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Epigenetics, Spermatogenesis, Chromatin, Germ Cells
Japan

Biography

Interested in dynamics of epigenetic status during mammalian development and in oncogenesis (tumorigenesis).

Activities

Employment (4)

Asahikawa Medical University: Asahikawa, Hokkaido, JP

2020-09-10 to present | Associate Professor (Department of Advanced Medical Science)
Employment
Source: Self-asserted source
Jun Ueda

Asahikawa Medical University: Asahikawa, Hokkaido, JP

2017-04-01 to 2020-09-09 | Associate Professor (Center for Advanced Research and Education)
Employment
Source: Self-asserted source
Jun Ueda

Chubu University: Kasugai, Aichi, JP

2014-10-20 to 2017-03-31 | Assistant Professor (Center for Education in Laboratory Animal Research)
Employment
Source: Self-asserted source
Jun Ueda

Osaka University: Suita, JP

2011-01-01 to 2014-10-19 | Research Assistant Professor (Research Institute for Microbial Diseases)
Employment
Source: Self-asserted source
Jun Ueda

Funding (9)

Development of Treatment for Hereditary Neurodegenerative Diseases by Chromatin Regulation

2022-04 to 2025-03 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 22K06063
Source: Self-asserted source
Jun Ueda

Investigation of the role of testis-specific histone variant H3t in higher order chromatin structure

2019-04 to 2022-03 | Grant
Ministry of Education, Culture, Sports, Science and Technology (Tokyo, JP)
GRANT_NUMBER: 19K06452
Source: Self-asserted source
Jun Ueda

Functional analysis of the essential role the histone variant H3t in sperm formation process

Source: Self-asserted source
Jun Ueda via DimensionsWizard

Hexokinase 2 and the MAS receptor signal analysis in the micro RNA introduced mouse cardiomyopathy

Source: Self-asserted source
Jun Ueda via DimensionsWizard

Chromatin dynamics analysis of male infertility and carcinogenic process

2016-04-01 to 2018-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 16H01319
Source: Self-asserted source
Jun Ueda via DimensionsWizard

Development of epigenetics visualization mouse and kinetic analysis of the occurrence and de-differentiation process using them

Source: Self-asserted source
Jun Ueda via DimensionsWizard

Live-cell Imaging Analysis of Mouse Embryonic Stem Cell Derivation Processes

2011-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 23870017
Source: Self-asserted source
Jun Ueda via DimensionsWizard

The mechanism of the acquisition of germ cell-specific epigenome and its reconstruction in vitro.

Source: Self-asserted source
Jun Ueda via DimensionsWizard

Complex analysis of the essential role Prdm14 molecule in mammalian germ cell formation

Source: Self-asserted source
Jun Ueda via DimensionsWizard

Works (43)

Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice.

Scientific reports
2024-09-12 | Journal article
Contributors: Takayuki Kawaguchi; Hashimoto M; Nakagawa R; Minami R; Ikawa M; Nakayama JI; Ueda J
Source: Self-asserted source
Jun Ueda

Visualizing histone H4K20me1 in knock-in mice expressing the mCherry-tagged modification-specific intracellular antibody

Histochemistry and Cell Biology
2024-07 | Journal article
Contributors: Yuko Sato; Maoko Takenoshita; Miku Ueoka; Jun Ueda; Kazuo Yamagata; Hiroshi Kimura
Source: check_circle
Crossref

Transfusions of Blood Products Derived from Genetic Vaccine Recipients: Safety Concerns and Proposals for Specific Measures

2024-05-29 | Preprint
Contributors: Jun Ueda; Hideyuki Motohashi; Yuriko Hirai; Kenji Yamamoto; Yasufumi Murakami; Masanori Fukushima; Akinori Fujisawa
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

HIF3A gene disruption causes abnormal alveoli structure and early neonatal death

PLOS ONE
2024-05-08 | Journal article
Contributors: Tomoki Kawahata; Jörn Karhausen; Kitaru Tanaka; Kyohei Oyama; Jun Ueda; Kensaku Okamoto; Yuichi Makino
Source: check_circle
Crossref

Visualizing histone H4K20me1 in knock-in mice expressing the mCherry-tagged modification-specific intracellular antibody

2024-03-14 | Preprint
Contributors: Yuko Sato; Maoko Takenoshita; Miku Ueoka; Jun Ueda; Kazuo Yamagata; Hiroshi Kimura
Source: check_circle
Crossref

Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges

International Journal of Molecular Sciences
2023-03-01 | Journal article
Contributors: Jun Ueda; Taiga Yamazaki; Hiroshi Funakoshi
Source: check_circle
Crossref

Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway

Journal of Gastroenterology
2022-03 | Journal article
Part of ISSN: 0944-1174
Part of ISSN: 1435-5922
Contributors: Hidemasa Kawabata; Yusuke Ono; Nobue Tamamura; Kyohei Oyama; Jun Ueda; Hiroki Sato; Kenji Takahashi; Kenzui Taniue; Tetsuhiro Okada; Syugo Fujibayashi et al.
Source: Self-asserted source
Jun Ueda
grade
Preferred source (of 2)‎

Importance of real-time measurement of sperm head morphology in intracytoplasmic sperm injection

Zygote
2022-02 | Journal article
Contributors: Fumiaki Itoi; Toshinobu Miyamoto; Takehiro Himaki; Hiroyuki Honnma; Miho Sano; Jun Ueda
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

A critical role of STING-triggered tumor-migrating neutrophils for anti-tumor effect of intratumoral cGAMP treatment.

Cancer immunology, immunotherapy : CII
2021-01-28 | Journal article
Source: Self-asserted source
Jun Ueda

Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice

International Journal of Molecular Sciences
2021-01-28 | Journal article
Contributors: Michihiro Hashimoto; Ayumi Goto; Yuki Endo; Masataka Sugimoto; Jun Ueda; Hitoshi Yamashita
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Cellular & Molecular Biology Letters
2020-12 | Journal article
Part of ISSN: 1425-8153
Part of ISSN: 1689-1392
Source: Self-asserted source
Jun Ueda

Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance

Journal of Gastroenterology
2020-09-16 | Journal article
Part of ISSN: 0944-1174
Part of ISSN: 1435-5922
Source: Self-asserted source
Jun Ueda

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.

eLife
2020-09-01 | Journal article
Source: Self-asserted source
Jun Ueda

Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation.

BMB reports
2020-07-08 | Journal article
Source: Self-asserted source
Jun Ueda

IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95.

Bone research
2020-02-10 | Journal article
Source: Self-asserted source
Jun Ueda

Defined oocyte collection time is critical for reproducible in vitro fertilization in rats of different strains.

Theriogenology
2020-01-07 | Journal article
Source: Self-asserted source
Jun Ueda

Contour-Aware Residual W-Net for Nuclei Segmentation

Procedia Computer Science
2019 | Journal article
Part of ISSN: 1877-0509
Source: Self-asserted source
Jun Ueda

Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice

PLOS ONE
2019-07-22 | Journal article
Contributors: Fusako Kitaura; Sebastian D. Fugmann; Miyuki Yuno; Toshitsugu Fujita; Shigeharu Wakana; Jun Ueda; Kazuo Yamagata; Hodaka Fujii
Source: check_circle
Crossref

Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features

Gastroenterology
2019-02 | Journal article
Contributors: Yuko Omori; Yusuke Ono; Mishie Tanino; Hidenori Karasaki; Hiroshi Yamaguchi; Toru Furukawa; Katsuro Enomoto; Jun Ueda; Atsuko Sumi; Jin Katayama et al.
Source: check_circle
Crossref

A microfluidic device for isolating intact chromosomes from single mammalian cells and probing their folding stability by controlling solution conditions

Scientific Reports
2018-09 | Journal article
Part of ISSN: 2045-2322
Contributors: Tomohiro Takahashi; Kennedy O. Okeyo; Jun Ueda; Kazuo Yamagata; Masao Washizu; Hidehiro Oana
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search

Extraction of Cell Nuclei using CNN Features

Procedia Computer Science
2017 | Journal article
Part of ISSN: 1877-0509
Contributors: Yuya Tsukada; Yuji Iwahori; Kenji Funahashi; Mami Jose; Jun Ueda; Takashi Iwamoto
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search

Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway

PLOS ONE
2017-11 | Journal article
Part of ISSN: 1932-6203
Contributors: Jolene Caifeng Ho; Lissa Nurrul Abdullah; Qing You Pang; Sudhakar Jha; Edward Kai-Hua Chow; Henry Yang; Hiroyuki Kato; Lorenz Poellinger; Jun Ueda; Kian Leong Lee et al.
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search

The normality of sperm in an infertile man with ring chromosome 15: a case report

Journal of Assisted Reproduction and Genetics
2017-10 | Journal article
Part of ISSN: 1058-0468
Contributors: Kazuyo Nishikawa; Fumiaki Itoi; Miki Nagahara; Mami Jose; Ayumi Matsunaga; Jun Ueda; Takashi Iwamoto
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Nucleic Acids Research
2017-05 | Journal article
Part of ISSN: 0305-1048
Contributors: Yuichiro Semba; Akihito Harada; Kazumitsu Maehara; Shinya Oki; Chikara Meno; Jun Ueda; Kazuo Yamagata; Atsushi Suzuki; Mitsuho Onimaru; Jumpei Nogami et al.
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search

Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation

Scientific Reports
2017-03-03 | Journal article
Contributors: Luna Yamaguchi; Atsuya Nishiyama; Toshinori Misaki; Yoshikazu Johmura; Jun Ueda; Kyohei Arita; Koji Nagao; Chikashi Obuse; Makoto Nakanishi
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

Cell Reports
2017-01 | Journal article
Contributors: Jun Ueda; Akihito Harada; Takashi Urahama; Shinichi Machida; Kazumitsu Maehara; Masashi Hada; Yoshinori Makino; Jumpei Nogami; Naoki Horikoshi; Akihisa Osakabe et al.
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search

A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation

Journal of Molecular Biology
2016-10 | Journal article
Contributors: Yuko Sato; Tomoya Kujirai; Ritsuko Arai; Haruhiko Asakawa; Chizuru Ohtsuki; Naoki Horikoshi; Kazuo Yamagata; Jun Ueda; Takahiro Nagase; Tokuko Haraguchi et al.
Source: Self-asserted source
Jun Ueda via Crossref Metadata Search
grade
Preferred source (of 2)‎

The impact of mechanical stress on stem cell properties: The link between cell shape and pluripotency.

2016-01 | Journal article
DOI:

10:14670/hh-11-665

Contributors: Ho JC; Ueda J; Shimizu T
Source: Self-asserted source
Jun Ueda via Europe PubMed Central

The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

2014-10 | Journal article
DOI:

10.1128/MCB.00099-14

PMID:

25071150

Contributors: Ueda J; Ho JC; Lee KL; Kitajima S; Yang H; Sun W; Fukuhara N; Zaiden N; Chan SL; Tachibana M et al.
Source: Self-asserted source
Jun Ueda via Europe PubMed Central

Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO.

2014-06 | Journal article
DOI:

10.1016/j.stemcr.2014.05.008

PMID:

24936475

PMC:

PMC4050349

Contributors: Ueda J; Maehara K; Mashiko D; Ichinose T; Yao T; Hori M; Sato Y; Kimura H; Ohkawa Y; Yamagata K
Source: Self-asserted source
Jun Ueda via Europe PubMed Central

A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo

Genes & Development
2013 | Journal article
DOI:

10.1101/gad.221176.113

Part of ISSN:

0890-9369

Contributors: Dang Vinh Do; Ueda, Jun; Messerschmidt, Daniel M.; Lorthongpanich, Chanchao; Zhou, Yi; Feng, Bo; Guo, Guoji; Lin, Peiyu J.; Hossain, Md Zakir; Zhang, Wenjun et al.
Source: Self-asserted source
Jun Ueda via ResearcherID

Genetically encoded system to track histone modification in vivo

Scientific Reports
2013 | Journal article
DOI:

10.1038/srep02436

Part of ISSN:

2045-2322

Contributors: Sato, Yuko; Mukai, Masanori; Ueda, Jun; Muraki, Michiko; Stasevich, Timothy J.; Horikoshi, Naoki; Kujirai, Tomoya; Kita, Hiroaki; Kimura, Taisuke; Hira, Seiji et al.
Source: Self-asserted source
Jun Ueda via ResearcherID

Long-term live-cell imaging of mammalian preimplantation development and derivation process of pluripotent stem cells from the embryos

Development Growth & Differentiation
2013 | Journal article
DOI:

10.1111/dgd.12048

Part of ISSN:

0012-1592

Contributors: Yamagata, Kazuo; Ueda, Jun
Source: Self-asserted source
Jun Ueda via ResearcherID

MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility

Science
2013 | Journal article
DOI:

10.1126/science.1237999

Part of ISSN:

0036-8075

Contributors: Hasuwa, Hidetoshi; Ueda, Jun; Ikawa, Masahito; Okabe, Masaru
Source: Self-asserted source
Jun Ueda via ResearcherID

PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.

2013-03 | Journal article
DOI:

10.1016/j.stem.2012.12.012

PMID:

23333148

Contributors: Yamaji M; Ueda J; Hayashi K; Ohta H; Yabuta Y; Kurimoto K; Nakato R; Yamada Y; Shirahige K; Saitou M
Source: Self-asserted source
Jun Ueda via Europe PubMed Central

Dual Inhibition of Src and GSK3 Maintains Mouse Embryonic Stem Cells, Whose Differentiation is Mechanically Regulated by Src Signaling

Stem Cells
2012 | Journal article
DOI:

10.1002/stem.1119

Contributors: Shimizu, Takeshi; Ueda, Jun; Ho, Jolene Caifeng; Iwasaki, Katsuhiko; Poellinger, Lorenz; Harada, Ichiro; Sawada, Yasuhiro
Source: Self-asserted source
Jun Ueda via ResearcherID

Survival and death of epiblast cells during embryonic stem cell derivation revealed by long-term live-cell imaging with an Oct4 reporter system

Developmental Biology
2010 | Journal article
DOI:

10.1016/j.ydbio.2010.07.021

Part of ISSN:

0012-1606

Contributors: Yamagata, K; Ueda, J; Mizutani, E; Saitou, M; Wakayama, T
Source: Self-asserted source
Jun Ueda via ResearcherID

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

Nature Structural & Molecular Biology
2008 | Journal article
DOI:

10.1038/nsmb.1476

Contributors: Epsztejn-Litman, Silvina; Feldman, Nirit; Abu-Remaileh, Monther; Shufaro, Yoel; Gerson, Ariela; Ueda, Jun; Deplus, Rachel; Fuks, Francois; Shinkai, Yoichi; Cedar, Howard et al.
Source: Self-asserted source
Jun Ueda via ResearcherID

Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a

Genes To Cells
2007 | Journal article
DOI:

10.1111/j.1365-2443.2007.01098.x

Part of ISSN:

1356-9597

Contributors: Nishida, M; Kato, M; Kato, Y; Sasai, N; Ueda, J; Tachibana, M; Shinkai, Y; Yamaguchi, M
Source: Self-asserted source
Jun Ueda via ResearcherID

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP

Journal of Biological Chemistry
2006 | Journal article
DOI:

10.1074/jbc.M603087200

Part of ISSN:

0021-9258

Contributors: Ueda, J; Tachibana, M; Ikura, T; Shinkai, Y
Source: Self-asserted source
Jun Ueda via ResearcherID

[Histone lysine methylation and epigenetics].

2006-11 | Journal article
Contributors: Ueda J; Shinkai Y
Source: Self-asserted source
Jun Ueda via Europe PubMed Central

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

Genes & Development
2005 | Journal article
DOI:

10.1101/gad.1284005

Part of ISSN:

0890-9369

Contributors: Tachibana, M; Ueda, J; Fukuda, M; Takeda, N; Ohta, T; Iwanari, H; Sakihama, T; Kodama, T; Hamakubo, T; Shinkai, Y
Source: Self-asserted source
Jun Ueda via ResearcherID

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.

2002-07 | Journal article
Contributors: Tachibana M; Sugimoto K; Nozaki M; Ueda J; Ohta T; Ohki M; Fukuda M; Takeda N; Niida H; Kato H et al.
Source: Self-asserted source
Jun Ueda via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for PloS one. (1)