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Scopus Author ID: 6507666936
Scopus Author ID: 57201998112
Loop profile: 1599977
SciProfiles: 425171

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Employment (4)

AbbVie: Warsaw, PL

2023-05-01 to present | Pipeline Medical Science Liaison (Global Medical Affairs)
Employment
Source: Self-asserted source
Jakub Szymczyk

University of Wrocław: Wrocław, Lower Silesia, PL

2016-10-01 to present | PhD Candidate (Department of Protein Engineering)
Employment
Source: Self-asserted source
Jakub Szymczyk

Pure Biologics (Poland): Wrocław, PL

2022-10-01 to 2023-04-30 | R&D Scientist (Protein Group)
Employment
Source: Self-asserted source
Jakub Szymczyk

University of Wrocław: Wrocław, PL

2020-10-08 to 2022-09-30 | Scietific assistant (Department of Protein Engineering)
Employment
Source: Self-asserted source
Jakub Szymczyk

Education and qualifications (2)

University of Wrocław: Wrocław, Lower Silesia, PL

2014-10-01 to 2016-09-30 | Master of Science in Biotechnology (Department of Protein Engineering, Faculty of Biotechnology)
Education
Source: Self-asserted source
Jakub Szymczyk

University of Wrocław: Wrocław, Lower Silesia, PL

2011-10-01 to 2014-09-30 | Bachelor (Department of Cellular Molecular Biology, Faculty of Biotechnology)
Education
Source: Self-asserted source
Jakub Szymczyk

Works (13)

Overcoming drug resistance of cancer cells by targeting the FGF1/FGFR1 axis with honokiol or FGF ligand trap

Frontiers in Pharmacology
2024-09-12 | Journal article
DOI: 10.3389/fphar.2024.1459820
Part of ISSN: 1663-9812
Contributors: Jakub Szymczyk; Martyna Sochacka; Martyna Biadun; Katarzyna Dominika Sluzalska; Danuta Witkowska; Malgorzata Zakrzewska
Source: Self-asserted source
Jakub Szymczyk

Intracellular FGF1 protects cells from apoptosis through direct interaction with p53

Cellular and Molecular Life Sciences
2023-10 | Journal article
DOI: 10.1007/s00018-023-04964-9
Contributors: Agata Lampart; Daniel Krowarsch; Martyna Biadun; Vigdis Sorensen; Jakub Szymczyk; Katarzyna Sluzalska; Antoni Wiedlocha; Jacek Otlewski; Malgorzata Zakrzewska
Source: check_circle
Crossref

FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway

Biomedicines
2023-06-29 | Journal article
DOI: 10.3390/biomedicines11071856
Contributors: Jakub Szymczyk; Aleksandra Czyrek; Jacek Otlewski; Malgorzata Zakrzewska
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential

International Journal of Biological Macromolecules
2022-10 | Journal article
DOI: 10.1016/j.ijbiomac.2022.07.105
Part of ISSN: 0141-8130
Contributors: Jakub Szymczyk
Source: Self-asserted source
Jakub Szymczyk

FGF1 protects FGFR1-overexpressing cancer cells against drugs targeting tubulin polymerization by activating AKT via two independent mechanisms

Frontiers in Oncology
2022-10-06 | Journal article
DOI: 10.3389/fonc.2022.1011762
Part of ISSN: 2234-943X
Contributors: Jakub Szymczyk
Source: Self-asserted source
Jakub Szymczyk

Drug Conjugation via Maleimide–Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies

Molecular Pharmaceutics
2022-05-02 | Journal article
DOI: 10.1021/acs.molpharmaceut.1c00946
Part of ISSN: 1543-8384
Part of ISSN: 1543-8392
Source: Self-asserted source
Jakub Szymczyk

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

Molecular Medicine
2021-12 | Journal article
DOI: 10.1186/s10020-021-00306-2
Part of ISSN: 1076-1551
Part of ISSN: 1528-3658
Source: Self-asserted source
Jakub Szymczyk

FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance

Cancers
2021-11 | Journal article | Author
DOI: 10.3390/cancers13225796
Contributors: Jakub Szymczyk; Katarzyna Dominika Służalska; Izabela Materla; Lukasz Opalinski; Jacek Otlewski; Malgorzata Zakrzewska
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent

Frontiers in Pharmacology
2021-11-12 | Journal article
DOI: 10.3389/fphar.2021.748936
Part of ISSN: 1663-9812
Source: Self-asserted source
Jakub Szymczyk

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

Cell Communication and Signaling
2020-12 | Journal article
DOI: 10.1186/s12964-020-00573-2
Part of ISSN: 1478-811X
Source: Self-asserted source
Jakub Szymczyk
grade
Preferred source (of 2)‎

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization.

Molecular oncology
2020-07-03 | Journal article
DOI: 10.1002/1878-0261.12740
PMID: 32511887
PMC: PMC7463352
Source: Self-asserted source
Jakub Szymczyk
grade
Preferred source (of 2)‎

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

International Journal of Molecular Sciences
2018-05-10 | Journal article
DOI: 10.3390/ijms19051435
Part of ISSN: 1422-0067
Source: Self-asserted source
Jakub Szymczyk
grade
Preferred source (of 3)‎

FHF1: a new fibroblast growth factor involved in cell signaling
Source: Self-asserted source
Jakub Szymczyk

Peer review (1 review for 1 publication/grant)

Review activity for Cell communication and signaling. (1)
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