Personal information

Activities

Employment (1)

Medical University of Vienna Center for Brain Research: Wien, AT

2001-06-01 to present | Associate Professor (Pathobiology of the Nervous System)
Employment
Source: Self-asserted source
Margot Ernst

Education and qualifications (1)

Georgia Institute of Technology: Atlanta, GA, US

1987-09 to 1992-06 | PhD (Chemistry)
Education
Source: Self-asserted source
Margot Ernst

Funding (3)

Ligands for the GABA-A Receptor a+/b- interface

2014 to 2018 | Grant
FWF (Austrian Science Fund) (Vienna, AT)
GRANT_NUMBER:

P 27746

Source: Self-asserted source
Margot Ernst

Identification of drug binding sites in GABA-A receptors

2007-03-01 to 2012-02-29 | Grant
Austrian Science Fund (Vienna, AT)
GRANT_NUMBER:

P 19653-B11

GRANT_NUMBER: P 19653-B11
Source: Self-asserted source
Margot Ernst via DimensionsWizard

alpha6- containing GABAAR in neuropsychiatric disorders

Grant
Austrian Science Fund FWF (Vienna, AT)
GRANT_NUMBER:

I 3206

Source: Self-asserted source
Margot Ernst

Works (50 of 74)

Items per page:
Page 1 of 2

GABA<sub>A</sub> receptor-mediated seizure liabilities: a mixed-methods screening approach.

Cell biology and toxicology
2023-04-24 | Journal article
Contributors: Bampali K; Filip Tadeusz Koniuszewski; Vogel FD; Fabjan J; Christos Andronis; Lekka E; Virvillis V; Seidel T; Delaunois A; Royer L et al.
Source: Self-asserted source
Margot Ernst

β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis

Communications Biology
2022-08-03 | Journal article
Contributors: Aleksandra Garifulina; Theres Friesacher; Marco Stadler; Eva-Maria Zangerl-Plessl; Margot Ernst; Anna Stary-Weinzinger; Anita Willam; Steffen Hering
Source: check_circle
Crossref

Back Cover: Unravelling the Turn‐On Fluorescence Mechanism of a Fluorescein‐Based Probe in GABAA Receptors (Angew. Chem. Int. Ed. 30/2022)

Angewandte Chemie International Edition
2022-07-25 | Journal article
Contributors: Nadja K. Singer; Pedro A. Sánchez‐Murcia; Margot Ernst; Leticia González
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Crossref

Rücktitelbild: Unravelling the Turn‐On Fluorescence Mechanism of a Fluorescein‐Based Probe in GABAA Receptors (Angew. Chem. 30/2022)

Angewandte Chemie
2022-07-25 | Journal article
Contributors: Nadja K. Singer; Pedro A. Sánchez‐Murcia; Margot Ernst; Leticia González
Source: check_circle
Crossref

Unravelling the Turn‐On Fluorescence Mechanism of a Fluorescein‐Based Probe in GABAA Receptors

Angewandte Chemie International Edition
2022-07-25 | Journal article
Contributors: Nadja K. Singer; Pedro A. Sánchez‐Murcia; Margot Ernst; Leticia González
Source: check_circle
Crossref

Unravelling the Turn‐On Fluorescence Mechanism of a Fluorescein‐Based Probe in GABAA Receptors

Angewandte Chemie
2022-07-25 | Journal article
Contributors: Nadja K. Singer; Pedro A. Sánchez‐Murcia; Margot Ernst; Leticia González
Source: check_circle
Crossref

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels.

Frontiers in molecular biosciences
2022-05-09 | Journal article
Contributors: Filip Tadeusz Koniuszewski; Florian Daniel Vogel; Bampali K; Fabjan J; Seidel T; Scholze P; Schmiedhofer PB; Langer T; Ernst M
Source: Self-asserted source
Margot Ernst

Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABA<sub>A</sub> receptors by two distinct mechanisms.

British journal of pharmacology
2022-03-07 | Journal article | Author
Contributors: Konstantina Bampali; Filip Tadeusz Koniuszewski; Luca L. Silva; Rehman S; Florian Daniel Vogel; Seidel T; Petra Scholze; Zirpel F; Arthur Garon; Langer T et al.
Source: Self-asserted source
Margot Ernst

A de novo missense variant in GABRA4 alters receptor function in an epileptic and neurodevelopmental phenotype.

Epilepsia
2022-02-12 | Journal article | Author
Contributors: Florian Daniel Vogel; Martin Krenn; Dominik Sebastian Westphal; Elisabeth Graf; Matias Wagner; Leiz S; Filip Tadeusz Koniuszewski; Augé-Stock M; Kramer G; Petra Scholze et al.
Source: Self-asserted source
Margot Ernst

A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C

Molecular Pharmacology
2021-01 | Journal article
Contributors: Xenia Simeone; Filip Koniuszewski; Markus Müllegger; Andreas Smetka; Friederike Steudle; Roshan Puthenkalam; Margot Ernst; Petra Scholze
Source: check_circle
Crossref

Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Archives of Toxicology
2020-08-05 | Journal article
Contributors: Christos Andronis; João Pedro Silva; Eftychia Lekka; Vassilis Virvilis; Helena Carmo; Konstantina Bampali; Margot Ernst; Yang Hu; Irena Loryan; Jacques Richard et al.
Source: check_circle
Crossref

Allosteric GABAA Receptor Modulators—A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility

Molecules
2020-02-24 | Journal article
Contributors: Blanca Angelica Vega Alanis; Maria Teresa Iorio; Luca L. Silva; Konstantina Bampali; Margot Ernst; Michael Schnürch; Marko D. Mihovilovic
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A novel de novo variant of GABRA1 causes increased sensitivity for GABA in vitro

Scientific Reports
2020-02-11 | Journal article
Contributors: Friederike Steudle; Sabah Rehman; Konstantina Bampali; Xenia Simeone; Zsofia Rona; Erwin Hauser; Wolfgang M. Schmidt; Petra Scholze; Margot Ernst
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Crossref

GABA<sub>A</sub> Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain—Can the Promiscuity Code Be Cracked?

International Journal of Molecular Sciences
2020-01 | Journal article | Author
Contributors: Maria Teresa Iorio; Florian Daniel Vogel; Filip Koniuszewski; Petra Scholze; Sabah Rehman; Xenia Simeone; Michael Schnürch; Marko D. Mihovilovic; Margot Ernst
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
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Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA <inf>A</inf> receptors

European Journal of Pain (United Kingdom)
2019 | Journal article
EID:

2-s2.0-85061056415

Contributors: Vasović, D.; Divović, B.; Treven, M.; Knutson, D.E.; Steudle, F.; Scholze, P.; Obradović, A.; Fabjan, J.; Brković, B.; Sieghart, W. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Variations on a scaffold - Novel GABAA receptor modulators

European Journal of Medicinal Chemistry
2019-10 | Journal article
Contributors: Maria Teresa Iorio; Sabah Rehman; Konstantina Bampali; Berthold Stoeger; Michael Schnürch; Margot Ernst; Marko D. Mihovilovic
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Crossref

Phenotypic variability of GABRA1-related epilepsy in monozygotic twins.

Annals of clinical and translational neurology
2019-09-30 | Journal article
Contributors: Martin Krenn; Ernst M; Matthias Tomschik; Treven M; Wagner M; Dominik Sebastian Westphal; Meitinger T; Ekaterina Pataraia; Zimprich F; Aull-Watschinger S
Source: Self-asserted source
Margot Ernst

Defined concatenated α6α1β3γ2 GABAA receptor constructs reveal dual action of pyrazoloquinolinone allosteric modulators

Bioorganic & Medicinal Chemistry
2019-06 | Journal article
Contributors: X. Simeone; M.T. Iorio; D.C.B. Siebert; S. Rehman; M. Schnürch; M.D. Mihovilovic; M. Ernst
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Crossref

Attaining in vivo selectivity of positive modulation of α3βγ2 GABA<inf>A</inf> receptors in rats: A hard task!

European Neuropsychopharmacology
2018 | Journal article
EID:

2-s2.0-85048182641

Contributors: Batinić, B.; Stanković, T.; Stephen, M.R.; Kodali, R.; Tiruveedhula, V.V.; Li, G.; Scholze, P.; Marković, B.D.; Obradović, A.L.; Ernst, M. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABA<inf>A</inf>R) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability

Journal of Medicinal Chemistry
2018 | Journal article
EID:

2-s2.0-85044203204

Contributors: Knutson, D.E.; Kodali, R.; Divović, B.; Treven, M.; Stephen, M.R.; Zahn, N.M.; Dobričić, V.; Huber, A.T.; Meirelles, M.A.; Verma, R.S. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Different Benzodiazepines Bind with Distinct Binding Modes to GABA<inf>A</inf> Receptors

ACS Chemical Biology
2018 | Journal article
EID:

2-s2.0-85047377557

Contributors: Elgarf, A.A.; Siebert, D.C.B.; Steudle, F.; Draxler, A.; Li, G.; Huang, S.; Cook, J.M.; Ernst, M.; Scholze, P.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Diversity matters: combinatorial information coding by GABA<inf>A</inf> receptor subunits during spatial learning and its allosteric modulation

Cellular Signalling
2018 | Journal article
EID:

2-s2.0-85049916232

Contributors: Szodorai, E.; Bampali, K.; Romanov, R.A.; Kasper, S.; Hökfelt, T.; Ernst, M.; Lubec, G.; Harkany, T.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Engineered Flumazenil Recognition Site Provides Mechanistic Insight Governing Benzodiazepine Modulation in GABA<inf>A</inf>Receptors

ACS Chemical Biology
2018 | Journal article
EID:

2-s2.0-85049852343

Contributors: Siebert, D.C.B.; Bampali, K.; Puthenkalam, R.; Varagic, Z.; Sarto-Jackson, I.; Scholze, P.; Sieghart, W.; Mihovilovic, M.D.; Schnürch, M.; Ernst, M.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Expeditious synthesis of polyacetylenic water hemlock toxins and their effects on the major GABA<inf>A</inf> receptor isoform

Chemical Communications
2018 | Journal article
EID:

2-s2.0-85042411476

Contributors: Berger, M.; Chen, Y.; Bampali, K.; Ernst, M.; Maulide, N.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Negative allosteric modulation of alpha 5-containing GABA <inf>A</inf> receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice

Psychopharmacology
2018 | Journal article
EID:

2-s2.0-85041000322

Contributors: Xu, N.Z.; Ernst, M.; Treven, M.; Cerne, R.; Wakulchik, M.; Li, X.; Jones, T.M.; Gleason, S.D.; Morrow, D.; Schkeryantz, J.M. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

SAR-Guided Scoring Function and Mutational Validation Reveal the Binding Mode of CGS-8216 at the α1+/γ2- Benzodiazepine Site

Journal of Chemical Information and Modeling
2018 | Journal article
EID:

2-s2.0-85050590861

Contributors: Siebert, D.C.B.; Wieder, M.; Schlener, L.; Scholze, P.; Boresch, S.; Langer, T.; Schnürch, M.; Mihovilovic, M.D.; Richter, L.; Ernst, M. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation

Journal of Natural Products
2018 | Journal article
EID:

2-s2.0-85057102810

Contributors: Rycek, L.; Ticli, V.; Pyszkowski, J.; Latkolik, S.; Liu, X.; Atanasov, A.G.; Steinacher, T.; Bauer, R.; Schuster, D.; Dirsch, V.M. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

The Benzodiazepine Binding Sites of GABA<inf>A</inf> Receptors

Trends in Pharmacological Sciences
2018 | Journal article
EID:

2-s2.0-85046116775

Contributors: Sigel, E.; Ernst, M.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Towards functional selectivity for α6β3γ2 GABA<inf>A</inf> receptors: a series of novel pyrazoloquinolinones

British Journal of Pharmacology
2018 | Journal article
EID:

2-s2.0-85038840242

Contributors: Treven, M.; Siebert, D.C.B.; Holzinger, R.; Bampali, K.; Fabjan, J.; Varagic, Z.; Wimmer, L.; Steudle, F.; Scholze, P.; Schnürch, M. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation

Neuropharmacology
2018-09 | Journal article
Contributors: Pi-Chuan Fan; Tzu-Hsuan Lai; Chia Chun Hor; Ming Tatt Lee; Pokai Huang; Werner Sieghart; Margot Ernst; Daniel E. Knutson; James Cook; Lih-Chu Chiou
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Cerebellar α6‐subunit‐containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

British Journal of Pharmacology
2018-06 | Journal article
Contributors: Lih‐Chu Chiou; Hsin‐Jung Lee; Margot Ernst; Wei‐Jan Huang; Jui‐Feng Chou; Hon‐Lie Chen; Akihiro Mouri; Liang‐Chieh Chen; Marco Treven; Takayoshi Mamiya et al.
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Molecular tools for GABA<inf>A</inf> receptors: High affinity ligands for β1-containing subtypes

Scientific Reports
2017 | Journal article
EID:

2-s2.0-85025149993

Contributors: Simeone, X.; Siebert, D.C.B.; Bampali, K.; Varagic, Z.; Treven, M.; Rehman, S.; Pyszkowski, J.; Holzinger, R.; Steudle, F.; Scholze, P. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABA<inf>A</inf>receptor ligand MP-III-024

Brain Research Bulletin
2017 | Journal article
EID:

2-s2.0-85016137378

Contributors: Fischer, B.; Schlitt, R.; Hamade, B.; Rehman, S.; Ernst, M.; Poe, M.; Li, G.; Kodali, R.; Arnold, L.; Cook, J.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

α subunits in GABAA receptors are dispensable for GABA and diazepam action

Scientific Reports
2017-11-14 | Journal article
Contributors: Nisa Wongsamitkul; Maria C. Maldifassi; Xenia Simeone; Roland Baur; Margot Ernst; Erwin Sigel
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Development of GABA<inf>A</inf>Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments

Molecular Pharmaceutics
2016 | Journal article
EID:

2-s2.0-84973661516

Contributors: Forkuo, G.S.; Guthrie, M.L.; Yuan, N.Y.; Nieman, A.N.; Kodali, R.; Jahan, R.; Stephen, M.R.; Yocum, G.T.; Treven, M.; Poe, M.M. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABA<inf>A</inf>receptors containing the α5 subunit

European Journal of Pharmacology
2016 | Journal article
EID:

2-s2.0-84988476311

Contributors: Stamenić, T.T.; Poe, M.M.; Rehman, S.; Santrač, A.; Divović, B.; Scholze, P.; Ernst, M.; Cook, J.M.; Savić, M.M.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

First in vivo testing of compounds targeting group 3 medulloblastomas using an implantable microdevice as a new paradigm for drug development

Journal of Biomedical Nanotechnology
2016 | Journal article
EID:

2-s2.0-84964758617

Contributors: Jonas, O.; Calligaris, D.; Methuku, K.R.; Poe, M.M.; Francois, J.P.; Tranghese, F.; Changelian, A.; Sieghart, W.; Ernst, M.; Pomeranz Krummel, D.A. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABA<inf>A</inf> receptors

Neuropharmacology
2016 | Journal article
EID:

2-s2.0-84969640950

Contributors: Hoerbelt, P.; Ramerstorfer, J.; Ernst, M.; Sieghart, W.; Thomson, J.L.; Hough, L.B.; Fleck, M.W.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Structural studies of GABA<inf>A</inf>receptor binding sites: Which experimental structure tells us what?

Frontiers in Molecular Neuroscience
2016 | Journal article
EID:

2-s2.0-84978524330

Contributors: Puthenkalam, R.; Hieckel, M.; Simeone, X.; Suwattanasophon, C.; Feldbauer, R.V.; Ecker, G.F.; Ernst, M.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABA<inf>A</inf>) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy

Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-85003442743

Contributors: Poe, M.M.; Methuku, K.R.; Li, G.; Verma, A.R.; Teske, K.A.; Stafford, D.C.; Arnold, L.A.; Cramer, J.W.; Jones, T.M.; Cerne, R. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Targeting the γ-Aminobutyric Acid A Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction

American Journal of Respiratory Cell and Molecular Biology
2016-04 | Journal article
Contributors: Gene T. Yocum; George Gallos; Yi Zhang; Rajwana Jahan; Michael Rajesh Stephen; Zdravko Varagic; Roshan Puthenkalam; Margot Ernst; James M. Cook; Charles W. Emala
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Erratum: Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABA<inf>A</inf>receptor ligands (Bioorganic and Medicinal Chemistry Letters (2015) 25:2 (400-403))

Bioorganic and Medicinal Chemistry Letters
2015 | Journal article
EID:

2-s2.0-84939978695

Contributors: Rycek, L.; Puthenkalam, R.; Schnürch, M.; Ernst, M.; Mihovilovic, M.D.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

GABA<inf>A</inf> receptor subtypes: Structural variety raises hope for new therapy concepts,GABA<inf>A</inf>-Rezeptorsubtypen: Strukturelle Vielfalt gibt Hoffnung auf neue Therapiekonzepte

Neuroforum
2015 | Journal article
EID:

2-s2.0-84954206178

Contributors: Ernst, M.; Sieghart, W.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Identification of the putative binding pocket of valerenic acid on GABA<inf>A</inf> receptors using docking studies and site-directed mutagenesis

British Journal of Pharmacology
2015 | Journal article
EID:

2-s2.0-84956796490

Contributors: Luger, D.; Poli, G.; Wieder, M.; Stadler, M.; Ke, S.; Ernst, M.; Hohaus, A.; Linder, T.; Seidel, T.; Langer, T. et al.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands.

2015-01 | Journal article
DOI:

10.1016/j.bmcl.2014.10.091

PMID:

25510374

Contributors: Rycek L; Puthenkalam R; Schnürch M; Ernst M; Mihovilovic MD
Source: Self-asserted source
Margot Ernst via Europe PubMed Central
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A pentasymmetric open channel blocker for Cys-loop receptor channels.

2014 | Journal article
DOI:

10.1371/journal.pone.0106688

PMID:

25184303

PMC:

PMC4153658

Contributors: Carta V; Pangerl M; Baur R; Puthenkalam R; Ernst M; Trauner D; Sigel E
Source: Self-asserted source
Margot Ernst via Europe PubMed Central
grade
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Accelerated discovery of novel benzodiazepine ligands by experiment-guided virtual screening

ACS Chemical Biology
2014 | Journal article
EID:

2-s2.0-84906242978

Contributors: Middendorp, S.J.; Puthenkalam, R.; Baur, R.; Ernst, M.; Sigel, E.
Source: Self-asserted source
Margot Ernst via Scopus - Elsevier

Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.

2014-06 | Journal article
DOI:

10.1007/s11064-013-1156-3

PMID:

24072672

PMC:

PMC3921099

Contributors: Mirheydari P; Ramerstorfer J; Varagic Z; Scholze P; Wimmer L; Mihovilovic MM; Sieghart W; Ernst M
Source: Self-asserted source
Margot Ernst via Europe PubMed Central
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Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors.

2013-07 | Journal article
DOI:

10.1111/jnc.12270

PMID:

23600744

Contributors: Baur R; Kielar M; Richter L; Ernst M; Ecker GF; Sigel E
Source: Self-asserted source
Margot Ernst via Europe PubMed Central
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Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface.

2013-05 | Journal article
DOI:

10.1111/bph.12151

PMID:

23472852

Contributors: Varagic Z; Wimmer L; Schnürch M; Mihovilovic MD; Huang S; Rallapalli S; Cook JM; Mirheydari P; Ecker GF; Sieghart W et al.
Source: Self-asserted source
Margot Ernst via Europe PubMed Central
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Page 1 of 2

Peer review (18 reviews for 10 publications/grants)

Review activity for Amino acids. (1)
Review activity for EBioMedicine. (2)
Review activity for European journal of pharmacology. (1)
Review activity for F1000Research. (1)
Review activity for JoVE. (1)
Review activity for Nature (5)
Review activity for Nature communications (3)
Review activity for Neurochemistry international. (2)
Review activity for Toxics. (1)
Review activity for Toxins. (1)