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Proteomics

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Germany

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Employment (2)

Deutsches Zentrum für Neurodegenerative Erkrankungen München: Munich, DE

2013-09-01 to present | Scientist (Neuroproteomics)
Employment
Source: Self-asserted source
Stephan Müller

Helmholtz-Zentrum für Umweltforschung UFZ: Leipzig, DE

2009-07-01 to 2013-05-31 | PhD student (Proteomics)
Employment
Source: Self-asserted source
Stephan Müller

Works (36)

Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

Communications Biology
2024-10-22 | Journal article
DOI: 10.1038/s42003-024-07057-w
Contributors: Seda Yasa; Elisabeth S. Butz; Alessio Colombo; Uma Chandrachud; Luca Montore; Sarah Tschirner; Matthias Prestel; Steven D. Sheridan; Stephan A. Müller; Janos Groh et al.
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Crossref

The late onset Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis

2024-09-16 | Preprint
DOI: 10.1101/2024.09.13.612888
Contributors: Georg Jocher; Stephan A. Müller; Hung-En Hsia; Miranda Lastra Osua; Gözde Özcelik; Laura I. Hofmann; Marlene Aßfalg; Lina Dinkel; Xiao Feng; Kai Schlepckow et al.
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Crossref

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging

Nature Aging
2024-03-22 | Journal article
DOI: 10.1038/s43587-024-00598-z
Contributors: Katalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Nathalie Beaufort; Rainer Malik; Martina Schifferer; Mihail Ivilinov Todorov; Dennis Crusius; Sophie Robinson; Andree Schmidt et al.
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Crossref

Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution

Science Advances
2023-10-27 | Journal article
DOI: 10.1126/sciadv.adi8986
Contributors: Laura M. Bartos; Sabrina V. Kirchleitner; Zeynep Ilgin Kolabas; Stefanie Quach; Alexander Beck; Julia Lorenz; Jens Blobner; Stephan A. Mueller; Selin Ulukaya; Luciano Hoeher et al.
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Crossref

Reactivated endogenous retroviruses promote protein aggregate spreading

Nature Communications
2023-08-18 | Journal article
DOI: 10.1038/s41467-023-40632-z
Contributors: Shu Liu; Stefanie-Elisabeth Heumüller; André Hossinger; Stephan A. Müller; Oleksandra Buravlova; Stefan F. Lichtenthaler; Philip Denner; Ina M. Vorberg
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Crossref

Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions

Nature Metabolism
2023-07-10 | Journal article
DOI: 10.1038/s42255-023-00838-3
Contributors: Yi-Heng Tai; Daniel Engels; Giuseppe Locatelli; Ioanna Emmanouilidis; Caroline Fecher; Delphine Theodorou; Stephan A. Müller; Simon Licht-Mayer; Mario Kreutzfeldt; Ingrid Wagner et al.
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A MICROGLIAL ACTIVITY STATE BIOMARKER PANEL DIFFERENTIATES FTD-GRANULIN AND ALZHEIMER’S DISEASE PATIENTS FROM CONTROLS

2023-06-18 | Preprint
DOI: 10.1101/2023.06.15.545187
Contributors: Ida Pesämaa; Stephan A. Müller; Sophie Robinson; Alana Darcher; Dominik Paquet; Henrik Zetterberg; Stefan F. Lichtenthaler; Christian Haass
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Crossref

Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution

2023-01-27 | Preprint
DOI: 10.1101/2023.01.26.522174
Contributors: Laura M Bartos; Sabrina V Kirchleitner; Zeynep Ilgin Kolabas; Stefanie Quach; Jens Blobner; Stephan A Mueller; Selin Ulukaya; Luciano Hoeher; Izabela Horvath; Karin Wind-Mark et al.
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Crossref

Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae

Nature Communications
2022-11-28 | Journal article
DOI: 10.1038/s41467-022-34538-5
Contributors: Christine Rother; Ruth E. Uhlmann; Stephan A. Müller; Juliane Schelle; Angelos Skodras; Ulrike Obermüller; Lisa M. Häsler; Marius Lambert; Frank Baumann; Ying Xu et al.
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Crossref

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Nature Communications
2021-10-19 | Journal article
DOI: 10.1038/s41467-021-25855-2
Contributors: Shu Liu; André Hossinger; Stefanie-Elisabeth Heumüller; Annika Hornberger; Oleksandra Buravlova; Katerina Konstantoulea; Stephan A. Müller; Lydia Paulsen; Frederic Rousseau; Joost Schymkowitz et al.
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Crossref

OAS1/RNase L executes RIG-I ligand–dependent tumor cell apoptosis

Science Immunology
2021-07-29 | Journal article
DOI: 10.1126/sciimmunol.abe2550
Contributors: Daniel F. R. Boehmer; Simone Formisano; Carina C. de Oliveira Mann; Stephan A. Mueller; Michael Kluge; Philipp Metzger; Meino Rohlfs; Christine Hörth; Lorenz Kocheise; Stefan F. Lichtenthaler et al.
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Crossref

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Nature Communications
2021-02-24 | Journal article
DOI: 10.1038/s41467-021-21428-5
Contributors: Alessio Colombo; Lina Dinkel; Stephan A. Müller; Laura Sebastian Monasor; Martina Schifferer; Ludovico Cantuti-Castelvetri; Jasmin König; Lea Vidatic; Tatiana Bremova-Ertl; Andrew P. Lieberman et al.
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Crossref

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

Journal of Biological Chemistry
2020-09 | Journal article
DOI: 10.1074/jbc.RA120.012601
Contributors: Chek Ziu Koo; Neale Harrison; Peter J. Noy; Justyna Szyroka; Alexandra L. Matthews; Hung-En Hsia; Stephan A. Müller; Johanna Tüshaus; Joelle Goulding; Katie Willis et al.
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Crossref

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

eLife
2020-06-08 | Journal article
DOI: 10.7554/eLife.54083
Contributors: Laura Sebastian Monasor; Stephan A Müller; Alessio Vittorio Colombo; Gaye Tanrioever; Jasmin König; Stefan Roth; Arthur Liesz; Anna Berghofer; Anke Piechotta; Matthias Prestel et al.
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Crossref

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

Journal of Experimental Medicine
2020-05-04 | Journal article
DOI: 10.1084/jem.20191390
Contributors: Maria Inês Cunha; Minhui Su; Ludovico Cantuti-Castelvetri; Stephan A. Müller; Martina Schifferer; Minou Djannatian; Ioannis Alexopoulos; Franziska van der Meer; Anne Winkler; Tjakko J. van Ham et al.
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Crossref

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Nature Neuroscience
2019-10 | Journal article
DOI: 10.1038/s41593-019-0479-z
Contributors: Caroline Fecher; Laura Trovò; Stephan A. Müller; Nicolas Snaidero; Jennifer Wettmarshausen; Sylvia Heink; Oskar Ortiz; Ingrid Wagner; Ralf Kühn; Jana Hartmann et al.
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Crossref

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.

EMBO reports
2019-05 | Journal article
DOI: 10.15252/embr.201948133
PMID: 31061204
PMC: PMC6500957
Contributors: Papadopoulou AA; Müller SA; Mentrup T; Shmueli MD; Niemeyer J; Haug-Kröper M; von Blume J; Mayerhofer A; Feederle R; Schröder B et al.
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.

EMBO molecular medicine
2019-04 | Journal article
DOI: 10.15252/emmm.201809695
PMID: 30833305
PMC: PMC6460357
Contributors: Brummer T; Müller SA; Pan-Montojo F; Yoshida F; Fellgiebel A; Tomita T; Endres K; Lichtenthaler SF
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.

EMBO reports
2019-02 | Journal article
DOI: 10.15252/embr.201846449
PMID: 30733280
Contributors: Niemeyer J; Mentrup T; Heidasch R; Müller SA; Biswas U; Meyer R; Papadopoulou AA; Dederer V; Haug-Kröper M; Adamski V et al.
Source: Self-asserted source
Stephan Müller via Europe PubMed Central
grade
Preferred source (of 2)‎

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Nature neuroscience
2019-01 | Journal article
DOI: 10.1038/s41593-018-0296-9
PMID: 30617257
Contributors: Parhizkar S; Arzberger T; Brendel M; Kleinberger G; Deussing M; Focke C; Nuscher B; Xiong M; Ghasemigharagoz A; Katzmarski N et al.
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor.

Scientific reports
2018-10 | Journal article
DOI: 10.1038/s41598-018-32910-4
PMID: 30279425
PMC: PMC6168507
Contributors: Scilabra SD; Pigoni M; Pravatá V; Schätzl T; Müller SA; Troeberg L; Lichtenthaler SF
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Profound functional and molecular diversity of mitochondria revealed by cell type-specific profiling in vivo

2018-08 | Other
DOI: 10.1101/403774
OTHER-ID:

PPR54227
Contributors: Fecher C; Trovò L; Müller SA; Snaidero N; Wettmarshausen J; Heink S; Ortiz O; Wagner I; Kühn R; Hartmann J et al.
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

CADASIL brain vessels show a HTRA1 loss-of-function profile.

Acta neuropathologica
2018-05 | Journal article
DOI: 10.1007/s00401-018-1853-8
PMID: 29725820
Contributors: Zellner A; Scharrer E; Arzberger T; Oka C; Domenga-Denier V; Joutel A; Lichtenthaler SF; Müller SA; Dichgans M; Haffner C
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome.

Molecular & cellular proteomics : MCP
2018-05 | Journal article
DOI: 10.1074/mcp.ra118.000608
PMID: 29716987
Contributors: Herber J; Njavro J; Feederle R; Schepers U; Müller UC; Bräse S; Müller SA; Lichtenthaler SF
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Proteome Data Improves Protein Function Prediction in the Interactome of Helicobacter pylori.

Molecular & cellular proteomics : MCP
2018-02 | Journal article
DOI: 10.1074/mcp.RA117.000474
PMID: 29414760
PMC: PMC5930399
Contributors: Wuchty S; Müller SA; Caufield JH; Häuser R; Aloy P; Kalkhof S; Uetz P
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

Proteomics
2017-01 | Journal article
DOI: 10.1002/pmic.201600423
PMID: 27991726
Contributors: Serdaroglu A; Müller SA; Schepers U; Bräse S; Weichert W; Lichtenthaler SF; Kuhn PH
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Proteomic Substrate Identification for Membrane Proteases in the Brain.

Frontiers in molecular neuroscience
2016-10 | Journal article
DOI: 10.3389/fnmol.2016.00096
PMID: 27790089
PMC: PMC5062031
Contributors: Müller SA; Scilabra SD; Lichtenthaler SF
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

Molecular neurodegeneration
2016-10 | Journal article
DOI: 10.1186/s13024-016-0134-z
PMID: 27716410
PMC: PMC5053352
Contributors: Pigoni M; Wanngren J; Kuhn PH; Munro KM; Gunnersen JM; Takeshima H; Feederle R; Voytyuk I; De Strooper B; Levasseur MD et al.
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

Matrix biology : journal of the International Society for Matrix Biology
2016-07 | Journal article
DOI: 10.1016/j.matbio.2016.07.004
PMID: 27476612
Contributors: Scilabra SD; Yamamoto K; Pigoni M; Sakamoto K; Müller SA; Papadopoulou A; Lichtenthaler SF; Troeberg L; Nagase H; Kadomatsu K
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.

The Journal of cell biology
2015-11 | Journal article
DOI: 10.1083/jcb.201503128
PMID: 26553928
PMC: PMC4639873
Contributors: Schulz AM; Stutte S; Hogl S; Luckashenak N; Dudziak D; Leroy C; Forné I; Imhof A; Müller SA; Brakebusch CH et al.
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Molecular & cellular proteomics : MCP
2015-07 | Journal article
DOI: 10.1074/mcp.M114.041533
PMID: 26139848
PMC: PMC4597136
Contributors: Dislich B; Wohlrab F; Bachhuber T; Müller SA; Kuhn PH; Hogl S; Meyer-Luehmann M; Lichtenthaler SF
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Stable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori.

Journal of proteomics
2015-05 | Journal article
DOI: 10.1016/j.jprot.2015.05.011
PMID: 25979772
Contributors: Müller SA; Pernitzsch SR; Haange SB; Uetz P; von Bergen M; Sharma CM; Kalkhof S
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Integration of conventional quantitative and phospho-proteomics reveals new elements in activated Jurkat T-cell receptor pathway maintenance.

Proteomics
2014-12 | Journal article
DOI: 10.1002/pmic.201400119
PMID: 25348772
Contributors: Jouy F; Müller SA; Wagner J; Otto W; von Bergen M; Tomm JM
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Identification of new protein coding sequences and signal peptidase cleavage sites of Helicobacter pylori strain 26695 by proteogenomics.

Journal of proteomics
2013-05 | Journal article
DOI: 10.1016/j.jprot.2013.04.036
PMID: 23665149
Contributors: Müller SA; Findeiß S; Pernitzsch SR; Wissenbach DK; Stadler PF; Hofacker IL; von Bergen M; Kalkhof S
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Quantitative proteomics reveals altered expression of extracellular matrix related proteins of human primary dermal fibroblasts in response to sulfated hyaluronan and collagen applied as artificial extracellular matrix.

Journal of materials science. Materials in medicine
2012-09 | Journal article
DOI: 10.1007/s10856-012-4760-x
PMID: 22990618
PMC: PMC3506194
Contributors: Müller SA; van der Smissen A; von Feilitzsch M; Anderegg U; Kalkhof S; von Bergen M
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

RNAcode: robust discrimination of coding and noncoding regions in comparative sequence data.

RNA (New York, N.Y.)
2011-02 | Journal article
DOI: 10.1261/rna.2536111
PMID: 21357752
PMC: PMC3062170
Contributors: Washietl S; Findeiss S; Müller SA; Kalkhof S; von Bergen M; Hofacker IL; Stadler PF; Goldman N
Source: Self-asserted source
Stephan Müller via Europe PubMed Central

Peer review (2 reviews for 2 publications/grants)

Review activity for JoVE. (1)
Review activity for Translational neurodegeneration. (1)
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