Personal information

Other IDs

SciProfiles: 305927

Keywords

prodrug, drug delivery, transporters

Countries

Finland

Activities

Collapse all

Employment (1)

University of Eastern Finland: Kuopio, FI

2008 to present | Professor in pharmaceutical chemistry (School of Pharmacy)
Employment
Source: Self-asserted source
Jarkko Rautio

Education and qualifications (2)

University of Kuopio: Kuopio, FI

1996-09 to 2000-09 | PhD (Department of Pharmaceutical Chemistry)
Education
Source: Self-asserted source
Jarkko Rautio

University of Kuopio: Kuopio, FI

1992-09-01 to 1996-09-01 | MSc (Department of Pharmaceutical Chemistry)
Education
Source: Self-asserted source
Jarkko Rautio

Funding (1)

LAT1-targeted prodrugs for improved drug delivery to invasive glioma cells

2017-09 to 2021-08 | Grant
Academy of Finland (Helsinki, FI)
GRANT_NUMBER:

308329
Source: Self-asserted source
Jarkko Rautio

Works (50 of 68)

Items per page:
Page 1 of 2

Protective Role and Enhanced Intracellular Uptake of Curcumin in Retinal Cells Using Self-Emulsifying Drug Delivery Systems (SNEDDS)

Pharmaceuticals
2025-02-17 | Journal article
DOI: 10.3390/ph18020265
Contributors: Elide Zingale; Sebastiano Masuzzo; Tatu Lajunen; Mika Reinisalo; Jarkko Rautio; Valeria Consoli; Agata Grazia D’Amico; Luca Vanella; Rosario Pignatello
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Protective Role and Enhanced Intracellular Uptake of Curcumin in Retinal Cells Using Self-Emulsifying Drug Delivery Systems (SNEDDS)

2025-01-20 | Preprint
DOI: 10.20944/preprints202501.1365.v1
Contributors: Elide Zingale; Sebastiano Masuzzo; Tatu Lajunen; Mika Reinisalo; Jarkko Rautio; Valeria Consoli; Agata G. D'Amico; Luca Vanella; Rosario Pignatello
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates

Chemical Society Reviews
2024 | Journal article
DOI: 10.1039/D2CS00957A
Contributors: Murugaiah A. M. Subbaiah; Jarkko Rautio; Nicholas A. Meanwell
Source: check_circle
Crossref

Towards New Delivery Agents for Boron Neutron Capture Therapy: Synthesis and In Vitro Evaluation of a Set of Fluorinated Carbohydrate Derivatives

Molecules
2024-09-09 | Journal article
DOI: 10.3390/molecules29174263
Contributors: Jelena Matović; Juulia Järvinen; Iris K. Sokka; Surachet Imlimthan; Olli Aitio; Mirkka Sarparanta; Jarkko Rautio; Filip S. Ekholm
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments

Pharmaceutics
2024-01-18 | Journal article
DOI: 10.3390/pharmaceutics16010125
Contributors: Elide Zingale; Angela Bonaccorso; Agata Grazia D’Amico; Rosamaria Lombardo; Velia D’Agata; Jarkko Rautio; Rosario Pignatello
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT)

Pharmaceutics
2023-11-23 | Journal article
DOI: 10.3390/pharmaceutics15122663
Contributors: Juulia Järvinen; Herkko Pulkkinen; Jarkko Rautio; Juri M. Timonen
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Development of Lyophilised Eudragit® Retard Nanoparticles for the Sustained Release of Clozapine via Intranasal Administration

Pharmaceutics
2023-05-21 | Journal article
DOI: 10.3390/pharmaceutics15051554
Contributors: Rosamaria Lombardo; Marika Ruponen; Jarkko Rautio; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Laura Calosi; Daniele Bani; Riikka Lampinen; Katja M. Kanninen; Anne M. Koivisto et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma

International Journal of Molecular Sciences
2022-07-30 | Journal article
DOI: 10.3390/ijms23158446
Contributors: Tarapong Srisongkram; Katayun Bahrami; Juulia Järvinen; Juri Timonen; Jarkko Rautio; Natthida Weerapreeyakul
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders

Pharmaceutics
2020-12-18 | Journal article
DOI: 10.3390/pharmaceutics12121230
Contributors: Shiv Bahadur; Dinesh M. Pardhi; Jarkko Rautio; Jessica M. Rosenholm; Kamla Pathak
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

Molecules
2020-06 | Journal article | Author
DOI: 10.3390/molecules25132968
Contributors: Michael Gütschow; Jean Jacques Vanden Eynde; Josef Jampilek; Congbao Kang; Arduino Aleksander Mangoni; Paola Fossa; Rafik Karaman; Andrea Trabocchi; Peter Scott; Johannes Reynisson et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

International Journal of Molecular Sciences
2020-03-20 | Journal article
DOI: 10.3390/ijms21062132
Contributors: Piman Pocasap; Natthida Weerapreeyakul; Juri Timonen; Juulia Järvinen; Jukka Leppänen; Jussi Kärkkäinen; Jarkko Rautio
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells

Molecules
2019-10-27 | Journal article
DOI: 10.3390/molecules24213869
Contributors: Tarapong Srisongkram; Natthida Weerapreeyakul; Jussi Kärkkäinen; Jarkko Rautio
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4

Molecules
2018-12 | Journal article | Author
DOI: 10.3390/molecules24010130
Contributors: Arduino Aleksander Mangoni; catherine guillou; Jean Jacques Vanden Eynde; Christopher Hulme; Josef Jampilek; Wei Li; Katalin Prokai-Tatrai; Jarkko Rautio; SIMONA COLLINA; Tiziano Tuccinardi et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2

Molecules
2017-12-28 | Journal article
DOI: 10.3390/molecules23010065
Contributors: Diego Muñoz-Torrero; Arduino Mangoni; Hong Liu; Christopher Hulme; Jarkko Rautio; Rafik Karaman; Maria De Sousa; Katalin Prokai-Tatrai; Jean-Marc Sabatier; Carlo Siciliano et al.
Source: check_circle
Crossref

Prodrugs – Recent approvals and a glimpse of the pipeline

European Journal of Pharmaceutical Sciences
2017-11 | Journal article
DOI: 10.1016/j.ejps.2017.08.002
Contributors: Jarkko Rautio; Jussi Kärkkäinen; Kenneth B. Sloan
Source: check_circle
Crossref

Prodrugs in medicinal chemistry and enzyme prodrug therapies.

Advanced drug delivery reviews
2017-09 | Journal article
DOI: 10.1016/j.addr.2017.06.013
PMID: 28676386
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes.

Molecules (Basel, Switzerland)
2017-05 | Journal article
DOI: 10.3390/molecules22050743
PMID: 28475136
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central
grade
Preferred source (of 2)‎

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

Bioorganic & medicinal chemistry
2016-11 | Journal article
DOI: 10.1016/j.bmc.2016.09.004
PMID: 27647366
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure.

Neurochemical research
2016-10 | Journal article
DOI: 10.1007/s11064-016-1996-8
PMID: 27412117
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2015-01 | Journal article
DOI: 10.1016/j.ejps.2014.09.025
PMID: 25305508
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.

Drug metabolism and disposition: the biological fate of chemicals
2015-01 | Journal article
DOI: 10.1124/dmd.114.059840
PMID: 25349125
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

Molecular cancer therapeutics
2015-01 | Journal article
DOI: 10.1158/1535-7163.mct-14-0113
PMID: 25351918
PMC: PMC4297195
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

ChemMedChem
2014-12 | Journal article
DOI: 10.1002/cmdc.201402281
PMID: 25205473
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug.

Bioorganic & medicinal chemistry letters
2014-11 | Journal article
DOI: 10.1016/j.bmcl.2014.09.019
PMID: 25248681
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Amino acids as promoieties in prodrug design and development.

Advanced drug delivery reviews
2013-10 | Journal article
DOI: 10.1016/j.addr.2012.10.001
PMID: 23099277
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

Pharmaceutical research
2013-10 | Journal article
DOI: 10.1007/s11095-012-0966-3
PMID: 24137801
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2013-07 | Journal article
DOI: 10.1016/j.ejps.2013.05.023
PMID: 23732628
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?

Therapeutic delivery
2013-03 | Journal article
DOI: 10.4155/tde.12.165
PMID: 23442072
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome p450-activated prodrugs.

Molecular pharmaceutics
2013-02 | Journal article
DOI: 10.1021/mp300330v
PMID: 22937971
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2013-02 | Journal article
DOI: 10.1016/j.ejps.2012.11.014
PMID: 23228412
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Inhibitors of LRRK2 kinase activity to probe the treatment option in Parkinson's disease.

Journal of medicinal chemistry
2012-11 | Journal article
DOI: 10.1021/jm301460x
PMID: 23078245
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

Journal of pharmaceutical sciences
2012-08 | Journal article
DOI: 10.1002/jps.23221
PMID: 22648910
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

[Prodrug technology in the development of medicinal agents].

Duodecim; laaketieteellinen aikakauskirja
2011 | Journal article
PMID: 21438349
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Prodrugs - an efficient way to breach delivery and targeting barriers.

Current topics in medicinal chemistry
2011 | Journal article
DOI: 10.2174/156802611797183230
PMID: 21671868
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.

Molecular pharmaceutics
2011-10 | Journal article
DOI: 10.1021/mp2001878
PMID: 21770378
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Prodrugs--from serendipity to rational design.

Pharmacological reviews
2011-09 | Journal article
DOI: 10.1124/pr.110.003459
PMID: 21737530
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Amino acid prodrugs for oral delivery: challenges and opportunities.

Therapeutic delivery
2011-08 | Journal article
PMID: 22826863
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Brain uptake of ketoprofen-lysine prodrug in rats.

International journal of pharmaceutics
2010-10 | Journal article
DOI: 10.1016/j.ijpharm.2010.08.019
PMID: 20727958
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor.

Bioorganic & medicinal chemistry letters
2010-04 | Journal article
DOI: 10.1016/j.bmcl.2010.02.057
PMID: 20231095
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography.

Journal of pharmaceutical and biomedical analysis
2009-10 | Journal article
DOI: 10.1016/j.jpba.2009.04.033
PMID: 19481899
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

Journal of medicinal chemistry
2009-07 | Journal article
DOI: 10.1021/jm900274q
PMID: 19522462
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.

Journal of medicinal chemistry
2009-05 | Journal article
DOI: 10.1021/jm8015409
PMID: 19402664
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Cytochrome P450-activated prodrugs: targeted drug delivery.

Current medicinal chemistry
2008 | Journal article
DOI: 10.2174/092986708785909120
PMID: 18855665
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Prodrug approaches for CNS delivery.

The AAPS journal
2008 | Journal article
DOI: 10.1208/s12248-008-9009-8
PMID: 18446509
PMC: PMC2751454
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2008-07 | Journal article
DOI: 10.1016/j.ejps.2008.02.121
PMID: 18403185
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Diclofenac readily penetrates the cerebrospinal fluid in children.

British journal of clinical pharmacology
2008-06 | Journal article
DOI: 10.1111/j.1365-2125.2008.03126.x
PMID: 18477264
PMC: PMC2485236
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

How readily does ketorolac penetrate cerebrospinal fluid in children?

Journal of clinical pharmacology
2008-04 | Journal article
DOI: 10.1177/0091270007313389
PMID: 18272673
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Prodrugs: design and clinical applications.

Nature reviews. Drug discovery
2008-03 | Journal article
DOI: 10.1038/nrd2468
PMID: 18219308
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Large neutral amino acid transporter enables brain drug delivery via prodrugs.

Journal of medicinal chemistry
2008-02 | Journal article
DOI: 10.1021/jm701175d
PMID: 18217702
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central

Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children.

Pediatrics
2007-10 | Journal article
DOI: 10.1542/peds.2007-0064
PMID: 17908721
Source: Self-asserted source
Jarkko Rautio via Europe PubMed Central
Items per page:
Page 1 of 2

Peer review (13 reviews for 5 publications/grants)

Review activity for International journal of pharmaceutics (2)
Review activity for Journal of medicinal chemistry. (4)
Review activity for Molecular pharmaceutics. (4)
Review activity for Nature communications (2)
Review activity for Nature reviews. (1)
How many people are using ORCID?