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Activities

Employment (1)

Washington University School of Medicine: St. Louis, MO, US

2015-01 to present | Principal Investigator / Associate Professor
Employment
Source: Self-asserted source
Brian DeBosch

Education and qualifications (2)

Washington University School of Medicine: St. Louis, MO, US

2001-07 to 2008-05 | MD, PhD (Biology and Biomedical Sciences)
Education
Source: Self-asserted source
Brian DeBosch

University of Michigan: Ann Arbor, MI, US

1997-08 to 2001-05 | B.S./Cell & Molecular Biology, German Language & Literature (College of Literature, Science & Arts)
Education
Source: Self-asserted source
Brian DeBosch

Works (19)

A New Tool to Study the DREADDed Peripheral Nervous System

Gastroenterology
2025-02 | Journal article
Contributors: Amber L. Alhadeff; Brian J. DeBosch
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Crossref

A Structure-function Analysis of Hepatocyte Arginase 2 Reveals Mitochondrial Ureahydrolysis as a Determinant of Glucose Oxidation

Cellular and Molecular Gastroenterology and Hepatology
2024 | Journal article
Contributors: Yiming Zhang; Jiameng Sun; Henry D. Wasserman; Joshua A. Adams; Cassandra B. Higgins; Shannon C. Kelly; Louise Lantier; Brian J. DeBosch
Source: check_circle
Crossref

Acquisition of Epithelial Plasticity and the Potential Origins of Biphenotypic Cells in Chronic Liver Injury

Gastroenterology
2024-12 | Journal article
Contributors: Stefani Tica; Brian Debosch
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Crossref

Survival of the Fittest: Clonal Selection of Somatic Mutations Reveals Targets to Abate Chronic Liver Injury

Gastroenterology
2024-05 | Journal article
Contributors: Natalie M. Niemi; Brian J. Debosch
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Crossref

Deploying Lactulose as a Prebiotic to Reduce Complications of Chronic Liver Disease

Gastroenterology
2024-03 | Journal article
Contributors: Lori R. Holtz; Brian J. DeBosch
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Crossref

Bariatric Surgery for the Treatment of NASH—An Old Solution to a Newer Problem?

Gastroenterology
2023-10 | Journal article
Contributors: Stefani Tica; Brian J. Debosch
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Crossref

Next-Generation Farnesoid X Receptor Agonists in NASH Treatment: Are We There Yet?

Gastroenterology
2023-08 | Journal article
Contributors: Brian J. DeBosch
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Crossref

Obeying the Law: Energy Balance in Alternate-Day Fasting, Exercise, or Both Together in Patients With Obesity and NAFLD

Gastroenterology
2023-07 | Journal article
Contributors: Brian Debosch
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Crossref

Guardian, Intermediary, or Perpetrator? New Insights Into Environmental Exposure, the Gut Microbiome, and Nonalcoholic Fatty Liver Disease

Gastroenterology
2023-03 | Journal article
Contributors: Jiameng Sun; Brian Debosch
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Crossref

A deCIDEdly New Germline Mutation That Protects Against Liver Disease

Gastroenterology
2023-02 | Journal article
Contributors: Brian J. DeBosch
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Crossref

Driving arginine catabolism to activate systemic autophagy

Autophagy Reports
2022-12-31 | Journal article
Contributors: Yiming Zhang; Brian N. Finck; Brian J. DeBosch
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Crossref

Targeting De Novo Lipogenesis by Different Approaches Shows Promise in Nonalcoholic Steatohepatitis

Gastroenterology
2022-11 | Journal article
Contributors: Brian DeBosch
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Splitting Hairs: Folliculin Parts the Good From the Bad in mTORC1 Control Over Lipid Metabolism

Gastroenterology
2022-08 | Journal article
Contributors: Brian DeBosch
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Crossref

SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase

Nature Communications
2022-02-28 | Journal article
Contributors: Cassandra B. Higgins; Allyson L. Mayer; Yiming Zhang; Michael Franczyk; Samuel Ballentine; Jun Yoshino; Brian J. DeBosch
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Crossref

Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism

Cell Reports Medicine
2022-01 | Journal article
Contributors: Yiming Zhang; Cassandra B. Higgins; Brian A. Van Tine; John S. Bomalaski; Brian J. DeBosch
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Crossref

Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction

The FEBS Journal
2021-06 | Journal article
Contributors: Jacqueline Kading; Brian N. Finck; Brian J. DeBosch
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Microbial and metabolic impacts of trehalose and trehalose analogues

Gut Microbes
2020-09-02 | Journal article
Contributors: Yiming Zhang; Brian J. DeBosch
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Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile

Chemical Communications
2019 | Journal article
Contributors: Noah D. Danielson; James Collins; Alicyn I. Stothard; Qing Qing Dong; Karishma Kalera; Peter J. Woodruff; Brian J. DeBosch; Robert A. Britton; Benjamin M. Swarts
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Crossref

TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose

Autophagy
2018-11-02 | Journal article
Contributors: Yiming Zhang; Cassandra B. Higgins; Allyson L. Mayer; Indira U. Mysorekar; Babak Razani; Mark J. Graham; Paul W. Hruz; Brian J. DeBosch
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Peer review (6 reviews for 3 publications/grants)

Review activity for Journal of molecular medicine. (1)
Review activity for Nature communications (1)
Review activity for Nature metabolism. (4)