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Researcher Name Resolver ID: 1000080633263
ResearcherID: C-7164-2018

Keywords

Nucleic acid chemistry, Oligonucleotide drug, RNA binding small molecules

Countries

Japan

Activities

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Employment (8)

Institute of Science Tokyo: Tokyo, JP

2024-10-01 to present | Specially Appointed Junior Associate Professor (Institute of Integrated Science)
Employment
Source: Self-asserted source
Takeshi Yamada

Osaka University: Osaka, JP

2023 to present | Visiting Researcher
Employment
Source: Self-asserted source
Takeshi Yamada

Tokyo Medical and Dental University: Bunkyo-ku, Tokyo, JP

2023-04-01 to 2024-09-30 | Specially appointed junior associate professor (Nucleotide and Peptide Drug Discovery Center)
Employment
Source: Self-asserted source
Takeshi Yamada

Osaka University: Osaka, JP

2020-01-15 to 2023-03-31 | Assistant Professor (ISIR)
Employment
Source: Self-asserted source
Takeshi Yamada

Osaka University: Osaka, JP

2015-07 to 2020-01-14 | Specially appointed assistant professor (ISIR)
Employment
Source: Self-asserted source
Takeshi Yamada

Osaka University: Osaka, JP

2014-08 to 2015-06 | Postdoc (ISIR)
Employment
Source: Self-asserted source
Takeshi Yamada

Aoyama Gakuin University: Tokyo, JP

2012-04 to 2014-07 | Assistant professor (College of science and engineering)
Employment
Source: Self-asserted source
Takeshi Yamada

Tokyo Institute of Technology: Tokyo, JP

2011-04 to 2012-04 | Postdoc (Department of life science)
Employment
Source: Self-asserted source
Takeshi Yamada

Education and qualifications (1)

Tokyo Institute of Technology: Tokyo, JP

2011-03 | Ph. D (Department of life science)
Education
Source: Self-asserted source
Takeshi Yamada

Funding (5)

Development of ASOs which up-regulate back-splicing producing circular RNAs

2022-04-01 to 2025-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.12871580
GRANT_NUMBER: 22K05315
Source: Self-asserted source
Takeshi Yamada via DimensionsWizard

Development of small molecules that spontaneously oligomerize on trinucleotide repeats

2019-04 to 2022-03 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.8436088
GRANT_NUMBER: 19K05693
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 2)‎

Development of small molecules that selectively hydrolyze excessive elongated RNA repeats

2017-04-01 to 2019-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://grants.uberresearch.com/501100001691/17K14516/Development-of-small-molecules-that-selectively-hydrolyze-excessive-elongated-RNA-repeats
GRANT_NUMBER: 17K14516
Source: Self-asserted source
Takeshi Yamada via DimensionsWizard
grade
Preferred source (of 2)‎

CAG to suppress the over-extension of the repeat creation of small molecule ligands

2015-04-01 to 2017-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://grants.uberresearch.com/501100001691/15K17885/CAG-to-suppress-the-over-extension-of-the-repeat-creation-of-small-molecule-ligands
GRANT_NUMBER: 15K17885
Source: Self-asserted source
Takeshi Yamada via DimensionsWizard

Chemical Biology Studies on Trinucleotide Repeat Disease using Repeat-Binding Molecules

2014-01-01 to 2019-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.6129644
GRANT_NUMBER: 26000007
Source: Self-asserted source
Takeshi Yamada via DimensionsWizard

Works (25)

Clustering on Surface Plasmon Resonance Profiles to Improve Hit Assignment of Small Molecules Targeting CAG Repeat DNA

Advanced Intelligent Discovery
2025-01-15 | Journal article
DOI: 10.1002/aidi.202400020
Contributors: Qingwen Chen; Takeshi Yamada; Hiroaki Santo; Eitaro Murakami; Asako Murata; Yasuyuki Matsushita; Kazuhiko Nakatani
Source: check_circle
Crossref

Machine learning approach toward generating the focused molecule library targeting CAG repeat DNA

Digital Discovery
2024 | Journal article
DOI: 10.1039/d3dd00160a
Part of ISSN: 2635-098X
Contributors: Qingwen Chen; Takeshi Yamada; Asako Murata; Ayako Sugai; Yasuyuki Matsushita; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 2)‎

NMR analysis of <sup>15</sup>N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA

Chemical Communications
2024 | Journal article
DOI: 10.1039/d4cc00544a
Part of ISSN: 1359-7345
Part of ISSN: 1364-548X
Contributors: Takeshi Yamada; Shuhei Sakurabayashi; Noriaki Sugiura; Hitoshi Haneoka; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 2)‎

The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding

Bioorganic &amp; Medicinal Chemistry Letters
2024-10 | Journal article
DOI: 10.1016/j.bmcl.2024.129985
Part of ISSN: 0960-894X
Contributors: Shuhei Sakurabayashi; Takeshi Yamada; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada

Utility of oligonucleotide in upregulating circular RNA production in a cellular model

Scientific Reports
2024-04-06 | Journal article
DOI: 10.1038/s41598-024-58663-x
Part of ISSN: 2045-2322
Contributors: Lu Ni; Takeshi Yamada; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada

A New Small Molecule DoNA Binding to CAG Repeat RNA

Bioorganic &amp; Medicinal Chemistry
2023-12 | Journal article
DOI: 10.1016/j.bmc.2023.117580
Part of ISSN: 0968-0896
Contributors: Qingwen Chen; Takeshi Yamada; Koichi Miyagawa; Asako Murata; Mitsuo Shoji; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada

Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Chemical Communications
2022 | Journal article
DOI: 10.1039/d1cc06936e
Part of ISSN: 1359-7345
Part of ISSN: 1364-548X
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 3)‎

NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

Nucleic Acids Research
2022-09-12 | Journal article
DOI: 10.1093/nar/gkac740
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Takeshi Yamada
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 3)‎

Assembly of ruthenium complexes on double strand DNA using mismatch binding ligand

Chemical Communications
2020 | Journal article
DOI: 10.1039/d0cc01863e
Part of ISSN: 1359-7345
Part of ISSN: 1364-548X
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 2)‎

Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat

Biochemistry
2020-07-09 | Journal article
DOI: 10.1021/acs.biochem.0c00333
Part of ISSN: 0006-2960
Contributors: Yuki Yagi; Takeshi Yamada; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search
grade
Preferred source (of 2)‎

CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

Chemical Communications
2018 | Journal article
DOI: 10.1039/c8cc06757k
Part of ISSN: 1359-7345
Contributors: Takeshi Yamada; Shouta Miki; Lu Ni; kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search
grade
Preferred source (of 2)‎

Expanding chemical space of DNA-binding molecules with three base-binding units

Bioorganic & Medicinal Chemistry Letters
2018-07 | Journal article
DOI: 10.1016/j.bmcl.2018.07.024
Part of ISSN: 0960-894X
Contributors: Yuki Yagi; Haruo Aikawa; Takeshi Yamada; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search
grade
Preferred source (of 2)‎

Absorption Characteristics and Quantum Yields of Singlet Oxygen Generation of Thioguanosine Derivatives

Photochemistry and Photobiology
2018-02-08 | Journal article
DOI: 10.1111/php.12900
Part of ISSN: 0031-8655
Contributors: Shoma Miyata; Takeshi Yamada; Tasuku Isozaki; Hideyuki Sugimura; Yao-Zhong Xu; Tadashi Suzuki
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Acid Dissociation Equilibrium and Singlet Molecular Oxygen Quantum Yield of Acetylated 6,8–Dithioguanosine in Aqueous Buffer Solution

The Journal of Physical Chemistry B
2018-02-08 | Journal article
DOI: 10.1021/acs.jpcb.8b00517
Part of ISSN: 1520-6106
Contributors: Shoma Miyata; Mina Hoshino; Tasuku Isozaki; Takeshi Yamada; Hideyuki Sugimura; Yao Zhong Xu; Tadashi Suzuki
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search
grade
Preferred source (of 2)‎

Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G–G Mismatch DNA

Organic Letters
2017-07 | Journal article
DOI: 10.1021/acs.orglett.7b01632
Contributors: Takeshi Yamada; Shouta Miki; Anisa Ul’Husna; Akiko Michikawa; Kazuhiko Nakatani
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

ChemInform Abstract: Stereoselective Access to (Z)-α,γ-Diazido-α,β-unsaturated Esters via Lewis Acid-Mediated 1,3-Diazidation of α,α-Dimethoxy-β,γ-unsaturated Esters with Trimethylsilyl Azide.

ChemInform
2015-08 | Journal article
DOI: 10.1002/chin.201535062
Contributors: Naomi Kishii; Saeka Negishi; Takeshi Yamada; Hideyuki Sugimura
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Stereoselective access to (Z)-α,γ-diazido-α,β-unsaturated esters via Lewis acid-mediated 1,3-diazidation of α,α-dimethoxy-β,γ-unsaturated esters with trimethylsilyl azide

Tetrahedron Letters
2015-05 | Journal article
DOI: 10.1016/j.tetlet.2015.04.047
Contributors: Naomi Kishii; Saeka Negishi; Takeshi Yamada; Hideyuki Sugimura
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Synthesis and Exon-Skipping Activity of Chemically Modified RNAs

Chemical Biology of Nucleic Acids
2014 | Other
DOI: 10.1007/978-3-642-54452-1_27
Contributors: Yoshiaki Masaki; Takeshi Yamada; Hisao Saneyoshi; Akihiro Ohkubo; Kohji Seio; Mitsuo Sekine
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Synthesis and properties of base or sugar modified RNA derivatives

Collection Symposium Series
2014 | Conference paper
DOI: 10.1135/css201414167
Contributors: Mitsuo Sekine; Yoshiaki Masaki; Takeshi Yamada; Youdai Ishii; Keishi Yamamoto; Natsuki Okaniwa; Takeshi Kanamori; Hisashi Saneyoshi; Hirosuke Tsunoda; Akihiro Ohkubo et al.
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 2)‎

ChemInform Abstract: Stereoselective Formation of Tetrahydrofuran Rings via [3 + 2] Annulation: Total Synthesis of Plakortone L.

ChemInform
2014-11 | Journal article
DOI: 10.1002/chin.201450206
Contributors: Hideyuki Sugimura; Shougo Sato; Kensei Tokudome; Takeshi Yamada
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Stereoselective Formation of Tetrahydrofuran Rings via [3 + 2] Annulation: Total Synthesis of Plakortone L

Organic Letters
2014-06 | Journal article
DOI: 10.1021/ol501446w
Contributors: Hideyuki Sugimura; Shougo Sato; Kensei Tokudome; Takeshi Yamada
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Synthesis and properties of oligonucleotides modified with 2′-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives

Organic & Biomolecular Chemistry
2014-06 | Journal article
DOI: 10.1039/c4ob01260g
Contributors: Takeshi Yamada; Yoshiaki Masaki; Natsuki Okaniwa; Takashi Kanamori; Akihiro Ohkubo; Hirosuke Tsunoda; Kohji Seio; Mitsuo Sekine
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Synthesis and biological properties of 2'-O-modified oligoribonucleotide derivatives

Collection Symposium Series
2011 | Conference paper
DOI: 10.1135/css201112240
Contributors: Takeshi Yamada; Natsuki Okaniwa; Yoshiaki Masaki; Yasuhiro Okuno; Ryuta Miyasaka; Hiroyuki Tsunoda; Akihiro Ohkubo; Kohji Seio; Tetsuya Nagata; Yoshitsugu Aoki et al.
Source: Self-asserted source
Takeshi Yamada
grade
Preferred source (of 2)‎

Synthesis of 2′-O-[2-(N-Methylcarbamoyl)ethyl]ribonucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides

The Journal of Organic Chemistry
2011-05-06 | Journal article
DOI: 10.1021/jo101963z
Contributors: Takeshi Yamada; Natsuki Okaniwa; Hisao Saneyoshi; Akihiro Ohkubo; Kohji Seio; Tetsuya Nagata; Yoshitsugu Aoki; Shin’ichi Takeda; Mitsuo Sekine
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search

Versatile Site-Specific Conjugation of Small Molecules to siRNA Using Click Chemistry

The Journal of Organic Chemistry
2011-03-04 | Journal article
DOI: 10.1021/jo101761g
Contributors: Takeshi Yamada; Chang Geng Peng; Shigeo Matsuda; Haripriya Addepalli; K. Narayanannair Jayaprakash; Md. Rowshon Alam; Kathy Mills; Martin A. Maier; Klaus Charisse; Mitsuo Sekine et al.
Source: Self-asserted source
Takeshi Yamada via Crossref Metadata Search
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