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Employment (6)

Treeline Biosciences: Watertown, Massachusetts, US

2022-06-06 to present | Senior Scientist (Lead Discovery)
Employment
Source: Self-asserted source
Marc Hoemberger

NextRNA Therapeutics: Cambridge, MA, US

2021-08-17 to 2022-05-20 | Scientist II, Biochemist (Biochemistry & Structural Biology)
Employment
Source: Self-asserted source
Marc Hoemberger

Biogen Inc: Cambridge, MA, US

2021-01-01 to 2021-08-16 | Scientist II (Bioassays & High-Throughput Screens)
Employment
Source: Self-asserted source
Marc Hoemberger

Biogen Inc: Cambridge, MA, US

2019-03-18 to 2020-12-31 | Scientist I, Enzymologist (Bioassays & High-Throughput Screens)
Employment
Source: Self-asserted source
Marc Hoemberger

Howard Hughes Medical Institute - Brandeis University: Waltham, MA, US

2018-08-15 to 2019-03-01
Employment
Source: Self-asserted source
Marc Hoemberger

Brandeis University: Waltham, MA, US

2012-08-31 to 2018-08-15 | PhD (Biochemistry)
Employment
Source: Self-asserted source
Marc Hoemberger

Education and qualifications (3)

Brandeis University: Waltham, MA, US

2012-08-31 to 2018-08-15 | PhD (Biochemistry)
Education
Source: Self-asserted source
Marc Hoemberger

University of Lübeck: Lübeck, Schleswig-Holstein, DE

2010-10-01 to 2012-07-31 | M.Sc. (Molecular Life Science)
Education
Source: Self-asserted source
Marc Hoemberger

University of Lübeck: Lübeck, Schleswig-Holstein, DE

2007-10-01 to 2010-09-30 | B.Sc. (Molecular Life Sciences)
Education
Source: Self-asserted source
Marc Hoemberger

Works (11)

Predicting multiple conformations via sequence clustering and AlphaFold2

Nature
2024-01-25 | Journal article
Contributors: Hannah K. Wayment-Steele; Adedolapo Ojoawo; Renee Otten; Julia M. Apitz; Warintra Pitsawong; Marc Hömberger; Sergey Ovchinnikov; Lucy Colwell; Dorothee Kern
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From primordial clocks to circadian oscillators

Nature
2023-04-06 | Journal article
Contributors: Warintra Pitsawong; Ricardo A. P. Pádua; Timothy Grant; Marc Hoemberger; Renee Otten; Niels Bradshaw; Nikolaus Grigorieff; Dorothee Kern
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Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors

Bioorganic & Medicinal Chemistry Letters
2022-03 | Journal article
Part of ISSN: 0960-894X
Contributors: Bin Ma; Claire M. Metrick; Chungang Gu; Marc Hoemberger; Bekim Bajrami; Eris Bame; Jiansheng Huang; Michael Mingueneau; Paramasivam Murugan; Joseph C. Santoro et al.
Source: Self-asserted source
Marc Hoemberger

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

Journal of Medicinal Chemistry
2022-01-27 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Brian Hopkins; Eris Bame; Bekim Bajrami; Cheryl Black; Tonika Bohnert; Carrie Boiselle; Doug Burdette; Jeremy C. Burns; Luisette Delva; Douglas Donaldson et al.
Source: Self-asserted source
Marc Hoemberger

Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase

Proceedings of the National Academy of Sciences
2020 | Journal article
Contributors: Hoemberger, Marc; Pitsawong, Warintra; Kern, Dorothee
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Allosteric modulation of a human protein kinase with monobodies

Proceedings of the National Academy of Sciences
2019 | Journal article
Contributors: Zorba, Adelajda; Nguyen, Vy; Koide, Akiko; Hoemberger, Marc; Zheng, Yuejiao; Kutter, Steffen; Kim, Chansik; Koide, Shohei; Kern, Dorothee
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Probing the transition state in enzyme catalysis by high-pressure NMR dynamics

Nature Catalysis
2019 | Journal article
Contributors: Stiller, John B.; Kerns, S. Jordan; Hoemberger, Marc; Cho, Young-Jin; Otten, Renee; Hagan, Michael F.; Kern, Dorothee
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Evolutionary drivers of thermoadaptation in enzyme catalysis

Science
2017 | Journal article
Contributors: Vy Nguyen; Wilson, Christopher; Hoemberger, Marc; Stiller, John B.; Agafonov, Roman V.; Kutter, Steffen; English, Justin; Theobald, Douglas L.; Kern, Dorothee
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Natural evolution sheds light on modern drug resistance in protein kinases

Protein Science
2015 | Journal article
Contributors: Hoemberger, Marc; Wilson, Christopher; Agafonov, Roman; Kern, Dorothee
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Using ancient protein kinases to unravel a modern cancer drug's mechanism

Science
2015 | Journal article
Contributors: Wilson, C.; Agafonov, R. V.; Hoemberger, M.; Kutter, S.; Zorba, A.; Halpin, J.; Buosi, V.; Otten, R.; Waterman, D.; Theobald, D. L. et al.
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Probing an Ancient Protein's Dynamics with NMR

Biophysical Journal
2014 | Journal article
Contributors: Hoemberger, Marc S.; Wilson, Christopher G.; Kern, Dorothee
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