Personal information

ankyrins, axon initial segment, neuronal polarity, structural biology, chemcial biology
China

Activities

Employment (2)

University of Science and Technology of China: Hefei, Anhui, CN

2016-03-01 to present | Principle Investigator (School of Life Sciences)
Employment
Source: Self-asserted source
CHAO WANG

Hong Kong University of Science and Technology: Kowloon, HK

2014-07-01 to 2016-02-29 | Research Associate (Division of Life Science)
Employment
Source: Self-asserted source
CHAO WANG

Education and qualifications (2)

Hong Kong University of Science and Technology: Kowloon, HK

2009-08-22 to 2014-06-30 | Doctor Degree in Biochemistry (Department of Biochemistry)
Education
Source: Self-asserted source
CHAO WANG

Shanghai Jiao Tong University: Shanghai, CN

2005-09-01 to 2009-06-30 | Bachelor (School of Life Science and Technology)
Education
Source: Self-asserted source
CHAO WANG

Works (26)

Endocytosis restricts dendrite branching via removing ectopically localized branching ligands

Nature Communications
2024-11-07 | Journal article
Contributors: Jie Fang; Wenli Jiang; Weixia Zhao; Jie Wang; Beibei Cao; Nan Wang; Baohui Chen; Chao Wang; Wei Zou
Source: check_circle
Crossref

Structural basis for the dynamic chaperoning of disordered clients by Hsp90

Nature Structural & Molecular Biology
2024-10 | Journal article
Contributors: Xiaozhan Qu; Shuo Zhao; Chanjuan Wan; Lei Zhu; Tuo Ji; Paolo Rossi; Junfeng Wang; Charalampos G. Kalodimos; Chao Wang; Weiya Xu et al.
Source: check_circle
Crossref

Hypothalamus-sympathetic-liver axis mediates the early phase of stress-induced hyperglycemia in the male mice

Nature Communications
2024-10-05 | Journal article
Contributors: Ling Liu; Zhaohuan Huang; Jian Zhang; Mengtian Wang; Ting Yue; Wei Wang; Yue Wu; Zhi Zhang; Wei Xiong; Chao Wang et al.
Source: check_circle
Crossref

Neuronal Scaffold Protein ARMS Interacts with Synaptotagmin-4 C2AB through the Ankyrin Repeat Domain with an Unexpected Mode

International Journal of Molecular Sciences
2023-11-30 | Journal article
Contributors: Fa Zhang; Jiasheng Chen; Yahong Li; Jin Ye; Chao Wang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Structural basis for the dynamic chaperoning of disordered clients by Hsp90

2023-09-14 | Preprint
Contributors: Chengdong Huang; Xiaozhan Qu; Shuo Zhao; Chanjuan Wan; Lei Zhu; Paolo Rossi; Junfeng Wang; Charalampos Kalodimos; Chao Wang; Weiya Xu
Source: check_circle
Crossref

Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs

Science Advances
2023-05-12 | Journal article
Contributors: Meng Zhang; Aili Cao; Lin Lin; Ying Chen; Yuan Shang; Chao Wang; Mingjie Zhang; Jinwei Zhu
Source: check_circle
Crossref

Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment

Journal of Biological Chemistry
2022-09 | Journal article
Contributors: Liping He; Wenli Jiang; Jianchao Li; Chao Wang
Source: check_circle
Crossref

Promotion of row 1–specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia

Science Advances
2022-06-10 | Journal article
Contributors: Yingdong Shi; Lin Lin; Chao Wang; Jinwei Zhu
Source: check_circle
Crossref

AnkG-Neurofascin complex structure reveals binding mechanisms required for integrity of the AIS

2022-04-28 | Preprint
Contributors: Liping He; Wenli Jiang; Jianchao Li; Chao Wang
Source: check_circle
Crossref

Crystal structure of the PDZ4 domain of MAGI2 in complex with PBM of ARMS reveals a canonical PDZ recognition mode

Neurochemistry International
2021-10 | Journal article
Contributors: Yanshen Zhang; Zhiwen Zhong; Jin Ye; Chao Wang
Source: check_circle
Crossref

Double inhibition and activation mechanisms of Ephexin family RhoGEFs

Proceedings of the National Academy of Sciences
2021-02-23 | Journal article
Contributors: Meng Zhang; Lin Lin; Chao Wang; Jinwei Zhu
Source: check_circle
Crossref

Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission

Nature Communications
2021-01-12 | Journal article
Source: Self-asserted source
CHAO WANG
grade
Preferred source (of 2)‎

Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability.

The Biochemical journal
2020-12-11 | Journal article
Source: Self-asserted source
CHAO WANG

Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP

Molecular Psychiatry
2020-11-25 | Journal article
Part of ISSN: 1359-4184
Source: Self-asserted source
CHAO WANG
grade
Preferred source (of 2)‎

Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity.

Nature cell biology
2020-05-04 | Journal article
Source: Self-asserted source
CHAO WANG

Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance

Proceedings of the National Academy of Sciences
2020-01-14 | Journal article
Contributors: Jin Ye; Jianchao Li; Fei Ye; Yan Zhang; Mingjie Zhang; Chao Wang
Source: check_circle
Crossref

Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.

Structure (London, England : 1993)
2019-03-21 | Journal article
Source: Self-asserted source
CHAO WANG

Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation.

Circulation
2018-12-04 | Journal article
Source: Self-asserted source
CHAO WANG

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Nature Communications
2018-06-29 | Journal article
Contributors: Hongbin He; Hua Jiang; Yun Chen; Jin Ye; Aoli Wang; Chao Wang; Qingsong Liu; Gaolin Liang; Xianming Deng; Wei Jiang et al.
Source: check_circle
Crossref

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

Nature Chemical Biology
2018-06-04 | Journal article
Part of ISSN: 1552-4450
Contributors: Jianchao Li; Ruichi Zhu; Keyu Chen; Hui Zheng; Hongyu Zhao; Chongzhen Yuan; Hong Zhang; Chao Wang; Mingjie Zhang
Source: Self-asserted source
CHAO WANG via Crossref Metadata Search

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

The Journal of Experimental Medicine
2017-10-11 | Journal article
Part of ISSN: 0022-1007
Contributors: Hua Jiang; Hongbin He; Yun Chen; Wei Huang; Jinbo Cheng; Jin Ye; Aoli Wang; Jinhui Tao; Chao Wang; Qingsong Liu et al.
Source: Self-asserted source
CHAO WANG via Crossref Metadata Search

Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions

eLife
2017-08 | Journal article
Part of ISSN: 2050-084X
Contributors: Keyu Chen; Jianchao Li; Chao Wang; Zhiyi Wei; Mingjie Zhang
Source: Self-asserted source
CHAO WANG via Crossref Metadata Search

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome

Circulation: Cardiovascular Genetics
2017-01 | Journal article
Part of ISSN: 1942-325X
Contributors: Leigh Anne Swayne; Nathaniel P. Murphy; Sirisha Asuri; Lena Chen; Xiaoxue Xu; Sarah McIntosh; Chao Wang; Peter J. Lancione; Jason D. Roberts; Charles Kerr et al.
Source: Self-asserted source
CHAO WANG via Crossref Metadata Search

Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency

Journal of Clinical Investigation
2015-07 | Journal article
Part of ISSN: 0021-9738
Contributors: Damaris N. Lorenzo; Jane A. Healy; Janell Hostettler; Jonathan Davis; Jiayu Yang; Chao Wang; Hans Ewald Hohmeier; Mingjie Zhang; Vann Bennett
Source: Self-asserted source
CHAO WANG via Crossref Metadata Search

Structural basis of diverse membrane target recognitions by ankyrins

eLife
2014-11-10 | Journal article
Part of ISSN: 2050-084X
Contributors: Chao Wang; Zhiyi Wei; Keyu Chen; Fei Ye; Cong Yu; Vann Bennett; Mingjie Zhang
Source: Self-asserted source
CHAO WANG via Crossref Metadata Search

Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function

Proceedings of the National Academy of Sciences
2012-03 | Journal article
Part of ISSN: 0027-8424
Contributors: C. Wang; C. Yu; F. Ye; Z. Wei; M. Zhang
Source: Self-asserted source
CHAO WANG via Crossref Metadata Search

Peer review (2 reviews for 2 publications/grants)

Review activity for Communications biology. (1)
Review activity for Nature communications (1)