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Scopus Author ID: 7005566715

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Employment (5)

University of Kansas Medical Center: Kansas City, US

2024-07 to present | Professor (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Jeroen Roelofs

University of Kansas Medical Center: Kansas City, Kansas, US

2019-08-11 to 2024-06 | Associate Professor (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Jeroen Roelofs

Kansas State University: Manhattan, KS, US

2016-06-01 to 2019-08-10 | Associate Professor (Division of Biology)
Employment
Source: Self-asserted source
Jeroen Roelofs

Kansas State University: Manhattan, KS, US

2009-10-01 to 2016-05-31 | Assistant Professor (Division of Biology)
Employment
Source: Self-asserted source
Jeroen Roelofs

Harvard Medical School: Boston, MA, US

2001-09-08 to 2009-09-30 | Postdocteral research fellow (Cell Biology)
Employment
Source: Self-asserted source
Jeroen Roelofs

Education and qualifications (1)

University of Groningen: Groningen, NL

2003-03 | Ph.D. (Mathematics and Life Sciences)
Education
Source: Self-asserted source
Jeroen Roelofs

Funding (4)

Proteasome homeostasis and substrate prioritization

2023-09-15 to 2028-06-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.13615831
GRANT_NUMBER: R35GM149314
Source: Self-asserted source
Jeroen Roelofs via DimensionsWizard

Mechanism of degradation of the proteasome through autophagy

2016-05-01 to 2021-04-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.5124478
GRANT_NUMBER: R01GM118660
Source: Self-asserted source
Jeroen Roelofs via DimensionsWizard

Allosteric Mechanisms Controlling the Formation of Different Proteasome Complexes

2015-05-01 to 2018-04-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://grants.uberresearch.com/100000057/R15GM112142/Allosteric-Mechanisms-Controlling-the-Formation-of-Different-Proteasome-Complexes
GRANT_NUMBER: 1R15GM112142-01A1
Source: Self-asserted source
Jeroen Roelofs via DimensionsWizard

Studying Proteasome Assembly Using a Combination of Modeling and Experiment

2014-06-01 to 2017-05-31 | Grant
National Science Foundation - Directorate for Biological Sciences (Arlington, US)
URL: https://grants.uberresearch.com/100000076/1412262/Studying-Proteasome-Assembly-Using-a-Combination-of-Modeling-and-Experiment
GRANT_NUMBER: 1412262
Source: Self-asserted source
Jeroen Roelofs via DimensionsWizard

Works (41)

Proteasome condensate formation is driven by multivalent interactions with shuttle factors and ubiquitin chains

Proceedings of the National Academy of Sciences
2024-03-05 | Journal article
DOI: 10.1073/pnas.2310756121
Contributors: Kenrick A. Waite; Gabrielle Vontz; Stella Y. Lee; Jeroen Roelofs
Source: check_circle
Crossref

In vitroreconstitution of theM.tbproteasome core particle reveals conserved aspects of bacterial proteasome assembly

2023-07-05 | Preprint
DOI: 10.1101/2023.07.05.547829
Contributors: Anupama Kante; Jeroen Roelofs; Eric J. Deeds
Source: check_circle
Crossref

Proteaphagy and the Trafficking of Proteasomes under Nutrient Stress Conditions

Autophagy Reports
2022-12-31 | Journal article
DOI: 10.1080/27694127.2022.2040764
Contributors: Kenrick A Waite; Jeroen Roelofs
Source: check_circle
Crossref

Proteasome granule formation is regulated through mitochondrial respiration and kinase signaling

Journal of Cell Science
2022-09-01 | Journal article
DOI: 10.1242/jcs.259778
Contributors: Kenrick A. Waite; Jeroen Roelofs
Source: check_circle
Crossref

Proteaphagy is specifically regulated and requires factors dispensable for general autophagy

Journal of Biological Chemistry
2022-01 | Journal article
DOI: 10.1016/j.jbc.2021.101494
Contributors: Kenrick A. Waite; Alicia Burris; Gabrielle Vontz; Angelica Lang; Jeroen Roelofs
Source: check_circle
Crossref

Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis.

Nature structural & molecular biology
2021-04-12 | Journal article | Author
DOI: 10.1038/s41594-021-00583-9
PMID: 33846632
PMC: PMC8160580
Contributors: Helena M Schnell; Richard M Walsh Jr; Shaun Rawson; Kaur M; Bhanu MK; Tian G; Miguel A Prado; Angel Guerra Moreno; Joao A Paulo; Steven Gygi et al.
Source: Self-asserted source
Jeroen Roelofs

The Extent of Extended-Ubiquitin Binding to the Proteasome

Structure
2020 | Journal article
DOI: 10.1016/j.str.2020.04.013
EID:

2-s2.0-85083857319

Part of ISBN:

18784186 09692126
Contributors: Roelofs, J.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Tagging the proteasome active site β5 causes tag specific phenotypes in yeast.

Scientific reports
2020-10-22 | Journal article
DOI: 10.1038/s41598-020-75126-1
PMID: 33093623
PMC: PMC7582879
Source: Self-asserted source
Jeroen Roelofs

Cooperativity in Proteasome Core Particle Maturation

iScience
2020-05 | Journal article
DOI: 10.1016/j.isci.2020.101090
Contributors: Anjana Suppahia; Pushpa Itagi; Alicia Burris; Faith Mi Ge Kim; Alexander Vontz; Anupama Kante; Seonghoon Kim; Wonpil Im; Eric J. Deeds; Jeroen Roelofs
Source: check_circle
Crossref

Native gel approaches in studying proteasome assembly and chaperones

Methods in Molecular Biology
2018 | Book chapter
DOI: 10.1007/978-1-4939-8706-1_16
EID:

2-s2.0-85053823488

Part of ISBN:

10643745
Contributors: Roelofs, J.; Suppahia, A.; Waite, K.A.; Park, S.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Physiological and molecular characterization of hydroxyphenylpyruvate dioxygenase (HPPD)-inhibitor resistance in Palmer Amaranth (Amaranthus palmeri S.Wats.)

Frontiers in Plant Science
2017 | Journal article
DOI: 10.3389/fpls.2017.00555
EID:

2-s2.0-85018583160

Part of ISBN:

1664462X
Contributors: Nakka, S.; Godar, A.S.; Wani, P.S.; Thompson, C.R.; Peterson, D.E.; Roelofs, J.; Jugulam, M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Autophagy
2016 | Journal article
DOI: 10.1080/15548627.2016.1147886
EID:

2-s2.0-85054826264

Part of ISBN:

15548635 15548627
Contributors: Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; Adams, C.M.; Adams, P.D.; Adeli, K. et al.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy
2016 | Journal article
DOI: 10.1080/15548627.2015.1100356
EID:

2-s2.0-85013763791

Part of ISBN:

15548635 15548627
Contributors: Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; Adams, C.M.; Adams, P.D.; Adeli, K. et al.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep27873
EID:

2-s2.0-84975076561

Part of ISBN:

20452322
Contributors: Wani, P.S.; Suppahia, A.; Capalla, X.; Ondracek, A.; Roelofs, J.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particle

J. Biol. Chem.
2015 | Journal article
DOI: 10.1074/jbc.m115.699124
Contributors: Kenrick A. Waite; Alina De La Mota-Peynado; Gabrielle Vontz; Jeroen Roelofs
Source: Self-asserted source
Jeroen Roelofs via Crossref Metadata Search
grade
Preferred source (of 2)‎

Proteasome inhibition by bortezomib: A left hook and a right punch

EBioMedicine
2015-07 | Journal article
DOI: 10.1016/j.ebiom.2015.07.009
Contributors: Jeroen Roelofs
Source: Self-asserted source
Jeroen Roelofs via Crossref Metadata Search

Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association

Nat Comms
2015-03 | Journal article
DOI: 10.1038/ncomms7384
Contributors: Prashant S. Wani; Michael A. Rowland; Alex Ondracek; Eric J. Deeds; Jeroen Roelofs
Source: Self-asserted source
Jeroen Roelofs via Crossref Metadata Search
grade
Preferred source (of 2)‎

1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain

2014 | Journal article
DOI:

10.1107/S2053230X14003884

EID:

2-s2.0-84905448136
Contributors: Singh, C.R.; Lovell, S.; Mehzabeen, N.; Chowdhury, W.Q.; Geanes, E.S.; Battaile, K.P.; Roelofs, J.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Reconfiguration of the proteasome during chaperone-mediated assembly

2013 | Journal article
DOI:

10.1038/nature12123

EID:

2-s2.0-84878131964
Contributors: Park, S.; Li, X.; Kim, H.M.; Singh, C.R.; Tian, G.; Hoyt, M.A.; Lovell, S.; Battaile, K.P.; Zolkiewski, M.; Coffino, P. et al.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome

2013 | Journal article
DOI:

10.1074/jbc.M113.491662

EID:

2-s2.0-84885586226
Contributors: De La Mota-Peynado, A.; Lee, S.Y.-C.; Pierce, B.M.; Wani, P.; Singh, C.R.; Roelofs, J.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein

2011 | Journal article
DOI:

10.1074/jbc.M111.280875

EID:

2-s2.0-80054703106
Contributors: Lee, S.Y.-C.; De La Mota-Peynado, A.; Roelofs, J.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Assembly manual for the proteasome regulatory particle: The first draft

2010 | Journal article
DOI:

10.1042/BST0380006

EID:

2-s2.0-76449108472
Contributors: Park, S.; Tian, G.; Roelofs, J.; Finley, D.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Assembly, structure, and function of the 26S proteasome

2010 | Journal article
DOI:

10.1016/j.tcb.2010.03.007

EID:

2-s2.0-77954314106
Contributors: Bedford, L.; Paine, S.; Sheppard, P.W.; Mayer, R.J.; Roelofs, J.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Chaperone-mediated pathway of proteasome regulatory particle assembly

2009 | Journal article
DOI:

10.1038/nature08063

EID:

2-s2.0-67149112112
Contributors: Roelofs, J.; Park, S.; Haas, W.; Tian, G.; McAllister, F.E.; Huo, Y.; Lee, B.-H.; Zhang, F.; Shi, Y.; Gygi, S.P. et al.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Hexameric assembly of the proteasomal ATPases is templated through their C termini

2009 | Journal article
DOI:

10.1038/nature08065

EID:

2-s2.0-67149121057
Contributors: Park, S.; Roelofs, J.; Kim, W.; Robert, J.; Schmidt, M.; Gygi, S.P.; Finley, D.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites

2007 | Journal article
DOI:

10.1038/nsmb1335

EID:

2-s2.0-36849059755
Contributors: Kleijnen, M.F.; Roelofs, J.; Park, S.; Hathaway, N.A.; Glickman, M.; King, R.W.; Finley, D.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

A proteomic strategy for quantifying polyubiquitin chain topologies

2006 | Journal article
DOI:

10.1560/1JVL-J4EE-FVW4-MXRE

EID:

2-s2.0-33646164293
Contributors: Xu, P.; Cheng, D.; Duong, D.M.; Rush, J.; Roelofs, J.; Finley, D.; Peng, J.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Activation of soluble guanylyl cyclase at the leading edge during Dictyostelium chemotaxis

2005 | Journal article
DOI:

10.1091/mbc.E04-08-0701

EID:

2-s2.0-12844278556
Contributors: Veltman, D.M.; Roelofs, J.; Engel, R.; Visser, A.J.W.G.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches

2004 | Journal article
DOI:

10.1242/jcs.01143

EID:

2-s2.0-3543062015
Contributors: Postma, M.; Roelofs, J.; Goedhart, J.; Loovers, H.M.; Visser, A.J.W.G.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

A proteomics approach to understanding protein ubiquitination

2003 | Journal article
DOI:

10.1038/nbt849

EID:

2-s2.0-0041706156
Contributors: Peng, J.; Schwartz, D.; Elias, J.E.; Thoreen, C.C.; Cheng, D.; Marsischky, G.; Roelofs, J.; Finley, D.; Gygi, S.P.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

CGMP signalling: Different ways to create a pathway

2003 | Journal article
DOI:

10.1016/S0168-9525(02)00044-6

EID:

2-s2.0-0037370584
Contributors: Roelofs, J.; Smith, J.L.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Phosducin-like proteins in Dictyostelium discoideum: Implications for the phosducin family of proteins

2003 | Journal article
DOI:

10.1093/emboj/cdg508

EID:

2-s2.0-0141642022
Contributors: Blaauw, M.; Knol, J.C.; Kortholt, A.; Roelofs, J.; Ruchira; Postma, M.; Visser, A.J.W.G.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Uniform cAMP Stimulation of Dictyostelium Cells Induces Localized Patches of Signal Transduction and Pseudopodia

2003 | Journal article
DOI:

10.1091/mbc.E03-08-0566

EID:

2-s2.0-0344012465
Contributors: Postma, M.; Roelofs, J.; Goedhart, J.; Gadella, T.W.J.; Visser, A.J.W.G.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Characterization of two unusual guanylyl cyclases from Dictyostelium

2002 | Journal article
DOI:

10.1074/jbc.M111437200

EID:

2-s2.0-0037088636
Contributors: Roelofs, J.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Deducing the origin of soluble adenylyl cyclase, a gene lost in multiple lineages

Molecular Biology and Evolution
2002 | Journal article
EID: 2-s2.0-0036900083
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier
grade
Preferred source (of 2)‎

Genes lost during evolution

Nature
2001 | Journal article
EID: 2-s2.0-0035963319
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier
grade
Preferred source (of 2)‎

GTPγS Regulation of a 12-Transmembrane Guanylyl Cyclase Is Retained after Mutation to an Adenylyl Cyclase

2001 | Journal article
DOI:

10.1074/jbc.M105154200

EID:

2-s2.0-0035798548
Contributors: Roelofs, J.; Loovers, H.M.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Guanylate cyclase in Dictyostelium discoideum with the topology of mammalian adenylate cyclase

2001 | Journal article
DOI:

10.1042/0264-6021:3540697

EID:

2-s2.0-0035868399
Contributors: Roelofs, J.; Snippe, H.; Kleineidam, R.G.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium

2001 | Journal article
DOI:

10.1042/0264-6021:3530635

EID:

2-s2.0-0035253081
Contributors: Kuwayama, H.; Snippe, H.; Derks, M.; Roelofs, J.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier

Reduced protein diffusion rate by cytoskeleton in vegetative and polarized Dictyostelium cells

Biophysical Journal
2001 | Journal article
EID: 2-s2.0-0034804337
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier
grade
Preferred source (of 2)‎

The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase

2001 | Journal article
DOI:

10.1093/emboj/20.16.4341

EID:

2-s2.0-0035881479
Contributors: Roelofs, J.; Meima, M.; Schaap, P.; Van Haastert, P.J.M.
Source: Self-asserted source
Jeroen Roelofs via Scopus - Elsevier
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