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SciProfiles: 1400338

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Employment (2)

university of science and technology: Daejeon, KR

Associate professor (Medical chemistry and pharmacology)
Employment
Source: Self-asserted source
Yong-Hee Cho

Korea Research Institute of Chemical Technology: Daejeon, KR

Senior Researcher
Employment
Source: Self-asserted source
Yong-Hee Cho

Education and qualifications (1)

Yonsei University: Seoul, KR

2009-03-01 to 2017-02-17 | PHD (Biotechnology)
Education
Source: Self-asserted source
Yong-Hee Cho

Works (21)

Discovery of novel benzosultam CRBN ligands

Bulletin of the Korean Chemical Society
2025-01 | Journal article
DOI: 10.1002/bkcs.12921
Contributors: Hoyeong Park; Santosh Shivanand Raikar; Yonghyo Kim; Chong Hak Chae; Yong‐Hee Cho; Pilho Kim
Source: check_circle
Crossref

Guidelines for Manufacturing and Application of Organoids: Lung

International Journal of Stem Cells
2024-05-30 | Journal article
DOI: 10.15283/ijsc24041
Contributors: Kyungtae Lim; Mi-Ok Lee; Jinwook Choi; Jung-Hyun Kim; Eun-Mi Kim; Chang Gyu Woo; Chaeuk Chung; Yong-Hee Cho; Seok-Ho Hong; Young-Jae Cho et al.
Source: check_circle
Crossref

API-2-Induced Cell Migration Is Overcome by Small Molecular Approaches Inhibiting β-Catenin

Current Issues in Molecular Biology
2022-11-29 | Journal article
DOI: 10.3390/cimb44120409
Contributors: Yonghyo Kim; Myoung-Hee Kang; Yong-Hee Cho
Source: check_circle
Crossref
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Preferred source (of 2)‎

Review on Advanced Cancer Modeling for a Cancer Study

Current Issues in Molecular Biology
2022-10-31 | Journal article
DOI: 10.3390/cimb44110362
Part of ISSN: 1467-3045
Contributors: Yong-Hee Cho
Source: Self-asserted source
Yong-Hee Cho

A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer

Cancer Research and Treatment
2022-10-15 | Journal article
DOI: 10.4143/crt.2021.986
Part of ISSN: 1598-2998
Part of ISSN: 2005-9256
Contributors: Eo Jin Kim; Yong-Hee Cho; Dong Ha Kim; Dae-Hyun Ko; Eun-Ju Do; Sang-Yeob Kim; Yong Man Kim; Jae Seob Jung; Yoonmi Kang; Wonjun Ji et al.
Source: Self-asserted source
Yong-Hee Cho

Discovery of a novel CDK7 inhibitor YPN-005 in small cell lung cancer

European Journal of Pharmacology
2021-09 | Journal article
DOI: 10.1016/j.ejphar.2021.174298
Part of ISSN: 0014-2999
Contributors: Yun Jung Choi; Hyeonjeong Lee; Da-Som Kim; Dong Ha Kim; Myoung-Hee Kang; Yong-Hee Cho; Chang-Min Choi; Jakyung Yoo; Kwang-Ok Lee; Eun Kyung Choi et al.
Source: Self-asserted source
Yong-Hee Cho

Establishment and Long-Term Expansion of Small Cell Lung Cancer Patient-Derived Tumor Organoids

International Journal of Molecular Sciences
2021-01-29 | Journal article
DOI: 10.3390/ijms22031349
Part of ISSN: 1422-0067
Contributors: Seon Young Choi; Yong-Hee Cho; Da-Som Kim; Wonjun Ji; Chang-Min Choi; Jae Cheol Lee; Jin Kyung Rho; Gi Seok Jeong
Source: Self-asserted source
Yong-Hee Cho

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

Cell Communication and Signaling
2020-12 | Journal article
DOI: 10.1186/s12964-020-0519-z
Part of ISSN: 1478-811X
Contributors: Yong-Hee Cho; Eun Ji Ro; Jeong-Su Yoon; Dong-Kyu Kwak; Jaebeom Cho; Dong Woo Kang; Ho-Young Lee; Kang-Yell Choi
Source: Self-asserted source
Yong-Hee Cho

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

Nature Communications
2020-10-21 | Journal article
DOI: 10.1038/s41467-020-19173-2
Contributors: Yong-Hee Cho; Eun Ji Ro; Jeong-Su Yoon; Tomohiro Mizutani; Dong-Woo Kang; Jong-Chan Park; Tae Il Kim; Hans Clevers; Kang-Yell Choi
Source: check_circle
Crossref

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

Experimental & Molecular Medicine
2020-05 | Journal article
DOI: 10.1038/s12276-020-0440-y
Part of ISSN: 1226-3613
Part of ISSN: 2092-6413
Contributors: Won-Ji Ryu; Jeong Dong Lee; Jong-Chan Park; Pu-Hyeon Cha; Yong-Hee Cho; Jee Ye Kim; Joo Hyuk Sohn; Soonmyung Paik; Kang-Yell Choi
Source: Self-asserted source
Yong-Hee Cho

A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties <i>via</i> Wnt/β‐catenin signaling

International Journal of Cancer
2020-05-15 | Journal article
DOI: 10.1002/ijc.32728
Part of ISSN: 0020-7136
Part of ISSN: 1097-0215
Contributors: Jeong-Ha Hwang; Junyong Yoon; Yong‐Hee Cho; Pu‐Hyeon Cha; Jong‐Chan Park; Kang-Yell Choi
Source: Self-asserted source
Yong-Hee Cho

Natural Killer Cells as a Potential Biomarker for Predicting Immunotherapy Efficacy in Patients with Non-Small Cell Lung Cancer

Targeted Oncology
2020-04 | Journal article
DOI: 10.1007/s11523-020-00712-2
Part of ISSN: 1776-2596
Part of ISSN: 1776-260X
Contributors: Yong-Hee Cho; Myeong Geun Choi; Dong Ha Kim; Yun Jung Choi; Seon Ye Kim; Ki Jung Sung; Jae Cheol Lee; Sang-Yeob Kim; Jin Kyung Rho; Chang-Min Choi
Source: Self-asserted source
Yong-Hee Cho

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

Cell Communication and Signaling
2019-12 | Journal article
DOI: 10.1186/s12964-019-0403-x
Part of ISSN: 1478-811X
Contributors: Eun Ji Ro; Yong-Hee Cho; Woo-Jeong Jeong; Jong-Chan Park; Do Sik Min; Kang-Yell Choi
Source: Self-asserted source
Yong-Hee Cho

A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both β-Catenin and RAS

Cancers
2019-04-08 | Journal article
DOI: 10.3390/cancers11040496
Part of ISSN: 2072-6694
Contributors: Won-Ji Ryu; Jae Eun Lee; Yong-Hee Cho; Gunho Lee; Mi-kyoung Seo; Sang-Kyu Lee; Jeong-Ha Hwang; Do Sik Min; Sung Hoon Noh; Soonmyung Paik et al.
Source: Self-asserted source
Yong-Hee Cho
grade
Preferred source (of 2)‎

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

Scientific Reports
2019-01-24 | Journal article
DOI: 10.1038/s41598-018-37059-8
Part of ISSN: 2045-2322
Contributors: Jieun Park; Yong-Hee Cho; Wook-Jin Shin; Sang-Kyu Lee; JaeHeon Lee; Taehyung Kim; Pu-Hyeon Cha; Jee Sun Yang; Jaebeom Cho; Do Sik Min et al.
Source: Self-asserted source
Yong-Hee Cho

β‐Catenin‐ <scp>RAS</scp> interaction serves as a molecular switch for <scp>RAS</scp> degradation via <scp>GSK</scp> 3β

EMBO reports
2018-12 | Journal article
DOI: 10.15252/embr.201846060
Part of ISSN: 1469-221X
Part of ISSN: 1469-3178
Contributors: Sang‐Kyu Lee; Woo‐Jeong Jeong; Yong‐Hee Cho; Pu‐Hyeon Cha; Jeong‐Su Yoon; Eun Ji Ro; Sooho Choi; Jeong‐Min Oh; Yunseok Heo; Hyuntae Kim et al.
Source: Self-asserted source
Yong-Hee Cho

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Experimental &amp; Molecular Medicine
2018-11 | Journal article
DOI: 10.1038/s12276-018-0182-2
Part of ISSN: 1226-3613
Part of ISSN: 2092-6413
Contributors: Sang-Kyu Lee; Yong-Hee Cho; Pu-Hyeon Cha; Jeong-Soo Yoon; Eun Ji Ro; Woo-Jeong Jeong; Jieun Park; Hyuntae Kim; Tae Il Kim; Do Sik Min et al.
Source: Self-asserted source
Yong-Hee Cho

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

Experimental &amp; Molecular Medicine
2018-06 | Journal article
DOI: 10.1038/s12276-018-0102-5
Part of ISSN: 1226-3613
Part of ISSN: 2092-6413
Contributors: Wookjin Shin; Sang-Kyu Lee; Jeong-Ha Hwang; Jong-Chan Park; Yong-Hee Cho; Eun Ji Ro; Yeonhwa Song; Haeng Ran Seo; Kang-Yell Choi
Source: Self-asserted source
Yong-Hee Cho

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

Oncotarget
2016-12-06 | Journal article
DOI: 10.18632/oncotarget.13172
Part of ISSN: 1949-2553
Contributors: Yong-Hee Cho; Pu-Hyeon Cha; Saluja Kaduwal; Jong-Chan Park; Sang-Kyu Lee; Jeong-Soo Yoon; Wookjin Shin; Hyuntae Kim; Eun Ji Ro; Kyung-Hwa Koo et al.
Source: Self-asserted source
Yong-Hee Cho

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Nature Chemical Biology
2016-08 | Journal article
DOI: 10.1038/nchembio.2103
Part of ISSN: 1552-4450
Part of ISSN: 1552-4469
Contributors: Pu-Hyeon Cha; Yong-Hee Cho; Sang-Kyu Lee; JaeHeon Lee; Woo-Jeong Jeong; Byoung-San Moon; Ji-Hye Yun; Jee Sun Yang; Sooho Choi; Juyong Yoon et al.
Source: Self-asserted source
Yong-Hee Cho

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells

Journal of Experimental Medicine
2015-07-27 | Journal article
DOI: 10.1084/jem.20141254
Part of ISSN: 1540-9538
Part of ISSN: 0022-1007
Contributors: Dong Woo Kang; Chi Yeol Choi; Yong-Hee Cho; Huasong Tian; Gilbert Di Paolo; Kang-Yell Choi; Do Sik Min
Source: Self-asserted source
Yong-Hee Cho
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