Personal information

Oral Pathology, Innate Immunity, Immunotherapy, Immune Engineering, Immunoprevention, Oral Cancer
United States

Activities

Employment (2)

The University of Texas MD Anderson Cancer Center: Houston, US

2024-03-01 to present | Associate Professor with Tenure (Head and Neck Surgery)
Employment
Source: Self-asserted source
Yu Lei; Yu L Lei

University of Michigan: Ann Arbor, US

2015-08-01 to 2024-02-29 | Associate Professor with Tenure (School of Dentistry)
Employment
Source: Self-asserted source
Yu Lei; Yu L Lei

Works (50 of 57)

Items per page:
Page 1 of 2

Multihead Attention U‐Net for Magnetic Particle Imaging–Computed Tomography Image Segmentation

Advanced Intelligent Systems
2024-10 | Journal article
Contributors: Aniwat Juhong; Bo Li; Yifan Liu; Chia‐Wei Yang; Cheng‐You Yao; Dalen W. Agnew; Yu Leo Lei; Gary D. Luker; Harvey Bumpers; Xuefei Huang et al.
Source: check_circle
Crossref

Immune escape of head and neck cancer mediated by the impaired MHC-I antigen presentation pathway

Oncogene
2024-02-02 | Journal article
Contributors: Xiaobo Luo; Yan Qiu; Zackary R. Fitzsimonds; Qiuhao Wang; Qianming Chen; Yu Leo Lei
Source: check_circle
Crossref

Front Cover

Journal of Biophotonics
2023-11 | Journal article
Contributors: Aniwat Juhong; Bo Li; Yifan Liu; Cheng‐You Yao; Chia‐Wei Yang; Dalen W. Agnew; Yu Leo Lei; Gary D. Luker; Harvey Bumpers; Xuefei Huang et al.
Source: check_circle
Crossref

Recurrent and convolutional neural networks for sequential multispectral optoacoustic tomography (MSOT) imaging

Journal of Biophotonics
2023-11 | Journal article
Contributors: Aniwat Juhong; Bo Li; Yifan Liu; Cheng‐You Yao; Chia‐Wei Yang; Dalen W. Agnew; Yu Leo Lei; Gary D. Luker; Harvey Bumpers; Xuefei Huang et al.
Source: check_circle
Crossref

Supervised capacity preserving mapping: a clustering guided visualization method for scRNA-seq data

Bioinformatics
2022-04-28 | Journal article
Contributors: Zhiqian Zhai; Yu L Lei; Rongrong Wang; Yuying Xie; Anthony Mathelier
Source: check_circle
Crossref

Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment

Oral Oncology
2021-09 | Journal article
Contributors: Janice L. Farlow; J. Chad Brenner; Yu L. Lei; Steven B. Chinn
Source: check_circle
Crossref

Machine learning-assisted immune profiling stratifies peri-implantitis patients with unique microbial colonization and clinical outcomes.

Theranostics
2021-05-03 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

STING controls nociception via type I interferon signalling in sensory neurons.

Nature
2021-01-13 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

[Stimulatory and inhibitory signaling pathways of the T cell-APC interaction and the effect of TLR agonists on APCs].

HNO
2020-10-30 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.

Cell
2020-06-16 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Up-regulation of hypoxia-inducible factor antisense as a novel approach to treat ovarian cancer.

Theranostics
2020-05-25 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination.

Nature communications
2020-05-04 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.

The Journal of clinical investigation
2020-04-01 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.

Journal of immunology (Baltimore, Md. : 1950)
2020-03-13 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting

Oral Oncology
2019-10 | Journal article
Part of ISSN: 1368-8375
Source: Self-asserted source
Yu Lei; Yu L Lei

Fast and robust deconvolution of tumor infiltrating lymphocyte from expression profiles using least trimmed squares

PLOS Computational Biology
2019-05-06 | Journal article
Contributors: Yuning Hao; Ilya Ioshikhes; Ming Yan; Blake R. Heath; Yu L. Lei; Yuying Xie
Source: check_circle
Crossref

Long non-coding RNA implicated in the invasion and metastasis of head and neck cancer: possible function and mechanisms

Molecular cancer
2018 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy

Biomaterials
2018 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response

OncoImmunology
2018-11-02 | Journal article
Contributors: Benjamin A. Kansy; Gulidanna Shayan; Hyun-Bae Jie; Sandra P. Gibson; Yu L. Lei; Sven Brandau; Stephan Lang; Nicole C Schmitt; Fei Ding; Yan Lin et al.
Source: check_circle
Crossref

PD-1 status in CD8+ T cells associates with survival and anti-PD-1 therapeutic outcomes in head and neck cancer

Cancer Research
2017 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1--TUFM protein complex

Oncogene
2016 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFN$γ$ That Induce PD-L1 Expression in Head and Neck Cancer

Cancer Research
2016 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer

Oral Oncology
2016 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

35 The role of toll-like receptor (TLR) agonists in combinational immunotherapy for head and neck cancer

Oral Oncology
2015 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Level of PD-1 expression on CD8+ T cells influence prognosis and respond to PD-1 therapy in a murine model

30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015)
2015 | Conference paper
Source: Self-asserted source
Yu Lei; Yu L Lei
grade
Preferred source (of 2)‎

P12 TLR8 agonist VTX-2337 sensitizes head and neck cancer cells to cetuximab

Oral Oncology
2015 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei
grade
Preferred source (of 2)‎

PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment

Cancer research
2015 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Characterization of EGFR expression in ameloblastic neoplasms

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
2014 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Editorial: Recent Advances in the Ancillary Studies for Diagnosing Odontogenic Carcinomas

Journal of Advanced Oral Research
2014 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Evaluation of SOX2 as a potential marker for ameloblastic carcinoma

Oral surgery, oral medicine, oral pathology and oral radiology
2014 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Identification of Mutations in the PYRIN-Containing NLR Genes (NLRP) in Head and Neck Squamous Cell Carcinoma

PLOS ONE
2014 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Phase I dendritic cell p53 peptide vaccine for head and neck cancer

Clinical Cancer Research
2014 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Generation and culture of mouse embryonic fibroblasts

Mouse Models of Innate Immunity: Methods and Protocols
2013 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Identification of Sox2 as a Marker for Ameloblastic Carcinoma

LABORATORY INVESTIGATION
2013 | Conference paper
Source: Self-asserted source
Yu Lei; Yu L Lei

Interpretation of SOX2 Immunohistochemical Stain in Ameloblastic Carcinoma: An Expanded Cohort

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
2013 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy

Autophagy
2013 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei
grade
Preferred source (of 2)‎

ASC-dependent RIP2 Kinase Regulates Reduced PGE2 Production in Chronic Periodontitis

Journal of Dental Research
2012 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei
grade
Preferred source (of 2)‎

Identification of NLRP Mutations in Head and Neck Squamous Cell Carcinoma

AMERICAN JOURNAL OF CLINICAL PATHOLOGY
2012 | Conference paper
Source: Self-asserted source
Yu Lei; Yu L Lei

Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools

Head and neck pathology
2012 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

The Mitochondrial Immune Signaling Complex

Nucleic Acid Sensors and Antiviral Immunity
2012 | Book chapter
Source: Self-asserted source
Yu Lei; Yu L Lei

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy

Immunity
2012 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei
grade
Preferred source (of 2)‎

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Nature immunology
2011 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-$κ$B signaling pathways

Immunity
2011 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome

Journal of Biological Chemistry
2011 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

Immunity
2011-06 | Journal article
Contributors: Irving C. Allen; Chris B. Moore; Monika Schneider; Yu Lei; Beckley K. Davis; Margaret A. Scull; Denis Gris; Kelly E. Roney; Albert G. Zimmermann; John B. Bowzard et al.
Source: Self-asserted source
Yu Lei; Yu L Lei via Crossref Metadata Search

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Nat Immunol
2011-04-10 | Journal article
Contributors: Haitao Wen; Denis Gris; Yu Lei; Sushmita Jha; Lu Zhang; Max Tze-Han Huang; Willie June Brickey; Jenny P-Y Ting
Source: Self-asserted source
Yu Lei; Yu L Lei via Crossref Metadata Search

How the noninflammasome NLRs function in the innate immune system

Science
2010 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Plexin-A4--semaphorin 3A signaling is required for Toll-like receptor--and sepsis-induced cytokine storm

Journal of Experimental Medicine
2010 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei

Plexin-A4/Semaphorin 3A Signaling is Required for TLR-and Sepsis-induced Cytokine Storm

Clinical Immunology
2010 | Journal article
Source: Self-asserted source
Yu Lei; Yu L Lei
grade
Preferred source (of 2)‎

Plexin-A4–semaphorin 3A signaling is required for Toll-like receptor– and sepsis-induced cytokine storm

J Exp Med
2010-11 | Journal article
Contributors: Haitao Wen; Yu Lei; So-Young Eun; Jenny P.-Y. Ting
Source: Self-asserted source
Yu Lei; Yu L Lei via Crossref Metadata Search
grade
Preferred source (of 3)‎
Items per page:
Page 1 of 2

Peer review (6 reviews for 4 publications/grants)

Review activity for Cell reports. (1)
Review activity for Head and neck pathology. (1)
Review activity for Journal for immunotherapy of cancer. (1)
Review activity for Nature communications (3)