Personal information

Photoreceptor, Retinal degeneration, Splicing, Post-translational protein modification, prenylation, Leber congenital Amaurosis, Small GTPase
United States

Activities

Employment (1)

West Virginia University: Morgantown, WV, US

2018-07-01 to present | Chair/Professor (Biochemistry and Molecular Medicine)
Employment
Source: Self-asserted source
Visvanathan Ramamurthy

Education and qualifications (3)

University of Washington: Seattle, WA, US

2004-01-01 to 2006-01-01 | Research Assistant Professor (Biochemistry)
Qualification
Source: Self-asserted source
Visvanathan Ramamurthy

Howard Hughes Medical Institute - University of Washington: Seattle, WA, US

1998-04-01 to 2005-12-31 (Biochemsitry)
Qualification
Source: Self-asserted source
Visvanathan Ramamurthy

Wesleyan University: Middletown, CT, US

1992-01-15 to 1998-03-03 | PhD (Molecular Biology and Biochemistry)
Education
Source: Self-asserted source
Visvanathan Ramamurthy

Funding (5)

Visual Sciences Center of Biomedical Research Excellence

2022-03-20 to 2027-01-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: P20GM144230
Source: Self-asserted source
Visvanathan Ramamurthy via DimensionsWizard

Biosynthesis and trafficking of phosphodiesterase in the retinal photoreceptors

2020 to 2025 | Grant
National Eye Institute (Md., Md., US)
GRANT_NUMBER: R01EY031346
Source: Self-asserted source
Visvanathan Ramamurthy

Importance of small GTPases in photoreceptor function

2017-04-01 to 2028-03-31 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: R01EY028035
Source: Self-asserted source
Visvanathan Ramamurthy via DimensionsWizard

Ciliopathies and Photoreceptor Function

2017-02-01 to 2019-01-31 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: R21EY027707
Source: Self-asserted source
Visvanathan Ramamurthy via DimensionsWizard

Photoreceptor neuron specific alternative splicing of messenger RNA

Source: Self-asserted source
Visvanathan Ramamurthy via DimensionsWizard

Works (37)

Excessive tubulin glutamylation leads to progressive cone-rod dystrophy and loss of outer segment integrity

Human Molecular Genetics
2024-04-18 | Journal article
Contributors: Rawaa Aljammal; Thamaraiselvi Saravanan; Tongju Guan; Scott Rhodes; Michael A Robichaux; Visvanathan Ramamurthy
Source: check_circle
Crossref

Prenylation is essential for the enrichment of cone phosphodiesterase-6 (PDE6) in outer segments and efficient cone phototransduction

Human Molecular Genetics
2023-08-26 | Journal article
Contributors: Faezeh Moakedi; Rawaa Aljammal; Deepak Poria; Thamaraiselvi Saravanan; Scott B Rhodes; Chyanne Reid; Tongju Guan; Vladimir J Kefalov; Visvanathan Ramamurthy
Source: check_circle
Crossref

HSP90α is needed for the survival of rod photoreceptors and regulates the expression of rod PDE6 subunits

Journal of Biological Chemistry
2023-06 | Journal article
Contributors: Daniella Munezero; Hunter Aliff; Ezequiel Salido; Thamaraiselvi Saravanan; Urikhan Sanzhaeva; Tongju Guan; Visvanathan Ramamurthy
Source: check_circle
Crossref

The Musashi proteins are post-transcriptional activators of protein expression and alternative exon splicing in vertebrate photoreceptors

2022-03-11 | Preprint
Contributors: Fatimah Matalkah; Bohye Jeong; Macie Sheridan; Eric Horstick; Visvanathan Ramamurthy; Peter Stoilov
Source: check_circle
Crossref

The 13A4 monoclonal antibody to the mouse PROM1 protein recognizes a structural epitope

2022-03-05 | Preprint
Contributors: Fatimah Matalkah; Scott Rhodes; Visvanathan Ramamurthy; Peter Stoilov
Source: check_circle
Crossref

The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice

Journal of Biological Chemistry
2021-01-09 | Journal article
Contributors: Jesse Sundar; Fatimah Matalkah; Bohye Jeong; Peter Stoilov; Visvanathan Ramamurthy
Source: check_circle
Crossref

Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision

The Journal of Neuroscience
2020-05-13 | Journal article
Contributors: Ezequiel M. Salido; Visvanathan Ramamurthy
Source: check_circle
Crossref

Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice.

PLoS genetics
2019-08-19 | Journal article
Source: Self-asserted source
Visvanathan Ramamurthy

Loss of MPC1 reprograms retinal metabolism to impair visual function.

Proceedings of the National Academy of Sciences of the United States of America
2019-02-11 | Journal article
Source: Self-asserted source
Visvanathan Ramamurthy

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2018-12-20 | Journal article
Source: Self-asserted source
Visvanathan Ramamurthy

ADP-Ribosylation Factor-Like 2 (ARL2) regulates cilia stability and development of outer segments in rod photoreceptor neurons.

Scientific reports
2018-11-16 | Journal article
Source: Self-asserted source
Visvanathan Ramamurthy

Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.

Frontiers in molecular neuroscience
2018-07-09 | Journal article
Source: Self-asserted source
Visvanathan Ramamurthy

ARL2BP, a protein linked to retinitis pigmentosa, is needed for normal photoreceptor cilia doublets and outer segment structure.

Molecular biology of the cell
2018-05-02 | Journal article
Source: Self-asserted source
Visvanathan Ramamurthy

Bardet-Biedl syndrome-8 (BBS8) protein is crucial for the development of outer segments in photoreceptor neurons.

Human molecular genetics
2018-01-01 | Journal article
Source: Self-asserted source
Visvanathan Ramamurthy

Analysis of Alternative Pre-RNA Splicing in the Mouse Retina Using a Fluorescent Reporter.

2016 | Journal article
Contributors: Murphy D; Kolandaivelu S; Ramamurthy V; Stoilov P
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

The Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate Retina

PLOS Genetics
2016-08-19 | Journal article
Contributors: Daniel Murphy; Claude Desplan; Benjamin Cieply; Russ Carstens; Visvanathan Ramamurthy; Peter Stoilov
Source: check_circle
Crossref

Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor Function.

2016-05 | Journal article
Contributors: Christiansen JR; Pendse ND; Kolandaivelu S; Bergo MO; Young SG; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.

2016-03 | Journal article
Contributors: Wright ZC; Singh RK; Alpino R; Goldberg AF; Sokolov M; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Alternative Splicing Shapes the Phenotype of a Mutation in BBS8 To Cause Nonsyndromic Retinitis Pigmentosa.

2015-05 | Journal article
Contributors: Murphy D; Singh R; Kolandaivelu S; Ramamurthy V; Stoilov P
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Viral-mediated vision rescue of a novel AIPL1 cone-rod dystrophy model.

2015-02 | Journal article
Contributors: Ku CA; Chiodo VA; Boye SL; Hayes A; Goldberg AF; Hauswirth WW; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Early alteration of retinal neurons in Aipl1-/- animals.

2014-05 | Journal article
Contributors: Singh RK; Kolandaivelu S; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

AIPL1, A protein linked to blindness, is essential for the stability of enzymes mediating cGMP metabolism in cone photoreceptor cells.

2014-02 | Journal article
Contributors: Kolandaivelu S; Singh RK; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins.

2013-09 | Journal article
Contributors: Gao X; Sinha S; Belcastro M; Woodard C; Ramamurthy V; Stoilov P; Sokolov M
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Cone phosphodiesterase-6α' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6β-deficient rd10 mouse.

2013-07 | Journal article
Contributors: Deng WT; Sakurai K; Kolandaivelu S; Kolesnikov AV; Dinculescu A; Li J; Zhu P; Liu X; Pang J; Chiodo VA et al.
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Transducin translocation contributes to rod survival and enhances synaptic transmission from rods to rod bipolar cells.

2013-07 | Journal article
Contributors: Majumder A; Pahlberg J; Boyd KK; Kerov V; Kolandaivelu S; Ramamurthy V; Sampath AP; Artemyev NO
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Greasing the protein biosynthesis machinery of photoreceptor neurons: Role for postprenylation processing of proteins.

2012-01 | Journal article
Contributors: Christiansen JR; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Gene therapy using self-complementary Y733F capsid mutant AAV2/8 restores vision in a model of early onset Leber congenital amaurosis.

2011-12 | Journal article
Contributors: Ku CA; Chiodo VA; Boye SL; Goldberg AF; Li T; Hauswirth WW; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.

2011-09 | Journal article
Contributors: Kolandaivelu S; Chang B; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.

2011-05 | Journal article
Contributors: Christiansen JR; Kolandaivelu S; Bergo MO; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cells.

2010-03 | Journal article
Contributors: Kirschman LT; Kolandaivelu S; Frederick JM; Dang L; Goldberg AF; Baehr W; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly.

2009-11 | Journal article
Contributors: Kolandaivelu S; Huang J; Hurley JB; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Rod photoreceptor differentiation in fetal and infant human retina.

2008-11 | Journal article
Contributors: Hendrickson A; Bumsted-O'Brien K; Natoli R; Ramamurthy V; Possin D; Provis J
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Biochemical function of the LCA linked protein, aryl hydrocarbon receptor interacting protein like-1 (AIPL1). Role of AIPL1 in retina.

2006 | Journal article
Contributors: Schwartz ML; Hurley JB; Ramamurthy V
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells.

2005-05 | Journal article
Contributors: Taylor MR; Kikkawa S; Diez-Juan A; Ramamurthy V; Kawakami K; Carmeliet P; Brockerhoff SE
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase.

2004-09 | Journal article
Contributors: Ramamurthy V; Niemi GA; Reh TA; Hurley JB
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins.

2003-10 | Journal article
Contributors: Ramamurthy V; Roberts M; van den Akker F; Niemi G; Reh TA; Hurley JB
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central

Functional characterization of missense mutations at codon 838 in retinal guanylate cyclase correlates with disease severity in patients with autosomal dominant cone-rod dystrophy.

2000-12 | Journal article
Contributors: Wilkie SE; Newbold RJ; Deery E; Walker CE; Stinton I; Ramamurthy V; Hurley JB; Bhattacharya SS; Warren MJ; Hunt DM
Source: Self-asserted source
Visvanathan Ramamurthy via Europe PubMed Central