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ResearcherID: E-9491-2012
Scopus Author ID: 24923187900
Researcher Name Resolver ID: 1000050700085

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Japan

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Employment (6)

University of Miyazaki: Miyazaki, JP

2021-04-01 to present | Assistant Professor (Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine)
Employment
Source: Self-asserted source
Takumi Ishizuka

University of Miyazaki: Miyazaki, JP

2016-03-31 to 2021-03-31 | Assistant Professor (Division of Chemistry, Department of Medical Sciences, Faculty of Medicine)
Employment
Source: Self-asserted source
Takumi Ishizuka

University of Miyazaki: Miyazaki, JP

2013-01-01 to 2016-03-31 | Research Assistant Professor (Division of Chemistry, Department of Medical Sciences, Faculty of Medicine)
Employment
Source: Self-asserted source
Takumi Ishizuka

RIKEN, SSBC: Yokohama, JP

2011-04 to 2012-12 | JSPS Research Fellow (Chemistry, PD)
Employment
Source: Self-asserted source
Takumi Ishizuka

The University of Tokyo: Meguro, JP

2009-04 to 2011-03 | JSPS Research Fellow (Chemistry, DC2) (Research Center for Advanced Science and Technology)
Employment
Source: Self-asserted source
Takumi Ishizuka

University of Parma: Parma, IT

2008-09 to 2008-12 | Visiting Researcher (Department of Organic and Industrial Chemistry)
Employment
Source: Self-asserted source
Takumi Ishizuka

Education and qualifications (3)

The University of Tokyo: Meguro, JP

2008-04-01 to 2011-03-31 | Ph.D (Department of Chemistry and Biotechnology)
Education
Source: Self-asserted source
Takumi Ishizuka

The University of Tokyo: Meguro, JP

2006-04-01 to 2008-03-31 | MS (Department of Bioengineering)
Education
Source: Self-asserted source
Takumi Ishizuka

Tokyo Institute of Technology: Yokohama, JP

2004-04-01 to 2006-03-31 | BS (School of Bioscience and Biotechnology)
Education
Source: Self-asserted source
Takumi Ishizuka

Funding (8)

細胞内RNA四重鎖を標的とする構造プローブ法の開発

2021-04-01 to 2024-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.9680395
GRANT_NUMBER: 21K05314
Source: Self-asserted source
Takumi Ishizuka via DimensionsWizard

分子結合技術を用いた新たな造影剤による革新的がんMRI画像化技術の開発

2020-04-01 to 2023-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.9198988
GRANT_NUMBER: 20K08000
Source: Self-asserted source
Takumi Ishizuka via DimensionsWizard

分子結合技術を用いた造影剤による革新的がんCT画像化技術の開発

2019-04-01 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.8438551
GRANT_NUMBER: 19K08156
Source: Self-asserted source
Takumi Ishizuka via DimensionsWizard

microRNA expression analysis by high-sensitivity fluorescence in situ hybridization method

2016-04-01 to 2019-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://grants.uberresearch.com/501100001691/16K08471/microRNA-expression-analysis-by-high-sensitivity-fluorescence-in-situ-hybridization-method
GRANT_NUMBER: 16K08471
Source: Self-asserted source
Takumi Ishizuka via DimensionsWizard

Development and application of new chemical modification method that allows the analysis of special quadruplex structure

Source: Self-asserted source
Takumi Ishizuka via DimensionsWizard

ヒトテロメアRNA分子における修飾の探索

2013-08 to 2015-03 | Grant
Ministry of Education, Culture, Sports, Science, and Technology (Tokyo, JP)
GRANT_NUMBER: 25888019
Source: Self-asserted source
Takumi Ishizuka

PNA/DNAグアニン四重鎖形成および蛍光性クリック反応の拡張と応用

2011-04 to 2012-12 | Grant
Ministry of Education, Culture, Sports, Science, and Technology (Tokyo, JP)
GRANT_NUMBER: 11J07372
Source: Self-asserted source
Takumi Ishizuka

PNAを応用した遺伝子工学ツールの拡張および二本鎖DNAを認識する新規分子の開発

2009-04 to 2011-03 | Grant
Ministry of Education, Culture, Sports, Science, and Technology (Tokyo, JP)
GRANT_NUMBER: 09J01812
Source: Self-asserted source
Takumi Ishizuka

Works (43)

Effect of Hepatic Lipid Overload on Accelerated Hepatocyte Proliferation Promoted by HGF Expression via the SphK1/S1PR2 Pathway in MCD-diet Mouse Partial Hepatectomy

Acta Histochemica et Cytochemica
2024-10-28 | Journal article
DOI: 10.1267/ahc.24-00046
Part of ISSN: 0044-5991
Part of ISSN: 1347-5800
Contributors: Baljinnyam Lkham-Erdene; Narantsog Choijookhuu; Toshiki Kubota; Tomofumi Uto; Shuya Mitoma; Shinichiro Shirouzu; Takumi Ishizuka; Kengo Kai; Kazuhiro Higuchi; Kham Mo Aung et al.
Source: Self-asserted source
Takumi Ishizuka

HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration

Journal of Histochemistry & Cytochemistry
2024-04 | Journal article
DOI: 10.1369/00221554241241569
Contributors: Narantsog Choijookhuu; Koichi Yano; Baljinnyam Lkham-Erdene; Shinichiro Shirouzu; Toshiki Kubota; Fidya; Takumi Ishizuka; Kengo Kai; Etsuo Chosa; Yoshitaka Hishikawa
Source: check_circle
Crossref

Protective role of estrogen through G-protein coupled receptor 30 in a colitis mouse model

Histochemistry and Cell Biology
2023-10-12 | Journal article
DOI: 10.1007/s00418-023-02235-z
Part of ISSN: 0948-6143
Part of ISSN: 1432-119X
Contributors: Fidya; Narantsog Choijookhuu; Makoto Ikenoue; Koichi Yano; Yu Yamaguma; Shinichiro Shirouzu; Kengo Kai; Takumi Ishizuka; Yoshitaka Hishikawa
Source: Self-asserted source
Takumi Ishizuka

Click chemistry for fluorescence imaging via combination of a BODIPY-based ‘turn-on’ probe and a norbornene glucosamine

Chemical Communications
2022 | Journal article
DOI: 10.1039/D2CC05359D
Contributors: Zhiyong He; Takumi Ishizuka; Yoshitaka Hishikawa; Yan Xu
Source: check_circle
Crossref

Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility

Journal of Ovarian Research
2022-12-20 | Journal article
DOI: 10.1186/s13048-022-01071-4
Part of ISSN: 1757-2215
Contributors: Shinichiro Shirouzu; Naohiro Sugita; Narantsog Choijookhuu; Yu Yamaguma; Kanako Takeguchi; Takumi Ishizuka; Mio Tanaka; Fidya Fidya; Kengo Kai; Etsuo Chosa et al.
Source: Self-asserted source
Takumi Ishizuka

An Advanced Detection System for In Situ Hybridization Using a Fluorescence Resonance Energy Transfer-based Molecular Beacon Probe

ACTA HISTOCHEMICA ET CYTOCHEMICA
2022-10-25 | Journal article
DOI: 10.1267/ahc.22-00075
Part of ISSN: 0044-5991
Part of ISSN: 1347-5800
Contributors: Narantsog Choijookhuu; Yasuaki Shibata; Takumi Ishizuka; Yan Xu; Takehiko Koji; Yoshitaka Hishikawa
Source: Self-asserted source
Takumi Ishizuka

Crucial role of high-mobility group box 2 in mouse ovarian follicular development through estrogen receptor beta

Histochemistry and Cell Biology
2022-01-13 | Journal article
DOI: 10.1007/s00418-022-02074-4
Part of ISSN: 0948-6143
Part of ISSN: 1432-119X
Source: Self-asserted source
Takumi Ishizuka

Systematic Approach to DNA Aptamer Design Using Amino Acid–Nucleic Acid Hybrids (ANHs) Targeting Thrombin

ACS Biomaterials Science & Engineering
2021-04-12 | Journal article
DOI: 10.1021/acsbiomaterials.1c00060
Contributors: Ji Hye Yum; Takumi Ishizuka; Koyuki Fukumoto; Daisuke Hori; Hong-Liang Bao; Yan Xu; Hiroshi Sugiyama; Soyoung Park
Source: check_circle
Crossref

Improving Thermodynamic Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Incorporation of 8-trifluoromethyl-2′-deoxyguanosine

Journal of Medicinal Chemistry
2021-01-14 | Journal article
DOI: 10.1021/acs.jmedchem.0c01711
Contributors: Hong-Liang Bao; Takumi Ishizuka; Atsushi Yamashita; Eiji Furukoji; Yujiro Asada; Yan Xu
Source: check_circle
Crossref

Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex

RSC Advances
2020 | Journal article
DOI: 10.1039/D0RA09413G
Contributors: Shogo Sasaki; Yue Ma; Takumi Ishizuka; Hong-Liang Bao; Takatsugu Hirokawa; Yan Xu; Masayuki Tera; Kazuo Nagasawa
Source: check_circle
Crossref

Characterization of Structure and Catalytic Activity of a Complex between Heme and an All Parallel-Stranded Tetrameric G-Quadruplex Formed from DNA/RNA Chimera Sequence d(TTA)r(GGG)dT

Bulletin of the Chemical Society of Japan
2020-05-15 | Journal article
DOI: 10.1246/bcsj.20200013
Part of ISSN: 0009-2673
Part of ISSN: 1348-0634
Source: Self-asserted source
Takumi Ishizuka

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

Cell
2020-03 | Journal article
DOI: 10.1016/j.cell.2020.02.050
Part of ISSN: 0092-8674
Contributors: Ting Zhang; Chaoran Yin; David F. Boyd; Giovanni Quarato; Justin P. Ingram; Maria Shubina; Katherine B. Ragan; Takumi Ishizuka; Jeremy Chase Crawford; Bart Tummers et al.
Source: Self-asserted source
Takumi Ishizuka via Crossref Metadata Search

A Nucleoside Derivative 5-Vinyluridine (VrU) for Imaging RNA in Cells and Animals

Bioconjugate Chemistry
2019-11-20 | Journal article
DOI: 10.1021/acs.bioconjchem.9b00643
Contributors: Hong-shan Liu; Takumi Ishizuka; Makiko Kawaguchi; Ryuichi Nishii; Hiroaki Kataoka; Yan Xu
Source: check_circle
Crossref

19F NMR Spectroscopy for the Analysis of DNA G-Quadruplex Structures Using 19F-Labeled Nucleobase

Methods in Molecular Biology
2019-08 | Other
DOI: 10.1007/978-1-4939-9666-7_26
Part of ISSN: 1064-3745
Contributors: Takumi Ishizuka; Hong-Liang Bao; Yan Xu
Source: Self-asserted source
Takumi Ishizuka via Crossref Metadata Search

Stability and properties of Z-DNA containing artificial nucleobase 2′-O-methyl-8-methyl guanosine

Bioorganic & Medicinal Chemistry
2019-01 | Journal article
DOI: 10.1016/j.bmc.2018.12.005
Contributors: Thananjeyan Balasubramaniyam; Takumi Ishizuka; Yan Xu
Source: check_circle
Crossref

2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA

Molecules
2018-10 | Journal issue or edition
DOI: 10.3390/molecules23102572
Source: Self-asserted source
Takumi Ishizuka
grade
Preferred source (of 3)‎

Studying DNA G-Quadruplex Aptamer by 19F NMR

ACS Omega
2017-12-31 | Journal article
DOI: 10.1021/acsomega.7b01405
Contributors: Takumi Ishizuka; Atsushi Yamashita; Yujiro Asada; Yan Xu
Source: check_circle
Crossref

A multi-functional guanine derivative for studying the DNA G-quadruplex structure

The Analyst
2017-09-01 | Journal article
DOI: 10.1039/C7AN00941K
Source: Self-asserted source
Takumi Ishizuka
grade
Preferred source (of 2)‎

Antiparallel RNA G-quadruplex Formed by Human Telomere RNA Containing 8-Bromoguanosine

Scientific Reports
2017-07-27 | Journal article
DOI: 10.1038/s41598-017-07050-w
Source: Self-asserted source
Takumi Ishizuka
grade
Preferred source (of 2)‎

A Simple and Sensitive 19F NMR Approach for Studying the Interaction of RNA G-Quadruplex with Ligand Molecule and Protein

ChemistrySelect
2017-05 | Journal article
DOI: 10.1002/slct.201700711
Contributors: Hong-Liang Bao; Takumi Ishizuka; Ayaka Iwanami; Takanori Oyoshi; Yan Xu
Source: Self-asserted source
Takumi Ishizuka via Crossref Metadata Search

Structure-Dependent Binding of hnRNPA1 to Telomere RNA

Journal of the American Chemical Society
2017-05-16 | Journal article
DOI: 10.1021/jacs.7b01599
Source: Self-asserted source
Takumi Ishizuka
grade
Preferred source (of 2)‎

Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G-, and U-Tetrads

Journal of the American Chemical Society
2017-02 | Journal article
DOI: 10.1021/jacs.6b12274
Contributors: Chao-Da Xiao; Takumi Ishizuka; Xiao-Qing Zhu; Yue Li; Hiroshi Sugiyama; Yan Xu
Source: Self-asserted source
Takumi Ishizuka via Crossref Metadata Search

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

Nucleic Acids Research
2017-02-09 | Journal article
DOI: 10.1093/nar/gkx109
Contributors: Hong-Liang Bao; Takumi Ishizuka; Takashi Sakamoto; Kenzo Fujimoto; Tamayo Uechi; Naoya Kenmochi; Yan Xu
Source: Self-asserted source
Takumi Ishizuka via Crossref Metadata Search

Click Chemistry Takes a Snapshot of DNA-RNA Hybrid G-Quadruplex in Living Cells

Journal of Nature and Science
2016-11-08 | Journal article
Source: Self-asserted source
Takumi Ishizuka

Fluorescence imaging of chromosomal DNA using click chemistry

Scientific Reports
2016-09 | Journal article
DOI: 10.1038/srep33217
Contributors: Takumi Ishizuka; Hong Shan Liu; Kenichiro Ito; Yan Xu
Source: Self-asserted source
Takumi Ishizuka via Crossref Metadata Search

Clipping of Telomere from Human Chromosomes Using a Chemistry-Based Artificial Restriction DNA Cutter

Current Protocols in Nucleic Acid Chemistry
2015-06-02 | Other
DOI: 10.1002/0471142700.nc0613s61
Contributors: Takumi Ishizuka; Yan Xu; Makoto Komiyama
Source: Self-asserted source
Takumi Ishizuka via Crossref Metadata Search

Finding a human telomere DNA-RNA hybrid G-quadruplex formed by human telomeric 6-mer RNA and 16-mer DNA using click chemistry: A protective structure for telomere end

Bioorganic & Medicinal Chemistry
2014 | Journal article
DOI: 10.1016/j.bmc.2014.05.053
WOSUID:

WOS:000340703500010
Contributors: Xu, Yan; Suzuki, Yuta; Ishizuka, Takumi; Xiao, Chao-Da; Liu, Xiao; Hayashi, Tetsuya; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

A Chemistry-Based Method To Detect Individual Telomere Length at a Single Chromosome Terminus

Journal of the American Chemical Society
2013 | Journal article
DOI: 10.1021/ja308481c
WOSUID:

WOS:000313143000004
Contributors: Ishizuka, Takumi; Xu, Yan; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Conjugation of Peptide Nucleic Acid with a Pyrrole/Imidazole Polyamide to Specifically Recognize and Cleave DNA

Angewandte Chemie-International Edition
2013 | Journal article
DOI: 10.1002/anie.201305489
WOSUID:

WOS:000328437200037
Contributors: Kameshima, Wataru; Ishizuka, Takumi; Minoshima, Masafumi; Yamamoto, Makoto; Sugiyama, Hiroshi; Xu, Yan; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

G-Rich Sequence-Specific Recognition and Scission of Human Genome by PNA/DNA Hybrid G-Quadruplex Formation

Angewandte Chemie-International Edition
2012 | Journal article
DOI: 10.1002/anie.201201176
WOSUID:

WOS:000306314300025
Contributors: Ishizuka, Takumi; Yang, Jie; Komiyama, Makoto; Xu, Yan
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres

Journal of Biological Chemistry
2012 | Journal article
DOI: 10.1074/jbc.M112.342030
WOSUID:

WOS:000312103000020
Contributors: Xu, Yan; Ishizuka, Takumi; Yang, Jie; Ito, Kenichiro; Katada, Hitoshi; Komiyama, Makoto; Hayashi, Tetsuya
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Site-specific functionalization of RNA molecules by an unnatural base pair transcription system via click chemistry

Chemical Communications
2012 | Journal article
DOI: 10.1039/c2cc36293g
WOSUID:

WOS:000309666900004
Contributors: Ishizuka, Takumi; Kimoto, Michiko; Sato, Akira; Hirao, Ichiro
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

A U-Tetrad Stabilizes Human Telomeric RNA G-Quadruplex Structure

Journal of the American Chemical Society
2010 | Journal article
DOI: 10.1021/ja909708a
WOSUID:

WOS:000278190600001
Contributors: Xu, Yan; Ishizuka, Takumi; Kimura, Takashi; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Consecutive Formation of G-Quadruplexes in Human Telomeric-Overhang DNA: A Protective Capping Structure for Telomere Ends

Angewandte Chemie-International Edition
2009 | Journal article
DOI: 10.1002/anie.200903858
WOSUID:

WOS:000270846600018
Contributors: Xu, Yan; Ishizuka, Takumi; Kurabayashi, Kaori; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Origin of High Fidelity in Target-Sequence Recognition by PNA-Ce(IV)/EDTA Combinations as Site-Selective DNA Cutters

Journal of the American Chemical Society
2009 | Journal article
DOI: 10.1021/ja808290e
WOSUID:

WOS:000263576100053
Contributors: Miyajima, Yoshitaka; Ishizuka, Takumi; Yamamoto, Yoji; Sumaoka, Jun; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Promotion of strand invasion by utilizing entropically-favored PNA.

Nucleic acids symposium series (2004)
2009 | Journal article
EID:

2-s2.0-77952475023
Contributors: Ishizuka, T.; Sforza, S.; Komiyama, M.
Source: Self-asserted source
Takumi Ishizuka via Scopus - Elsevier

SSB-Assisted Duplex Invasion of Preorganized PNA into Double-Stranded DNA

Chembiochem
2009 | Journal article
DOI: 10.1002/cbic.200900381
WOSUID:

WOS:000271816300006
Contributors: Ishizuka, Takumi; Tedeschi, Tullia; Corradini, Roberto; Komiyama, Makoto; Sforza, Stefano; Marchelli, Rosangela
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Strand invasion of conventional PNA to arbitrary sequence in DNA assisted by single-stranded DNA binding protein

Chemical Communications
2009 | Journal article
DOI: 10.1039/b813975j
WOSUID:

WOS:000263714900015
Contributors: Ishizuka, Takumi; Otani, Kosuke; Sumaoka, Jun; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences

Nucleic Acids Research
2008 | Journal article
DOI: 10.1093/nar/gkm1154
WOSUID:

WOS:000254294800014
Contributors: Ishizuka, Takumi; Yoshida, Junya; Yamamoto, Yoji; Sumaoka, Jun; Tedeschi, Tullia; Corradini, Roberto; Sforza, Stefano; Komiyama, Makoto
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Iron-catalyst-switched selective conjugate addition of Grignard reagents: alpha,beta,gamma,delta-unsaturated amides as versatile templates for asymmetric three-component coupling processes

Angewandte Chemie-International Edition
2008 | Journal article
DOI: 10.1002/anie.200801928
WOSUID:

WOS:000258835300025
Contributors: Okada, Satoshi; Arayama, Kyohei; Murayama, Ryuji; Ishizuka, Takumi; Hara, Keiichi; Hirone, Naoki; Hata, Takeshi; Urabe, Hirokazu
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Mismatch recognition in PNA double-duplex invasion.

Nucleic acids symposium series (2004)
2008 | Journal article
EID:

2-s2.0-78649422636
Contributors: Miyajima, Y.; Ishizuka, T.; Komiyama, M.
Source: Self-asserted source
Takumi Ishizuka via Scopus - Elsevier

Single-strand binding protein enhances invasion of a PNA strand to double-stranded DNA.

Nucleic acids symposium series (2004)
2008 | Journal article
EID:

2-s2.0-78649439626
Contributors: Ishizuka, T.; Komiyama, M.
Source: Self-asserted source
Takumi Ishizuka via Scopus - Elsevier

Solid-phase synthesis of pseudo-complementary peptide nucleic acids

Nature Protocols
2008 | Journal article
DOI: 10.1038/nprot.2008.6
WOSUID:

WOS:000254914500011
Contributors: Komiyama, Makoto; Aiba, Yuichiro; Ishizuka, Takumi; Sumaoka, Jun
Source: Self-asserted source
Takumi Ishizuka via ResearcherID
grade
Preferred source (of 2)‎

Peer review (3 reviews for 3 publications/grants)

Review activity for Biology methods & protocols. (1)
Review activity for Bioorganic & medicinal chemistry. (1)
Review activity for Chemical communications. (1)
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