Personal information

Oncobiology; Colorectal cancer; Phospholipase C epsilon; Epigenetic regulation

Activities

Employment (4)

Instituto de Medicina Molecular João Lobo Antunes: Lisbon, PT

2024-02-01 to present | Researcher (Multi-Cancer Profile Project)
Employment
Source: Self-asserted source
Marta Martins

Instituto de Medicina Molecular: Lisboa, PT

2014-04-01 to present | Mechanisms and relevance of phospholipase c epsilon downregulation in cancer (Lcosta unit)
Employment
Source: Self-asserted source
Marta Martins

University College London: London, GB

2013-01 to 2014-03 | Associate Researcher (Structural and Molecular Biology)
Employment
Source: Self-asserted source
Marta Martins

Institute of Cancer Research: London, London, GB

2009-01 to 2012-12 | Post-doc position (Molecular and Cell Biology)
Employment
Source: Self-asserted source
Marta Martins

Education and qualifications (2)

Université Paris Diderot: Paris, FR

2006-01 to 2008-12 | PhD - Biochemistry and Molecular Biology (Biochemistry and Molecular Enzymology of the Xenobiotics )
Education
Source: Self-asserted source
Marta Martins

Universidade do Porto Faculdade de Ciências: Porto, PT

2001-09 to 2005-12 | Biochemistry
Education
Source: Self-asserted source
Marta Martins

Funding (4)

PLCy1 expression in circulating tumour cells as a biomarker of cetuximab responses in metastatic colorectal cancer.

2023 to 2024 | Grant
Liga Portuguesa Contra o Cancro (Lisboa, PT)
Source: Self-asserted source
Marta Martins

Role of Phospholipase C epsilon as a Biomarker of Colorectal Cancer Progression

2015-02 to 2020-01 | Contract
Fundação para a Ciência e a Tecnologia (Portugal, PT)
Source: Self-asserted source
Marta Martins

Role of PLCg1 in resistance to anti-EGFR therapy

2015-01 to 2016-12 | Grant
Liga Portuguesa Contra o Cancro (Lisboa, PT)
Source: Self-asserted source
Marta Martins

Mechanisms and relevance of phospholipase c epsilon downregulation in cancer

2014-04 to 2015-03 | Grant
Foundation for Science and Tecnology (Lisboa, PT)
Source: Self-asserted source
Marta Martins

Works (31)

Therapeutic Potential of Deflamin against Colorectal Cancer Development and Progression

Cancers
2022-12 | Journal article | Author
Contributors: Sara Miguel Silva; Ana Cláudia Martins Cavaco; Bianca Basso; Joana Mota; Raquel Duarte; Miguel Costa; Luis Costa; Ana Lima; Luis Costa; Ricardo Ferreira et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Comprehensive Genomic Profiling of Cell-Free Circulating Tumor DNA Detects Response to Ribociclib Plus Letrozole in a Patient with Metastatic Breast Cancer

Biomolecules
2022-12-06 | Journal article
Contributors: Catarina Silveira; Ana Carla Sousa; Patrícia Corredeira; Marta Martins; Ana Rita Sousa; Arnaud Da Cruz Paula; Pier Selenica; David N. Brown; Mahdi Golkaram; Shannon Kaplan et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

Communications Biology
2022-09-09 | Journal article
Contributors: Daniel Sobral; Marta Martins; Shannon Kaplan; Mahdi Golkaram; Michael Salmans; Nafeesa Khan; Raakhee Vijayaraghavan; Sandra Casimiro; Afonso Fernandes; Paula Borralho et al.
Source: check_circle
Crossref

Kidney Cancer Biomarker Selection Using Regularized Survival Models

Cells
2022-07-27 | Journal article
Contributors: Carolina Peixoto; Marta Martins; Luís Costa; Susana Vinga
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes

International Journal of Molecular Sciences
2022-06-27 | Journal article
Contributors: Yann Le Gal; Agathe Filatre-Furcate; Dominique Lorcy; Olivier Jeannin; Thierry Roisnel; Vincent Dorcet; Diana Fontinha; Denise Francisco; Miguel Prudncio; Marta Martins et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer

Clinical Cancer Research
2022-01-03 | Journal article
Part of ISSN: 1078-0432
Part of ISSN: 1557-3265
Source: Self-asserted source
Marta Martins

HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome

npj Genomic Medicine
2021-02-15 | Journal article
Contributors: Mahdi Golkaram; Michael L. Salmans; Shannon Kaplan; Raakhee Vijayaraghavan; Marta Martins; Nafeesa Khan; Cassandra Garbutt; Aaron Wise; Joyee Yao; Sandra Casimiro et al.
Source: check_circle
Crossref

TCox: Correlation-Based Regularization Applied to Colorectal Cancer Survival Data

Biomedicines
2020-11-10 | Journal article
Contributors: Carolina Peixoto; Marta B. Lopes; Marta Martins; Luís Costa; Susana Vinga
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Biological properties of a new mixed lanthanide(III) complex incorporating a dypiridinium ylide

Inorganica Chimica Acta
2020-06 | Journal article
Part of ISSN: 0020-1693
Source: Self-asserted source
Marta Martins

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

2019-12 | Journal article
Part of ISSN: 1758-9193
Source: Self-asserted source
Marta Martins
grade
Preferred source (of 2)‎

On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities

Journal of Inorganic Biochemistry
2019-10 | Journal article
Part of ISSN: 0162-0134
Source: Self-asserted source
Marta Martins

Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) complexes

Journal of Inorganic Biochemistry
2019-09 | Journal article
Part of ISSN: 0162-0134
Source: Self-asserted source
Marta Martins
grade
Preferred source (of 2)‎

Frequent and persistent PLCG1 mutations in Sézary cells directly enhance PLCγ1 activity and stimulate NFκB, AP-1 and NFAT signaling. Short title: Gain-of-function PLCG1 mutations in Sézary Syndrome

Journal of Investigative Dermatology
2019-07 | Journal article
Part of ISSN: 0022-202X
Source: Self-asserted source
Marta Martins
grade
Preferred source (of 2)‎

Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools

2019-03-18 | Journal article
Part of ISSN: 1871-5206
Source: Self-asserted source
Marta Martins

Anti-EGFR Therapy to Treat Metastatic Colorectal Cancer: Not for All

2018 | Book chapter
Part of ISBN: 9783030027704
Part of ISBN: 9783030027711
Part of ISSN: 0065-2598
Part of ISSN: 2214-8019
Source: Self-asserted source
Marta Martins

Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa

2018-12-14 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Marta Martins

Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR

2018-07 | Journal article
Part of ISSN: 0006-3495
Source: Self-asserted source
Marta Martins

Tumor suppressor role of phospholipase C{varepsilon} in Ras-triggered cancers.

2014-03 | Journal article
DOI:

10.1073/pnas.1311500111

PMID:

24591640

PMC:

PMC3964118

Contributors: Martins M; McCarthy A; Baxendale R; Guichard S; Magno L; Kessaris N; El-Bahrawy M; Yu P; Katan M
Source: Self-asserted source
Marta Martins via Europe PubMed Central

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

2012 | Journal article
DOI:

10.1056/NEJMoa1102140

EID:

2-s2.0-84863030888

Contributors: Ombrello, M.J.; Remmers, E.F.; Sun, G.; Freeman, A.F.; Datta, S.; Torabi-Parizi, P.; Subramanian, N.; Bunney, T.D.; Baxendale, R.W.; Martins, M.S. et al.
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation

2012 | Journal article
DOI:

10.1016/j.str.2012.09.005

EID:

2-s2.0-84870534658

Contributors: Bunney, T.D.; Esposito, D.; Mas-Droux, C.; Lamber, E.; Baxendale, R.W.; Martins, M.; Cole, A.; Svergun, D.; Driscoll, P.C.; Katan, M.
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF.

2012-12 | Journal article
DOI:

10.1242/jcs.110007

PMID:

22992460

PMC:

PMC3575709

Contributors: Martins M; Warren S; Kimberley C; Margineanu A; Peschard P; McCarthy A; Yeo M; Marshall CJ; Dunsby C; French PM et al.
Source: Self-asserted source
Marta Martins via Europe PubMed Central

A Hypermorphic Missense Mutation in PLCG2 , Encoding Phospholipase C¿2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

The American Journal of Human Genetics
2012-10 | Journal article
SOURCE-WORK-ID:

cv-prod-id-942738

Contributors: Zhou, Qing; Lee, Geun-Shik; Brady, Jillian; Datta, Shrimati; Katan, Matilda; Sheikh, Afzal; Martins, Marta S.; et al.
Source: check_circle
CIÊNCIAVITAE

Insights into the phylogeny or arylamine N-acetyltransferases in fungi

Journal of Molecular Evolution
2010 | Journal article
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

Human arylamine N-acetyltransferase 1 (NAT1) as a target of chemotherapeutic drugs in breast cancer: Cisplatin as a model

Molecular and Cellular Pharmacology
2009 | Journal article
EID:

2-s2.0-77953460846

Contributors: Ragunathan, N.; Dairou, J.; Pluvinage, B.; Martins, M.; Dupret, J.-M.; Rodrigues-Lima, F.
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

An Acetyltransferase Conferring Tolerance to Toxic Aromatic Amine Chemicals

Journal of Biological Chemistry
2009-05-05 | Journal article
SOURCE-WORK-ID:

cv-prod-id-942741

Contributors: Martins, Marta; Rodrigues-Lima, Fernando; Dairou, Julien; Lamouri, Aazdine; Malagnac, Fabienne; Silar, Philippe; Dupret, Jean-Marie
Source: check_circle
CIÊNCIAVITAE

Functional and Structural Characterization of the Arylamine N-Acetyltransferase from the Opportunistic Pathogen Nocardia farcinica

Journal of Molecular Biology
2008 | Journal article
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: Molecular and cellular mechanisms of inhibition

Molecular Pharmacology
2008 | Journal article
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis

Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2007 | Journal article
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

The conserved glycine/alanine residue of the active-site loop containing the putative acetylCoA-binding motif is essential for the overall structural integrity of Mesorhizobium loti arylamine N-acetyltransferase 1

Biochemical and Biophysical Research Communications
2007 | Journal article
Source: Self-asserted source
Marta Martins via Scopus - Elsevier

Cloning and Molecular Characterization of Three ArylamineN-Acetyltransferase Genes fromBacillus anthracis:  Identification of Unusual Enzymatic Properties and Their Contribution to Sulfamethoxazole Resistance†

Biochemistry
2007-06 | Journal article
SOURCE-WORK-ID:

cv-prod-id-942746

Contributors: Pluvinage, Benjamin; Dairou, Julien; Possot, Odile M.; Martins, Marta; Fouet, Agnès; Dupret, Jean-Marie; Rodrigues-Lima, Fernando
Source: check_circle
CIÊNCIAVITAE

Pesticide-Derived Aromatic Amines and Their Biotransformation

Book chapter
Contributors: Marta Martins
Source: Self-asserted source
Marta Martins