Personal information

Biography

Richard Sharpe is based in the MRC/University Centre for Reproductive Health in Edinburgh where he heads a research programme on developmental disorders of (mainly male) reproductive health. He is a Professor in Edinburgh University College of Medicine & Veterinary Medicine. His expertise and research interests cover sexual differentiation, development and puberty (and disorders thereof), fetal programming, endocrinology, the effects of lifestyle (smoking, obesity, diet, use of personal care products) and environmental chemical exposures on reproductive development and function. He is increasingly interested in the inter-relationships between reproductive and wider aspects of health in relation to diet, obesity, inflammation and aging. He serves/has served on numerous advisory bodies in Europe and elsewhere, and as a member of Council for the Society for Endocrinology and as co-Chair of their Special Interest Group on ‘Endocrine disruptors’. He is a Deputy Editor of Human Reproduction. He has published >350 papers and has an H index of 65 (ISI) 80 (Google).

Activities

Employment (11)

Medical Research Council: London, London, GB

1993 to present | Special (Professorial level) Appointment
Employment
Source: Self-asserted source
Richard Sharpe

The University of Edinburgh: Edinburgh, Edinburgh, GB

2011 to 2018-05 | Programme Leader, MRC Centre for Reproductive Health
Employment
Source: Self-asserted source
Richard Sharpe

Medical Research Council: London, London, GB

1987 to 1993 | Senior Scientist, MRC Reproductive Biology Unit
Employment
Source: Self-asserted source
Richard Sharpe

Medical Research Council: London, London, GB

1981 to 1987 | Scientific Staff, Grade I tenured
Employment
Source: Self-asserted source
Richard Sharpe

Medical Research Council: London, London, GB

1985 | Visting Professor, Dept of Anatomy, Monash Univ, Melbourne
Employment
Source: Self-asserted source
Richard Sharpe

Medical Research Council: London, London, GB

1979 to 1981 | Scientific Staff, Grade II
Employment
Source: Self-asserted source
Richard Sharpe

Medical Research Council: London, London, GB

1978 to 1979 | Senior Research Officer
Employment
Source: Self-asserted source
Richard Sharpe

Medical Research Council: London, London, GB

1974 to 1978 | Research Officer
Employment
Source: Self-asserted source
Richard Sharpe

Medical Research Council: London, London, GB

1974 to 1978 | Research Officer
Employment
Source: Self-asserted source
Richard Sharpe

University of Bristol: Bristol, Bristol, GB

1973 to 1974 | Research Assistant
Employment
Source: Self-asserted source
Richard Sharpe

University of Bristol: Bristol, Bristol, GB

1970 to 1974 | Technician, Depart of Pharmacology
Employment
Source: Self-asserted source
Richard Sharpe

Education and qualifications (3)

Council for National Academic Awards: (now) The Open University, Milton Keynes, GB

1979 | PhD
Education
Source: Self-asserted source
Richard Sharpe

University of Bristol: Bristol, Bristol, GB

1975 | MSc
Education
Source: Self-asserted source
Richard Sharpe

University of London: London, London, GB

1970 | BSc (Honours Zoology)
Education
Source: Self-asserted source
Richard Sharpe

Works (50 of 77)

Items per page:
Page 1 of 2

Endocrine disruption and male reproductive disorders: unanswered questions

Human Reproduction
2024-09-01 | Journal article
Contributors: Richard M Sharpe
Source: check_circle
Crossref

Androgens and the masculinization programming window: human–rodent differences

Biochemical Society Transactions
2020-08-28 | Journal article
Contributors: Richard M. Sharpe
Source: check_circle
Crossref

Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.

2016 | Journal article
Contributors: Dean A; van den Driesche S; Wang Y; McKinnell C; Macpherson S; Eddie SL; Kinnell H; Hurtado-Gonzalez P; Chambers TJ; Stevenson K et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure.

2015-09 | Journal article
Contributors: Le Moal J; Sharpe RM; Jϕrgensen N; Levine H; Jurewicz J; Mendiola J; Swan SH; Virtanen H; Christin-Maître S; Cordier S et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.

2015-05 | Journal article
Contributors: van den Driesche S; Macdonald J; Anderson RA; Johnston ZC; Chetty T; Smith LB; McKinnell C; Dean A; Homer NZ; Jorgensen A et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.

2015-01 | Journal article
DOI:

10.1210/en.2014-1534

PMID:

25375036

PMC:

PMC4272396

Contributors: Mitchell RT; Mungall W; McKinnell C; Sharpe RM; Cruickshanks L; Milne L; Smith LB
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Dynamic changes in DNA modification states during late gestation male germ line development in the rat.

2014 | Journal article
DOI:

10.1186/1756-8935-7-19

PMID:

25225576

PMC:

PMC4163680

Contributors: Rose CM; van den Driesche S; Sharpe RM; Meehan RR; Drake AJ
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts.

2014-12 | Journal article
PMID:

25514601

Contributors: van den Driesche S; McKinnell C; Calarrão A; Kennedy L; Hutchison GR; Hrabalkova L; Jobling MS; Macpherson S; Anderson RA; Sharpe RM et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Lessons learned in andrology: learning from experience - getting it wrong is alright.

2014-09 | Journal article
DOI:

10.1111/j.2047-2927.2014.00242.x

PMID:

25124512

Contributors: Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Does grazing on biosolids treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?

2014-06 | Journal article
DOI:

10.2527/jas.2014-7763

PMID:

24948646

Contributors: Evans NP; Bellingham M; Sharpe RM; Cotinot C; Rhind SM; Kyle C; Erhard H; Hombach-Klonisch S; Lind PM; Fowler PA
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells.

2014-05 | Journal article
DOI:

10.1073/pnas.1320735111

PMID:

24753613

PMC:

PMC4020050

Contributors: Kilcoyne KR; Smith LB; Atanassova N; Macpherson S; McKinnell C; van den Driesche S; Jobling MS; Chambers TJ; De Gendt K; Verhoeven G et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: a role for miRNAs?

2014-05 | Journal article
DOI:

10.1016/j.semcdb.2014.04.006

PMID:

24718319

Contributors: van den Driesche S; Sharpe RM; Saunders PT; Mitchell RT
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole.

2014-02 | Journal article
DOI:

10.3109/10408444.2013.855163

PMID:

24274332

Contributors: Chambers JE; Greim H; Kendall RJ; Segner H; Sharpe RM; Van Der Kraak G
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

2014-01 | Journal article
DOI:

10.1038/modpathol.2013.246

PMID:

24457464

Contributors: Mitchell RT; E Camacho-Moll M; Macdonald J; Anderson RA; Kelnar CJ; E Camacho-Moll M; Sharpe RM; Smith LB; Grigor KM; Wallace WH et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.

2013 | Journal article
DOI:

10.1371/journal.pone.0061726

PMID:

23620786

PMC:

PMC3631175

Contributors: Mitchell RT; Sharpe RM; Anderson RA; McKinnell C; Macpherson S; Smith LB; Wallace WH; Kelnar CJ; van den Driesche S
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin.

2013 | Journal article
DOI:

10.1371/journal.pone.0062556

PMID:

23671609

PMC:

PMC3643956

Contributors: Dean A; Mungall W; McKinnell C; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

A plea for risk assessment of endocrine disrupting chemicals.

2013-12 | Journal article
DOI:

10.1016/j.tox.2013.07.018

PMID:

23939142

Contributors: Testai E; Galli CL; Dekant W; Marinovich M; Piersma AH; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Exposure to chemical cocktails before or after conception--- the effect of timing on ovarian development.

2013-08 | Journal article
DOI:

10.1016/j.mce.2013.06.016

PMID:

23791816

PMC:

PMC3731555

Contributors: Bellingham M; Amezaga MR; Mandon-Pepin B; Speers CJ; Kyle CE; Evans NP; Sharpe RM; Cotinot C; Rhind SM; Fowler PA
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Clinical review: Anogenital distance or digit length ratio as measures of fetal androgen exposure: relationship to male reproductive development and its disorders.

2013-06 | Journal article
DOI:

10.1210/jc.2012-4057

PMID:

23569219

Contributors: Dean A; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Obesogens and obesity--an alternative view?

2013-06 | Journal article
DOI:

10.1002/oby.20373

PMID:

23512350

Contributors: Sharpe RM; Drake AJ
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat.

2013-04 | Journal article
DOI:

10.1093/humrep/des465

PMID:

23321215

PMC:

PMC3600838

Contributors: McKinnell C; Mitchell RT; Morris K; Anderson RA; Kelnar CJ; Wallace WH; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep.

2013-03 | Journal article
DOI:

10.1016/j.mce.2012.12.022

PMID:

23291342

PMC:

PMC3581773

Contributors: Hombach-Klonisch S; Danescu A; Begum F; Amezaga MR; Rhind SM; Sharpe RM; Evans NP; Bellingham M; Cotinot C; Mandon-Pepin B et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

The downside of 'inappropriate messaging': new insight into the development of testicular germ cell tumours in young men?

2013-03 | Journal article
DOI:

10.1002/path.4167

PMID:

23335366

Contributors: Sharpe RM; Mitchell RT
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat.

2012 | Journal article
DOI:

10.1371/journal.pone.0030111

PMID:

22253897

PMC:

PMC3256232

Contributors: van den Driesche S; Kolovos P; Platts S; Drake AJ; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.

2012 | Journal article
DOI:

10.1371/journal.pone.0037064

PMID:

22615892

PMC:

PMC3355148

Contributors: van den Driesche S; Walker M; McKinnell C; Scott HM; Eddie SL; Mitchell RT; Seckl JR; Drake AJ; Smith LB; Anderson RA et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development.

2012-10 | Journal article
DOI:

10.1111/j.1365-2605.2012.01264.x

PMID:

22420564

Contributors: Auharek SA; Lara NL; Avelar GF; Sharpe RM; França LR
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Foetal and post-natal exposure of sheep to sewage sludge chemicals disrupts sperm production in adulthood in a subset of animals.

2012-06 | Journal article
DOI:

10.1111/j.1365-2605.2011.01234.x

PMID:

22150464

PMC:

PMC3440584

Contributors: Bellingham M; McKinnell C; Fowler PA; Amezaga MR; Zhang Z; Rhind SM; Cotinot C; Mandon-Pepin B; Evans NP; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats.

2012-06 | Journal article
DOI:

10.1111/j.1365-2605.2011.01236.x

PMID:

22248293

Contributors: Dean A; Smith LB; Macpherson S; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Sperm counts and fertility in men: a rocky road ahead. Science & Society Series on Sex and Science.

2012-05 | Journal article
DOI:

10.1038/embor.2012.50

PMID:

22491033

PMC:

PMC3343360

Contributors: Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate.

2012-03 | Journal article
DOI:

10.1210/jc.2011-2411

PMID:

22238399

Contributors: Mitchell RT; Childs AJ; Anderson RA; van den Driesche S; Saunders PT; McKinnell C; Wallace WH; Kelnar CJ; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells.

2012-02 | Journal article
DOI:

10.1111/j.1365-2605.2011.01150.x

PMID:

21651570

Contributors: Welsh M; Moffat L; Belling K; de França LR; Segatelli TM; Saunders PT; Sharpe RM; Smith LB
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats.

2012-01 | Journal article
DOI:

10.1530/REP-11-0239

PMID:

22016380

PMC:

PMC3245827

Contributors: Tyndall V; Broyde M; Sharpe R; Welsh M; Drake AJ; McNeilly AS
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Relative importance of prenatal and postnatal androgen action in determining growth of the penis and anogenital distance in the rat before, during and after puberty.

2011-12 | Journal article
DOI:

10.1111/j.1365-2605.2011.01175.x

PMID:

21631528

Contributors: van den Driesche S; Scott HM; MacLeod DJ; Fisken M; Walker M; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Sertoli cell numbers and spermatogenic efficiency are increased in inducible nitric oxide synthase mutant mice.

2011-12 | Journal article
DOI:

10.1111/j.1365-2605.2011.01209.x

PMID:

21831234

Contributors: Auharek SA; Avelar GF; Lara NL; Sharpe RM; França LR
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Pediatrics: endocrine disruption and human health effects--a call to action.

2011-11 | Journal article
DOI:

10.1038/nrendo.2011.165

PMID:

21931368

Contributors: Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability.

2011-10 | Journal article
DOI:

10.1111/j.1365-2605.2010.01140.x

PMID:

21332505

PMC:

PMC3229675

Contributors: Jobling MS; Hutchison GR; van den Driesche S; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Low sperm counts may be preventable.

2011-09 | Journal article
DOI:

10.1126/science.333.6048.1380-b

PMID:

21903792

Contributors: Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.

2011-09 | Journal article
DOI:

10.1210/en.2011-0282

PMID:

21733831

Contributors: Welsh M; Moffat L; McNeilly A; Brownstein D; Saunders PT; Sharpe RM; Smith LB
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics.

2010 | Journal article
DOI:

10.1371/journal.pone.0013632

PMID:

21049031

PMC:

PMC2964321

Contributors: Welsh M; Sharpe RM; Moffat L; Atanassova N; Saunders PT; Kilter S; Bergh A; Smith LB
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

2010 | Journal article
DOI:

10.1371/journal.pone.0014168

PMID:

21152390

PMC:

PMC2994754

Contributors: Willems A; Batlouni SR; Esnal A; Swinnen JV; Saunders PT; Sharpe RM; França LR; De Gendt K; Verhoeven G
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: relationship to blood-testis barrier integrity and prospects for biomonitoring.

2010-10 | Journal article
DOI:

10.1093/toxsci/kfq210

PMID:

20624998

PMC:

PMC2940408

Contributors: Elkin ND; Piner JA; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation.

2010-10 | Journal article
DOI:

10.1093/humrep/deq183

PMID:

20683063

PMC:

PMC2939754

Contributors: Mitchell RT; Saunders PT; Childs AJ; Cassidy-Kojima C; Anderson RA; Wallace WH; Kelnar CJ; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Maternal and fetal tissue accumulation of selected endocrine disrupting compounds (EDCs) following exposure to sewage sludge-treated pastures before or after conception.

2010-08 | Journal article
DOI:

10.1039/c0em00009d

PMID:

20676422

PMC:

PMC3175732

Contributors: Rhind SM; Kyle CE; Mackie C; McDonald L; Zhang Z; Duff EI; Bellingham M; Amezaga MR; Mandon-Pepin B; Loup B et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol.

2010-07 | Journal article
DOI:

10.1210/en.2009-1339

PMID:

20444943

PMC:

PMC3033689

Contributors: Welsh M; Moffat L; Jack L; McNeilly A; Brownstein D; Saunders PT; Sharpe RM; Smith LB
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Effects of environmental pollutants on the reproduction and welfare of ruminants.

2010-07 | Journal article
DOI:

10.1017/S1751731110000595

PMID:

20582145

PMC:

PMC2888112

Contributors: Rhind SM; Evans NP; Bellingham M; Sharpe RM; Cotinot C; Mandon-Pepin B; Loup B; Sinclair KD; Lea RG; Pocar P et al.
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Bisphenol a and metabolic syndrome.

2010-06 | Journal article
DOI:

10.1210/en.2010-0445

PMID:

20489050

Contributors: Sharpe RM; Drake AJ
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Foetal hypothalamic and pituitary expression of gonadotrophin-releasing hormone and galanin systems is disturbed by exposure to sewage sludge chemicals via maternal ingestion.

2010-06 | Journal article
DOI:

10.1111/j.1365-2826.2010.01974.x

PMID:

20236231

Contributors: Bellingham M; Fowler PA; Amezaga MR; Whitelaw CM; Rhind SM; Cotinot C; Mandon-Pepin B; Sharpe RM; Evans NP
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.

2010-06 | Journal article
DOI:

10.1210/en.2010-0108

PMID:

20392824

Contributors: Auharek SA; de Franca LR; McKinnell C; Jobling MS; Scott HM; Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Environmental/lifestyle effects on spermatogenesis.

2010-05 | Journal article
DOI:

10.1098/rstb.2009.0206

PMID:

20403879

PMC:

PMC2871918

Contributors: Sharpe RM
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central

Androgen action in the masculinization programming window and development of male reproductive organs.

2010-04 | Journal article
DOI:

10.1111/j.1365-2605.2009.01005.x

PMID:

20002220

Contributors: Macleod DJ; Sharpe RM; Welsh M; Fisken M; Scott HM; Hutchison GR; Drake AJ; van den Driesche S
Source: Self-asserted source
Richard Sharpe via Europe PubMed Central
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