Personal information

Activities

Employment (2)

Institute of Biomedical Sciences, University of Sao Paulo: Sao Paulo, Sao Paulo, BR

2023-06 to present | Professor and Principal Investigator (Immunology)
Employment
Source: Self-asserted source
Diego Costa

Ribeirao Preto Medical School, University of Sao Paulo: Ribeirao Preto, Sao Paulo, BR

2020-01-01 to present | Colaborating Investivator (Biochemistry and Immunology)
Employment
Source: Self-asserted source
Diego Costa

Education and qualifications (5)

National Institute of Allergy and Infectious Diseases: Bethesda, MD, US

2018-11-26 to 2019-12-10 | Special Volunteer (Laboratory of Parasitic Diseases)
Qualification
Source: Self-asserted source
Diego Costa

National Institute of Allergy and Infectious Diseases: Bethesda, MD, US

2012-11-26 to 2018-11-25 | Postdoctoral Fellow (Laboratory of Parasitic Diseases)
Qualification
Source: Self-asserted source
Diego Costa

Universidade de São Paulo: Ribeirão Preto, SP, BR

2008 to 2012 | Ph.D. in Immunology (Departamento de Bioquímica e Imunologia)
Education
Source: Self-asserted source
Diego Costa

Universidade de São Paulo: Ribeirão Preto, SP, BR

2006 to 2008 | Masters Degree in Immunology (Departmento de Bioquímica e imunologia)
Education
Source: Self-asserted source
Diego Costa

Universidade Estadual Paulista Júlio de Mesquita Filho: Botucatu, SP, BR

2002 to 2005 | Bachelor degree in Biomedical Sciences
Education
Source: Self-asserted source
Diego Costa

Works (38)

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model

Antimicrobial Agents and Chemotherapy
2023-12-22 | Journal article
Part of ISSN: 0066-4804
Part of ISSN: 1098-6596
Contributors: Jennie Ruelas Castillo; Pranita Neupane; Styliani Karanika; Stefanie Krug; Darla Quijada; Andrew Garcia; Samuel Ayeh; Addis Yilma; Diego L. Costa; Alan Sher et al.
Source: Self-asserted source
Diego Costa

BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility

Nature Microbiology
2023-12-08 | Journal article | Author
Part of ISSN: 2058-5276
Contributors: Eduardo Pinheiro Amaral; Sivaranjani Namasivayam; Artur Trancoso Lopo de Queiroz; Eduardo Fukutani; Kerry Hilligan; Kate Aberman; Logan Fisher; Caio César Barbosa Bomfim; Keith Kauffman; Jay Buchanan et al.
Source: Self-asserted source
Diego Costa

The Endogenous Retinoic Acid Receptor Pathway Is Exploited by <i>Mycobacterium tuberculosis</i> during Infection, Both In Vitro and In Vivo

The Journal of Immunology
2023-08-15 | Journal article | Author
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Contributors: YONNE KAROLINE TENÓRIO DE MENEZES; Carolina Eto; Joseana de Oliveira; Erica Larson; Daniel Augusto Gasparin Bueno Mendes; Greicy Brisa Malaquias Dias; Murilo Delgobo; Abigail K. Gubernat; Janelle L. Gleim; Eduarda Laís Munari et al.
Source: Self-asserted source
Diego Costa

Cell death induced by <scp>NLRP3</scp> –palmitate axis impairs pulmonary damage tolerance and aggravates immunopathology during obesity‐tuberculosis comorbidity

The Journal of Pathology
2023-03 | Journal article | Author
Part of ISSN: 0022-3417
Part of ISSN: 1096-9896
Contributors: Sandra Patricia Palma Albornoz; Thais Fernanda de Campos Fraga da Silva; de Carvalho, Renan V. H.; Tamara Silva Rodrigues; Ana Flávia Gembre; Rômulo Silva de Oliveira; Fernanda Mesquita de Souza; Giseli Furlan Correa; Leandra Ramalho; Daniela Carlos et al.
Source: Self-asserted source
Diego Costa

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Journal of Experimental Medicine
2022-11-07 | Journal article
Contributors: Eduardo P. Amaral; Taylor W. Foreman; Sivaranjani Namasivayam; Kerry L. Hilligan; Keith D. Kauffman; Caio Cesar Barbosa Bomfim; Diego L. Costa; Beatriz Barreto-Duarte; Clarissa Gurgel-Rocha; Monique Freire Santana et al.
Source: check_circle
Crossref

Recent Advances in Host-Directed Therapies for Tuberculosis and Malaria

Frontiers in Cellular and Infection Microbiology
2022-05-20 | Journal article
Part of ISSN: 2235-2988
Source: Self-asserted source
Diego Costa

Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis

Frontiers in Cellular and Infection Microbiology
2022-05-02 | Journal article
Part of ISSN: 2235-2988
Source: Self-asserted source
Diego Costa

Crosstalk between Heme Oxygenase-1 and Iron Metabolism in Macrophages: Implications for the Modulation of Inflammation and Immunity

Antioxidants
2022-04-27 | Journal article
Contributors: Joseana de Oliveira; Marina B. Denadai; Diego L. Costa
Source: check_circle
Crossref
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Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells

Pharmaceutics
2021-10-22 | Journal article
Contributors: Núbia Sabrina Martins; Thais Fernanda de Campos Fraga-Silva; Giseli Furlan Correa; Mèdéton Mahoussi Michaël Boko; Leandra Naira Zambelli Ramalho; Débora Munhoz Rodrigues; Juliana Issa Hori; Diego Luis Costa; Jairo Kenupp Bastos; Vânia Luiza Deperon Bonato
Source: check_circle
Crossref
grade
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Editorial: Host-Directed Therapies for Tuberculosis

Frontiers in Cellular and Infection Microbiology
2021-08-06 | Journal article
Part of ISSN: 2235-2988
Source: Self-asserted source
Diego Costa

Enhancement of CD4+ T Cell Function as a Strategy for Improving Antibiotic Therapy Efficacy in Tuberculosis: Does It Work?

Frontiers in Cellular and Infection Microbiology
2021-06-21 | Journal article
Part of ISSN: 2235-2988
Source: Self-asserted source
Diego Costa

Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection

Mucosal Immunology
2021-01 | Journal article
Contributors: Diego L. Costa; Eduardo P. Amaral; Sivaranjani Namasivayam; Lara R. Mittereder; Logan Fisher; Caio C. Bonfim; Aline Sardinha-Silva; Robert W. Thompson; Sara E. Hieny; Bruno B. Andrade et al.
Source: check_circle
Crossref

Modulation of Inflammation and Immune Responses by Heme Oxygenase-1: Implications for Infection with Intracellular Pathogens

Antioxidants
2020-11-30 | Journal article
Contributors: Diego L. Costa; Eduardo P. Amaral; Bruno B. Andrade; Alan Sher
Source: check_circle
Crossref
grade
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The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

PLOS Pathogens
2019-06-21 | Journal article
Contributors: Aline Sardinha-Silva; Eric Y. Denkers; Flávia C. Mendonça-Natividade; Camila F. Pinzan; Carla D. Lopes; Diego L. Costa; Damien Jacot; Fabricio F. Fernandes; André L. V. Zorzetto-Fernandes; Nicholas J. Gay et al.
Source: check_circle
Crossref

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

Journal of Experimental Medicine
2019-03-04 | Journal article
Contributors: Eduardo P. Amaral; Diego L. Costa; Sivaranjani Namasivayam; Nicolas Riteau; Olena Kamenyeva; Lara Mittereder; Katrin D. Mayer-Barber; Bruno B. Andrade; Alan Sher
Source: check_circle
Crossref
grade
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Lutzomyia Iongipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites

Frontiers in Immunology
2018 | Journal article
WOSUID:

WOS:000451663400001

Contributors: Luz, Nivea F.; DeSouza-Vieira, Thiago; De Castro, Waldione; Vivarini, Aislan Carvalho; Pereira, Lais; Franca, Riam Rocha; Silveira-Mattos, Paulo S.; Costa, Diego L.; Teixeira, Clarissa; Meneses, Claudio et al.
Source: Self-asserted source
Diego Costa via ResearcherID

Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy

Microbiome
2017 | Journal article
EID:

2-s2.0-85029034077

Contributors: Namasivayam, S.; Maiga, M.; Yuan, W.; Thovarai, V.; Costa, D.L.; Mittereder, L.R.; Wipperman, M.F.; Glickman, M.S.; Dzutsev, A.; Trinchieri, G. et al.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
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Mycobacterium tuberculosis induction of heme oxygenase-1 expression is dependent on oxidative stress and reflects treatment outcomes

Frontiers in Immunology
2017 | Journal article
EID:

2-s2.0-85020013424

Contributors: Rockwood, N.; Costa, D.L.; Amaral, E.P.; Du Bruyn, E.; Kubler, A.; Gil-Santana, L.; Fukutani, K.F.; Scanga, C.A.; Flynn, J.L.; Jackson, S.H. et al.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
Preferred source (of 2)‎

T1/ST2 deficient mice display protection against Leishmania infantum experimental infection

Acta Tropica
2017 | Journal article
EID:

2-s2.0-85018507963

Contributors: Khalid, K.E.; Nascimento, M.S.L.; Sacramento, L.A.; Costa, D.L.; Lima-Júnior, D.S.; Carregaro, V.; da Silva, J.S.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
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CCR2 signaling contributes to the differentiation of protective inflammatory dendritic cells in Leishmania braziliensis infection

Journal of Leukocyte Biology
2016 | Journal article
EID:

2-s2.0-84980390885

Contributors: Costa, D.L.; Lima-Júnior, D.S.; Nascimento, M.S.; Sacramento, L.A.; Almeida, R.P.; Carregaro, V.; Silva, J.S.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
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N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions

BMC Microbiology
2016 | Journal article
EID:

2-s2.0-84992700292

Contributors: Amaral, E.P.; Conceição, E.L.; Costa, D.L.; Rocha, M.S.; Marinho, J.M.; Cordeiro-Santos, M.; D'Império-Lima, M.R.; Barbosa, T.; Sher, A.; Andrade, B.B.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
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Pharmacological inhibition of host heme oxygenase-1 suppresses mycobacterium tuberculosis infection in vivo by a mechanism dependent on T lymphocytes

mBio
2016 | Journal article
EID:

2-s2.0-84994411701

Contributors: Costa, D.L.; Namasivayam, S.; Amaral, E.P.; Arora, K.; Chao, A.; Mittereder, L.R.; Maiga, M.; Boshoff, H.I.; Barry, C.E.; Goulding, C.W. et al.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
Preferred source (of 2)‎

Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes

Journal of Experimental Medicine
2016 | Journal article
EID:

2-s2.0-85008471323

Contributors: Kugler, D.G.; Flomerfelt, F.A.; Costa, D.L.; Laky, K.; Kamenyeva, O.; Mittelstadt, P.R.; Gress, R.E.; Rosshart, S.P.; Rehermann, B.; Ashwell, J.D. et al.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
Preferred source (of 3)‎

Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection

Infection and Immunity
2015 | Journal article
EID:

2-s2.0-84949660666

Contributors: Sacramento, L.; Trevelin, S.C.; Nascimento, M.S.; Lima-Jùnior, D.S.; Costa, D.L.; Almeida, R.P.; Cunha, F.Q.; Silva, J.S.; Carregaro, V.
Source: Self-asserted source
Diego Costa via Scopus - Elsevier
grade
Preferred source (of 2)‎

Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment.

2015-04 | Journal article
Contributors: Carregaro V; Ribeiro JM; Valenzuela JG; Souza-Júnior DL; Costa DL; Oliveira CJ; Sacramento LA; Nascimento MS; Milanezi CM; Cunha FQ et al.
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Interleukin 17A acts synergistically with interferon γ to promote protection against Leishmania infantum infection.

2015-03 | Journal article
Contributors: Nascimento MS; Carregaro V; Lima-Júnior DS; Costa DL; Ryffel B; Duthie MS; de Jesus A; de Almeida RP; da Silva JS
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Protective and pathological functions of CD8+ T cells in Leishmania braziliensis infection.

2015-03 | Journal article
Contributors: Cardoso TM; Machado Á; Costa DL; Carvalho LP; Queiroz A; Machado P; Scott P; Carvalho EM; Bacellar O
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis.

2015-03 | Journal article
Contributors: Costa DL; Cardoso TM; Queiroz A; Milanezi CM; Bacellar O; Carvalho EM; Silva JS
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis.

2015-02 | Journal article
Contributors: Peres RS; Liew FY; Talbot J; Carregaro V; Oliveira RD; Almeida SL; França RF; Donate PB; Pinto LG; Ferreira FI et al.
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Modulation of immune response by RAGE and TLR4 signalling in PBMCs of diabetic and non-diabetic patients.

2015-01 | Journal article
Contributors: Frasnelli SC; de Medeiros MC; Bastos Ade S; Costa DL; Orrico SR; Rossa Junior C
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Dual effect of Lutzomyia longipalpis saliva on Leishmania braziliensis infection is mediated by distinct saliva-induced cellular recruitment into BALB/c mice ear.

2013 | Journal article
Contributors: Carregaro V; Costa DL; Brodskyn C; Barral AM; Barral-Netto M; Cunha FQ; Silva JS
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis.

2013-12 | Journal article
Contributors: Costa DL; Guimarães LH; Cardoso TM; Queiroz A; Lago E; Roselino AM; Bacellar O; Carvalho EM; Silva JS
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
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Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.

2013-07 | Journal article
Contributors: Lima-Junior DS; Costa DL; Carregaro V; Cunha LD; Silva AL; Mineo TW; Gutierrez FR; Bellio M; Bortoluci KR; Flavell RA et al.
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

BALB/c mice infected with antimony treatment refractory isolate of Leishmania braziliensis present severe lesions due to IL-4 production.

2011 | Journal article
Contributors: Costa DL; Carregaro V; Lima-Júnior DS; Silva NM; Milanezi CM; Cardoso CR; Giudice Â; de Jesus AR; Carvalho EM; Almeida RP et al.
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Nucleosides from Phlebotomus papatasi salivary gland ameliorate murine collagen-induced arthritis by impairing dendritic cell functions.

2011-10 | Journal article
Contributors: Carregaro V; Sá-Nunes A; Cunha TM; Grespan R; Oliveira CJ; Lima-Junior DS; Costa DL; Verri WA Jr; Milanezi CM; Pham VM et al.
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response.

2011-08 | Journal article
Contributors: Machado PR; Rosa ME; Costa D; Mignac M; Silva JS; Schriefer A; Teixeira MM; Bacellar O; Carvalho EM
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
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Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes.

2010-09 | Journal article
Contributors: Pereira JC; Carregaro V; Costa DL; da Silva JS; Cunha FQ; Franco DW
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Effect of interleukin-10 on the Paracoccidioides brasiliensis killing by gamma-interferon activated human neutrophils.

2007 | Journal article
Contributors: Costa DL; Dias-Melicio LA; Acorci MJ; Bordon AP; Tavian EG; Peraçoli MT; Soares AM
Source: Self-asserted source
Diego Costa via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (4 reviews for 3 publications/grants)

Review activity for Communications biology. (1)
Review activity for Heliyon. (2)
Review activity for PLoS neglected tropical diseases (1)