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Universitätsklinikum Jena: Jena, Thüringen, DE

2001-04-01 to present | Senior Scientist (Neurology)
Employment
Source: Self-asserted source
Christiane Frahm

Works (50)

Voluntary Wheel Running in Old C57BL/6 Mice Reduces Age-Related Inflammation in the Colon but Not in the Brain

Cells
2022-02 | Journal article | Author
DOI: 10.3390/cells11030566
Contributors: Marie-Luise Ederer; Madlen Günther; Lena Best; Julia Lindner; Christoph Kaleta; Otto; Rowena Simon; Christiane Frahm
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior

Proceedings of the National Academy of Sciences of the United States of America
2021 | Journal article
DOI: 10.1073/pnas.2014784118
EID:

2-s2.0-85103609674

Part of ISSN: 10916490 00278424
Contributors: Graf, J.; Zhang, C.; Marguet, S.L.; Herrmann, T.; Flossmann, T.; Hinsch, R.; Rahmati, V.; Guenther, M.; Frahm, C.; Urbach, A. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Microbiota profiling in aging-associated inflammation and liver degeneration

International Journal of Medical Microbiology
2021 | Journal article
DOI: 10.1016/j.ijmm.2021.151500
EID:

2-s2.0-85103613723

Part of ISSN: 16180607 14384221
Contributors: Baumann, A.; Hernández-Arriaga, A.; Brandt, A.; Sánchez, V.; Nier, A.; Jung, F.; Kehm, R.; Höhn, A.; Grune, T.; Frahm, C. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Post-stroke dendritic arbor regrowth – A cortical repair process requiring the actin nucleator Cobl

bioRxiv
2021 | Other
DOI: 10.1101/2021.08.26.457764
EID:

2-s2.0-85115274217

Part of ISSN: 26928205
Contributors: Ji, Y.; Koch, D.; Delgado, J.G.; Günther, M.; Witte, O.W.; Kessels, M.M.; Frahm, C.; Qualmann, B.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Poststroke dendritic arbor regrowth requires the actin nucleator Cobl

PLoS Biology
2021 | Journal article
DOI: 10.1371/journal.pbio.3001399
EID:

2-s2.0-85122306428

Part of ISSN: 15457885 15449173
Contributors: Ji, Y.; Koch, D.; Delgado, J.G.; Günther, M.; Witte, O.W.; Kessels, M.M.; Frahm, C.; Qualmann, B.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network development in vivo

bioRxiv
2020 | Other
DOI: 10.1101/2020.07.13.200014
EID:

2-s2.0-85102909865

Part of ISSN: 26928205
Contributors: Graf, J.; Zhang, C.; Marguet, S.L.; Herrmann, T.; Flossmann, T.; Hinsch, R.; Rahmati, V.; Guenther, M.; Frahm, C.; Urbach, A. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

Genomics, Proteomics and Bioinformatics
2020 | Journal article
DOI: 10.1016/j.gpb.2020.12.001
EID:

2-s2.0-85104575623

Part of ISSN: 22103244 16720229
Contributors: Srivastava, A.; Barth, E.; Ermolaeva, M.A.; Guenther, M.; Frahm, C.; Marz, M.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Changes in oral microbial ecology of c57bl/6 mice at different ages associated with sampling methodology

Microorganisms
2019 | Journal article
DOI: 10.3390/microorganisms7090283
EID:

2-s2.0-85074326496

Part of ISSN: 20762607
Contributors: Hernández-Arriaga, A.; Baumann, A.; Witte, O.W.; Frahm, C.; Bergheim, I.; Camarinha-Silva, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Conserved aging-related signatures of senescence and inflammation in different tissues and species

Aging
2019 | Journal article
DOI: 10.18632/aging.102345
EID:

2-s2.0-85073645132

Part of ISSN: 19454589
Contributors: Barth, E.; Srivastava, A.; Stojiljkovic, M.; Frahm, C.; Axer, H.; Witte, O.W.; Marz, M.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly (Nature Communications, (2018), 9, 1, (327), 10.1038/s41467-017-02395-2)

Nature Communications
2019 | Journal article
DOI: 10.1038/s41467-019-10559-5
EID:

2-s2.0-85066612796

Part of ISSN: 20411723
Contributors: Irizar, P.A.; Schäuble, S.; Esser, D.; Groth, M.; Frahm, C.; Priebe, S.; Baumgart, M.; Hartmann, N.; Marthandan, S.; Menzel, U. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Stroke accelerates and uncouples intrinsic and synaptic excitability maturation of mouse hippocampal DCX <sup>+</sup> adult-born granule cells

Journal of Neuroscience
2019 | Journal article
DOI: 10.1523/JNEUROSCI.3303-17.2018
EID:

2-s2.0-85062272979

Part of ISSN: 15292401 02706474
Contributors: Ceanga, M.; Keiner, S.; Grünewald, B.; Haselmann, H.; Frahm, C.; Couillard-Després, S.; Witte, O.W.; Redecker, C.; Geis, C.; Kunze, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

The microbiome and neurodegenerative diseases,Mikrobiom und neurodegenerative Erkrankungen

Gastroenterologe
2019 | Journal article
DOI: 10.1007/s11377-019-0345-2
EID:

2-s2.0-85064267037

Part of ISSN: 1861969X 18619681
Contributors: Frahm, C.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia

Brain
2018 | Journal article
DOI: 10.1093/brain/awy034
EID:

2-s2.0-85047100514

Part of ISSN: 14602156 00068950
Contributors: Newton, T.; Allison, R.; Edgar, J.R.; Lumb, J.H.; Rodger, C.E.; Manna, P.T.; Rizo, T.; Kohl, Z.; Nygren, A.O.H.; Arning, L. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-017-02395-2
EID:

2-s2.0-85041351332

Part of ISSN: 20411723
Contributors: Aramillo Irizar, P.; Schäuble, S.; Esser, D.; Groth, M.; Frahm, C.; Priebe, S.; Baumgart, M.; Hartmann, N.; Marthandan, S.; Menzel, U. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Sigma 1 receptor activation modifies intracellular calcium exchange in the G93A<sup>hSOD1</sup> ALS model

Neuroscience
2017 | Journal article
DOI: 10.1016/j.neuroscience.2017.07.012
EID:

2-s2.0-85026464421

Part of ISSN: 18737544 03064522
Contributors: Tadić, V.; Malci, A.; Goldhammer, N.; Stubendorff, B.; Sengupta, S.; Prell, T.; Keiner, S.; Liu, J.; Guenther, M.; Frahm, C. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Transcriptional profiling reveals protective mechanisms in brains of long-lived mice

Neurobiology of Aging
2017 | Journal article
DOI: 10.1016/j.neurobiolaging.2016.12.016
EID:

2-s2.0-85009446583

Part of ISSN: 15581497 01974580
Contributors: Frahm, C.; Srivastava, A.; Schmidt, S.; Mueller, J.; Groth, M.; Guenther, M.; Ji, Y.; Priebe, S.; Platzer, M.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia

Molecular Neurobiology
2016 | Journal article
DOI: 10.1007/s12035-015-9472-z
EID:

2-s2.0-84944711012

Part of ISSN: 15591182 08937648
Contributors: Schmidt, C.; Frahm, C.; Schneble, N.; Müller, J.P.; Brodhun, M.; Franco, I.; Witte, O.W.; Hirsch, E.; Wetzker, R.; Bauer, R.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep26173
EID:

2-s2.0-84971367766

Part of ISSN: 20452322
Contributors: Jaenisch, N.; Liebmann, L.; Guenther, M.; Hubner, C.A.; Frahm, C.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

Nature Communications
2015 | Journal article
DOI: 10.1038/ncomms10043
EID:

2-s2.0-84948844004

Part of ISSN: 20411723
Contributors: Mansfeld, J.; Urban, N.; Priebe, S.; Groth, M.; Frahm, C.; Hartmann, N.; Gebauer, J.; Ravichandran, M.; Dommaschk, A.; Schmeisser, S. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

The spectrum of KIAA0196 variants, and characterization of a murine knockout: Implications for the mutational mechanism in hereditary spastic paraplegia type SPG8 Rare neurological diseases

Orphanet Journal of Rare Diseases
2015 | Journal article
DOI: 10.1186/s13023-015-0359-x
EID:

2-s2.0-84955398156

Part of ISSN: 17501172
Contributors: Jahic, A.; Khundadze, M.; Jaenisch, N.; Schüle, R.; Klimpe, S.; Klebe, S.; Frahm, C.; Kassubek, J.; Stevanin, G.; Schöls, L. et al.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Age-specific transcriptional response to stroke

Neurobiology of Aging
2014 | Journal article
DOI: 10.1016/j.neurobiolaging.2014.01.012
EID:

2-s2.0-84903365283

Part of ISSN: 01974580 15581497
Contributors: Sieber, M.W.; Guenther, M.; Jaenisch, N.; Albrecht-Eckardt, D.; Kohl, M.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice

Neuroscience Letters
2014 | Journal article
DOI: 10.1016/j.neulet.2014.04.043
EID:

2-s2.0-84901036284

Part of ISSN: 18727972 03043940
Contributors: Boehme, M.; Guenther, M.; Stahr, A.; Liebmann, M.; Jaenisch, N.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Pro-apoptotic function of GABA-related transcripts following stroke

Neurobiology of Disease
2014 | Journal article
DOI: 10.1016/j.nbd.2014.06.015
EID:

2-s2.0-84904898811

Part of ISSN: 1095953X 09699961
Contributors: Jaenisch, N.; Popp, A.; Guenther, M.; Schnabel, J.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Astrocytic Cx43 and Cx30 differentially modulate adult neurogenesis in mice

Neuroscience Letters
2013 | Journal article
DOI: 10.1016/j.neulet.2013.04.013
EID:

2-s2.0-84878564699

Part of ISSN: 03043940 18727972
Contributors: Liebmann, M.; Stahr, A.; Guenther, M.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke

PLoS ONE
2013 | Journal article
DOI: 10.1371/journal.pone.0052982
EID:

2-s2.0-84871855675

Part of ISSN: 19326203
Contributors: Sieber, M.W.; Jaenisch, N.; Brehm, M.; Guenther, M.; Linnartz-Gerlach, B.; Neumann, H.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Age dependence of excitatory-inhibitory balance following stroke

Neurobiology of Aging
2012 | Journal article
DOI: 10.1016/j.neurobiolaging.2010.11.019
EID:

2-s2.0-84861186802

Part of ISSN: 01974580 15581497
Contributors: Schmidt, S.; Bruehl, C.; Frahm, C.; Redecker, C.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Morg1<sup>+/-</sup> heterozygous mice are protected from experimentally induced focal cerebral ischemia

Brain Research
2012 | Journal article
DOI: 10.1016/j.brainres.2012.09.017
EID:

2-s2.0-84867334170

Part of ISSN: 00068993 18726240
Contributors: Stahr, A.; Frahm, C.; Kretz, A.; Bondeva, T.; Witte, O.W.; Wolf, G.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Attenuated inflammatory response in aged mice brains following stroke

PLoS ONE
2011 | Journal article
DOI: 10.1371/journal.pone.0026288
EID:

2-s2.0-80054766188

Part of ISSN: 19326203
Contributors: Sieber, M.W.; Claus, R.A.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia

Stroke
2010 | Journal article
DOI: 10.1161/STROKEAHA.109.570424
EID:

2-s2.0-77649152649

Part of ISSN: 00392499
Contributors: Jaenisch, N.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Inter-age variability of bona fide unvaried transcripts. Normalization of quantitative PCR data in ischemic stroke

Neurobiology of Aging
2010 | Journal article
DOI: 10.1016/j.neurobiolaging.2008.05.023
EID:

2-s2.0-77049093737

Part of ISSN: 01974580
Contributors: Sieber, M.W.; Guenther, M.; Kohl, M.; Witte, O.W.; Claus, R.A.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Substantial performance discrepancies among commercially available kits for reverse transcription quantitative polymerase chain reaction: A systematic comparative investigator-driven approach

Analytical Biochemistry
2010 | Journal article
DOI: 10.1016/j.ab.2010.03.007
EID:

2-s2.0-77952886657

Part of ISSN: 10960309 00032697
Contributors: Sieber, M.W.; Recknagel, P.; Glaser, F.; Witte, O.W.; Bauer, M.; Claus, R.A.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Adult and embryonic GAD transcripts are spatiotemporally regulated during postnatal development in the rat brain

PLoS ONE
2009 | Journal article
DOI: 10.1371/journal.pone.0004371
EID:

2-s2.0-84864286825

Part of ISSN: 19326203
Contributors: Popp, A.; Urbach, A.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Identification of ischemic regions in a rat model of stroke

PLoS ONE
2009 | Journal article
DOI: 10.1371/journal.pone.0004764
EID:

2-s2.0-62849087045

Part of ISSN: 19326203
Contributors: Popp, A.; Jaenisch, N.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy

Brain
2008 | Journal article
DOI: 10.1093/brain/awn095
EID:

2-s2.0-44949117514

Part of ISSN: 00068950 14602156
Contributors: Knopp, A.; Frahm, C.; Fidzinski, P.; Witte, O.W.; Behr, J.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy

Neurobiology of Disease
2007 | Journal article
DOI: 10.1016/j.nbd.2007.01.009
EID:

2-s2.0-34147096480

Part of ISSN: 09699961
Contributors: Tolner, E.A.; Frahm, C.; Metzger, R.; Gorter, J.A.; Witte, O.W.; Lopes da Silva, F.H.; Heinemann, U.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Temporal profile of connexin 43 expression after photothrombotic lesion in rat brain

Neuroscience
2007 | Journal article
DOI: 10.1016/j.neuroscience.2006.09.054
EID:

2-s2.0-33845226555

Part of ISSN: 03064522
Contributors: Haupt, C.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury

Molecular and Cellular Neuroscience
2007 | Journal article
DOI: 10.1016/j.mcn.2007.02.005
EID:

2-s2.0-34247377375

Part of ISSN: 10447431
Contributors: Haupt, C.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Stable expression of the vesicular GABA transporter following photothrombotic infarct in rat brain

Neuroscience
2006 | Journal article
DOI: 10.1016/j.neuroscience.2006.02.045
EID:

2-s2.0-33646775347

Part of ISSN: 03064522
Contributors: Frahm, C.; Siegel, G.; Grass, S.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

The combined use of non-radioactive in situ hybridization and real-time RT-PCR to assess gene expression in cryosections

Brain Research
2006 | Journal article
DOI: 10.1016/j.brainres.2006.08.037
EID:

2-s2.0-33750301033

Part of ISSN: 00068993
Contributors: Haupt, C.; Tolner, E.A.; Heinemann, U.; Witte, O.W.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

GABA neurons survive focal ischemic injury

Neuroscience
2004 | Journal article
DOI: 10.1016/j.neuroscience.2004.05.027
EID:

2-s2.0-3242678013

Part of ISSN: 03064522
Contributors: Frahm, C.; Haupt, C.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Ionotropic GABA receptors with mixed pharmacological properties of GABA <sub>A</sub> and GABA <sub>C</sub> receptors

European Journal of Pharmacology
2004 | Journal article
DOI: 10.1016/j.ejphar.2004.06.044
EID:

2-s2.0-4143144330

Part of ISSN: 00142999
Contributors: Hartmann, K.; Stief, F.; Draguhn, A.; Frahm, C.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Regulation of GABA transporter mRNA and protein after photothrombotic infarct in rat brain

Journal of Comparative Neurology
2004 | Journal article
DOI: 10.1002/cne.20282
EID:

2-s2.0-4444229575

Part of ISSN: 00219967
Contributors: Frahm, C.; Haupt, C.; Weinandy, F.; Siegel, G.; Bruehl, C.; Witte, O.W.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus

Epilepsy Research
2003 | Journal article
DOI: 10.1016/S0920-1211(02)00233-4
EID:

2-s2.0-0037236009

Part of ISSN: 09201211
Contributors: Frahm, C.; Stief, F.; Zuschratter, W.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Efficacy of background GABA uptake in rat hippocampal slices

NeuroReport
2001 | Journal article
DOI: 10.1097/00001756-200106130-00016
EID:

2-s2.0-0035854117

Part of ISSN: 09594965
Contributors: Frahm, C.; Engel, D.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

GAD and GABA transporter (GAT-1) mRNA expression in the developing rat hippocampus

Developmental Brain Research
2001 | Journal article
DOI: 10.1016/S0165-3806(01)00288-7
EID:

2-s2.0-0035861848

Part of ISSN: 01653806
Contributors: Frahm, C.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Plasticity of rat central inhibitory synapses through GABA metabolism

Journal of Physiology
2001 | Journal article
DOI: 10.1111/j.1469-7793.2001.00473.x
EID:

2-s2.0-0035449658

Part of ISSN: 00223751
Contributors: Engel, D.; Pahner, I.; Schulze, K.; Frahm, C.; Jarry, H.; Ahnert-Hilger, G.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Acute effects of γ-vinyl-GABA on low-magnesium evoked epileptiform activity in vitro

Epilepsy Research
2000 | Journal article
DOI: 10.1016/S0920-1211(00)00112-1
EID:

2-s2.0-0034129276

Part of ISSN: 09201211
Contributors: Engel, D.; Endermann, U.; Frahm, C.; Heinemann, U.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Presence of γ-aminobutyric acid transporter mRNA in interneurons and principal cells of rat hippocampus

Neuroscience Letters
2000 | Journal article
DOI: 10.1016/S0304-3940(00)01217-9
EID:

2-s2.0-0034698496

Part of ISSN: 03043940
Contributors: Frahm, C.; Engel, D.; Piechotta, A.; Heinemann, U.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Age-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro

European Journal of Pharmacology
1999 | Journal article
DOI: 10.1016/S0014-2999(99)00628-7
EID:

2-s2.0-0032785875

Part of ISSN: 00142999
Contributors: Sabau, A.; Frahm, C.; Pfeiffer, M.; Breustedt, J.-M.; Piechotta, A.; Numberger, M.; Engel, D.; Heinemann, U.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier

Laminar difference in GABA uptake and GAT-1 expression in rat CA1

Journal of Physiology
1998 | Journal article
DOI: 10.1111/j.1469-7793.1998.643bd.x
EID:

2-s2.0-0032211438

Part of ISSN: 00223751
Contributors: Engel, D.; Schmitz, D.; Gloveli, T.; Frahm, C.; Heinemann, U.; Draguhn, A.
Source: Self-asserted source
Christiane Frahm via Scopus - Elsevier
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