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Works (20)

The Cation−π Interaction in Chemistry and Biology

Chemical Reviews
2025-03-12 | Journal article
DOI: 10.1021/acs.chemrev.4c00707
Contributors: Dennis A. Dougherty
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Hydrogel encapsulation of a designed fluorescent protein biosensor for continuous measurements of sub-100 nanomolar nicotine

2024-12-02 | Preprint
DOI: 10.1101/2024.12.02.625538
Contributors: Aaron L. Nichols; Christopher B. Marotta; Daniel A. Wagenaar; Stephen L. Mayo; Dennis A. Dougherty; Henry A. Lester
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Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor

Journal of the American Chemical Society
2022-09-07 | Journal article
DOI: 10.1021/jacs.2c06495
Contributors: Hailey J. Knox; Hugo Rego Campello; Henry A. Lester; Timothy Gallagher; Dennis A. Dougherty
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5-HT3 Receptor MX Helix Contributes to Receptor Function

ACS Chemical Neuroscience
2022-08-03 | Journal article
DOI: 10.1021/acschemneuro.2c00339
Contributors: James Mocatta; Susanne M. Mesoy; Dennis A. Dougherty; Sarah C. R. Lummis
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Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids

Journal of the American Chemical Society
2022-05-18 | Journal article
DOI: 10.1021/jacs.2c02323
Contributors: Anand K. Muthusamy; Charlene H. Kim; Scott C. Virgil; Hailey J. Knox; Jonathan S. Marvin; Aaron L. Nichols; Bruce N. Cohen; Dennis A. Dougherty; Loren L. Looger; Henry A. Lester
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Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-methadone for Use in Cells, Organelles, and Biofluids

2022-02-26 | Preprint
DOI: 10.1101/2022.02.24.481226
Contributors: Anand K. Muthusamy; Charlene H. Kim; Scott C. Virgil; Hailey J. Knox; Jonathan S. Marvin; Aaron L. Nichols; Bruce N. Cohen; Dennis A. Dougherty; Loren L. Looger; Henry A. Lester
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Proline Residues Contribute to Efficient GABAp Receptor Function

ACS Chemical Neuroscience
2020-12-16 | Journal article
DOI: 10.1021/acschemneuro.0c00483
Contributors: Benjamin W. Baker; Dennis A. Dougherty; Sarah C. R. Lummis
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Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABAA Receptor

ACS Medicinal Chemistry Letters
2020-11-12 | Journal article
DOI: 10.1021/acsmedchemlett.0c00340
Contributors: Annet E. M. Blom; Justin Y. Su; Lindsay M. Repka; Sarah E. Reisman; Dennis A. Dougherty
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Successful Cessation Programs that Reduce Comorbidity may Explain Surprisingly Low Smoking Rates among Hospitalized COVID-19 Patients

Qeios
2020-05-27 | Journal article
DOI: 10.32388/WURFH0
Contributors: Bruce Cohen; Aaron Nichols; Stephen Grant; Zack Blumenfeld; Dennis Dougherty; R. Michael Alvarez; Beate Ritz; Henry A. Lester
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A general strategy for visible-light decaging based on the quinone cis-alkenyl lock

Chemical Communications
2019 | Journal article
DOI: 10.1039/C9CC01073D
Contributors: David P. Walton; Dennis A. Dougherty
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Charge-transfer heptamethine dyes for NIR singlet oxygen generation

Chemical Communications
2019 | Journal article
DOI: 10.1039/C9CC01096C
Contributors: John B. Jarman; Dennis A. Dougherty
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Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor

Journal of the American Chemical Society
2019-10-09 | Journal article
DOI: 10.1021/jacs.9b06580
Contributors: Annet E.M. Blom; Hugo Rego Campello; Henry A. Lester; Timothy Gallagher; Dennis A. Dougherty
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Binding Interactions of NS6740, a Silent Agonist of the α7 Nicotinic Acetylcholine Receptor

Molecular Pharmacology
2019-08 | Journal article
DOI: 10.1124/mol.119.116244
Contributors: Catriona E.W. Blunt; Dennis A. Dougherty
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Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT3 and nACh Receptors

ACS Chemical Neuroscience
2019-07-17 | Journal article
DOI: 10.1021/acschemneuro.9b00315
Contributors: Richard Mosesso; Dennis A. Dougherty; Sarah C. R. Lummis
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Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC

Biochemistry
2018-07-10 | Journal article
DOI: 10.1021/acs.biochem.8b00379
Contributors: Richard Mosesso; Dennis A. Dougherty; Sarah C. R. Lummis
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A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors

Journal of Biological Chemistry
2018-02 | Journal article
DOI: 10.1074/jbc.M117.810432
Contributors: Richard Mosesso; Dennis A. Dougherty
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A General Strategy for Visible-Light Decaging Based on the Quinone Trimethyl Lock

Journal of the American Chemical Society
2017-04-05 | Journal article
DOI: 10.1021/jacs.7b01548
Contributors: David P. Walton; Dennis A. Dougherty
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Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process

Journal of the American Chemical Society
2017-04-05 | Journal article
DOI: 10.1021/jacs.6b12007
Contributors: Clinton J. Regan; David P. Walton; Oliver S. Shafaat; Dennis A. Dougherty
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Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors

Biochemistry
2017-04-04 | Journal article
DOI: 10.1021/acs.biochem.7b00213
Contributors: Michael R. Post; Henry A. Lester; Dennis A. Dougherty
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Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors

eneuro
2017-03 | Journal article
DOI: 10.1523/ENEURO.0032-17.2017
Contributors: Michael R. Post; Gabrielle S. Tender; Henry A. Lester; Dennis A. Dougherty
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Peer review (16 reviews for 5 publications/grants)

Review activity for Biochemistry. (2)
Review activity for Chemical reviews. (2)
Review activity for Journal of chemical education. (1)
Review activity for Journal of the American Chemical Society. (10)
Review activity for Organic letters. (1)
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