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Works (18)

Quantum Cascade Laser Infrared Spectroscopy for Glycan Analysis of Glycoprotein Solutions

Analytical Chemistry
2024-07-30 | Journal article
DOI: 10.1021/acs.analchem.4c01772
Part of ISSN: 0003-2700
Part of ISSN: 1520-6882
Contributors: Seong-Min Kim; Yow-Ren Chang; Jake Melby; Yoen Joo Kim; Darryl Davis; Young Jong Lee
Source: Self-asserted source
Jake Melby

Small-Scale Serial Size Exclusion Chromatography (s3SEC) for High Sensitivity Top-Down Proteomics of Large Proteoforms

Analytical Chemistry
2024-02-05 | Journal article
DOI: 10.1021/acs.analchem.3c05733
Contributors: Holden T. Rogers; Jake A. Melby; Lauren E. Ehlers; Matthew S. Fischer; Eli J. Larson; Zhan Gao; Kalina J. Rossler; Daojing Wang; Andrew J. Alpert; Ying Ge
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Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics

Nature Communications
2023-12-18 | Journal article
DOI: 10.1038/s41467-023-43321-z
Contributors: Emily A. Chapman; David S. Roberts; Timothy N. Tiambeng; Jãán Andrews; Man-Di Wang; Emily A. Reasoner; Jake A. Melby; Brad H. Li; Donguk Kim; Andrew J. Alpert et al.
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Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics

Analytical Chemistry
2023-09-05 | Journal article
DOI: 10.1021/acs.analchem.3c01618
Contributors: Holden T. Rogers; David S. Roberts; Eli J. Larson; Jake A. Melby; Kalina J. Rossler; Austin V. Carr; Kyle A. Brown; Ying Ge
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High sensitivity top–down proteomics captures single muscle cell heterogeneity in large proteoforms

Proceedings of the National Academy of Sciences
2023-05-09 | Journal article
DOI: 10.1073/pnas.2222081120
Contributors: Jake A. Melby; Kyle A. Brown; Zachery R. Gregorich; David S. Roberts; Emily A. Chapman; Lauren E. Ehlers; Zhan Gao; Eli J. Larson; Yutong Jin; Justin R. Lopez et al.
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Lactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs

2023-05-06 | Preprint
DOI: 10.1101/2023.05.05.539642
Contributors: Kalina J. Rossler; Willem J. de Lange; Morgan W. Mann; Timothy J. Aballo; Jake A. Melby; Jianhua Zhang; Gina Kim; Elizabeth F. Bayne; Yanlong Zhu; Emily T. Farrell et al.
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Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-Down Proteomics

Journal of Proteome Research
2023-03-03 | Journal article
DOI: 10.1021/acs.jproteome.2c00729
Contributors: Emily A. Chapman; Timothy J. Aballo; Jake A. Melby; Tianhua Zhou; Scott J. Price; Kalina J. Rossler; Ienglam Lei; Paul C. Tang; Ying Ge
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MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing

2023-01-03 | Preprint
DOI: 10.1101/2023.01.02.522513
Contributors: Eli J. Larson; Melissa R. Pergande; Michelle E. Moss; Kalina J. Rossler; R. Kent Wenger; Boris Krichel; Harini Josyer; Jake A. Melby; David S. Roberts; Kyndalanne Pike et al.
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High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms

2022-12-31 | Preprint
DOI: 10.1101/2022.12.29.521273
Contributors: Jake A. Melby; Kyle A. Brown; Zachery R. Gregorich; David S. Roberts; Emily A. Chapman; Lauren E. Ehlers; Zhan Gao; Eli J. Larson; Yutong Jin; Justin Lopez et al.
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Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry

Journal of the American Chemical Society
2021-08-11 | Journal article
DOI: 10.1021/jacs.1c02713
Contributors: David S. Roberts; Morgan Mann; Jake A. Melby; Eli J. Larson; Yanlong Zhu; Allan R. Brasier; Song Jin; Ying Ge
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Ultrafast and Reproducible Proteomics from Small Amounts of Heart Tissue Enabled by Azo and timsTOF Pro

Journal of Proteome Research
2021-08-06 | Journal article
DOI: 10.1021/acs.jproteome.1c00446
Contributors: Timothy J. Aballo; David S. Roberts; Jake A. Melby; Kevin M. Buck; Kyle A. Brown; Ying Ge
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High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry

Analytical Chemistry
2021-07-27 | Journal article
DOI: 10.1021/acs.analchem.1c00150
Contributors: Eli J. Larson; David S. Roberts; Jake A. Melby; Kevin M. Buck; Yanlong Zhu; Shiyue Zhou; Linjie Han; Qunying Zhang; Ying Ge
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Novel Strategies to Address the Challenges in Top-Down Proteomics

Journal of the American Society for Mass Spectrometry
2021-06-02 | Journal article
DOI: 10.1021/jasms.1c00099
Contributors: Jake A. Melby; David S. Roberts; Eli J. Larson; Kyle A. Brown; Elizabeth F. Bayne; Song Jin; Ying Ge
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Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry

2021-03-01 | Preprint
DOI: 10.1101/2021.02.28.433291
Contributors: David S. Roberts; Morgan W. Mann; Jake A. Melby; Eli J. Larson; Yanlong Zhu; Allan R. Brasier; Song Jin; Ying Ge
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Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues

Journal of Proteome Research
2021-02-05 | Journal article
DOI: 10.1021/acs.jproteome.0c00830
Contributors: Jake A. Melby; Willem J. de Lange; Jianhua Zhang; David S. Roberts; Stanford D. Mitchell; Trisha Tucholski; Gina Kim; Andreas Kyrvasilis; Sean J. McIlwain; Timothy J. Kamp et al.
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Top-down proteomics: challenges, innovations, and applications in basic and clinical research

Expert Review of Proteomics
2020-10-02 | Journal article
DOI: 10.1080/14789450.2020.1855982
Contributors: Kyle A. Brown; Jake A. Melby; David S. Roberts; Ying Ge
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MASH Explorer: A Universal Software Environment for Top-Down Proteomics

Journal of Proteome Research
2020-09-04 | Journal article
DOI: 10.1021/acs.jproteome.0c00469
Part of ISSN: 1535-3893
Part of ISSN: 1535-3907
Source: Self-asserted source
Jake Melby

Top-Down Proteomics Reveals Myofilament Proteoform Heterogeneity among Various Rat Skeletal Muscle Tissues

Journal of Proteome Research
2020-01-03 | Journal article
DOI: 10.1021/acs.jproteome.9b00623
Contributors: Jake A. Melby; Yutong Jin; Ziqing Lin; Trisha Tucholski; Zhijie Wu; Zachery R. Gregorich; Gary M. Diffee; Ying Ge
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