2010-01-27 | Journal article
DOI: 10.1152/ajpcell.00325.2009
PMID: 20107038
PMC: PMC2867390
Source: Self-asserted source
Rajender K Motiani

Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2009-04-13 | Journal article
DOI: 10.1096/fj.09-131128
PMID: 19364762
PMC: PMC2717784
Source: Self-asserted source
Rajender K Motiani

Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.

Arthritis and rheumatism
2008-11-01 | Journal article
DOI: 10.1002/art.23958
PMID: 18975308
PMC: PMC2657141
Source: Self-asserted source
Rajender K Motiani

Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation.

Circulation research
2008-10-09 | Journal article
DOI: 10.1161/01.res.0000338496.95579.56
PMID: 18845811
PMC: PMC2682347
Source: Self-asserted source
Rajender K Motiani
How many people are using ORCID?