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peroxisome, ABC transporters, adrenoleukodystrophy
France

Activities

Employment (3)

University of Bourgogne: Dijon, FR

2012-09 to present | Professor of Biochemistry and Molecular Biology (IUT Dijon)
Employment
Source: Self-asserted source
Stephane Savary

University of Bourgogne: Dijon, FR

1998-09-01 to 2012-08-31 | Associate Professor of Biochemistry and Molecular Biology (IUT Dijon )
Employment
Source: Self-asserted source
Stephane Savary

University of Tours: Tours, FR

1996-09-01 to 1998-08-31 | Assistant Professor, Molecular Biology,
Employment
Source: Self-asserted source
Stephane Savary

Education and qualifications (3)

Université de Bourgogne: Dijon, FR

2004 | Habilitation to Supervise Researches
Education
Source: Self-asserted source
Stephane Savary

Aix-Marseille Université: Marseille, FR

1996 | PhD. Immunology
Education
Source: Self-asserted source
Stephane Savary

Aix-Marseille Université: Marseille, FR

1993 | MS Immunology
Education
Source: Self-asserted source
Stephane Savary

Works (50 of 51)

Items per page:
Page 1 of 2

Ribes nigrum leaf extract downregulates pro-inflammatory gene expression and regulates redox balance in microglial cells

BMC Complementary Medicine and Therapies
2025-02-12 | Journal article
Part of ISSN: 2662-7671
Contributors: Alvard Minasyan; Vivien Pires; Catherine Gondcaille; Mikayel Ginovyan; Marika Mróz; Stéphane Savary; Mustapha Cherkaoui-Malki; Barbara Kusznierewicz; Agnieszka Bartoszek; Pierre Andreoletti et al.
Source: Self-asserted source
Stephane Savary

Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes

Frontiers in Molecular Neuroscience
2025-01-30 | Journal article
Part of ISSN: 1662-5099
Contributors: Ali Tawbeh; Catherine Gondcaille; Fatima-Ezzahra Saih; Quentin Raas; Damien Loichot; Yannick Hamon; Céline Keime; Alexandre Benani; Francesca Di Cara; Mustapha Cherkaoui-Malki et al.
Source: Self-asserted source
Stephane Savary

Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model

Cell Reports
2024-02 | Journal article
Part of ISSN: 2211-1247
Contributors: Brendon D. Parsons; Daniel Medina-Luna; Michal Scur; Marinella Pinelli; Gayani S. Gamage; Rebecca A. Chilvers; Yannick Hamon; Ibrahim H.I. Ahmed; Stéphane Savary; Andrew P. Makrigiannis et al.
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation

Frontiers in Molecular Neuroscience
2023-12-18 | Journal article
Part of ISSN: 1662-5099
Contributors: Ali Tawbeh; Quentin Raas; Mounia Tahri-Joutey; Céline Keime; Romain Kaiser; Doriane Trompier; Boubker Nasser; Emma Bellanger; Marie Dessard; Yannick Hamon et al.
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

Peroxisomal defects in microglial cells induce a disease-associated microglial signature

Frontiers in Molecular Neuroscience
2023-04-17 | Journal article
Part of ISSN: 1662-5099
Contributors: Quentin Raas; Ali Tawbeh; Mounia Tahri-Joutey; Catherine Gondcaille; Céline Keime; Romain Kaiser; Doriane Trompier; Boubker Nasser; Valerio Leoni; Emma Bellanger et al.
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in Acox1−/− and Wild-Type BV-2 Microglial Cells

Antioxidants
2023-01-11 | Journal article
Contributors: Soukaina Essadek; Catherine Gondcaille; Stéphane Savary; Mohammad Samadi; Joseph Vamecq; Gérard Lizard; Riad El Kebbaj; Norbert Latruffe; Alexandre Benani; Boubker Nasser et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Protective Effect of Nopal Cactus (Opuntia ficus-indica) Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver

International Journal of Molecular Sciences
2022-10-06 | Journal article
Contributors: Mounia Tahri-Joutey; Fatima-Ezzahra Saih; Riad El Kebbaj; Catherine Gondcaille; Joseph Vamecq; Norbert Latruffe; Gérard Lizard; Stéphane Savary; Boubker Nasser; Mustapha Cherkaoui-Malki et al.
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Microgliosis: a double‐edged sword in the control of food intake

The FEBS Journal
2022-08-02 | Journal article
Part of ISSN: 1742-464X
Part of ISSN: 1742-4658
Contributors: Stephane Savary
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

The peroxisome: an up-and-coming organelle in immunometabolism

Trends in Cell Biology
2022-07 | Journal article
Part of ISSN: 0962-8924
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

Effects of a Short-Term Lipopolysaccharides Challenge on Mouse Brain and Liver Peroxisomal Antioxidant and β-oxidative Functions: Protective Action of Argan Oil

Pharmaceuticals
2022-04 | Journal article | Author
Contributors: Soukaina Essadek; Habiba BOUCHAB; Riad El Kebbaj; Catherine Gondcaille; Soufiane El Kamouni; Stephane Savary; Joseph Vamecq; Abdelkhalid Essamadi; Mustapha Cherkaoui-Malki; Boubker Nasser et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Peroxisomal ABC Transporters: An Update

International Journal of Molecular Sciences
2021-06-05 | Journal article
Contributors: Ali Tawbeh; Catherine Gondcaille; Doriane Trompier; Stéphane Savary
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Do ABC transporters regulate plasma membrane organization?

Cellular & Molecular Biology Letters
2020-12 | Journal article
Part of ISSN: 1425-8153
Part of ISSN: 1689-1392
Source: Self-asserted source
Stephane Savary

Peroxisomes in Immune Response and Inflammation

International Journal of Molecular Sciences
2019-08-08 | Journal article
Part of ISSN: 1422-0067
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: Novel microglial models for X-linked Adrenoleukodystrophy

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
2019-02 | Journal article
Part of ISSN: 1388-1981
Contributors: Q. Raas; C. Gondcaille; Y. Hamon; V. Leoni; C. Caccia; F. Ménétrier; G. Lizard; D. Trompier; S. Savary
Source: Self-asserted source
Stephane Savary via Crossref Metadata Search
grade
Preferred source (of 2)‎

A microglial cell model for acyl-CoA oxidase 1 deficiency

Biochim. Biophys. Acta
2018 | Journal article
Contributors: Raas, Q.; Saih, F. E.; Gondcaille, C.; Trompier, D.; Hamon, Y.; Leoni, V.; Caccia, C.; Nasser, B.; Jadot, M.; Menetrier, F. et al.
Source: Self-asserted source
Stephane Savary via ResearcherID
grade
Preferred source (of 2)‎

Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells.

Methods in molecular biology (Clifton, N.J.)
2017 | Journal article
Source: Self-asserted source
Stephane Savary via Europe PubMed Central

Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters.

International journal of molecular sciences
2017-07 | Journal article
Source: Self-asserted source
Stephane Savary via Europe PubMed Central
grade
Preferred source (of 2)‎

Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain.

Acta physiologica (Oxford, England)
2017-04 | Journal article
Source: Self-asserted source
Stephane Savary via Europe PubMed Central

Peroxisomal ATP-binding cassette transporters form mainly tetramers.

The Journal of biological chemistry
2017-04 | Journal article
Source: Self-asserted source
Stephane Savary via Europe PubMed Central

Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.

2016-02 | Journal article
Contributors: Zarrouk A; Nury T; Karym EM; Vejux A; Sghaier R; Gondcaille C; Andreoletti P; Trompier D; Savary S; Cherkaoui-Malki M et al.
Source: Self-asserted source
Stephane Savary via Europe PubMed Central

Brain peroxisomes

Biochimie
2014 | Journal article
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

LXR antagonists induce ABCD2 expression

Biochim Biophys Acta
2014 | Journal article
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists

Biochem Biophys Res Commun
2014 | Journal article
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

Structure-function analysis of peroxisomal ABC transporters using chimeric dimers

J Biol Chem
2014 | Journal article
Source: Self-asserted source
Stephane Savary
grade
Preferred source (of 2)‎

X-linked adrenoleukodystrophy

Colloquium Series on The Genetic Basis of Human Disease
2013 | Book
Contributors: Trompier, Doriane; Savary, Stéphane
Source: Self-asserted source
Stephane Savary via ResearcherID

EVIDENCE OF OXIDATIVE STRESS IN VERY LONG CHAIN FATTY ACID - TREATED OLIGODENDROCYTES AND POTENTIALIZATION OF ROS PRODUCTION USING RNA INTERFERENCE-DIRECTED KNOCKDOWN OF ABCD1 AND ACOX1 PEROXISOMAL PROTEINS

Neuroscience
2012 | Journal article
WOSUID:

WOS:000305376000001

Contributors: Baarine, M.; Andreoletti, P.; Athias, A.; Nury, T.; Zarrouk, A.; Ragot, K.; Vejux, A.; Riedinger, J. -M.; Kattan, Z.; Bessede, G. et al.
Source: Self-asserted source
Stephane Savary via ResearcherID

Fatty Acids - Induced Lipotoxicity and Inflammation

Current Drug Metabolism
2012 | Journal article
WOSUID:

WOS:000312203600002

Contributors: Savary, Stephane; Trompier, Doriane; Andreoletti, Pierre; Le Borgne, Francoise; Demarquoy, Jean; Lizard, Gerard
Source: Self-asserted source
Stephane Savary via ResearcherID

Peroxisomal ABC transporters and X-linked adrenoleukodystrophy

M S-Medecine Sciences
2012 | Journal article
WOSUID:

WOS:000313373900019

Contributors: Geillon, Flore; Trompier, Doriane; Gondcaille, Catherine; Lizard, Gerard; Savary, Stephane
Source: Self-asserted source
Stephane Savary via ResearcherID

PRO-OXIDATIVE ACTIVITIES OF Abcd1 OR Acox1 DEFICIENCY, AND OF VLCFA ON OLIGODENDROCYTES SUPPORT EVIDENCES OF LIPID PEROXIDATION IN X-ALD PATIENTS

European Journal of Neurology
2011 | Journal article
WOSUID:

WOS:000294806600067

Contributors: Baarine, M.; Ragot, K.; Kattan, Z.; Andreoletti, P.; Athias, A.; Savary, S.; Cherkaoui-Malki, M.; Lizard, G.
Source: Self-asserted source
Stephane Savary via ResearcherID

Substrate Specificity Overlap and Interaction between Adrenoleukodystrophy Protein (ALDP/ABCD1) and Adrenoleukodystrophy-related Protein (ALDRP/ABCD2)

Journal of Biological Chemistry
2011 | Journal article
WOSUID:

WOS:000288013300038

Contributors: Genin, EC; Geillon, F; Gondcaille, C; Athias, A; Gambert, P; Trompier, D; Savary, S
Source: Self-asserted source
Stephane Savary via ResearcherID

Induction of the adrenoleukodystrophy-related gene (ABCD2) by thyromimetics

Journal of Steroid Biochemistry and Molecular Biology
2009 | Journal article
WOSUID:

WOS:000268116800006

Contributors: Genin, EC; Gondcaille, C; Trompier, D; Savary, S
Source: Self-asserted source
Stephane Savary via ResearcherID

Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes

Journal of Neurochemistry
2009 | Journal article
WOSUID:

WOS:000269807900012

Contributors: Baarine, M; Ragot, K; Genin, EC; El Hajj, H; Trompier, D; Andreoletti, P; Ghandour, MS; Menetrier, F; Cherkaoui-Malki, M; Savary, S et al.
Source: Self-asserted source
Stephane Savary via ResearcherID

Effect of dietary polyunsaturated fatty acids on the expression of peroxisomal ABC transporters

Biochimie
2008 | Journal article
WOSUID:

WOS:000260239900019

Contributors: Leclercq, S; Skrzypski, J; Courvoisier, A; Gondcaille, C; Bonnetain, F; Andre, A; Chardigny, JM; Bellenger, S; Bellenger, J; Narce, M et al.
Source: Self-asserted source
Stephane Savary via ResearcherID

Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPAR alpha in rodents

Biochimie
2007 | Journal article
WOSUID:

WOS:000250952400003

Contributors: Gueugnon, F; Gondcaille, C; Leclercq, S; Bellenger, J; Bellenger, S; Narce, M; Pineau, T; Bonnetain, F; Savary, S
Source: Self-asserted source
Stephane Savary via ResearcherID

A novel cell model to study the function of the adrenoleukodystrophy-related protein

Biochemical and Biophysical Research Communications
2006 | Journal article
WOSUID:

WOS:000235313400024

Contributors: Gueugnon, F; Volodina, N; Taouil, JE; Lopez, TE; Gondcaille, C; Sequeira-Le Grand, A; Mooijer, PAW; Kemp, S; Wanders, RJA; Savary, S
Source: Self-asserted source
Stephane Savary via ResearcherID

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Journal of Cell Biology
2005 | Journal article
WOSUID:

WOS:000228327500009

Contributors: Gondcaille, C; Depreter, M; Fourcade, S; Lecca, MR; Leclercq, S; Martin, PGP; Pineau, T; Cadepond, F; ElEtr, M; Bertrand, N et al.
Source: Self-asserted source
Stephane Savary via ResearcherID

Dehydroepiandrosterone induction of the Abcd2 and Abcd3 genes encoding peroxisomal ABC transporters: implications for X-linked adrenoleukodystrophy.

2003 | Journal article
Contributors: Gueugnon F; Lambert F; Gondcaille C; Fourcade S; Bellenger J; Cadepond F; El Etr M; Savary S; Bugaut M
Source: Self-asserted source
Stephane Savary via Europe PubMed Central

Pharmacological induction of redundant genes for a therapy of X-ALD - Phenylbutyrate and other compounds

Peroxisomal Disorders and Regulation of Genes
2003 | Book
WOSUID:

WOS:000188894200037

Contributors: Bugaut, M; Fourcade, S; Gondcaille, C; Gueugnon, F; Depreter, M; Roels, F; Netik, A; Berger, J; Martin, P; Pineau, T et al.
Source: Self-asserted source
Stephane Savary via ResearcherID

Thyroid hormone induction of the adrenoleukodystrophy-related gene (ABCD2)

Molecular Pharmacology
2003 | Journal article
WOSUID:

WOS:000183013900014

Contributors: Fourcade, S; Savary, S; Gondcaille, C; Berger, J; Netik, A; Cadepond, F; El Etr, M; Molzer, B; Bugaut, M
Source: Self-asserted source
Stephane Savary via ResearcherID

Fibrate induction of the adrenoleukodystrophy-related gene (ABCD2) - Promoter analysis and role of the peroxisome proliferator-activated receptor PPAR alpha

European Journal of Biochemistry
2001 | Journal article
WOSUID:

WOS:000169474100016

Contributors: Fourcade, S; Savary, S; Albet, S; Gauthe, D; Gondcaille, C; Pineau, T; Bellenger, J; Bentejac, M; Holzinger, A; Berger, J et al.
Source: Self-asserted source
Stephane Savary via ResearcherID

Rat adrenoleukodystrophy-related (ALDR) gene: full-length cDNA sequence and new insight in expression

Biochimica Et Biophysica Acta-Gene Structure and Expression
2001 | Journal article
WOSUID:

WOS:000166849900010

Contributors: Albet, S; Bentejac, M; Savary, S; Gondcaille, C; Netik, A; Berger, J; Szpirer, C; Troffer-Charlier, N; Bugaut, M
Source: Self-asserted source
Stephane Savary via ResearcherID

Pharmacological therapy of X-ALD: thyroid hormone induction of the adrenoleukodystrophy-related gene

J Inherit Metab Dis
2000 | Journal article
SOURCE-WORK-ID:

0926180909654-3403

Contributors: Bugaut, M.; Fourcade, S.; Savary, S.; Gauthé, D.; Capdepond, F.; Gondcaille, C.; Lecca, M.R.; Berger, J.
Source: Self-asserted source
Stephane Savary via ResearcherID

Polydnaviruses, viral entities domesticated by the parasitoid wasps

Virologie
1999 | Journal article
ISSN:

1267-8694

Source: Self-asserted source
Stephane Savary

The excision of polydnavirus sequences from the genome of the wasp Cotesia congregata (Braconidae, Microgastrinae) is developmentally regulated but not strictly restricted to the ovaries in the adult

Insect Molecular Biology
1999 | Journal article
WOSUID:

WOS:000082665300003

Contributors: Savary, S; Drezen, JM; Tan, F; Beckage, NE; Periquet, G
Source: Self-asserted source
Stephane Savary via ResearcherID

Exon organisation of the mouse gene encoding the Adrenoleukodystrophy related protein (ALDRP)

European Journal of Human Genetics
1998 | Journal article
WOSUID:

WOS:000077962600018

Contributors: Broccardo, C; Troffer-Charlier, N; Savary, S; Mandel, JL; Chimini, G
Source: Self-asserted source
Stephane Savary via ResearcherID

Chromosomal localization of the adrenoleukodystrophy-related gene in man and mice

European Journal of Human Genetics
1997 | Journal article
WOSUID:

WOS:A1997XD69600007

Contributors: Savary, S; TrofferCharlier, N; Gyapay, G; Mattei, MG; Chimini, G
Source: Self-asserted source
Stephane Savary via ResearcherID

Excision of the polydnavirus chromosomal integrated EP1 sequence of the parasitoid wasp Cotesia congregata (Braconidae, Microgastinae) at potential recombinase binding sites

Journal of General Virology
1997 | Journal article
WOSUID:

WOS:A1997YJ43200006

Contributors: Savary, S; Beckage, N; Tan, F; Periquet, G; Drezen, JM
Source: Self-asserted source
Stephane Savary via ResearcherID

Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human

Genomics
1997 | Journal article
WOSUID:

WOS:A1997WU55600019

Contributors: Savary, S; Allikmets, R; Denizot, F; Luciani, MF; Mattei, MG; Dean, M; Chimini, G
Source: Self-asserted source
Stephane Savary via ResearcherID

A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern

Proceedings of the National Academy of Sciences of the United States of America
1996 | Journal article
WOSUID:

WOS:A1996TU64000057

Contributors: LombardPlatet, G; Savary, S; Sarde, CO; Mandel, JL; Chimini, G
Source: Self-asserted source
Stephane Savary via ResearcherID

Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene

Mammalian Genome
1996 | Journal article
WOSUID:

WOS:A1996VF85900007

Contributors: Savary, S; Denizot, F; Luciani, MF; Mattei, MG; Chimini, G
Source: Self-asserted source
Stephane Savary via ResearcherID
Items per page:
Page 1 of 2

Peer review (26 reviews for 17 publications/grants)

Review activity for Annals of clinical and translational neurology. (1)
Review activity for Annals of neurology. (1)
Review activity for Biochimica and biophysica acta. (1)
Review activity for Brain : (1)
Review activity for Cells. (1)
Review activity for Heliyon. (1)
Review activity for International journal of molecular sciences. (7)
Review activity for Journal of cellular biochemistry. (2)
Review activity for Journal of inherited metabolic disease. (3)
Review activity for Molecular and cellular neuroscience. (1)
Review activity for Neurochemistry international. (1)
Review activity for Pharmaceutics. (1)
Review activity for PloS one. (1)
Review activity for Scientific reports. (1)
Review activity for The application of clinical genetics (1)
Review activity for Tissue & cell. (1)
Review activity for Trends in cell biology. (1)