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Biography

I am an Australian molecular biologist currently employed as an Instructor at Dana-Farber Cancer Institute / Harvard Medical School.

My research focus is on characterising the roles and regulation of DNA maintenance proteins, to understand how their mutation and deregulation contributes to disease states.

Activities

Employment (4)

Harvard University: Boston, MA, US

2024-03-20 to present | Instructor (Radiation Oncology)
Employment
Source: Self-asserted source
Nicholas William Ashton

Dana-Farber Cancer Institute: Boston, MA, US

2023-09-01 to present | Instructor (Radiation Oncology)
Employment
Source: Self-asserted source
Nicholas William Ashton

National Institutes of Health: Bethesda, MD, US

2016-11-01 to 2023-09-30 | Visiting Fellow (The Eunice Kennedy Shriver National Institute of Child Health and Human Development)
Employment
Source: Self-asserted source
Nicholas William Ashton

Queensland University of Technology: Brisbane, QLD, AU

2016-09 to 2016-10 | Postdoctoral fellow (Institute of Health and Biomedical Innovation)
Employment
Source: Self-asserted source
Nicholas William Ashton

Education and qualifications (3)

Queensland University of Technology: Brisbane, QLD, AU

2013-02-01 to 2016-09-08 | Doctor of Philosophy (Institute of Health and Biomedical Innovation)
Education
Source: Self-asserted source
Nicholas William Ashton

Queensland University of Technology: Brisbane, QLD, AU

2012 to 2012 | Bachelor of Biomedical Science (Honours) (Institute of Health and Biomedical Innovation)
Education
Source: Self-asserted source
Nicholas William Ashton

Queensland University of Technology: Brisbane, QLD, AU

2009 to 2011 | Bachelor of Applied Science (School of Biomedical Science)
Education
Source: Self-asserted source
Nicholas William Ashton

Professional activities (4)

Environmental Mutagenesis and Genomics Society: Reston, Virginia, US

2022 to present
Membership
Source: Self-asserted source
Nicholas William Ashton

American Association For The Advancement of Science: Washington D.C., District of Columbia, US

2021 to present
Membership
Source: Self-asserted source
Nicholas William Ashton

Australian Society for Biochemistry and Molecular Biology: Brisbane, Queensland, AU

2017 to present
Membership
Source: Self-asserted source
Nicholas William Ashton

Australian Society for Medical Research: Brisbane, Queensland, AU

2014 to present
Membership
Source: Self-asserted source
Nicholas William Ashton

Funding (1)

Mechanisms of action of USP1 inhibitors in BRCA1-deficient cancers

2024-01 to 2024-12 | Award
Susan F. Smith Center for Women’s Cancers (Boston, Massachusetts, US)
Source: Self-asserted source
Nicholas William Ashton

Works (18)

DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation

2024-10-13 | Preprint
Contributors: Natália Cestari Moreno; Emilie J. Korchak; Marcela Teatin Latancia; Dana A. D’Orlando; Temidayo Adegbenro; Irina Bezsonova; Roger Woodgate; Nicholas W. Ashton
Source: check_circle
Crossref

A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases

Journal of Molecular Biology
2023-12 | Journal article
Contributors: Nicholas W. Ashton; Nancy Jaiswal; Natália Cestari Moreno; Irina V. Semenova; Dana A. D'Orlando; Marcela Teatin Latancia; Justyna McIntyre; Roger Woodgate; Irina Bezsonova
Source: check_circle
Crossref

Strand specificity of ribonucleotide excision repair in Escherichia coli

Nucleic Acids Research
2023-02-28 | Journal article
Contributors: Krystian Łazowski; Mahmood Faraz; Alexandra Vaisman; Nicholas W Ashton; Piotr Jonczyk; Iwona J Fijalkowska; Anders R Clausen; Roger Woodgate; Karolina Makiela-Dzbenska
Source: check_circle
Crossref

COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks

Communications Biology
2021-04-19 | Journal article
Contributors: Amila Suraweera; Neha S. Gandhi; Sam Beard; Joshua T. Burgess; Laura V. Croft; Emma Bolderson; Ali Naqi; Nicholas W. Ashton; Mark N. Adams; Kienan I. Savage et al.
Source: check_circle
Crossref

Nuclear magnetic resonance spectral data of the USP7 TRAF and UBL1-2 domains in complex with DNA polymerase ι peptides

Data in Brief
2021-02 | Journal article
Part of ISSN: 2352-3409
Source: Self-asserted source
Nicholas William Ashton

DNA polymerase ι interacts with both the TRAF-like and UBL1-2 domains of USP7

Journal of Molecular Biology
2021-01 | Journal article
Source: Self-asserted source
Nicholas William Ashton
grade
Preferred source (of 2)‎

Ubiquitin and ubiquitin-Like proteins are essential regulators of DNA damage bypass

Cancers
2020-10-02 | Journal article
Part of ISSN: 2072-6694
Source: Self-asserted source
Nicholas William Ashton
grade
Preferred source (of 3)‎

USP7 is a master regulator of genome stability

Frontiers in Cell and Developmental Biology
2020-08-05 | Journal article
Source: Self-asserted source
Nicholas William Ashton
grade
Preferred source (of 2)‎

A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization.

Nucleic acids research
2017-08 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases.

DNA repair
2017-06 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

hSSB1 associates with and promotes stability of the BLM helicase.

BMC molecular biology
2017-05 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.

Scientific reports
2016 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes.

BMC molecular biology
2016-12 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.

Nucleic acids research
2016-09 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.

Nucleic acids research
2015-10 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

DNA repair pathways and their therapeutic potential in lung cancer

Lung Cancer Management
2014 | Journal article
Contributors: Burgess, Joshua T.; Croft, Laura V.; Wallace, Nathan C.; Stephenson, Sally-Anne; Adams, Mark N.; Ashton, Nicholas W.; Solomon, Benjamin; O'Byrne, Ken; Richard, Derek J.
Source: check_circle
Web of Science Researcher Profile Sync

Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation.

BMC molecular biology
2014 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

Human single-stranded DNA binding proteins are essential for maintaining genomic stability.

BMC molecular biology
2013-04 | Journal article
Source: Self-asserted source
Nicholas William Ashton via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (45 reviews for 14 publications/grants)

Review activity for Biomolecules. (3)
Review activity for Cancers. (5)
Review activity for Cell cycle. (2)
Review activity for Cell death and differentiation. (1)
Review activity for Computational and Structural Biotechnology Journal (2)
Review activity for DNA repair. (4)
Review activity for International journal of molecular sciences. (14)
Review activity for International journal of molecular sciences. (6)
Review activity for Molecular biology reports. (1)
Review activity for Molecular biology reports. (1)
Review activity for Molecular therapy oncolytics. (1)
Review activity for NAR cancer. (2)
Review activity for Nucleic acids research. (1)
Review activity for Oncogene. (2)