Personal information

Emails & domains

Verified email domains

Websites & social links

http://www.ncl.ac.uk/chemistry/staff/profile/mikewaring.html#background

Keywords

Medicinal Chemistry, Drug discovery, Organic chemistry, Chemical biology, Chemistry

Countries

United Kingdom

Activities

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Employment (3)

Newcastle University: Newcastle upon Tyne, Newcastle upon Tyne, GB

2015-09 to present | Professor of Medicinal Chemistry (Chemistry)
Employment
Source: Self-asserted source
Michael Waring

AstraZeneca Alderley Park: Macclesfield, Cheshire, GB

2001-07 to 2015-08 | Principal Scientist (Medicinal Chemistry)
Employment
Source: Self-asserted source
Michael Waring

University of Texas at Austin: Austin, TX, US

2000-01 to 2001-07 | Post doctoral researcher (Chemistry and Biochemistry)
Employment
Source: Self-asserted source
Michael Waring

Education and qualifications (2)

University of Manchester: Manchester, Manchester, GB

1996-09 to 1999-09 | PhD (Chemistry)
Education
Source: Self-asserted source
Michael Waring

University of Manchester: Manchester, Manchester, GB

1993-09 to 1996-06 | BSc (Chemistry)
Education
Source: Self-asserted source
Michael Waring

Funding (2)

Allosteric Inhibitors of SOS

2017-03 to 2019-03 | Grant
Pancreatic Cancer Research Fund (London, GB)
Source: Self-asserted source
Michael Waring

The Drug Discovery Programme at the Northern Institute for Cancer Research

2015 to 2020 | Grant
Cancer Research UK (London, GB)
Source: Self-asserted source
Michael Waring

Works (50 of 119)

Items per page:
Page 1 of 3

2.12 Micelle-Mediated Synthesis

2024 | Book chapter
DOI: 10.1055/sos-SD-241-00187
Contributors: J. S. Graham; H. A. Stanway-Gordon; M. J. Waring
Source: check_circle
Crossref

An analysis of the physicochemical properties of oral drugs from 2000 to 2022

RSC Medicinal Chemistry
2024 | Journal article
DOI: 10.1039/D4MD00160E
Contributors: Rachael Pirie; Harriet A. Stanway-Gordon; Hannah L. Stewart; Kirsty L. Wilson; Summer Patton; Jack Tyerman; Daniel J. Cole; Katherine Fowler; Michael J. Waring
Source: check_circle
Crossref

Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction

2024-06-03 | Preprint
DOI: 10.1101/2024.06.03.596235
Contributors: Ian Hope; Martin E. M. Noble; Michael J. Waring; E. M. Martin Noble; Jane A. Endicott; Natalie J. Tatum
Source: check_circle
Crossref

Micelle‐Promoted Reductive Amination of DNA‐Conjugated Amines for DNA‐Encoded Library Synthesis

Chemistry – A European Journal
2024-04-11 | Journal article
DOI: 10.1002/chem.202400239
Contributors: Matthew J. Anderson; Thomas P. Carton; Catherine L. A. Salvini; James J. Crawford; Garry Pairaudeau; Michael J. Waring
Source: check_circle
Crossref

Conformational study into N-alkyl-N′-aryl ureas to inform drug discovery

Bioorganic & Medicinal Chemistry
2023-08 | Journal article
DOI: 10.1016/j.bmc.2023.117387
Contributors: Hannah L. Stewart; Marta Bon; Corinne Wills; Mathew P. Martin; Lan Z. Wang; Eilidh S. Mackenzie; Paul G. Waddell; Michael J. Waring
Source: check_circle
Crossref

Micelle‐Mediated Sonogashira Coupling for DNA‐Encoded Library Synthesis

Chemistry – A European Journal
2023-07-26 | Journal article
DOI: 10.1002/chem.202300603
Contributors: Jessica S. Graham; Harriet A. Stanway‐Gordon; Michael J. Waring
Source: check_circle
Crossref

Development of a Micellar-Promoted Heck Reaction for the Synthesis of DNA-Encoded Libraries

Bioconjugate Chemistry
2023-03-08 | Journal article
DOI: 10.1021/acs.bioconjchem.3c00051
Contributors: Harriet A. Stanway-Gordon; Jake A. Odger; Michael J. Waring
Source: check_circle
Crossref

On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries

Angewandte Chemie
2022-01-17 | Journal article
DOI: 10.1002/ange.202111927
Contributors: Harriet A. Stanway‐Gordon; Jessica S. Graham; Michael J. Waring
Source: check_circle
Crossref

On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries

Angewandte Chemie International Edition
2022-01-17 | Journal article
DOI: 10.1002/anie.202111927
Contributors: Harriet A. Stanway‐Gordon; Jessica S. Graham; Michael J. Waring
Source: check_circle
Crossref

Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid

RSC Advances
2021 | Journal article
DOI: 10.1039/D1RA05539A
Contributors: Mélanie Uguen; Conghao Gai; Lukas J. Sprenger; Hang Liu; Andrew G. Leach; Michael J. Waring
Source: check_circle
Crossref

Functional Group Tolerance of a Micellar on-DNA Suzuki–Miyaura Cross-Coupling Reaction for DNA-Encoded Library Design

The Journal of Organic Chemistry
2021-12-17 | Journal article
DOI: 10.1021/acs.joc.1c02259
Contributors: James H. Hunter; Marco Potowski; Harriet A. Stanway-Gordon; Andrew Madin; Garry Pairaudeau; Andreas Brunschweiger; Michael J. Waring
Source: check_circle
Crossref

Micellar Buchwald–Hartwig Coupling of Aryl and Heteroarylamines for the Synthesis of DNA-Encoded Libraries

The Journal of Organic Chemistry
2021-12-03 | Journal article
DOI: 10.1021/acs.joc.1c02325
Contributors: Jessica S. Graham; James H. Hunter; Michael J. Waring
Source: check_circle
Crossref

Cyclizations and fragmentations in the alkylation of 6‐chloro‐5‐hydroxy‐4‐aminopyrimidines with aminoalkyl chlorides

Journal of Heterocyclic Chemistry
2021-04 | Journal article
DOI: 10.1002/jhet.4228
Contributors: Edwige M. H. Picazo; Amy B. Heptinstall; David M. Wilson; Céline Cano; Bernard T. Golding; Michael J. Waring
Source: check_circle
Crossref

The Maturation of DNA Encoded Libraries: Opportunities for New Users

Future Medicinal Chemistry
2021-01 | Journal article
DOI: 10.4155/fmc-2020-0285
Contributors: Daniel Conole; James H Hunter; Michael J Waring
Source: check_circle
Crossref

High Fidelity Suzuki–Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants

Bioconjugate Chemistry
2020-01-15 | Journal article
DOI: 10.1021/acs.bioconjchem.9b00838
Contributors: James H. Hunter; Lisa Prendergast; Louis F. Valente; Andrew Madin; Garry Pairaudeau; Michael J. Waring
Source: check_circle
Crossref

Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine

Journal of Medicinal Chemistry
2019-07-25 | Journal article
DOI: 10.1021/acs.jmedchem.9b00447
Contributors: Reggie Bosma; Zhiyong Wang; Albert J. Kooistra; Nick Bushby; Sebastiaan Kuhne; Jelle van den Bor; Michael J. Waring; Chris de Graaf; Iwan J. de Esch; Henry F. Vischer et al.
Source: check_circle
Crossref

Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics

Molecular Pharmacology
2017 | Journal article
DOI: 10.1124/mol.116.105551
Source: Self-asserted source
Michael Waring

AZD5153: a novel bivalent BET bromodomain inhibitor highly active against hematologic malignancies

Molecular Cancer Therapeutics
2016 | Journal article
Source: Self-asserted source
Michael Waring

Enhanced cytocompatibility and functional group content of poly (L-lysine) dendrimers by grafting with poly (oxazolines)

Polymer Chemistry
2016 | Journal article
Source: Self-asserted source
Michael Waring

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3 R)-4-[2-[4-[1-(3-Methoxy-[1, 2, 4] triazolo [4, 3-b] pyridazin-6-yl)-4-piperidyl] phenoxy] ethyl]-1, 3-dimethyl-piperazin-2-one (AZD5153)

Journal of medicinal chemistry
2016 | Journal article
Source: Self-asserted source
Michael Waring

Potent and selective bivalent inhibitors of BET bromodomains

Nature Chemical Biology
2016 | Journal article
Source: Self-asserted source
Michael Waring

Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers

Journal of Controlled Release
2016 | Journal article
Source: Self-asserted source
Michael Waring

A safe and scalable synthesis of 2-hydroxy-3-alkoxypropionates by epoxide ring opening

Tetrahedron Letters
2015 | Journal article
Source: Self-asserted source
Michael Waring

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Nature reviews Drug discovery
2015 | Journal article
Source: Self-asserted source
Michael Waring

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Nature reviews Drug discovery
2015 | Journal article
Source: Self-asserted source
Michael Waring

Challenges in the Medicinal Chemical Optimization of Binding Kinetics

Thermodynamics and Kinetics of Drug Binding
2015 | Book chapter
Source: Self-asserted source
Michael Waring

Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40

MedChemComm
2015 | Journal article
Source: Self-asserted source
Michael Waring

Discovery of potent, selective small molecule inhibitors of $α$-subtype of type III phosphatidylinositol-4-kinase (PI4KIII$α$)

Bioorganic & medicinal chemistry letters
2015 | Journal article
Source: Self-asserted source
Michael Waring

275 Modulation of PIP2 levels through small molecule inhibition of PIP5K

European Journal of Cancer
2014 | Journal article
Source: Self-asserted source
Michael Waring

An Improved Method for Difluorocyclopropanation of Alkenes

Synlett
2014 | Journal article
Source: Self-asserted source
Michael Waring

Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor

2014 | Other
Source: Self-asserted source
Michael Waring

Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor

2014 | Other
Source: Self-asserted source
Michael Waring

Medicinal chemistry optimisation of binding kinetics

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
2014 | Conference paper
Source: Self-asserted source
Michael Waring

Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase $α$-but not $β$-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation

Chemical Communications
2014 | Journal article
Source: Self-asserted source
Michael Waring

Potential strategies for increasing drug-discovery productivity

Future medicinal chemistry
2014 | Journal article
Source: Self-asserted source
Michael Waring

An Improved Method for Difluorocyclopropanation of Alkenes

Synlett
2014-06 | Journal article
DOI: 10.1055/s-0033-1341155
Contributors: Joseph Sweeney; Duncan Gill; Neil McLay; Michael Waring; Christopher Wilkinson
Source: Self-asserted source
Michael Waring via Crossref Metadata Search

Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1

MedChemComm
2013 | Journal article
Source: Self-asserted source
Michael Waring

Matched triplicate design sets in the optimisation of glucokinase activators--maximising medicinal chemistry information content

MedChemComm
2013 | Journal article
Source: Self-asserted source
Michael Waring

Optimisation of biphenyl acetic acid inhibitors of diacylglycerol acetyl transferase 1--the discovery of AZD2353

MedChemComm
2013 | Journal article
Source: Self-asserted source
Michael Waring

Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets--the discovery of AZD3651 and AZD9485

MedChemComm
2013 | Journal article
Source: Self-asserted source
Michael Waring

Phosphatidylinositol-4-kinase-Potent and selective inhibitors of PI4K$α$ and PI4K$β$.

2013 | Other
Source: Self-asserted source
Michael Waring

Property-Based Design in the Optimisation of Benzamide Glucokinase Activators

Progress in Medicinal Chemistry
2013 | Other
DOI: 10.1016/b978-0-444-62652-3.00001-6
Contributors: Darren McKerrecher; Michael J. Waring
Source: Self-asserted source
Michael Waring via Crossref Metadata Search

Property-based design in the optimisation of benzamide glucokinase activators: from hit to clinic

Prog Med Chem
2013 | Journal article
Source: Self-asserted source
Michael Waring

Structure-and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)

Journal of medicinal chemistry
2013 | Journal article
Source: Self-asserted source
Michael Waring

Structure-and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)

Journal of medicinal chemistry
2013 | Journal article
Source: Self-asserted source
Michael Waring

Property based optimisation of glucokinase activators--discovery of the phase IIb clinical candidate AZD1656

MedChemComm
2012 | Journal article
Source: Self-asserted source
Michael Waring

Room-temperature palladium-catalyzed coupling of heteroaryl amines with aryl or heteroaryl bromides

Synlett
2012 | Journal article
Source: Self-asserted source
Michael Waring

The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold

Bioorganic & medicinal chemistry letters
2012 | Journal article
Source: Self-asserted source
Michael Waring

Chemical compounds 785

2012-11 | Other
Source: Self-asserted source
Michael Waring

Benzamide derivatives useful as histone deacetylase inhibitors

2012-08 | Other
Source: Self-asserted source
Michael Waring
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Peer review (57 reviews for 11 publications/grants)

Review activity for ACS chemical biology. (3)
Review activity for ACS medicinal chemistry letters. (5)
Review activity for Bioconjugate chemistry. (3)
Review activity for Bioorganic & medicinal chemistry. (1)
Review activity for Chemistry. (1)
Review activity for Journal of medicinal chemistry. (37)
Review activity for Journal of organic chemistry. (1)
Review activity for Journal of the American Chemical Society. (3)
Review activity for Molecular pharmaceutics. (1)
Review activity for Nature (1)
Review activity for Organic process research & development. (1)
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