Personal information

Other IDs

Scopus Author ID: 7004684559

Keywords

Organic Synthesis, Medicinal Chemistry

Countries

Japan

Activities

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Employment (3)

Toyama Daigaku: Toyama, JP

2010-04 to present | Full Professor
Employment
Source: Self-asserted source
Naoki Toyooka

Toyama Daigaku: Toyama, JP

2001-04 to 2010-03 | Associate Professor
Employment
Source: Self-asserted source
Naoki Toyooka

Toyama Daigaku: Toyama, JP

1989-04 to 2001-03 | Assistant Professor
Employment
Source: Self-asserted source
Naoki Toyooka

Education and qualifications (1)

Kindai University: higashiosaka, JP

1979-04-01 to 1989-03-31
Education
Source: Self-asserted source
Naoki Toyooka

Funding (1)

Sato Memorial Award

Award
Pharmaceutical and Medical Device Regulatory Science Society of Japan (Tokyo, JP)
Source: Self-asserted source
Naoki Toyooka

Works (50 of 127)

Items per page:
Page 1 of 3

Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner

Cells
2024-10 | Journal article | Author
DOI: 10.3390/cells13201711
Contributors: Abdul Hayee; Eiji Kobayashi; Chihiro Motozono; Hiroshi Hamana; Ha Thi Viet My; Takuya Okada; Naoki Toyooka; Satoshi Yamaguchi; Tatsuhiko Ozawa; Hiroyuki Kishi
Source: check_circle
Multidisciplinary Digital Publishing Institute

A New Method for Albuminuria Measurement Using a Specific Reaction between Albumin and the Luciferin of the Firefly Squid <i>Watasenia scintillans</i>

International Journal of Molecular Sciences
2022-07 | Journal article | Author
DOI: 10.3390/ijms23158342
Contributors: Tetsuya Ishimoto; Takuya Okada; Shiho Fujisaka; Kunimasa Yagi; Kazuyuki Tobe; Naoki Toyooka; Hisashi Mori
Source: check_circle
Multidisciplinary Digital Publishing Institute

Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent-<i>cis</i>-195A and <i>cis</i>-211A

Molecules
2021-12 | Journal article | Author
DOI: 10.3390/molecules26247529
Contributors: Takuya Okada; Naizhen Wu; Katsuki Takashima; Jungoh Ishimura; Hiroyuki Morita; Takuya Ito; Takeshi Kodama; Yuhei Yamasaki; Shin-ichi Akanuma; Yoshiyuki Kubo et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of <i>Kaempferia parviflora</i>

Plants
2021-01 | Journal article | Author
DOI: 10.3390/plants10020229
Contributors: sijia sun; MinJo Kim; Dya Fita Dibwe; Ashraf M. Omar; Sirivan Athikomkulchai; Ampai Phrutivorapongkul; Takuya Okada; Kiyoshi Tsuge; Naoki Toyooka; Suresh Awale
Source: check_circle
Multidisciplinary Digital Publishing Institute

Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H<sub>2</sub>S/Ca<sub>v</sub>3.2 Signaling in Mice

Cells
2020-07 | Journal article | Author
DOI: 10.3390/cells9081748
Contributors: Shiori Hiramoto; Maho Tsubota; Kaoru Yamaguchi; Kyoko Okazaki; Aya Sakaegi; Yuki Toriyama; Junichi Tanaka; Fumiko Sekiguchi; Hiroyasu Ishikura; Hidenori Wake et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

AS1949490, an inhibitor of 5'-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons

Eur. J. Pharmacol. 2019, 851, 69-79.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice

Toxicology, 2019, 413, 33-39.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

Design and Synthesis of Functionalized Coumarins as Potential Anti-austerity Agents that Eliminates Cancer Cell's Tolerance to Nutrition Starvation

Bioorg. Med. Chem. Lett. 2019, 29, 1779-1784.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

Formal Syntheses of (-)-Lepadiformines A, C and (-)-Fasicularin

J. Org. Chem. 2019, 84, 5222-5229.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

Formal Synthesis of Gephyrotoxin 287C

Heterocycles, 2019, 99, 649-660.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

Identification and Total Synthesis of Novel Bis-Methylene-Interrupted Odd-Chain Fatty Acids with a Terminal Olefin that Activate PPM1A in Ovaries of the Limpet Cellana toreuma

Marine Drugs, 2019, 17, 410.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis and odor properties of Phantolide analogues in racemic and optically active forms

Flavour Fragr. J. 2019, 34, 113-123.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice

J. Pharmacol. Sci. 2019, 139, 129-132.
2019 | Journal article
Source: Self-asserted source
Naoki Toyooka

Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice

Neuropharmacology 2018, 138, 232-244.
2018 | Journal article
Source: Self-asserted source
Naoki Toyooka

Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers

Bioorg. Med. Chem. 2018, 26, 4410-4427.
2018 | Journal article
Source: Self-asserted source
Naoki Toyooka

Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase

Bioorg. Med. Chem. Lett. 2018, 28, 441-445.
2018 | Journal article
Source: Self-asserted source
Naoki Toyooka

In silico screening identified novel small-molecule antagonists of PAC1 receptor

J. Pharmacol. Exp. Ther. 2018, 365, 1-8.
2018 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of 8-deoxypumiliotoxin 193H and 9-deoxyhomopumiliotoxin 207O

Tetrahedron Lett. 2018, 59, 3797-3800.
2018 | Journal article
Source: Self-asserted source
Naoki Toyooka

(4Z, 15Z)-Octadecadienoic Acid Inhibits Glycogen Synthase Kinase-3β and Glucose Production in H4IIE Cells

Lipids 52, 295-301.
2017 | Journal article
Source: Self-asserted source
Naoki Toyooka

A novel serine racemase inhibitor suppresses neuronal over-activation in vivo

Bioorg. Med. Chem. 25, 3736-3745.
2017 | Journal article
Source: Self-asserted source
Naoki Toyooka

Evaluation of compound selectivity of aldo-keto reductases using differential scanning fluorimetry

J. Biochem. 161, 215-222.
2017 | Journal article
Source: Self-asserted source
Naoki Toyooka

Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of DMDP cyclic isothioureas

Bioorg. Med. Chem. 25, 107-115.
2017 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis and Odor Properties of Phantolide Analogues

Tetrahedron 73, 2089-2099.
2017 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis and Cisplatin Resistance of Lung Cancer Cells

J. Med. Chem. 60, 8441-8445.
2017 | Journal article
Source: Self-asserted source
Naoki Toyooka

Creating an Adaptive Technology Using a Cheminformatics System to Read Aloud Chemical Compound Names for People with Visual Disabilities

J. Chem. Educ. 93, 496-503.
2016 | Journal article
Source: Self-asserted source
Naoki Toyooka

Syntheses and odor properties of optically active dimethyl octenone and its analogues

Tetrahedron: Asymmetry 27, 285-293.
2016 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer

Bioorg. Med. Chem. Lett. 26, 2577-2579.
2016 | Journal article
Source: Self-asserted source
Naoki Toyooka

Timed administration of suvorexant, a dual orexin receptor antagonist, improved sleep and glucose metabolism in type 2 diabetic db/db mice

Endocrinology 157, 4146-4157.
2016 | Journal article
Source: Self-asserted source
Naoki Toyooka

Acquisition of doxorubicin resistance facilitates invasive potentials of gastric cancer MKN45 cells through up-regulating aldo-keto reductase 1B10

Chem. Biol. Interact. 230, 30-39.
2015 | Journal article
Source: Self-asserted source
Naoki Toyooka

Enantiodivergent strategy for the synthesis of polyhydroxylated pyrrolizidines and evaluation of their inhibitory activities against glycosidases

Tetrahedron Lett. 56, 331-334.
2015 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis and evaluations of GLP-1 secretion and anti-diabetic effect in KKAy mice of new tricyclic compounds

Heterocycles 90, 372-404.
2015 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1

Org. Biomol. Chem. 13, 7487-7499.
2015 | Journal article
Source: Self-asserted source
Naoki Toyooka

Discovery of novel adenylyl cyclase inhibitor by cell-based screening

Biol. Pharm. Bull. 37, 1689-1693.
2014 | Journal article
Source: Self-asserted source
Naoki Toyooka

In silico and pharmacological screenings identify novel serine racemase inhibitors

Bioorg. Med. Chem. Lett. 24, 3732-3735.
2014 | Journal article
Source: Self-asserted source
Naoki Toyooka

Laboratory and practical synthesis of suvorexant, a selective dual orexin receptor antagonist

Tetrahedron Lett. 55, 5778-5780.
2014 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of 8-Amino-(dihydrofuran-fused Perhydrophenanthrene) via copper-mediated amination reaction

Heterocycles 88, 755-763.
2014 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent

Bioorg. Med. Chem. Lett. 24, 604-608.
2014 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3

Bioorg. Med. Chem. 22, 5220-5233.
2014 | Journal article
Source: Self-asserted source
Naoki Toyooka

Dietary alkaloid sequestration in a poison frog: An experimental test of alkaloid uptake in melanophryniscus stelzneri (Bufonidae)

J. Chem. Ecol. 39, 1400-1406.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Enantiodivergent synthesis of the quinolizidine poison frog alkaloid 195C

Tetrahedron 69, 10311-10315.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Lipase-mediated preparation of optically active isomers of cyclamen aldehyde

J. Mol. Catal. B: Enzymatic 96, 27-33.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2)

Eur. J. Med. Chem. 62, 649-660.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation

Bioorg. Med. Chem. Lett. 23, 4907-4910.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Stereoselective total synthesis of (-)-batzellasides A, B, and C

Eur. J. Org. Chem. 2841-2848.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer’s disease agent

Bioorg. Med. Chem. 21, 4459-4471.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis and antitumor activity of des-AB analogue of steroidal saponin OSW-1

Tetrahedron 69, 8019-8024.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy

Eur. J. Med. Chem. 60, 78-88.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis and biological evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-L-fucosidases

Bioorg. Med. Chem. 21, 6565-6573.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as the inhibitor for AKR1B10

Bioorg. Med. Chem. 21, 6378-6384.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka

Synthesis of phenylalkyl substituted polyhydroxypiperidines as potent inhibitors for α-L-fucosidases

Tetrahedron 69, 10653-10661.
2013 | Journal article
Source: Self-asserted source
Naoki Toyooka
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Peer review (26 reviews for 7 publications/grants)

Review activity for ACS omega. (3)
Review activity for Bioorganic chemistry. (2)
Review activity for ChemMedChem. (1)
Review activity for Journal of medicinal chemistry. (2)
Review activity for Journal of natural products. (3)
Review activity for Journal of organic chemistry. (12)
Review activity for Organic letters. (3)
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