Personal information

Neurosciences; mitochondria; Oxidative stress; Cell Signaling; Neurodegenative disorders
Portugal

Biography

Lígia Fão obtained her Master Degree in Biomedical Engineering with Specialization in Neurosciences, in September 2016, from the University of Coimbra, Portugal. She developed her Master’s thesis at “Mitochondria and Neurodegenerative Disorders” laboratory (current designation) at the CNC-Center for Neuroscience and Cell Biology, UC, entitled “Amyloid-beta peptide-evoked Src signalling and redox changes in hippocampal cells” under the supervision of Doctor Ana Cristina Rego and Doctor Sandra Mota. In June 2017, she obtained an investigator fellowship at CNC, and she worked in the project “HEALTHY AGING 2020 - Changes in neurogenesis and mitochondrial function in Alzheimer's and Huntington's disease.” Moreover, in September 2017, she integrated the Doctoral Program in Health Sciences from the Faculty of Medicine of the University of Coimbra. Currently, Lígia's PhD thesis is focus on Huntington’s Disease (HD). HD is a neurodegenerative disorder with no effective therapies and that share many features with other diseases so she believes that her PhD project will promote a better knowledge regarding HD etiopathogenesis and other related neurodegenerative disorders that share common features.

Activities

Employment (4)

CNC.IBILI: Coimbra, PT

2019-12-01 to present | PhD Fellowship from FCT (Faculty of Medicine)
Employment
Source: Self-asserted source
Lígia Fão

Center for Neuroscince and cell Biology: Coimbra, PT

2017-06-01 to 2019-11-30 | MSc Researcher Fellow
Employment
Source: Self-asserted source
Lígia Fão

Center for Neuroscince and cell Biology: Coimbra, Coimbra, PT

2016-09-22 to 2017-05-01 | Voluntary Researcher (“Mitochondrial Dysfunction and Signaling in Neurodegeneration” group)
Employment
Source: Self-asserted source
Lígia Fão

Center for Neuroscince and cell Biology: Coimbra, Coimbra, PT

2015-09-01 to 2016-09-21 | Master Thesis (Mitochondrial Dysfunction and Signaling in Neurodegeneration” group )
Employment
Source: Self-asserted source
Lígia Fão

Education and qualifications (2)

Faculty of Medicine: Coimbra, PT

2017-09-01 to present | PhD Student - Doctoral Programme in Health Sciences (Faculty of Medicine)
Education
Source: Self-asserted source
Lígia Fão

Universidade de Coimbra: Coimbra, Coimbra, PT

2011-09-01 to 2016-09-21 | Master (Faculty of Sciences and Technology)
Education
Source: Self-asserted source
Lígia Fão

Funding (1)

Transcriptional activity modulation in Alzheimer's disease by inhibitors of histone deacetylases

2018-09 to 2021-08 | Grant
FCT - Fundação da Ciência e Tecnologia (Coimbra, PT)
GRANT_NUMBER:

PTDC/MED-TOX/32316/2017

Source: Self-asserted source
Lígia Fão
grade
Preferred source (of 2)‎

Works (19)

Uncovering the Early Events Associated with Oligomeric Aβ-Induced Src Activation

Antioxidants
2023-09 | Journal article | Author
Contributors: Sandra I Mota; Lígia Fão; Coelho, Patrícia RD; A. Cristina Rego
Source: check_circle
Multidisciplinary Digital Publishing Institute

Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases

Ageing Research Reviews
2022-09 | Journal article
SOURCE-WORK-ID:

cv-prod-id-3181402

Contributors: Coelho, Patrícia; Fão L; Mota, Sandra; Rego, A. Cristina
Source: check_circle
CIÊNCIAVITAE

Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease

Antioxidants & Redox Signaling
2022-08-05 | Journal article
SOURCE-WORK-ID:

cv-prod-id-3181406

Contributors: Fão L; Coelho, Patrícia; Duarte, Luís; Vilaça, Rita; Hayden, Michael R.; Mota, Sandra I.; Rego, Ana Cristina
Source: check_circle
CIÊNCIAVITAE

c-Src/Fyn decreased levels in Huntington’s Disease – impact on mitochondrial function and ROS formation.

SPN 2021
2021-12-01 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-3181407

Contributors: Fão, Lígia; Coelho, Patrícia; Mota, Sandra I.; Ana Cristina Carvalho Rego
Source: check_circle
CIÊNCIAVITAE

Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

Biomedicines
2021-11-05 | Journal article
SOURCE-WORK-ID:

cv-prod-id-3181401

Contributors: Magalhães, João Duarte; Fão L; Vilaça, Rita; Cardoso, Sandra Morais; Rego, Ana Cristina
Source: check_circle
CIÊNCIAVITAE

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

BMC Biology
2021-03-24 | Journal article
SOURCE-WORK-ID:

cv-prod-id-3181403

Contributors: Naia, Luana; Pinho, Catarina M.; Dentoni, Giacomo; Liu, Jianping; Leal, Nuno Santos; Ferreira, Duarte M. S.; Schreiner, Bernadette; et al.
Source: check_circle
CIÊNCIAVITAE

Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics

Free Radical Biology and Medicine
2021-02 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2430685

Contributors: Naia, Luana; Carmo, Catarina; Campesan, Susanna; Fão, Lígia; Cotton, Victoria E.; Valero, Jorge; Lopes, Carla; et al.
Source: check_circle
CIÊNCIAVITAE

Mitochondrial and redox-based therapeutic strategies in Huntington's disease

Antioxidants and Redox Signaling
2020-04-06 | Journal article
Source: Self-asserted source
Lígia Fão
grade
Preferred source (of 2)‎

Modified Glutamatergic Postsynapse in Neurodegenerative Disorders

Neuroscience
2019-12 | Journal article
Part of ISSN: 0306-4522
Source: Self-asserted source
Lígia Fão
grade
Preferred source (of 2)‎

c-Src/Fyn role in Huntington’s Disease progression

23rd Annual Meeting of the Portuguese Society of Human Genetics.
2019-11-14 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1254135

Contributors: Fão, Lígia; Sandra Isabel Freitas Mota; Ana Cristina Carvalho Rego
Source: check_circle
CIÊNCIAVITAE

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Ageing Research Reviews
2019-09 | Journal article
Source: Self-asserted source
Lígia Fão
grade
Preferred source (of 2)‎

c-Src regulated Nrf2 activity through PKCd after an oxidant stimulus.

Portuguese Society of Neurosciences.
2019-06-01 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1254225

Contributors: Fão, Lígia
Source: check_circle
CIÊNCIAVITAE

c-Src regulates Nrf2 activity through PKCδ after oxidant stimulus

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2019-04 | Journal article
Source: Self-asserted source
Lígia Fão
grade
Preferred source (of 2)‎

Regulation of Nrf2 activity by Src Kinase Family and PKCd after an oxidant stimulus.

9th Meeting on Signal Transduction
2018-09-21 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1254236

Contributors: Fão, Lígia
Source: check_circle
CIÊNCIAVITAE

Oligomeric amyloid-beta peptide-induced redox dendritic mitochondrial changes in mature hippocampal neurons: role of NMDA receptors and Src kinase.

. MitoPorto International Symposium
2018-07-13 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1254255

Contributors: Fão, Lígia
Source: check_circle
CIÊNCIAVITAE

Crosstalk between Src kinase and Nrf2 following oxidant stimulus - mitochondria and nucleus as relevant subcellular targets; and NMDA receptor-dependent redox changes and modified dendritic mitochondria following exposure to oligomeric amyloid-beta peptide in mature hippocampal neurons.

MitoPorto International Symposium
2017-05-26 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1254266

Contributors: Fão, Lígia
Source: check_circle
CIÊNCIAVITAE

Amyloid-beta peptide-evoked Src signaling and redox changes in hippocampal cells

Universidade de Coimbra Faculdade de Ciencias e Tecnologia
2016-09-21 | Dissertation or Thesis
SOURCE-WORK-ID:

cv-prod-id-739754

Contributors: Fão, Lígia
Source: check_circle
CIÊNCIAVITAE

Induction of oxidative stress by amyloid-beta1-42 in mature hippocampal neurons: linking Src activity to Alzheimer’s disease.

. XL Portuguese Genetics Conference.
2016-06-03 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1254279

Contributors: Fão, Lígia
Source: check_circle
CIÊNCIAVITAE

Role of src kinase in oligomeric amyloid-betainduced early oxidative stress in mature hippocampal neurons - a link to alzheimer’s disease.

Synaptic Functions & Dysfunctions in Brain Disease – ISN
2016-06-01 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1254341

Contributors: Fão, Lígia; Sandra Isabel Freitas Mota; Ana Cristina Carvalho Rego
Source: check_circle
CIÊNCIAVITAE

Peer review (1 review for 1 publication/grant)

Review activity for Metabolic brain disease. (1)