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Works (16)

Ras S89D mutation induced allosteric changes that promoted its nucleotide exchange and signaling activation

International Journal of Biological Macromolecules
2025-03 | Journal article
DOI: 10.1016/j.ijbiomac.2025.139538
Contributors: Yuling Li; Wenxin Huang; Lu Guo; Qingxiang Sun
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The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside

MedComm
2024-08 | Journal article
DOI: 10.1002/mco2.664
Contributors: Xiaofei Shen; Hongling Yang; Yang Yang; Xianjun Zhu; Qingxiang Sun
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Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors

Journal of Medicinal Chemistry
2023-09-14 | Journal article
DOI: 10.1021/acs.jmedchem.3c00549
Contributors: Lunan Jian; Robert Zscherp; Ulrike Beutling; Xiaofei Shen; Shiyang Xu; Xia Zhang; Mark Brönstrup; Philipp Klahn; Qingxiang Sun
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Cryo-EM structure of the Mon1–Ccz1–RMC1 complex reveals molecular basis of metazoan RAB7A activation

Proceedings of the National Academy of Sciences
2023-05-30 | Journal article
DOI: 10.1073/pnas.2301725120
Contributors: Xin Yong; Guowen Jia; Zhe Liu; Chunzhuang Zhou; Jiamin Yi; Yingying Tang; Li Chen; Lu Chen; Yuan Wang; Qingxiang Sun et al.
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Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach

Journal of Medicinal Chemistry
2023-01-26 | Journal article
DOI: 10.1021/acs.jmedchem.2c01772
Contributors: Wenxin Huang; Jia-Xi Wang; Xiaofei Shen; Yuqin Lei; Xueqin Chen; Da Jia; Xia Zhang; Qingxiang Sun
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Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors

Cellular and Molecular Life Sciences
2022-01 | Journal article
DOI: 10.1007/s00018-021-04022-2
Contributors: Yuping Tan; Xia Zhou; Yanqiu Gong; Kun Gou; Youfu Luo; Da Jia; Lunzhi Dai; Yinglan Zhao; Qingxiang Sun
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Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN

Cellular and Molecular Life Sciences
2021-12 | Journal article
DOI: 10.1007/s00018-021-03992-7
Contributors: Jialin Yao; Yingfeng Tu; Congcong Shen; Qiao Zhou; Hengyi Xiao; Da Jia; Qingxiang Sun
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Chromosome Region Maintenance 1 (XPO1/CRM1) as an Anticancer Target and Discovery of Its Inhibitor

Journal of Medicinal Chemistry
2021-11-11 | Journal article
DOI: 10.1021/acs.jmedchem.1c01145
Contributors: Song Liu; Wenliang Qiao; Qingxiang Sun; Youfu Luo
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Nuclear Import Receptors and hnRNP K Mediates Nuclear and Stress Granule Localization of SIRLOIN

2021-07-12 | Other
DOI: 10.21203/rs.3.rs-680424/v1
Contributors: Jialin Yao; Qiao Zhou; Hengyi Xiao; Da Jia; Qingxiang Sun
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Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin

Journal of Natural Products
2021-05-28 | Journal article
DOI: 10.1021/acs.jnatprod.0c01231
Contributors: Yuqin Lei; Yuling Li; Yuping Tan; Zhiyong Qian; Qiao Zhou; Da Jia; Qingxiang Sun
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Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1

Journal of Medicinal Chemistry
2021-05-27 | Journal article
DOI: 10.1021/acs.jmedchem.0c01675
Contributors: Yuqin Lei; Qi An; Xiao-fei Shen; Min Sui; Chungen Li; Da Jia; Youfu Luo; Qingxiang Sun
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Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor

International Journal of Nanomedicine
2021-04 | Journal article
DOI: 10.2147/IJN.S266398
Contributors: Min Sui; Meimei Xiong; Yuling Li; Qiao Zhou; Xiaofei Shen; Da Jia; Maling Gou; Qingxiang Sun
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Design and structural characterization of autoinhibition-compromised full-length Ran

Signal Transduction and Targeted Therapy
2021-02-03 | Journal article
DOI: 10.1038/s41392-020-00398-y
Contributors: Yuping Tan; Yuqing Zhang; Qiao Zhou; Da Jia; Qingxiang Sun
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GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation

Molecular Biomedicine
2020-12 | Journal article
DOI: 10.1186/s43556-020-00011-2
Contributors: Jinhan Zhou; Yuping Tan; Yuqing Zhang; Aiping Tong; Xiaofei Shen; Xiaodong Sun; Da Jia; Qingxiang Sun
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Engineering chromosome region maintenance 1 fragments that bind to nuclear export signals

Protein Science
2020-06 | Journal article
DOI: 10.1002/pro.3724
Contributors: Yuqin Lei; Qi An; Yuqing Zhang; Ping Luo; Youfu Luo; Xiaofei Shen; Da Jia; Qingxiang Sun
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Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals

eLife
2019-04-25 | Journal article
DOI: 10.7554/eLife.41331
Contributors: Yuling Li; Jinhan Zhou; Sui Min; Yang Zhang; Yuqing Zhang; Qiao Zhou; Xiaofei Shen; Da Jia; Junhong Han; Qingxiang Sun
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Peer review (9 reviews for 5 publications/grants)

Review activity for Bioorganic chemistry. (3)
Review activity for Communications biology. (1)
Review activity for Current genetics. (1)
Review activity for iScience. (2)
Review activity for Molecular biomedicine. (2)
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