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Employment (1)

Maine Medical Center: Portland, ME, US

2007-11-01 to present | Director of Translational Medicine- Senior Scientist (MMCRI)
Employment
Source: Self-asserted source
clifford rosen

Education and qualifications (2)

State University of New York Upstate Medical University: Syracuse, NY, US

1971-09-15 to 1975-06-01 | MD (MD)
Education
Source: Self-asserted source
clifford rosen

University of Maine: Orono, ME, US

1967-09-15 to 1971-06-06 | bs (biochemistry)
Education
Source: Self-asserted source
clifford rosen

Funding (5)

Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism &Energy Balance

2011-09-30 to 2015-06-30 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: 5R24DK092759-04
GRANT_NUMBER: 5R24DK092759-04
Source: Self-asserted source
clifford rosen via DimensionsWizard

Misty: a model for central regulation of bone remodeling

2011-09-01 to 2016-05-31 | Grant
National Institute on Aging (Bethesda, US)
GRANT_NUMBER: 5R01AG040217-04
GRANT_NUMBER: 5R01AG040217-04
Source: Self-asserted source
clifford rosen via DimensionsWizard

Determination of the Mechanisms by which IGFBP-2 Stimulates Bone Remodeling

2011-08-01 to 2016-07-31 | Grant
National Institute of Arthritis and Musculoskeletal and Skin Diseases (Bethesda, US)
GRANT_NUMBER: 5R01AR061164-04
GRANT_NUMBER: 5R01AR061164-04
Source: Self-asserted source
clifford rosen via DimensionsWizard

Interdisciplinary study of marrow adiposity, mineral metabolism,and energy balanc

2009-12-22 to 2011-09-29 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: 1R24DK084970-01
GRANT_NUMBER: 1R24DK084970-01
Source: Self-asserted source
clifford rosen via DimensionsWizard

Genetics of IGF1 and Bone Density: The Role of Nocturnin

1998-07-22 to 2014-06-30 | Grant
National Institute of Arthritis and Musculoskeletal and Skin Diseases (Bethesda, US)
GRANT_NUMBER: 5R01AR045433-15
GRANT_NUMBER: 5R01AR045433-15
Source: Self-asserted source
clifford rosen via DimensionsWizard

Works (32)

Calorie restriction induces mandible bone loss by regulating mitochondrial function

Bone
2025-01 | Journal article
DOI: 10.1016/j.bone.2024.117326
Contributors: Linyi Liu; Phuong T. Le; Victoria E. DeMambro; Tiange Feng; Hanghang Liu; Wangyang Ying; Roland Baron; Clifford J. Rosen
Source: check_circle
Crossref

Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022

The Journal of Clinical Endocrinology & Metabolism
2025-01-15 | Journal article
DOI: 10.1210/clinem/dgae840
Contributors: Alexander O Everhart; Juan P Brito; Bart L Clarke; Jeph Herrin; Pinar Karaca-Mandic; Kurt A Kennel; Nehu Parimi; Clifford J Rosen; Mark Takagi; Rozalina G McCoy
Source: check_circle
Crossref

Atlas of Fshr expression from novel reporter mice

eLife
2025-01-08 | Journal article
DOI: 10.7554/eLife.93413.3
Contributors: Hongqian Chen; Hui-Qing Fang; Jin-Tao Liu; Shi-Yu Chang; Li-Ben Cheng; Ming-Xin Sun; Jian-Rui Feng; Ze-Min Liu; Yong-Hong Zhang; Clifford J Rosen et al.
Source: check_circle
Crossref

Atlas of Fshr expression from novel reporter mice

eLife
2025-01-08 | Journal article
DOI: 10.7554/eLife.93413
Contributors: Hongqian Chen; Hui-Qing Fang; Jin-Tao Liu; Shi-Yu Chang; Li-Ben Cheng; Ming-Xin Sun; Jian-Rui Feng; Ze-Min Liu; Yong-Hong Zhang; Clifford J Rosen et al.
Source: check_circle
Crossref

Correction: Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

eLife
2024-11-11 | Journal article
DOI: 10.7554/eLife.104341
Contributors: Eben G Estell; Phuong T Le; Yosta Vegting; Hyeonwoo Kim; Christiane Wrann; Mary L Bouxsein; Kenichi Nagano; Roland Baron; Bruce M Spiegelman; Clifford J Rosen
Source: check_circle
Crossref

A view on vitamin D: a pleiotropic factor?

Nature Reviews Endocrinology
2024-04 | Journal article
DOI: 10.1038/s41574-023-00942-0
Contributors: Andrea Giustina; Marise Lazaretti-Castro; Adrian R. Martineau; Rebecca S. Mason; Clifford J. Rosen; Inez Schoenmakers
Source: check_circle
Crossref

Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss

Nature Reviews Endocrinology
2023-11 | Journal article
DOI: 10.1038/s41574-023-00879-4
Contributors: Clifford J. Rosen; Mark C. Horowitz
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Crossref

The Multifaceted Roles of Bone Marrow Adipocytes in Bone and Hematopoietic Homeostasis

The Journal of Clinical Endocrinology & Metabolism
2023-11-17 | Journal article
DOI: 10.1210/clinem/dgad355
Contributors: Ziru Li; Clifford J Rosen
Source: check_circle
Crossref

Transcriptomic network analysis of brain and bone reveals shared molecular mechanisms underlying Alzheimer’s Disease and related dementias (ADRD) and Osteoporosis

2023-10-28 | Preprint
DOI: 10.1101/2023.10.26.559969
Contributors: Archana Nagarajan; Jason Laird; Obiadada Ugochukwu; Sjur Reppe; Kaare Gautvik; Ryan D. Ross; David A. Bennett; Clifford Rosen; Douglas P. Kiel; Lenora A. Higginbotham et al.
Source: check_circle
Crossref

Development and biophysical characterization of a humanized FSH–blocking monoclonal antibody therapeutic formulated at an ultra-high concentration

eLife
2023-06-19 | Journal article
DOI: 10.7554/eLife.88898
Contributors: Satish Rojekar; Anusha R Pallapati; Judit Gimenez-Roig; Funda Korkmaz; Farhath Sultana; Damini Sant; Clement M Haeck; Anne Macdonald; Se-Min Kim; Clifford J Rosen et al.
Source: check_circle
Crossref

Development and Biophysical Characterization of a Humanized FSH–Blocking Monoclonal Antibody Therapeutic Formulated at an Ultra–High Concentration

2023-05-11 | Preprint
DOI: 10.1101/2023.05.11.540323
Contributors: Satish Rojekar; Anusha R. Pallapati; Judit Gimenez–Roig; Funda Korkmaz; Farhath Sultana; Damini Sant; Clement Haeck; Anne Macdonald; Se-Min Kim; Clifford J. Rosen et al.
Source: check_circle
Crossref

New Insights into Calorie Restriction Induced Bone Loss

Endocrinology and Metabolism
2023-04-30 | Journal article
DOI: 10.3803/EnM.2023.1673
Contributors: Linyi Liu; Clifford J. Rosen
Source: check_circle
Crossref

PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

eLife
2023-04-26 | Journal article
DOI: 10.7554/eLife.83345
Contributors: Hanghang Liu; Akane Wada; Isabella Le; Phuong T Le; Andrew WF Lee; Jun Zhou; Francesca Gori; Roland Baron; Clifford J Rosen
Source: check_circle
Crossref

The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease

Current Osteoporosis Reports
2023-02 | Journal article
DOI: 10.1007/s11914-022-00763-6
Contributors: Carolyn Chlebek; Clifford J. Rosen
Source: check_circle
Crossref

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

eLife
2023-02-01 | Journal article
DOI: 10.7554/eLife.82537
Contributors: Yi Fan; Ping Lyu; Ruiye Bi; Chen Cui; Ruoshi Xu; Clifford J Rosen; Quan Yuan; Chenchen Zhou
Source: check_circle
Crossref

PTH regulates osteogenesis and suppresses adipogenesis through Zfp 467 in a feed-forward, cyclic AMP-dependent manner

2022-10-10 | Preprint
DOI: 10.1101/2022.10.10.511580
Contributors: Hanghang Liu; Akane Wada; Isabella Le; Phuong T Le; Andrew WF Lee; Jun Zhou; Francesca Gori; Roland Baron; Clifford J. Rosen
Source: check_circle
Crossref

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

2022-09-14 | Preprint
DOI: 10.1101/2022.09.13.507807
Contributors: Yi Fan; Ping Lyu; Ruiye Bi; Chen Cui; Ruoshi Xu; Clifford J. Rosen; Quan Yuan; Chenchen Zhou
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Crossref

EXTENSIVE EXPERTISE IN ENDOCRINOLOGY: My quarter century quest to understand the paradox of marrow adiposity

European Journal of Endocrinology
2022-08-01 | Journal article
DOI: 10.1530/EJE-22-0499
Contributors: Clifford J Rosen
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Crossref

Reply to ‘The emerging evidence for non-skeletal health benefits of vitamin D supplementation in adults’

Nature Reviews Endocrinology
2022-05 | Journal article
DOI: 10.1038/s41574-022-00647-w
Contributors: Roger Bouillon; Despoina Manousaki; Cliff Rosen; Katerina Trajanoska; Fernando Rivadeneira; J. Brent Richards
Source: check_circle
Crossref

Post-acute sequelae of COVID-19: A metabolic perspective

eLife
2022-03-23 | Journal article
DOI: 10.7554/eLife.78200
Contributors: Philipp E Scherer; John P Kirwan; Clifford J Rosen
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Crossref

The health effects of vitamin D supplementation: evidence from human studies

Nature Reviews Endocrinology
2022-02 | Journal article
DOI: 10.1038/s41574-021-00593-z
Contributors: Roger Bouillon; Despoina Manousaki; Cliff Rosen; Katerina Trajanoska; Fernando Rivadeneira; J. Brent Richards
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Crossref

PFAS and Potential Adverse Effects on Bone and Adipose Tissue Through Interactions With PPARγ

Endocrinology
2021-12-01 | Journal article
DOI: 10.1210/endocr/bqab194
Contributors: Andrea B Kirk; Stephani Michelsen-Correa; Cliff Rosen; Clyde F Martin; Bruce Blumberg
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Crossref

Osteoporosis and Dementia: Establishing a Link

Journal of Bone and Mineral Research
2021-11 | Journal article
DOI: 10.1002/jbmr.4431
Contributors: Christine W. Lary; Clifford J. Rosen; Douglas P. Kiel
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Crossref

Higher hospitalization and mortality rates among SARS-CoV-2 infected Persons in Rural America

2021-10-07 | Other
DOI: 10.1101/2021.10.05.21264543
Contributors: Alfred Jerrod Anzalone; Ronald Horswell; Brian Hendricks; San Chu; William Hillegass; William Beasley; Jeremy Harper; Clifford Rosen; Lucio Miele; James McClay et al.
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Crossref

Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Nature Communications
2021-06-07 | Journal article
DOI: 10.1038/s41467-021-23649-0
Contributors: Basel M. Al-Barghouthi; Larry D. Mesner; Gina M. Calabrese; Daniel Brooks; Steven M. Tommasini; Mary L. Bouxsein; Mark C. Horowitz; Clifford J. Rosen; Kevin Nguyen; Samuel Haddox et al.
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Crossref

Emerging insights into the comparative effectiveness of anabolic therapies for osteoporosis

Nature Reviews Endocrinology
2021-01-04 | Journal article
DOI: 10.1038/s41574-020-00426-5
Contributors: Eben G. Estell; Clifford J. Rosen
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Crossref

Saturated and Unsaturated Bone Marrow Lipids Have Distinct Effects on Bone Density and Fracture Risk in Older Adults

Journal of Bone and Mineral Research
2020-12-01 | Journal article
DOI: 10.1002/jbmr.4504
Contributors: Gina N. Woods; Susan K. Ewing; Anne L. Schafer; Vilmundur Gudnason; Sigurdur Sigurdsson; Thomas Lang; Trisha F. Hue; Deborah M. Kado; Eric Vittinghoff; Clifford Rosen et al.
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Systems genetics analyses in Diversity Outbred mice inform human bone mineral density GWAS and identifyQsox1as a novel determinant of bone strength

2020-06-24 | Preprint
DOI: 10.1101/2020.06.24.169839
Contributors: Basel M. Al-Barghouthi; Larry D. Mesner; Gina M. Calabrese; Daniel Brooks; Steven M. Tommasini; Mary L. Bouxsein; Mark C. Horowitz; Clifford J. Rosen; Kevin Nguyen; Samuel Haddox et al.
Source: check_circle
Crossref

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update

The Journal of Clinical Endocrinology & Metabolism
2020-03-01 | Journal article
DOI: 10.1210/clinem/dgaa048
Contributors: Dolores Shoback; Clifford J Rosen; Dennis M Black; Angela M Cheung; M Hassan Murad; Richard Eastell
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Crossref

Early reduced bone formation following burn injury in rats is not inversely related to marrow adiposity

Osteoporosis and Sarcopenia
2019-09 | Journal article
DOI: 10.1016/j.afos.2019.08.001
Contributors: Amina El Ayadi; Ron C. Helderman; Celeste C. Finnerty; David N. Herndon; Clifford J. Rosen; Gordon L. Klein
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Response to Letter to the Editor: “Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline”

The Journal of Clinical Endocrinology & Metabolism
2019-08-01 | Journal article
DOI: 10.1210/jc.2019-00777
Contributors: Richard Eastell; Clifford J Rosen
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Crossref

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline

The Journal of Clinical Endocrinology & Metabolism
2019-05-01 | Journal article
DOI: 10.1210/jc.2019-00221
Contributors: Richard Eastell; Clifford J Rosen; Dennis M Black; Angela M Cheung; M Hassan Murad; Dolores Shoback
Source: check_circle
Crossref

Peer review (2 reviews for 2 publications/grants)

Review activity for International journal of obesity. (1)
Review activity for Nature medicine. (1)
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