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Employment (5)

University of California San Francisco: San Francisco, CA, US

2014-12 to present | Professor Emeritus (Diabetes Center)
Employment
Source: Self-asserted source
Steinunn Baekkeskov

Ecole Polytechnique Federale de Lausanne, School of Life Sciences: Lausanne, VD, CH

2012-02 to 2017-05 | Visiting Professor (Institute of Bioengineering)
Employment
Source: Self-asserted source
Steinunn Baekkeskov

University of California San Francisco: San Francisco, CA, US

1989-07 to 2014-11 | Professor (Medicine and Microbiology/Immunology, Horan Markarian Chair of Diabetes)
Employment
Source: Self-asserted source
Steinunn Baekkeskov

Hagedorn Research Institute: Gentofte, Copenhagen, DK

1984-03 to 1989-07 | Senior Scientist, Group Leader (Targets of Autoimmunity in Type 1 Diabetes)
Employment
Source: Self-asserted source
Steinunn Baekkeskov

Hagedorn Research Institute: Gentofte, Copenhagen, DK

1980-01 to 1984-01 | Doctorate Student, Scientist (Autoimmunity in Type 1 Diabetes)
Employment
Source: Self-asserted source
Steinunn Baekkeskov

Education and qualifications (1)

University of Copenhagen: Copenhagen, DK

1980 to 1984 | Ph.D. (Biochemistry)
Education
Source: Self-asserted source
Steinunn Baekkeskov

Professional activities (5)

University of California San Francisco: San Francisco, California, US

2014-12 to present | Professor Emeritus (Medicine and Microbiology/Immunology, Diabetes Center)
Invited position
Source: Self-asserted source
Steinunn Baekkeskov

UCSF Diabetes Center: San Francisco, CA, US

1996 to 2014 | Horan Markarian Chair of Diabetes
Invited position
Source: Self-asserted source
Steinunn Baekkeskov

NIH Office of the Director: Md., Md., US

1991 to 1993 | NIH-Shannon Award
Invited position
Source: Self-asserted source
Steinunn Baekkeskov

Juvenile Diabetes Research Foundation International: NY, NY, US

1984 to 1987 | JDRF Career Development Award
Invited position
Source: Self-asserted source
Steinunn Baekkeskov

Juvenile Diabetes Research Foundation: New York, New York, US

1982 to 1984 | JDRF Fellowship
Invited position
Source: Self-asserted source
Steinunn Baekkeskov

Works (50 of 63)

Items per page:
Page 1 of 2

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Nature Metabolism
2019-11 | Journal article
DOI: 10.1038/s42255-019-0135-7
Part of ISSN: 2522-5812
Source: Self-asserted source
Steinunn Baekkeskov

Erratum: Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Scientific Reports
2017-09 | Journal article
DOI: 10.1038/srep46801
Part of ISSN: 2045-2322
Source: Self-asserted source
Steinunn Baekkeskov

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Scientific Reports
2017-05 | Journal article
DOI: 10.1038/srep45961
Part of ISSN: 2045-2322
Source: Self-asserted source
Steinunn Baekkeskov

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Advanced Drug Delivery Reviews
2017-05 | Journal article
DOI: 10.1016/j.addr.2017.06.007
Part of ISSN: 0169-409X
Source: Self-asserted source
Steinunn Baekkeskov

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

Diabetes
2017-02 | Journal article
DOI: 10.2337/db16-0671
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Steinunn Baekkeskov
grade
Preferred source (of 3)‎

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Diabetes
2016-09 | Journal article
DOI: 10.2337/db16-0180
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Steinunn Baekkeskov

Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons

PLOS ONE
2015-02-03 | Journal article
DOI: 10.1371/journal.pone.0117130
Part of ISSN: 1932-6203
Source: Self-asserted source
Steinunn Baekkeskov

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

The Journal of Cell Biology
2010-09-06 | Journal article
DOI: 10.1083/jcb.200912101
Part of ISSN: 0021-9525
Part of ISSN: 1540-8140
Source: Self-asserted source
Steinunn Baekkeskov

Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice

Journal of Autoimmunity
2009-08 | Journal article
DOI: 10.1016/j.jaut.2009.02.004
Part of ISSN: 0896-8411
Source: Self-asserted source
Steinunn Baekkeskov

Palmitoylation cycles and regulation of protein function (Review)

Molecular Membrane Biology
2009-01 | Journal article
DOI: 10.1080/09687680802680108
Part of ISSN: 0968-7688
Part of ISSN: 1464-5203
Source: Self-asserted source
Steinunn Baekkeskov

A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes

Journal of Cell Science
2008-02-15 | Journal article
DOI: 10.1242/jcs.011916
Part of ISSN: 0021-9533
Part of ISSN: 1477-9137
Source: Self-asserted source
Steinunn Baekkeskov

Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro

Journal of Neurochemistry
2005-09-19 | Journal article
DOI: 10.1111/j.1471-4159.2005.03469.x
Part of ISSN: 0022-3042
Source: Self-asserted source
Steinunn Baekkeskov

Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters

Journal of Cell Science
2004-03-23 | Journal article
DOI: 10.1242/jcs.01030
Part of ISSN: 0021-9533
Part of ISSN: 1477-9137
Source: Self-asserted source
Steinunn Baekkeskov

A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65

The Journal of Cell Biology
2002-09-30 | Journal article
DOI: 10.1083/jcb.200205053
Part of ISSN: 0021-9525
Part of ISSN: 1540-8140
Source: Self-asserted source
Steinunn Baekkeskov

Suppressive Effect of Glutamic Acid Decarboxylase 65-Specific Autoimmune B Lymphocytes on Processing of T Cell Determinants Located Within the Antibody Epitope

The Journal of Immunology
2002-07-15 | Journal article
DOI: 10.4049/jimmunol.169.2.665
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Source: Self-asserted source
Steinunn Baekkeskov

Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety

European Journal of Immunology
2002-01 | Journal article
DOI: 10.1002/1521-4141(200201)32:1<113::aid-immu113>3.0.co;2-c
Part of ISSN: 0014-2980
Part of ISSN: 1521-4141
Source: Self-asserted source
Steinunn Baekkeskov

Does GAD have a unique role in triggering IDDM?

Journal of autoimmunity
2000-11-01 | Journal article
DOI: 10.1006/jaut.2000.0443
PMID: 11040068
Source: Self-asserted source
Steinunn Baekkeskov

Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.

American journal of physiology. Endocrinology and metabolism
2000-09-01 | Journal article
DOI: 10.1152/ajpendo.2000.279.3.e684
PMID: 10950838
Source: Self-asserted source
Steinunn Baekkeskov

A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants.

Transplantation
2000-05-01 | Journal article
DOI: 10.1097/00007890-200005150-00014
PMID: 10830216
Source: Self-asserted source
Steinunn Baekkeskov

Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients.

Diabetologia
2000-05-01 | Journal article
DOI: 10.1007/s001250051349
PMID: 10855535
Source: Self-asserted source
Steinunn Baekkeskov

A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival.

Transplantation
2000-04-01 | Journal article
DOI: 10.1097/00007890-200004150-00039
PMID: 10798768
Source: Self-asserted source
Steinunn Baekkeskov

The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65.

The Journal of biological chemistry
1999-12-01 | Journal article
DOI: 10.1074/jbc.274.52.37200
PMID: 10601283
Source: Self-asserted source
Steinunn Baekkeskov

The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release.

Proceedings of the National Academy of Sciences of the United States of America
1999-10-01 | Journal article
DOI: 10.1073/pnas.96.22.12911
PMID: 10536022
PMC: PMC23160
Source: Self-asserted source
Steinunn Baekkeskov

Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
1999-05-01 | Journal article
DOI: 10.1055/s-2007-978750
PMID: 10422732
Source: Self-asserted source
Steinunn Baekkeskov

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.

Journal of molecular biology
1999-04-01 | Journal article
DOI: 10.1006/jmbi.1999.2655
PMID: 10222205
Source: Self-asserted source
Steinunn Baekkeskov

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

Proceedings of the National Academy of Sciences of the United States of America
1999-02-01 | Journal article
DOI: 10.1073/pnas.96.4.1698
PMID: 9990087
PMC: PMC15565
Source: Self-asserted source
Steinunn Baekkeskov

Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells

Diabetes
1998-12-01 | Journal article
DOI: 10.2337/diabetes.47.12.1848
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Steinunn Baekkeskov

Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

Science (New York, N.Y.)
1998-11-01 | Journal article
DOI: 10.1126/science.282.5393.1504
PMID: 9822384
PMC: PMC2851625
Source: Self-asserted source
Steinunn Baekkeskov

Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

Proceedings of the National Academy of Sciences of the United States of America
1997-12-01 | Journal article
DOI: 10.1073/pnas.94.25.14060
PMID: 9391152
PMC: PMC28432
Source: Self-asserted source
Steinunn Baekkeskov

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction.

Nature medicine
1997-07-01 | Journal article
DOI: 10.1038/nm0797-738
PMID: 9212099
Source: Self-asserted source
Steinunn Baekkeskov

Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha.

The Journal of biological chemistry
1997-01-01 | Journal article
DOI: 10.1074/jbc.272.3.1548
PMID: 8999827
Source: Self-asserted source
Steinunn Baekkeskov

Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase.

Journal of immunology (Baltimore, Md. : 1950)
1996-12-01 | Journal article
PMID: 8943434
Source: Self-asserted source
Steinunn Baekkeskov

Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.

The Journal of clinical investigation
1996-06-01 | Journal article
DOI: 10.1172/jci118732
PMID: 8675688
PMC: PMC507370
Source: Self-asserted source
Steinunn Baekkeskov

Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population.

Diabetologia
1994-09-01 | Journal article
DOI: 10.1007/bf00400948
PMID: 7806022
Source: Self-asserted source
Steinunn Baekkeskov

Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.

The Journal of experimental medicine
1994-08-01 | Journal article
DOI: 10.1084/jem.180.2.595
PMID: 7519242
PMC: PMC2191592
Source: Self-asserted source
Steinunn Baekkeskov

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65.

The Journal of cell biology
1994-03-01 | Journal article
DOI: 10.1083/jcb.124.6.927
PMID: 8132714
PMC: PMC2119982
Source: Self-asserted source
Steinunn Baekkeskov

Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

Diabetes
1993-12-01 | Journal article
DOI: 10.2337/diab.42.12.1799
PMID: 8243826
Source: Self-asserted source
Steinunn Baekkeskov

Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines.

Molecular and cellular biology
1993-07-01 | Journal article
DOI: 10.1128/mcb.13.7.4223
PMID: 8391634
PMC: PMC359972
Source: Self-asserted source
Steinunn Baekkeskov

Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID).

Diabetologia
1993-06-01 | Journal article
DOI: 10.1007/bf02743266
PMID: 8335172
Source: Self-asserted source
Steinunn Baekkeskov

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.

Proceedings of the National Academy of Sciences of the United States of America
1993-04-01 | Journal article
DOI: 10.1073/pnas.90.7.2832
PMID: 7681990
PMC: PMC46190
Source: Self-asserted source
Steinunn Baekkeskov

The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.

Autoimmunity
1993-01-01 | Journal article
DOI: 10.3109/08916939309008857
PMID: 7692998
Source: Self-asserted source
Steinunn Baekkeskov

Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas.

Molecular Endocrinology
1992-08 | Journal article
DOI: 10.1210/mend.6.8.1406710
Part of ISSN: 0888-8809
Part of ISSN: 1944-9917
Source: Self-asserted source
Steinunn Baekkeskov

Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain.

The Journal of cell biology
1992-07-01 | Journal article
DOI: 10.1083/jcb.118.2.309
PMID: 1321158
PMC: PMC2290048
Source: Self-asserted source
Steinunn Baekkeskov

Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.

The Journal of biological chemistry
1991-12-01 | Journal article
PMID: 1744145
Source: Self-asserted source
Steinunn Baekkeskov

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.

Nature
1990-09-01 | Journal article
DOI: 10.1038/347151a0
PMID: 1697648
Source: Self-asserted source
Steinunn Baekkeskov

Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.

The Journal of biological chemistry
1990-01-01 | Journal article
PMID: 2403561
Source: Self-asserted source
Steinunn Baekkeskov

The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitus.

Current topics in microbiology and immunology
1990-01-01 | Journal article
DOI: 10.1007/978-3-642-75741-9_8
PMID: 2073783
Source: Self-asserted source
Steinunn Baekkeskov

Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen.

Diabetes
1989-09-01 | Journal article
DOI: 10.2337/diab.38.9.1133
PMID: 2670643
Source: Self-asserted source
Steinunn Baekkeskov

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

Proceedings of the National Academy of Sciences of the United States of America
1988-12-01 | Journal article
DOI: 10.1073/pnas.85.23.9037
PMID: 2848253
PMC: PMC282658
Source: Self-asserted source
Steinunn Baekkeskov

Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes

Diabetologia
1988-08 | Journal article
DOI: 10.1007/bf00264766
Part of ISSN: 0012-186X
Part of ISSN: 1432-0428
Source: Self-asserted source
Steinunn Baekkeskov
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