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Scopus Author ID: 35404765200

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Employment (9)

University of Massachusetts Medical School: Worcester, Massachusetts, US

2019-08 to present | Vice Chair for Research (Medicine)
Employment
Source: Self-asserted source
Kate Fitzgerald

University of Massachusetts Medical School: Worcester, Massachusetts, US

2016 to present | Worcester Foundation Chair in Biomedical Sciences (Medicine)
Employment
Source: Self-asserted source
Kate Fitzgerald

University of Massachusetts Medical School: Worcester, Massachusetts, US

2014 to present | Director, Program in Innate Immunity (Infectious Diseases & Immunology)
Employment
Source: Self-asserted source
Kate Fitzgerald

Norwegian Institute of Science and Technology: Trondheim, NO

2014 to present | Adjunct Professor (Center for Inflammation Research)
Employment
Source: Self-asserted source
Kate Fitzgerald

University of Massachusetts Medical School: Worcester, US

2012 to present | Professor of Medicine (tenured) (Infectious Diseases & Immunology)
Employment
Source: Self-asserted source
Kate Fitzgerald

University of Massachusetts Medical School: Worcester, US

2007 to 2012 | Associate Professor (tenured) (Infectious Diseases & Immunology)
Employment
Source: Self-asserted source
Kate Fitzgerald

University of Massachusetts Medical School: Worcester, US

2004 to 2007 | Assistant Professor (Infectious Diseases & Immunology)
Employment
Source: Self-asserted source
Kate Fitzgerald

Univeristy of Massachusetts Medical School: Worcester, US

2001 to 2004 | Instructor in the laboratory of Douglas T. Golenbock, M.D. (Infectious Diseases & Immunology)
Employment
Source: Self-asserted source
Kate Fitzgerald

Trinity College: Dublin, IE

1999 to 2001 | Post-doctoral fellow in the laboratory of Luke O’ Neill, Ph.D.,
Employment
Source: Self-asserted source
Kate Fitzgerald

Education and qualifications (2)

Trinity College: Dublin, IE

1999 to 1999 | PhD, Biochemistry
Education
Source: Self-asserted source
Kate Fitzgerald

Univeristy College Cork: Cork, IE

1995 to 1995 | B.Sc. Biochemistry
Qualification
Source: Self-asserted source
Kate Fitzgerald

Professional activities (83)

Wellcome Trust: London, GB

Ad hoc Panel member
Service
Source: Self-asserted source
Kate Fitzgerald

The American Society of Microbiology : Washington, US

Membership
Source: Self-asserted source
Kate Fitzgerald

The American Association of Immunologists : Rockville, Maryland, US

Membership
Source: Self-asserted source
Kate Fitzgerald

Society for Leukocyte Biology: Bethesda, US

Membership
Source: Self-asserted source
Kate Fitzgerald

Science Foundation Ireland: Dublin, IE

Ad hoc panel member
Service
Source: Self-asserted source
Kate Fitzgerald

Science: Washington, US

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

PNAS: Washington, US

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

NIH : Bethesda, US

Review Panel member: Reviewing of PO1 applications.
Service
Source: Self-asserted source
Kate Fitzgerald

NIH: Bethesda, US

Ad hoc member, Innate Immunity and Inflammation Study Section
Service
Source: Self-asserted source
Kate Fitzgerald

Nature, Nature Immunology, Nature Reviews in Immunology: New York City, US

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

Keystone Symposium Innate Immunity: Dublin, IE

Co-Chair (Mechanisms linking with Adaptive Immunity)
Service
Source: Self-asserted source
Kate Fitzgerald

Journal of Immunology: Rockville, Maryland, US

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

Journal of Experimental Medicine: New York City, US

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

Journal of Biological Chemistry: Rockville , Maryland, US

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

International Innate Immunity and Endotoxin Society (IIIES): Cleveland , Ohio, US

Membership
Source: Self-asserted source
Kate Fitzgerald

International Cytokine and Interferon Society : Oradell, US

Membership
Source: Self-asserted source
Kate Fitzgerald

European Journal of Immunology: London, GB

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

Concern Foundation : Los Angeles, California, US

Ad hoc panel member, Concern Foundation Study Section.
Service
Source: Self-asserted source
Kate Fitzgerald

Cell, Immunity, Trends in Immunology : Cambridge, Massachusetts, US

Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

British Biotechnology and Biological Sciences Research Council: Swindon, Wiltshire, GB

Ad hoc Member
Service
Source: Self-asserted source
Kate Fitzgerald

American Society for Biochemistry and Molecular Biology : Rockville, Maryland, US

Membership
Source: Self-asserted source
Kate Fitzgerald

Health Research Board: Dublin, IE

Ad hoc panel member
Service
Source: Self-asserted source
Kate Fitzgerald

Inzen Therapeutics: Cambridge, US

2019 to present | Scientific Consultant
Service
Source: Self-asserted source
Kate Fitzgerald

Avammune: Philadelphia, Pennsylvania, US

2019 to present | Scientific Advisory Board Member
Service
Source: Self-asserted source
Kate Fitzgerald

Quench Bio Inc: Cambridge, US

2018 to present | Scientific Advisory Board Member
Service
Source: Self-asserted source
Kate Fitzgerald

Mersana Therapeutics: Cambridge, US

2018 to present | Scientific Consultant
Service
Source: Self-asserted source
Kate Fitzgerald

Janssen Pharmaceuticals: Horsham, Pennsylvania, US

2018 to present | Scientific Consultant
Service
Source: Self-asserted source
Kate Fitzgerald

International Cytokine and Interferon Society : Oradell, US

2017 to present | Council Member
Service
Source: Self-asserted source
Kate Fitzgerald

University of Vermont: Burlington, Vermont, US

2016 to present | Scientific Advisor, University of Vermont COBRE Program (R. Budd)
Service
Source: Self-asserted source
Kate Fitzgerald

Science: Washington, US

2014-07 to present | Board of Reviewing Editors
Service
Source: Self-asserted source
Kate Fitzgerald

Science: Washington, US

2014 to present | Member, Board of Reviewing Editors
Service
Source: Self-asserted source
Kate Fitzgerald

NIH: Bethesda, US

2013 to present | Host, NIH Summer Undergraduate Program
Service
Source: Self-asserted source
Kate Fitzgerald

NIAID: Bethesda, US

2019 to 2023 | Board Member, NIAID Board of Scientific Counselors
Service
Source: Self-asserted source
Kate Fitzgerald

Max Planck Institute for Infection Biology,: Berlin, DE

2019 to 2022 | Scientific Advisory Board Member
Service
Source: Self-asserted source
Kate Fitzgerald

Burroughs Wellcome Fund : Research Triangle Park, North Carolina, US

2019 to 2022 | Advisory Committee Member, Investigators in the Pathogenesis of Infectious Disease competitive program
Service
Source: Self-asserted source
Kate Fitzgerald

NodThera Inc: Lexington, Massachusetts, US

2019 to 2019 | Scientific Advisory Board Member
Service
Source: Self-asserted source
Kate Fitzgerald

International Cytokine and Interferon Society : Oradell, US

2019 to 2019 | President Elect
Service
Source: Self-asserted source
Kate Fitzgerald

Generation Bio: Cambridge, US

2019 to 2019 | Scientific Advisory Board Member
Service
Source: Self-asserted source
Kate Fitzgerald

NIAID/NIH : Bethesda, US

2018-12 to 2018-12 | Ad Hoc member, Board of Scientific Councilors
Service
Source: Self-asserted source
Kate Fitzgerald

International Cytokine and Interferon Society Meeting: Boston, US

2018-09 to 2018-09 | Co-Chair
Service
Source: Self-asserted source
Kate Fitzgerald

EMBO Inflammasome Workshop: Munich, DE

2018-09 to 2018-09 | Co-Chair
Service
Source: Self-asserted source
Kate Fitzgerald

Toll2018: Porto, PT

2018-06 to 2018-06 | Co-Chair
Service
Source: Self-asserted source
Kate Fitzgerald

University of Massachusetts Medical School: Worcester, US

2018 | Chancellors Medal for Distinguished Scholarship
Distinction
Source: Self-asserted source
Kate Fitzgerald

International Cytokine and Interferon Society: Oradell, US

2017 to 2018 | Co-Chair, Awards Committee
Service
Source: Self-asserted source
Kate Fitzgerald

American Association of Immunologists : Rockville, Maryland, US

2017 to 2018 | Chair, Nominating Committee,
Service
Source: Self-asserted source
Kate Fitzgerald

American Association of Immunologists: Rockville, Maryland, US

2017 to 2018 | Member, Abstract Programming Committee
Service
Source: Self-asserted source
Kate Fitzgerald

Kenneth Rainin Foundation: Oakland, California, US

2016 to 2018 | Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

University College Cork: Cork, IE

2017 | Alumni Achievement Award
Distinction
Source: Self-asserted source
Kate Fitzgerald

NIH : Bethesda, US

2017 to 2017 | Ad hoc Reviewer for Special Emphasis Panel
Service
Source: Self-asserted source
Kate Fitzgerald

NIH: Bethesda, US

2016-01 to 2017-01 | Reviewer for DP2 Innovator Awards
Service
Source: Self-asserted source
Kate Fitzgerald

Trinity College Dublin : Dublin, IE

2003 to 2017 | Coordinator, Undergraduate Summer Research Program
Service
Source: Self-asserted source
Kate Fitzgerald

Keystone Symposium: Killarney, IE

2016-04 to 2016-04 | Co-Chair (Myeloid Cells, )
Service
Source: Self-asserted source
Kate Fitzgerald

University of Massachusetts Medical School: Worcester, US

2016 | Women in Science and Health Achievement Award
Distinction
Source: Self-asserted source
Kate Fitzgerald

NIH-NIAID : Bethesda, Maryland, US

2016 | MERIT Award Recipient
Distinction
Source: Self-asserted source
Kate Fitzgerald

European Journal of Immunology : London, GB

2007 to 2016 | Associate Editor
Service
Source: Self-asserted source
Kate Fitzgerald

Toll2015: Marbella, ES

2015-09 to 2015-09 | Organizing Committee member September 2015.
Service
Source: Self-asserted source
Kate Fitzgerald

Lupus Research Institute: New York City, US

2014-09 to 2015-09 | Reviewer
Service
Source: Self-asserted source
Kate Fitzgerald

American Society of Microbiology: New Oleans, Louisiana, US

2015-04 to 2015-04 | Chair (Division E)
Service
Source: Self-asserted source
Kate Fitzgerald

Irish Government and Science Foundation: Dublin, IE

2015 | Saint Patricks Day Medal (awarded to a distinguished Irish Scientist, Engineer or technology leader in the US annually)
Distinction
Source: Self-asserted source
Kate Fitzgerald

Faseb: Snowmass, Colorado, US

2014-06 to 2014-06 | Co-Chair (Biology of the Immune System)
Service
Source: Self-asserted source
Kate Fitzgerald

International Cytokine and Interferon Society: Oradell, New Jersey, US

2014 | The Milstein Award for Excellence in Interferon and Cytokine research
Distinction
Source: Self-asserted source
Kate Fitzgerald

American Society of Microbiology: Washington, D.C, US

2014 | Eli Lilly and Company-Elanco Research Award
Distinction
Source: Self-asserted source
Kate Fitzgerald

Keystone Symposium, Innate Immunity to Viruses: Keystone, Colorado, US

2014-01 to 2014-01 | Co-Chair
Service
Source: Self-asserted source
Kate Fitzgerald

Journal of Immunology : Rockville , Maryland, US

2011 to 2014 | Section Editor
Service
Source: Self-asserted source
Kate Fitzgerald

NIH: Bethesda, US

2013-10 to 2013-10 | Ad Hoc review Panel Member, IHD
Service
Source: Self-asserted source
Kate Fitzgerald

Abcam Inflammasome Meeting: Boston, Ma, US

2013-06 to 2013-06 | Chair
Service
Source: Self-asserted source
Kate Fitzgerald

NIH: Bethesda, US

2013-01 to 2013-01 | Review panel member, Ad Hoc Transformative Research Grant
Service
Source: Self-asserted source
Kate Fitzgerald

EMBO/EMBL Symposium: New Perspectives on Immunity to Infection: Heidelberg, DE

2012-05 to 2012-05 | Co-Chair
Service
Source: Self-asserted source
Kate Fitzgerald

NIH: Bethesda, US

2012-03 to 2012-03 | Ad HocReview Panel Member, CMI-I
Service
Source: Self-asserted source
Kate Fitzgerald

NIH: Bethesda, US

2012-01 to 2012-01 | Ad Hoc Panel review member, Special Emphasis Panel review of RFA
Service
Source: Self-asserted source
Kate Fitzgerald

New England Regional Center of Excellence: Innate Immunity Workshop: Dedham, Massachusetts, US

2011-09 to 2011-09 | Organizing Committee member
Service
Source: Self-asserted source
Kate Fitzgerald

The Vilcek Foundation: New York City, New York, US

2011 | Vilcek Award for Creative Promise in Biomedical Sciences (Finalist)
Distinction
Source: Self-asserted source
Kate Fitzgerald

Irish Times, Irish Society of Immunology: Dublin, IE

2011 | Irish Times, Irish Society of Immunology Annual Award
Distinction
Source: Self-asserted source
Kate Fitzgerald

Toll2011, Advances in Pattern Recognition and Signaling: Milan, IT

2011 to 2011 | Co-Chair
Service
Source: Self-asserted source
Kate Fitzgerald

Journal of Immunology : Rockville, Maryland, US

2009 to 2011 | Associate Editor
Service
Source: Self-asserted source
Kate Fitzgerald

Toll2008, Recent Advances in Pattern Recognition: Lisbon, PT

2008-09 to 2008-09 | Organizing Committee member
Service
Source: Self-asserted source
Kate Fitzgerald

Pattern Recognition Receptors and Human Disease: Cambridge, GB

2007-08 to 2007-08 | Organizing Committee member
Service
Source: Self-asserted source
Kate Fitzgerald

Toll2006: Recent Advances in Pattern Recognition: Salvador, BR

2006-03 to 2006-03 | Organizing Committee member
Service
Source: Self-asserted source
Kate Fitzgerald

Keystone Symposium Innate Immunity Meeting: Banff, Alberta, CA

2006-02 to 2006-02 | Organizing Committee member (Innate Immunity Signaling Workshop)
Service
Source: Self-asserted source
Kate Fitzgerald

International Cytokine Society : Orlando, Florida, US

2003 | International Cytokine Society Young Investigator Award
Distinction
Source: Self-asserted source
Kate Fitzgerald

Wellcome: London, GB

2002 | Wellcome Trust International Research Award
Distinction
Source: Self-asserted source
Kate Fitzgerald

International Cytokine and Interferon Society: Oradell, New Jersey, US

2002 | Milstein Young Investigator Award
Distinction
Source: Self-asserted source
Kate Fitzgerald

Irish Royal Academy of Medicine: Dublin, IE

1995 | ‘Donegan Medal’
Distinction
Source: Self-asserted source
Kate Fitzgerald

Funding (12)

Lnc’ing RNA to antiviral defense

2019-09 to 2021-08 | Grant
NIH/NIAID (Bethesda, US)
GRANT_NUMBER:

1 R21 AI147208-01

Source: Self-asserted source
Kate Fitzgerald

Caspase-8 as a focal hub in effector-triggered immunity

2019-07 to 2024-06 | Grant
NIH/NIAID (Bethesda, US)
Source: Self-asserted source
Kate Fitzgerald

Tuning of Programmable pathways to Limit Epidemics of Influenza (TOPPLE-FLU)

2019-04 to 2023-03 | Grant
DOD (Washington, D, US)
GRANT_NUMBER:

HR001118S0037-PREPARE-FP-08

Source: Self-asserted source
Kate Fitzgerald

Suppression of the I IFN gene signature by the long non-coding RNA-Lucat-1

2018-12 to 2020-10 | Grant
NIH/NIAID (Bethesda, US)
GRANT_NUMBER:

R21AI142231-01

Source: Self-asserted source
Kate Fitzgerald

Training in the Molecular Basis of Autoimmunity and Autoinflammation

2018-09 to 2023-08 | Grant
NIH/NIAMS (Bethesda, US)
GRANT_NUMBER:

T32 AI132152-01A1

Source: Self-asserted source
Kate Fitzgerald

Cytosolic DNAS pathways in the pathogenesis of SLE and other autoimmune diseases with excessive type I IFN signaling

2018-02 to 2021-02 | Contract
Glaxosmithkline (Philadelphia, PA, US)
Source: Self-asserted source
Kate Fitzgerald

Characterization of systemic autoimmunity in a murine model of SAVI

2018-02 to 2021-01 | Grant
Lupus Research Alliance (New York City, US)
Source: Self-asserted source
Kate Fitzgerald

The STING pathway and cytosolic nucleic acid sensors in bone homeostasis

2017-07 to 2022-05 | Grant
NIH/NIAMS (Bethesda, US)
GRANT_NUMBER:

1 R01 AR071037-01A1

Source: Self-asserted source
Kate Fitzgerald

Regulation of Lupus by Cytosolic DNA Sensors

2017-01 to 2021-12 | Grant
NIH/NIAID (Bethesda, US)
GRANT_NUMBER:

R01AI128358-03

Source: Self-asserted source
Kate Fitzgerald

Systems Biology of the Immune Response to Live and Inactivated Dengue Virus

2016-09 to 2018-08 | Grant
University of Rhode Island (South Kingstown, Rhode Island, US)
GRANT_NUMBER:

DoD W81XWH-16-2-0031

Source: Self-asserted source
Kate Fitzgerald

Innate Immune Activation in Malaria

2008-07 to 2019-08 | Grant
NIH/NIAID (Bethesda, US)
GRANT_NUMBER:

R01 AI079293-10

Source: Self-asserted source
Kate Fitzgerald

Gene Regulation in Innate Immunity.

2006-03 to 2019-11 | Grant
NIH/NIAID (Bethesda, US)
GRANT_NUMBER:

R37 AI067497-10

Source: Self-asserted source
Kate Fitzgerald

Works (50 of 280)

Items per page:
Page 1 of 6

DNA-sensing pathways in health, autoinflammatory and autoimmune diseases

Nature Immunology
2024-11 | Journal article
DOI: 10.1038/s41590-024-01966-y
Contributors: Mingqi Dong; Katherine A. Fitzgerald
Source: check_circle
Crossref

Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primates

2024-11-03 | Preprint
DOI: 10.1101/2024.11.01.621501
Contributors: Martin P. Steinbuck; Lochana M. Seenappa; Wei Zhan; Erica Palmer; Aniela Jakubowski; Xavier Cabana-Puig; Mimi M. Jung; Lisa K. McNeil; Christopher M. Haqq; Katherine A. Fitzgerald et al.
Source: check_circle
Crossref

Activation of autoreactive lymphocytes in the lung by STING gain-of-function mutation expressing radioresistant cells

JCI Insight
2024-07-18 | Journal article
DOI: 10.1172/jci.insight.174331
Contributors: Kevin MingJie Gao; Kristy Chiang; Sharon Subramanian; Xihui Yin; Paul J. Utz; Kerstin NĂ¼ndel; Kate A. Fitzgerald; Ann Marshak-Rothstein
Source: check_circle
Crossref

Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration

Cell Reports
2024-04 | Journal article
DOI: 10.1016/j.celrep.2024.114114
Contributors: Kevin MingJie Gao; Kristy Chiang; Zhaozhao Jiang; Filiz T. Korkmaz; Harish P. Janardhan; Chinmay M. Trivedi; Lee J. Quinton; Sebastien Gingras; Katherine A. Fitzgerald; Ann Marshak-Rothstein
Source: check_circle
Crossref

Lnc-ing RNA to intestinal homeostasis and inflammation

Trends in Immunology
2024-02 | Journal article
DOI: 10.1016/j.it.2023.12.005
Contributors: Katherine A. Fitzgerald; Liraz Shmuel-Galia
Source: check_circle
Crossref

Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells

2023-07-28 | Preprint
DOI: 10.1101/2023.07.28.551002
Contributors: Kevin MingJie Gao; Kerstin NĂ¼ndel; Kristy Chiang; Xihui Yin; Paul J. Utz; Kate Fitzgerald; Ann Marshak-Rothstein
Source: check_circle
Crossref

Expression of a STING Gain-of-function Mutation in Endothelial Cells Initiates Lymphocytic Infiltration of the Lungs

2023-07-27 | Preprint
DOI: 10.1101/2023.07.27.550897
Contributors: Kevin MingJie Gao; Kristy Chiang; Filiz T Korkmaz; Harish Palleti Janardhan; Chinmay M. Trivedi; Lee J. Quinton; Sebastien Gingras; Katherine A. Fitzgerald; Ann Marshak-Rothstein
Source: check_circle
Crossref

Long non-coding RNAs: definitions, functions, challenges and recommendations

Nature Reviews Molecular Cell Biology
2023-06 | Journal article
DOI: 10.1038/s41580-022-00566-8
Contributors: John S. Mattick; Paulo P. Amaral; Piero Carninci; Susan Carpenter; Howard Y. Chang; Ling-Ling Chen; Runsheng Chen; Caroline Dean; Marcel E. Dinger; Katherine A. Fitzgerald et al.
Source: check_circle
Crossref

ERADication of STING limits inflammation

Nature Cell Biology
2023-05 | Journal article
DOI: 10.1038/s41556-023-01142-8
Contributors: Kevin MingJie Gao; Katherine A. Fitzgerald
Source: check_circle
Crossref

A path towards personalized medicine for autoinflammatory and related diseases

Nature Reviews Rheumatology
2023-03 | Journal article
DOI: 10.1038/s41584-022-00904-2
Contributors: Jonathan J. Miner; Katherine A. Fitzgerald
Source: check_circle
Crossref

TBK1 inhibition unleashes RIPK1, resensitizing tumors to immunotherapy

Trends in Immunology
2023-03 | Journal article
DOI: 10.1016/j.it.2023.01.009
Contributors: Michelle A. Kelliher; Katherine A. Fitzgerald
Source: check_circle
Crossref

Intracellular Sensing of DNA in Autoinflammation and Autoimmunity

Arthritis & Rheumatology
2022-10 | Journal article
DOI: 10.1002/art.42256
Contributors: Susan MacLauchlan; Katherine A. Fitzgerald; Ellen M. Gravallese
Source: check_circle
Crossref

CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates

2022-05-02 | Preprint
DOI: 10.21203/rs.3.rs-1576788/v1
Contributors: Katherine Fitzgerald; Yongzhi Chen; Xuqiu Lei; Zhaozhao Jiang; Fiachra Humphries; Nicholas Mustone; Irene Ramos; Tinaye Mutetwa; Ana Fernandez-Sesma
Source: check_circle
Crossref

Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

Nature Communications
2022-01-10 | Journal article
DOI: 10.1038/s41467-021-27701-x
Contributors: Lili Gu; David Casserly; Gareth Brady; Susan Carpenter; Adrian P. Bracken; Katherine A. Fitzgerald; Leonie Unterholzner; Andrew G. Bowie
Source: check_circle
Crossref

Loosening the grip on nuclear cGAS

Nature Genetics
2020-12-23 | Journal article
DOI: 10.1038/s41588-020-00746-2
Contributors: Fiachra Humphries; Katherine A. Fitzgerald
Source: check_circle
Crossref

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Nature Communications
2020-12-11 | Journal article
DOI: 10.1038/s41467-020-20165-5
Contributors: Shiuli Agarwal; Tim Vierbuchen; Sreya Ghosh; Jennie Chan; Zhaozhao Jiang; Richard K. Kandasamy; Emiliano Ricci; Katherine A. Fitzgerald
Source: check_circle
Crossref

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

2020-08-12 | Preprint
DOI: 10.1101/2020.08.12.248252
Contributors: Michael C. Kiritsy; Laurisa M. Ankley; Justin D. Trombley; Gabrielle P. Huizinga; Audrey E. Lord; Pontus Orning; Roland Elling; Katherine A. Fitzgerald; Andrew J. Olive
Source: check_circle
Crossref

Assembling the inflammasome, piece by piece

Journal of Immunology
2019 | Journal article
DOI: 10.4049/jimmunol.1900764
EID:

2-s2.0-85071453131
Contributors: Humphries, F.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM

Immunity
2019 | Journal article
DOI: 10.1016/j.immuni.2019.04.005
EID:

2-s2.0-85067179215
Contributors: Carty, M.; Kearney, J.; Shanahan, K.A.; Hams, E.; Sugisawa, R.; Connolly, D.; Doran, C.G.; Muñoz-Wolf, N.; GĂ¼rtler, C.; Fitzgerald, K.A. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Control of antiviral innate immune response by protein geranylgeranylation

Science Advances
2019 | Journal article
DOI: 10.1126/sciadv.aav7999
EID:

2-s2.0-85066337349
Contributors: Yang, S.; Harding, A.T.; Sweeney, C.; Miao, D.; Swan, G.; Zhou, C.; Jiang, Z.; Fitzgerald, K.A.; Hammer, G.; Bergo, M.O. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

DNA sensing by the cGAS–STING pathway in health and disease

Nature Reviews Genetics
2019 | Journal article
DOI: 10.1038/s41576-019-0151-1
EID:

2-s2.0-85069914432
Contributors: Motwani, M.; Pesiridis, S.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

HiChIRP reveals RNA-associated chromosome conformation

Nature Methods
2019 | Journal article
DOI: 10.1038/s41592-019-0407-x
EID:

2-s2.0-85066486422
Contributors: Mumbach, M.R.; Granja, J.M.; Flynn, R.A.; Roake, C.M.; Satpathy, A.T.; Rubin, A.J.; Qi, Y.; Jiang, Z.; Shams, S.; Louie, B.H. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models

Proceedings of the National Academy of Sciences of the United States of America
2019 | Journal article
DOI: 10.1073/pnas.1818281116
EID:

2-s2.0-85064404925
Contributors: Motwani, M.; Pawaria, S.; Bernier, J.; Moses, S.; Henry, K.; Fang, T.; Burkly, L.; Marshak-Rothstein, A.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus

Molecular Cell
2019 | Journal article
DOI: 10.1016/j.molcel.2019.09.021
EID:

2-s2.0-85072522728
Contributors: Humphries, F.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Immature lung TNFR2 <sup>−</sup> conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo

Mucosal Immunology
2019 | Journal article
DOI: 10.1038/s41385-018-0098-0
EID:

2-s2.0-85055130515
Contributors: Mansouri, S.; Patel, S.; Katikaneni, D.S.; Blaauboer, S.M.; Wang, W.; Schattgen, S.; Fitzgerald, K.; Jin, L.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Gasdermins and their role in immunity and inflammation

Journal of Experimental Medicine
2019-11-04 | Journal article
DOI: 10.1084/jem.20190545
Contributors: Pontus Orning; Egil Lien; Katherine A. Fitzgerald
Source: check_circle
Crossref

A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1β Release in Response to a Pathogenic Fungus

Journal of Infectious Diseases
2018 | Journal article
DOI: 10.1093/infdis/jix568
EID:

2-s2.0-85040540708
Contributors: Ketelut-Carneiro, N.; Ghosh, S.; Levitz, S.M.; Fitzgerald, K.A.; Da Silva, J.S.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome

Journal of Dental Research
2018 | Journal article
DOI: 10.1177/0022034518760855
EID:

2-s2.0-85045066678
Contributors: Papinska, J.; Bagavant, H.; Gmyrek, G.B.; Sroka, M.; Tummala, S.; Fitzgerald, K.A.; Deshmukh, U.S.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

CGAS drives noncanonical-inflammasome activation in age-related macular degeneration

Nature Medicine
2018 | Journal article
DOI: 10.1038/nm.4450
EID:

2-s2.0-85040339678
Contributors: Kerur, N.; Fukuda, S.; Banerjee, D.; Kim, Y.; Fu, D.; Apicella, I.; Varshney, A.; Yasuma, R.; Fowler, B.J.; Baghdasaryan, E. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

CNBP controls IL-12 gene transcription and Th1 immunity

Journal of Experimental Medicine
2018 | Journal article
DOI: 10.1084/jem.20181031
EID:

2-s2.0-85057870768
Contributors: Chen, Y.; Sharma, S.; Assis, P.A.; Jiang, Z.; Elling, R.; Olive, A.J.; Hang, S.; Bernier, J.; Huh, J.R.; Sassetti, C.M. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Cutting edge: Plasmodium falciparum induces trained innate immunity

Journal of Immunology
2018 | Journal article
DOI: 10.4049/jimmunol.1701010
EID:

2-s2.0-85044759935
Contributors: Schrum, J.E.; Crabtree, J.N.; Dobbs, K.R.; Kiritsy, M.C.; Reed, G.W.; Gazzinelli, R.T.; Netea, M.G.; Kazura, J.W.; Dent, A.E.; Fitzgerald, K.A. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Cyclic GMP-AMP Synthase is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type i IFN in Malaria

Journal of Immunology
2018 | Journal article
DOI: 10.4049/jimmunol.1701048
EID:

2-s2.0-85044765016
Contributors: Gallego-Marin, C.; Schrum, J.E.; Andrade, W.A.; Shaffer, S.A.; Giraldo, L.F.; Lasso, A.M.; Kurt-Jones, E.A.; Fitzgerald, K.A.; Golenbock, D.T.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Cytokines and long Noncoding RNAs

Cold Spring Harbor Perspectives in Biology
2018 | Journal article
DOI: 10.1101/cshperspect.a028589
EID:

2-s2.0-85047971903
Contributors: Carpenter, S.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity

Journal of Immunology
2018 | Journal article
DOI: 10.4049/jimmunol.1701229
EID:

2-s2.0-85044729921
Contributors: O'Donnell, J.A.; Lehman, J.; Roderick, J.E.; Martinez-Marin, D.; Zelic, M.; Doran, C.; Hermance, N.; Lyle, S.; Pasparakis, M.; Fitzgerald, K.A. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation

Journal of Clinical Investigation
2018 | Journal article
DOI: 10.1172/JCI98219
EID:

2-s2.0-85049836329
Contributors: Mande, P.; Zirak, B.; Ko, W.-C.; Taravati, K.; Bride, K.L.; Brodeur, T.Y.; Deng, A.; Dresser, K.; Jiang, Z.; Ettinger, R. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

Immunity
2018 | Journal article
DOI: 10.1016/j.immuni.2018.07.006
EID:

2-s2.0-85052987561
Contributors: Banerjee, I.; Behl, B.; Mendonca, M.; Shrivastava, G.; Russo, A.J.; Menoret, A.; Ghosh, A.; Vella, A.T.; Vanaja, S.K.; Sarkar, S.N. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2

Cell Reports
2018 | Journal article
DOI: 10.1016/j.celrep.2018.10.027
EID:

2-s2.0-85055586960
Contributors: Elling, R.; Robinson, E.K.; Shapleigh, B.; Liapis, S.C.; Covarrubias, S.; Katzman, S.; Groff, A.F.; Jiang, Z.; Agarwal, S.; Motwani, M. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
DOI: 10.1073/pnas.1806239115
EID:

2-s2.0-85052738022
Contributors: Hansen, A.L.; Buchan, G.J.; RĂ¼hl, M.; Mukai, K.; Salvatore, S.R.; Ogawa, E.; Andersen, S.D.; Iversen, M.B.; Thielke, A.L.; Gunderstofte, C. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-05861-7
EID:

2-s2.0-85052656171
Contributors: Olagnier, D.; Brandtoft, A.M.; Gunderstofte, C.; Villadsen, N.L.; Krapp, C.; Thielke, A.L.; Laustsen, A.; Peri, S.; Hansen, A.L.; Bonefeld, L. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

Science
2018 | Journal article
DOI: 10.1126/science.aau2818
EID:

2-s2.0-85056594811
Contributors: Orning, P.; Weng, D.; Starheim, K.; Ratner, D.; Best, Z.; Lee, B.; Brooks, A.; Xia, S.; Wu, H.; Kelliher, M.A. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

cGAS Micro-Manages Genotoxic Stress

Immunity
2017 | Journal article
DOI: 10.1016/j.immuni.2017.09.020
EID:

2-s2.0-85042190336
Contributors: Motwani, M.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Immunobiology of long noncoding RNAs

Annual Review of Immunology
2017 | Book
DOI: 10.1146/annurev-immunol-041015-055459
EID:

2-s2.0-85018347359
Contributors: Atianand, M.K.; Caffrey, D.R.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

IRF3 and type i interferons fuel a fatal response to myocardial infarction

Nature Medicine
2017 | Journal article
DOI: 10.1038/nm.4428
EID:

2-s2.0-85034837637
Contributors: King, K.R.; Aguirre, A.D.; Ye, Y.-X.; Sun, Y.; Roh, J.D.; Ng, R.P.; Kohler, R.H.; Arlauckas, S.P.; Yoshiko, V.; Savo, A. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Kinase activities of RIPK1 and RIPK3 can direct IFN-β synthesis induced by lipopolysaccharide

Journal of Immunology
2017 | Journal article
DOI: 10.4049/jimmunol.1601717
EID:

2-s2.0-85019883237
Contributors: Saleh, D.; Najjar, M.; Zelic, M.; Shah, S.; Nogusa, S.; Polykratis, A.; Paczosa, M.K.; Gough, P.J.; Bertin, J.; Whalen, M. et al.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

MIR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)

Journal of Biological Chemistry
2017 | Journal article
DOI: 10.1074/jbc.M116.749325
EID:

2-s2.0-85017368562
Contributors: Kalantari, P.; Harandi, O.F.; Agarwal, S.; Rus, F.; Kurt-Jones, E.A.; Fitzgerald, K.A.; Caffrey, D.R.; Golenbock, D.T.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice

Arthritis and Rheumatology
2017 | Journal article
DOI: 10.1002/art.39863
EID:

2-s2.0-85010906046
Contributors: Baum, R.; Sharma, S.; Organ, J.M.; Jakobs, C.; Hornung, V.; Burr, D.B.; Marshak-Rothstein, A.; Fitzgerald, K.A.; Gravallese, E.M.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

Taking the STING out of TLR-driven autoimmune diseases: Good, bad, or indifferent?

Journal of Leukocyte Biology
2017 | Journal article
DOI: 10.1189/jlb.3MR0316-115R
EID:

2-s2.0-85008500774
Contributors: Pawaria, S.; Sharma, S.; Baum, R.; NĂ¼ndel, K.; Busto, P.; Gravallese, E.M.; Fitzgerald, K.A.; Marshak-Rothstein, A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

The pyhin protein P205 regulates the inflammasome by controlling asc expression

Journal of Immunology
2017 | Journal article
DOI: 10.4049/jimmunol.1700823
EID:

2-s2.0-85032014226
Contributors: Ghosh, S.; Wallerath, C.; Covarrubias, S.; Hornung, V.; Carpenter, S.; Fitzgerald, K.A.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

A cGAS-independent STING/IRF7 pathway mediates the immunogenicity of DNA vaccines

Journal of Immunology
2016 | Journal article
DOI: 10.4049/jimmunol.1501836
EID:

2-s2.0-84953284810
Contributors: Suschak, J.J.; Wang, S.; Fitzgerald, K.A.; Lu, S.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier

A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

Cell Reports
2016 | Journal article
DOI: 10.1016/j.celrep.2016.06.011
EID:

2-s2.0-84992512820
Contributors: Tzeng, T.-C.; Schattgen, S.; Monks, B.; Wang, D.; Cerny, A.; Latz, E.; Fitzgerald, K.; Golenbock, D.T.
Source: Self-asserted source
Kate Fitzgerald via Scopus - Elsevier
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