Brennan Wadsworth (0000-0002-9183-227X)

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I am a postdoctoral fellow in the laboratory of Dr. Randall S. Johnson at the Karolinska Institutet in Stockholm, Sweden, investigating the role of cellular oxygen sensing in directing cellular metabolism and the resulting effects on epigenetics.
I completed my PhD under the supervision of Dr. Kevin L. Bennewith at the University of British Columbia while conducting my research at the British Columbia Cancer Research Institute, in Vancouver, Canada. My PhD work investigated solid tumour perfusion, tumour hypoxia, and the role of cancer associated fibroblasts in the development of tumour vascular dysfunction leading to perfusion-limited hypoxia.

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Karolinska Institutet: Solna, Stockholm County, SE

2021-02 to present | Postdoctoral Fellow (Cell and Molecular Biology)

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Brennan Wadsworth

https://orcid.org/0000-0002-9183-227X

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Employment (3)

Karolinska Institutet: Solna, Stockholm County, SE

BC Cancer: Vancouver, BC, CA

BC Cancer Agency: Vancouver, British Columbia, CA

Education and qualifications (2)

University of British Columbia: Vancouver, British Columbia, CA

University of Waterloo: Waterloo, ON, CA

Professional activities (1)

Radiation Research Society: MT, MT, US

Works (21)

A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

Relating Macroscopic PET Radiomics Features to Microscopic Tumor Phenotypes Using a Stochastic Mathematical Model of Cellular Metabolism and Proliferation

A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue

A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue

Glutarate regulates T cell metabolism and anti-tumour immunity

Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth.

Transiently hypoxic tumour cell turnover and radiation sensitivity in human tumour xenografts

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development.

Evaluation of 18F-EF5 for detection of hypoxia in localized adenocarcinoma of the prostate

Receptor-Type Protein Tyrosine Phosphatase Alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.

Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer

Angiotensin II type 1 receptor blocker telmisartan inhibits the development of transient hypoxia and improves tumour response to radiation.

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice.

IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner.

Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours.

2-18F-Fluoroethanol Is a PET Reporter of Solid Tumor Perfusion.

Maraviroc decreases CCL8-mediated migration of CCR5(+) regulatory T cells and reduces metastatic tumor growth in the lungs.

Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype.