Personal information

Other IDs

Scopus Author ID: 35218798800

Keywords

chemical biology, medicinal chemistry, kinase signal transduction

Biography

I received my Ph.D. in chemistry under the guidance of Prof. Yong Tang from Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, where I have developed novel methodologies of synthesizing functionalized cyclopropanes, expoxides, and aziridines via ylide route in 2006. After that, I moved to United States and worked with Prof. Nathanael S. Gray as research fellow at Dana-Farber Cancer Institute, Harvard Medical School, developing potent and selective kinase inhibitors, both as a tool compound for delineating kinase function and as a lead for drug development. Since 2012, I set up my research laboratory at school of life sciences, Xiamen University, CHINA. Our research is focused on development of small molecule modulators for targeting disease-related kinases and epigenetic enzymes. I have published 38 research papers including Nature, Cancer Cell, Nature Chemical Biology, J. Am. Chem. Soc., J. Med. Chem. and so on.

Activities

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Employment (2)

Harvard Medical School: Boston, MA, US

2006-08-07 to 2012-03-29 | Research Fellow (Department of Biological Chemistry and Molecular Pharmacology)
Employment
Source: Self-asserted source
Xianming Deng

Dana Farber Cancer Institute: Boston, MA, US

2006-08-07 to 2012-03-29 | Research Fellow (Department of Cancer Biology)
Employment
Source: Self-asserted source
Xianming Deng

Education and qualifications (2)

Shanghai Institute of Organic Chemistry: Shanghai, CN

2001-09-01 to 2006-07-10 | Ph.D
Education
Source: Self-asserted source
Xianming Deng

Xiamen University: Xiamen, Fujian, CN

1997-09-01 to 2001-07-01 | B.S. (Chemistry)
Education
Source: Self-asserted source
Xianming Deng

Works (50 of 100)

Items per page:
Page 1 of 2

Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility

Organic Letters
2020 | Journal article
DOI: 10.1021/acs.orglett.0c01387
EID:

2-s2.0-85085692882

Part of ISBN:

15237052 15237060
Contributors: Zhang, L.; Wang, Y.; Huang, W.; Wei, Y.; Jiang, Z.; Kong, L.; Wu, A.-A.; Hu, Z.; Huang, H.; Xu, Q. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Bioorganic and Medicinal Chemistry Letters
2020 | Journal article
DOI: 10.1016/j.bmcl.2020.127021
EID:

2-s2.0-85079195313

Part of ISBN:

14643405 0960894X
Contributors: Chen, Y.; He, H.; Jiang, H.; Li, L.; Hu, Z.; Huang, H.; Xu, Q.; Zhou, R.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant

European Journal of Medicinal Chemistry
2020 | Journal article
DOI: 10.1016/j.ejmech.2020.112755
EID:

2-s2.0-85089955393

Part of ISBN:

17683254 02235234
Contributors: Li, X.; Su, J.; Yang, Y.; Lian, W.; Deng, Z.; Yang, Z.; Chen, G.; Zhang, B.; Dong, C.; Liu, X. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma

European Journal of Medicinal Chemistry
2020 | Journal article
DOI: 10.1016/j.ejmech.2020.112697
EID:

2-s2.0-85089373317

Part of ISBN:

17683254 02235234
Contributors: Deng, Z.; Chen, G.; Liu, S.; Li, Y.; Zhong, J.; Zhang, B.; Li, L.; Huang, H.; Wang, Z.; Xu, Q. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Modulation of brain cation-Cl<sup>−</sup> cotransport via the SPAK kinase inhibitor ZT-1a

Nature Communications
2020 | Journal article
DOI: 10.1038/s41467-019-13851-6
EID:

2-s2.0-85077574154

Part of ISBN:

20411723
Contributors: Zhang, J.; Bhuiyan, M.I.H.; Zhang, T.; Karimy, J.K.; Wu, Z.; Fiesler, V.M.; Zhang, J.; Huang, H.; Hasan, M.N.; Skrzypiec, A.E. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Pharmacological Targeting of Vacuolar H<sup>+</sup>-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

Cell Chemical Biology
2020 | Journal article
DOI: 10.1016/j.chembiol.2020.06.011
EID:

2-s2.0-85088217071

Part of ISBN:

24519448 24519456
Contributors: Wang, Y.; Zhang, L.; Wei, Y.; Huang, W.; Li, L.; Wu, A.-A.; Dastur, A.; Greninger, P.; Bray, W.M.; Zhang, C.-S. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 H-benzo[ e]pyrimido[5,4- b][1,4]diazepin-6-one Scaffold

Journal of Medicinal Chemistry
2020 | Journal article
DOI: 10.1021/acs.jmedchem.0c00596
EID:

2-s2.0-85088610350

Part of ISBN:

15204804 00222623
Contributors: Ferguson, F.M.; Liu, Y.; Harshbarger, W.; Huang, L.; Wang, J.; Deng, X.; Capuzzi, S.J.; Muratov, E.N.; Tropsha, A.; Muthuswamy, S. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition

Advanced Science
2020 | Journal article
DOI: 10.1002/advs.202001129
EID:

2-s2.0-85087204181

Part of ISBN:

21983844
Contributors: Li, Y.; Liu, Z.; Li, L.; Lian, W.; He, Y.; Khalil, E.; Mäkilä, E.; Zhang, W.; Torrieri, G.; Liu, X. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

FEBS Letters
2020 | Journal article
DOI: 10.1002/1873-3468.13812
EID:

2-s2.0-85085710862

Part of ISBN:

18733468 00145793
Contributors: Li, W.; Ni, H.; Wu, S.; Han, S.; Chen, C.; Li, L.; Li, Y.; Gui, F.; Han, J.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases

Journal of Biological Chemistry
2019 | Journal article
DOI: 10.1074/jbc.RA118.003822
EID:

2-s2.0-85063546611

Part of ISBN:

1083351X 00219258
Contributors: Tian, M.; Zeng, T.; Liu, M.; Han, S.; Lin, H.; Lin, Q.; Li, L.; Jiang, T.; Li, G.; Lin, H. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk<sup>C481S</sup> mutation in B-cell malignancies

British Journal of Pharmacology
2019 | Journal article
DOI: 10.1111/bph.14809
EID:

2-s2.0-85076380755

Part of ISBN:

14765381 00071188
Contributors: Gui, F.; Jiang, J.; He, Z.; Li, L.; Li, Y.; Deng, Z.; Lu, Y.; Wu, X.; Chen, G.; Su, J. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Close-loop dynamic nanohybrids on collagen-ark with: In situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Materials Horizons
2019 | Journal article
DOI: 10.1039/c8mh01145a
EID:

2-s2.0-85061386724

Part of ISBN:

20516355 20516347
Contributors: Liu, Z.; Li, Y.; Li, W.; Lian, W.; Kemell, M.; Hietala, S.; Figueiredo, P.; Li, L.; Mäkilä, E.; Ma, M. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance

Science Bulletin
2019 | Journal article
DOI: 10.1016/j.scib.2019.04.019
EID:

2-s2.0-85064456101

Part of ISBN:

20959281 20959273
Contributors: Yang, C.; Pang, X.; Chen, W.; Wang, X.; Lin, G.; Chu, C.; Zhang, X.; Deng, X.; Chen, X.; Liu, G.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: Stereocontrolled access to bridged [4.2.1] lactones

Chemical Science
2019 | Journal article
DOI: 10.1039/c9sc00079h
EID:

2-s2.0-85062630390

Part of ISBN:

20416539 20416520
Contributors: Li, L.; Zhu, X.-Q.; Zhang, Y.-Q.; Bu, H.-Z.; Yuan, P.; Chen, J.; Su, J.; Deng, X.; Ye, L.-W.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis

Cell
2019 | Journal article
DOI: 10.1016/j.cell.2019.01.002
EID:

2-s2.0-85061833317

Part of ISBN:

10974172 00928674
Contributors: Yin, C.; Zhu, B.; Zhang, T.; Liu, T.; Chen, S.; Liu, Y.; Li, X.; Miao, X.; Li, S.; Mi, X. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair

Acta Biomaterialia
2019 | Journal article
DOI: 10.1016/j.actbio.2019.03.047
EID:

2-s2.0-85063942850

Part of ISBN:

18787568 17427061
Contributors: Tao, J.; Zhang, J.; Du, T.; Xu, X.; Deng, X.; Chen, S.; Liu, J.; Chen, Y.; Liu, X.; Xiong, M. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

A novel microtubule inhibitor overcomes multidrug resistance in tumors

Cancer Research
2018 | Journal article
DOI: 10.1158/0008-5472.CAN-18-0455
EID:

2-s2.0-85054897790

Part of ISBN:

15387445 00085472
Contributors: Ning, N.; Yu, Y.; Wu, M.; Zhang, R.; Zhang, T.; Zhu, C.; Huang, L.; Yun, C.-H.; Benes, C.H.; Zhang, J. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-06556-9
EID:

2-s2.0-85054555938

Part of ISBN:

20411723
Contributors: Liu, M.; Zeng, T.; Zhang, X.; Liu, C.; Wu, Z.; Yao, L.; Xie, C.; Xia, H.; Lin, Q.; Xie, L. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

CRISPR/Cas9 and its application in drugs development

Yaoxue Xuebao
2018 | Journal article
DOI: 10.16438/j.05l3-4870.20l7-0644
EID:

2-s2.0-85044772588

Part of ISBN:

05134870
Contributors: Di, L.; Li, L.; Xian-Ming, D.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Development of three-dimensional brain arteriovenous malformation model for patient communication and young neurosurgeon education

British Journal of Neurosurgery
2018 | Journal article
DOI: 10.1080/02688697.2018.1424320
EID:

2-s2.0-85040962573

Part of ISBN:

1360046X 02688697
Contributors: Dong, M.; Chen, G.; Qin, K.; Ding, X.; Zhou, D.; Peng, C.; Zeng, S.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.8b00753
EID:

2-s2.0-85048366471

Part of ISBN:

15204804 00222623
Contributors: Huang, W.; Sun, X.; Li, Y.; He, Z.; Li, L.; Deng, Z.; Huang, X.; Han, S.; Zhang, T.; Zhong, J. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

ERK5 is activated by oncogenic BRAF and promotes melanoma growth

Oncogene
2018 | Journal article
DOI: 10.1038/s41388-018-0164-9
EID:

2-s2.0-85042546952

Part of ISBN:

14765594 09509232
Contributors: Tusa, I.; Gagliardi, S.; Tubita, A.; Pandolfi, S.; Urso, C.; Borgognoni, L.; Wang, J.; Deng, X.; Gray, N.S.; Stecca, B. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

Biomaterials
2018 | Journal article
DOI: 10.1016/j.biomaterials.2018.09.024
EID:

2-s2.0-85054663589

Part of ISBN:

18785905 01429612
Contributors: Li, W.; Li, Y.; Liu, Z.; Kerdsakundee, N.; Zhang, M.; Zhang, F.; Liu, X.; Bauleth-Ramos, T.; Lian, W.; Mäkilä, E. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Advanced Materials
2018 | Journal article
DOI: 10.1002/adma.201703393
EID:

2-s2.0-85031117541

Part of ISBN:

15214095 09359648
Contributors: Liu, Z.; Li, Y.; Li, W.; Xiao, C.; Liu, D.; Dong, C.; Zhang, M.; Mäkilä, E.; Kemell, M.; Salonen, J. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.7b01847
EID:

2-s2.0-85052335458

Part of ISBN:

15204804 00222623
Contributors: Czarna, A.; Wang, J.; Zelencova, D.; Liu, Y.; Deng, X.; Choi, H.G.; Zhang, T.; Zhou, W.; Chang, J.W.; Kildalsen, H. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-04947-6
EID:

2-s2.0-85049324408

Part of ISBN:

20411723
Contributors: He, H.; Jiang, H.; Chen, Y.; Ye, J.; Wang, A.; Wang, C.; Liu, Q.; Liang, G.; Deng, X.; Jiang, W. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains

ACS Chemical Biology
2018 | Journal article
DOI: 10.1021/acschembio.7b00638
EID:

2-s2.0-85052316103

Part of ISBN:

15548937 15548929
Contributors: Wang, J.; Erazo, T.; Ferguson, F.M.; Buckley, D.L.; Gomez, N.; Muñoz-Guardiola, P.; Diéguez-Martínez, N.; Deng, X.; Hao, M.; Massefski, W. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells

Stem Cell Reports
2018 | Journal article
DOI: 10.1016/j.stemcr.2018.08.016
EID:

2-s2.0-85054769192

Part of ISBN:

22136711
Contributors: Tusa, I.; Cheloni, G.; Poteti, M.; Gozzini, A.; DeSouza, N.H.; Shan, Y.; Deng, X.; Gray, N.S.; Li, S.; Rovida, E. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases

EMBO Molecular Medicine
2018 | Journal article
DOI: 10.15252/emmm.201708689
EID:

2-s2.0-85043453363

Part of ISBN:

17574684 17574676
Contributors: Huang, Y.; Jiang, H.; Chen, Y.; Wang, X.; Yang, Y.; Tao, J.; Deng, X.; Liang, G.; Zhang, H.; Jiang, W. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Cancer Cell
2017 | Journal article
DOI: 10.1016/j.ccell.2017.04.004
EID:

2-s2.0-85019059302

Part of ISBN:

18783686 15356108
Contributors: Zhang, S.; Chen, Q.; Liu, Q.; Li, Y.; Sun, X.; Hong, L.; Ji, S.; Liu, C.; Geng, J.; Zhang, W. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Journal of Experimental Medicine
2017 | Journal article
DOI: 10.1084/jem.20171419
EID:

2-s2.0-85033403371

Part of ISBN:

15409538 00221007
Contributors: Jiang, H.; He, H.; Chen, Y.; Huang, W.; Cheng, J.; Ye, J.; Wang, A.; Tao, J.; Wang, C.; Liu, Q. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins

Antiviral Research
2017 | Journal article
DOI: 10.1016/j.antiviral.2016.12.006
EID:

2-s2.0-85006263940

Part of ISBN:

18729096 01663542
Contributors: Beelontally, R.; Wilkie, G.S.; Lau, B.; Goodmaker, C.J.; Ho, C.M.K.; Swanson, C.M.; Deng, X.; Wang, J.; Gray, N.S.; Davison, A.J. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway

Applied Microbiology and Biotechnology
2017 | Journal article
DOI: 10.1007/s00253-017-8187-7
EID:

2-s2.0-85013381970

Part of ISBN:

14320614 01757598
Contributors: Jin, K.; Li, L.; Sun, X.; Xu, Q.; Song, S.; Shen, Y.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

New 12,8-Eudesmanolides from Eutypella sp. 1-15

Journal of Antibiotics
2017 | Journal article
DOI: 10.1038/ja.2017.89
EID:

2-s2.0-85030106528

Part of ISBN:

18811469 00218820
Contributors: Wang, Y.; Wang, Y.; Wu, A.-A.; Zhang, L.; Hu, Z.; Huang, H.; Xu, Q.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Nonomuraea ceibae sp. nov., an actinobacterium isolated from Ceiba speciosa rhizosphere

International Journal of Systematic and Evolutionary Microbiology
2017 | Journal article
DOI: 10.1099/ijsem.0.001782
EID:

2-s2.0-85020414382

Part of ISBN:

14665026
Contributors: Wang, F.; Shi, J.; Huang, Y.; Wu, Y.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Targeting BRK-positive breast cancers with small-molecule kinase inhibitors

Cancer Research
2017 | Journal article
DOI: 10.1158/0008-5472.CAN-16-1038
EID:

2-s2.0-85009250161

Part of ISBN:

15387445 00085472
Contributors: Jiang, J.; Gui, F.; He, Z.; Li, L.; Li, Y.; Li, S.; Wu, X.; Deng, Z.; Sun, X.; Huang, X. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

A Landscape of Pharmacogenomic Interactions in Cancer

Cell
2016 | Journal article
DOI: 10.1016/j.cell.2016.06.017
EID:

2-s2.0-84979649916

Part of ISBN:

10974172 00928674
Contributors: Iorio, F.; Knijnenburg, T.A.; Vis, D.J.; Bignell, G.R.; Menden, M.P.; Schubert, M.; Aben, N.; Gonçalves, E.; Barthorpe, S.; Lightfoot, H. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling

Cell Reports
2016 | Journal article
DOI: 10.1016/j.celrep.2016.05.071
EID:

2-s2.0-84991063920

Part of ISBN:

22111247
Contributors: Hwang, S.-Y.; Deng, X.; Byun, S.; Lee, C.; Lee, S.-J.; Suh, H.; Zhang, J.; Kang, Q.; Zhang, T.; Westover, K.D. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors

ACS Medicinal Chemistry Letters
2016 | Journal article
DOI: 10.1021/acsmedchemlett.6b00209
EID:

2-s2.0-84991449945

Part of ISBN:

19485875
Contributors: Ferguson, F.M.; Ni, J.; Zhang, T.; Tesar, B.; Sim, T.; Kim, N.D.; Deng, X.; Brown, J.R.; Zhao, J.J.; Gray, N.S.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Cancer Research
2016 | Journal article
DOI: 10.1158/0008-5472.CAN-15-0817
EID:

2-s2.0-84958957121

Part of ISBN:

15387445 00085472
Contributors: Maxson, J.E.; Abel, M.L.; Wang, J.; Deng, X.; Reckel, S.; Luty, S.B.; Sun, H.; Gorenstein, J.; Hughes, S.B.; Bottomly, D. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition

Science Signaling
2016 | Journal article
DOI: 10.1126/scisignal.aaj2227
EID:

2-s2.0-84991786815

Part of ISBN:

19379145 19450877
Contributors: Zhang, J.; Deng, X.; Kahle, K.T.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Science Translational Medicine
2016 | Journal article
DOI: 10.1126/scitranslmed.aaf2304
EID:

2-s2.0-84983518011

Part of ISBN:

19466242 19466234
Contributors: Fan, F.; He, Z.; Kong, L.-L.; Chen, Q.; Yuan, Q.; Zhang, S.; Ye, J.; Liu, H.; Sun, X.; Geng, J. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis

Molecular Pharmaceutics
2016 | Journal article
DOI: 10.1021/acs.molpharmaceut.6b00564
EID:

2-s2.0-84994494799

Part of ISBN:

15438392 15438384
Contributors: Huang, X.; Huang, W.; Li, L.; Sun, X.; Song, S.; Xu, Q.; Zhang, L.; Wei, B.-G.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Two New Ring A-Cleaved Lanostane-Type Triterpenoids and Four Known Steroids Isolated from Endophytic Fungus Glomerella sp. F00244

Helvetica Chimica Acta
2016 | Journal article
DOI: 10.1002/hlca.201600039
EID:

2-s2.0-84980000600

Part of ISBN:

15222675 0018019X
Contributors: Guo, K.; Fang, H.; Gui, F.; Wang, Y.; Xu, Q.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Aspertetranones A-D, Putative Meroterpenoids from the Marine Algal-Associated Fungus Aspergillus sp. ZL0-1b14

Journal of Natural Products
2015 | Journal article
DOI: 10.1021/acs.jnatprod.5b00487
EID:

2-s2.0-84945321374

Part of ISBN:

15206025 01633864
Contributors: Wang, Y.; Qi, S.; Zhan, Y.; Zhang, N.; Wu, A.-A.; Gui, F.; Guo, K.; Yang, Y.; Cao, S.; Hu, Z. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Cytochalasans and sesquiterpenes from eutypella scoparia 1-15

Natural Product Communications
2015 | Journal article
DOI: 10.1177/1934578x1501001203
EID:

2-s2.0-84954240886

Part of ISBN:

15559475 1934578X
Contributors: Qi, S.; Wang, Y.; Zheng, Z.; Qingyan, X.U.; Deng, X.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Journal of Medicinal Chemistry
2015 | Journal article
DOI: 10.1021/jm500480k
EID:

2-s2.0-84920827062

Part of ISBN:

15204804 00222623
Contributors: Tan, L.; Nomanbhoy, T.; Gurbani, D.; Patricelli, M.; Hunter, J.; Geng, J.; Herhaus, L.; Zhang, J.; Pauls, E.; Ham, Y. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1521740112
EID:

2-s2.0-84952682714

Part of ISBN:

10916490 00278424
Contributors: Yin, J.; Leavenworth, J.W.; Li, Y.; Luo, Q.; Xie, H.; Liu, X.; Huang, S.; Yan, H.; Fu, Z.; Zhang, L.Y. et al.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Four new cycloheximide derivatives from Streptomyces sp. h-119

Records of Natural Products
2015 | Journal article
EID:

2-s2.0-84928102813

Part of ISBN:

13076167
Contributors: Yang, D.; Xu, Q.Y.; Deng, X.M.; Song, S.Y.; Hu, Z.Y.; Zheng, Z.H.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier

Heat shock protein 90 inhibitor mycoepoxydiene modulates kinase signaling in cervical cancer cells and inhibits in-vivo tumor growth

Anti-Cancer Drugs
2015 | Journal article
DOI: 10.1097/CAD.0000000000000135
EID:

2-s2.0-84939872839

Part of ISBN:

14735741 09594973
Contributors: Lin, P.; Yi, Y.; Lu, M.; Wang, M.; Yang, Y.; Lu, Y.; Song, S.; Zheng, Z.; Deng, X.; Zhang, L.
Source: Self-asserted source
Xianming Deng via Scopus - Elsevier
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Peer review (20 reviews for 9 publications/grants)

Review activity for ACS central science. (1)
Review activity for ACS infectious diseases. (1)
Review activity for Acta pharmaceutica sinica B. (2)
Review activity for Advanced science. (1)
Review activity for Bioorganic chemistry. (2)
Review activity for Cell discovery. (1)
Review activity for Journal of medicinal chemistry. (10)
Review activity for Journal of natural products. (1)
Review activity for Journal of the American Chemical Society. (1)
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